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Differential radio-sensitivities of human chromosomes 1 and 2 in one donor in interphase- and metaphase-spreads after 60Co gamma-irradiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Differences in radio-sensitivities of chromosomes have implications in genetic damage, chromosome organization, and chromosome function. Designing research experiments based on our vital findings may bring benefit to radiation-induced risk assessment, therapeutics and development of chromosome specific biomarkers.
Source: BMC Medical Physics - June 16, 2009 Category: Physics Authors: Rupak PathakAdarsh RamakumarUma SubramanianPataje Prasanna Source Type: journals

Prognostic implication of late gadolinium enhancement on cardiac MRI in light chain (AL) amyloidosis on long term follow upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Late gadolinium enhancement is common and is associated with poor long-term survival in light chain amyloidosis, even after adjustment for heart failure class presentation. The prognostic significance of late gadolinium enhancement in this disease may be useful in patient risk-stratification.
Source: BMC Medical Physics - May 5, 2009 Category: Physics Authors: Raymond Q Migrino, Richard Christenson, Aniko Szabo, Megan Bright, Seth Truran and Parameswaran Hari Source Type: journals

Average arterial input function for quantitative dynamic contrast enhanced magnetic resonance imaging of neck nodal metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found no statistically significant overall bias in Ktrans or ve estimates derived from Avg-AIF, generated from a limited population, as compared with Ind-AIFs. However, further study is needed to determine whether calibration is needed across the range of Ktrans. The Avg-AIF obtained from a limited population may be used for pharmacokinetic modeling of DCE-MRI data in larger population studies with neck nodal metastases. Further validation of the Avg-AIF approach with a larger population and in multiple regions is desirable.
Source: BMC Medical Physics - April 7, 2009 Category: Physics Authors: Amita Shukla-Dave, Nancy Lee, Hilda Stambuk, Ya Wang, Wei Huang, Howard T Thaler, Snehal G Patel, Jatin P Shah and Jason A Koutcher Source Type: journals

Bone turnover markers are correlated with total skeletal uptake of 99mTc-methylene diphosphonate (99mTc-MDP)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was done to validate bone turnover markers using total skeletal uptake (TSU) of 99mTc-MDP. Methods: 22 postmenopausal women (52-80 years) volunteered to participate. Scintigraphy was performed by injecting 520 MBq of 99mTc-MDP and taking whole body images after 3 minutes, and 5 hours. TSU was calculated from these two images by taking into account the urinary loss and soft tissue uptake. Bone turnover markers used were bone specific alkaline phosphatase (S-Bone ALP), three different assays for serum osteocalcin (OC), tartrate resistant acid phosphatase 5b (S-TRACP5b), serum C-terminal cross-linked telopeptides ...
Source: BMC Medical Physics - March 30, 2009 Category: Physics Authors: Janaka Lenora, Kristina Norrgren, Ola Thorsson, Per Wollmer, Karl J. Obrant and Kaisa K. Ivaska Source Type: journals

Repeatability of regional myocardial blood flow calculation in 82-Rb PET imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of the study show that software calculation of MBF and CFR with Rb-82 myocardial PET imaging is highly repeatable for global values and has good repeatability for regional values.
Source: BMC Medical Physics - January 29, 2009 Category: Physics Authors: Karin Knesaurek, Josef Machac and Zhuangyu Zhang Source Type: journals

Repeatability of regional myocardial blood flow calculation in 82Rb PET imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results of the study show that software calculation of MBF and CFR with 82Rb myocardial PET imaging is highly repeatable for global values and has good repeatability for regional values.
Source: BMC Medical Physics - January 29, 2009 Category: Physics Authors: Karin Knešaurek, Josef Machac and Zhuangyu Zhang Source Type: journals

Chemotherapeutic Treatment Efficacy and Sensitivity are Increased by Adjuvant Alternating Electric Fields (TTFields)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that combining chemotherapeutic cancer treatment with TTFields may increase chemotherapeutic efficacy and sensitivity without increasing treatment related toxicity.
Source: BMC Medical Physics - January 8, 2009 Category: Physics Authors: Eilon D Kirson, Rosa S Schneiderman, Vladimir Dbaly, Frantisek Tovarys, Josef Vymazal, Aviran Itzhaki, Daniel Mordechovich, Zoya Gurvich, Esther Shmueli, Dorit Goldsher, Yoram Wasserman and Yoram Palti Source Type: journals

Multiple window spatial registration error of a gamma camera: 133-Ba point source as a replacement of the NEMA procedureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The 133Ba point source method measures the multiple window spatial registration error with essentially the same accuracy as the NEMA-recommended procedure, but is easier and safer to use and has the potential to replace the current standard procedure.
Source: BMC Medical Physics - December 9, 2008 Category: Physics Authors: Helmar Bergmann, Gregory Minear, Maria Raith and Peter M Schaffarich Source Type: journals

Influence of increased target dose inhomogeneity on margins for breathing motion compensation in conformal stereotactic body radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Treatment planning with inhomogeneous dose distributions in the target volume required smaller margins for compensation of breathing induced target motion with the consequence of lower doses to the surrounding organs-at-risk.
Source: BMC Medical Physics - December 3, 2008 Category: Physics Authors: Anne Richter, Kurt Baier, Jurgen Meyer, Jurgen Wilbert, Thomas Krieger, Michael Flentje and Matthias Guckenberger Source Type: journals

Determinants of Vaccination Coverage in Rural NigeriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this survey was to assess vaccination coverage and its determinants in this rural community in Nigeria Methods: A cross-sectional survey was conducted in September 2006, which included the use of interviewer-administered questionnaire to assess knowledge of mothers of children aged 12-23 months and vaccination coverage. Survey participants were selected following the World Health Organization's (WHO) immunization coverage cluster survey design. Vaccination coverage was assessed by vaccination card and maternal history. A child was said to be fully immunized if he or she had received all of the following va...
Source: BMC Medical Physics - November 5, 2008 Category: Physics Authors: Olumuyiwa O Odusanya, Ewan F Alufohai, Francois P Meurice and Vincent I Ahonkhai Source Type: journals

NEOadjuvant therapy monitoring with PET and CT in Esophageal Cancer (NEOPEC-trial)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to compare FDG-PET and CT-scan for the early prediction of non-response to preoperative chemoradiotherapy in patients with potentially curable esophageal cancer. Methods/design: Prognostic accuracy study, embedded in a randomized multicenter Dutch trial comparing neoadjuvant chemoradiotherapy for 5 weeks followed by surgery versus surgery alone for esophageal cancer. This prognostic accuracy study is performed only in the neoadjuvant arm of the randomized trial. In 6 centers, 150 consecutive patients will be included over a 3 year period. FDG-PET and CT-scan will be performed before and 2 weeks after the st...
Source: BMC Medical Physics - July 31, 2008 Category: Physics Authors: Mark van Heijl, Jikke M.T. Omloo, Mark I. van Berge Henegouwen, Olivier R.C. Busch, Hugo W. Tilanus, Patrick M.M. Bossuyt, Otto S. Hoekstra, Jaap Stoker, Maarten C.C.M. Hulshof, Ate van der Gaast, Grard A.P. Nieuwenhuijzen, Han J. Bonenkamp, John TH.M. Pl Source Type: journals

A computerized Infusion Pump for control of tissue tracer concentration during Positron Emission Tomography in vivo Pharmacokinetic/Pharmacodynamic measurementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The UIPump-system is suitable for use in PET-research for assessment of PK/PD properties by simulation of different tracer tissue kinetics in vivo.
Source: BMC Medical Physics - May 30, 2008 Category: Physics Authors: Olof Eriksson, Andreas Wallberg, Stina Syvänen, Raymond Josephsson, Bengt Långström and Mats Bergström Source Type: journals

Perfusion scanning using 99mTc-HMPAO detects early cerebrovascular changes in the diabetic ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: 99mTc-HMPAO brain scan may be useful in the detection of early atherosclerotic changes in the diabetic rat brain.
Source: BMC Medical Physics - March 13, 2008 Category: Physics Authors: Fatma J Al-Saeedi Source Type: journals

Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET imagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The computer-assisted lateralization of TLE using ZPET provides an accurate, fast and objective way of seizure evaluation.
Source: BMC Medical Physics - November 2, 2007 Category: Physics Authors: Ching-yee Oliver Wong, James Gannon, Jeffrey Bong, Christiana O Wong and Gopal B Saha Source Type: journals

Comparison of 2D, 3D high dose and 3D low dose gated myocardial 82Rb PET imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: 2D and 3D HD gating Rb-82 PET cardiac studies have similar contrast, ejection fractions and noise levels. 3D LD gating imaging, gave comparable results in terms of contrast, EF and noise to either 2D or 3D HD gating PET imaging. 3D LD PET gated imaging can make Rb-82 PET cardiac imaging more affordable with significantly less radiation exposure to the patients.
Source: BMC Medical Physics - October 22, 2007 Category: Physics Authors: Karin Knešaurek, Josef Machac and Jong Ho Kim Source Type: journals

Toxicology evaluation of radiotracer doses of 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) for human PET imaging: Laboratory analysis of serial blood samples and comparison to previously investigated therapeutic FLT dosesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study shows no evidence of toxicity or complications attributable to 18F-FLT injected intravenously.
Source: BMC Medical Physics - July 3, 2007 Category: Physics Authors: Eric Turcotte, Linda W Wiens, John R Grierson, Lanell M Peterson, Mark H Wener and Hubert Vesselle Source Type: journals

Comparison of manual and semi-automated delineation of regions of interest for radioligand PET imaging analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: SABRE demonstrated significant time savings and no significant difference in reproducibility over manual methods, justifying the use of SABRE in serotonin 1a receptor radioligand PET imaging analysis. This implies that semi-automated ROI delineation is a valid methodology for future PET imaging analysis.
Source: BMC Medical Physics - January 29, 2007 Category: Physics Authors: Tiffany W Chow, Shinichiro Takeshita, Kie Honjo, Christina E Pataky, Peggy L St Jacques, Maggie L Kusano, Curtis B Caldwell, Joel Ramirez, Sandra Black and Nicolaas PLG Verhoeff Source Type: journals

Variation in heart rate influences the assessment of transient ischemic dilation in myocardial perfusion scintigraphyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Normal variation in heart rate between the stress and rest components of myocardial perfusion scans is common and can influence TID ratios in patients with normal and abnormal cardiac scans.
Source: BMC Medical Physics - January 11, 2007 Category: Physics Authors: William D Leslie, Daniel P Levin and Sandor J Demeter Source Type: journals

Comparison of 18F SPECT with PET in myocardial imaging: A realistic thorax-cardiac phantom studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: For smaller defects the 99mTc/18F SPECT imaging cannot entirely replace the more expensive 82Rb/18F PET for myocardial perfusion/viability imaging, due to poorer image spatial resolution and poorer defect contrast.
Source: BMC Medical Physics - October 31, 2006 Category: Physics Authors: Karin Knešaurek and Josef Machac Source Type: journals

A statistical investigation of normal regional intra-subject heterogeneity of brain metabolism and perfusion by F-18 FDG and O-15 H2O PET imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The co-registered cerebral metabolism and perfusion z maps demonstrated regional heterogeneity but with attractively low coefficient of variations in the correlation markers.
Source: BMC Medical Physics - July 12, 2006 Category: Physics Authors: Ching-yee Oliver Wong, Joseph Thie, Marianne Gaskill, Richard Ponto, Jack Hill, Hai-yan Tian, Helena Balon, Dafang Wu, Darlene Fink-Bennett and Conrad Nagle Source Type: journals

Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: a histopathological correlationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: PET FDG activity correlated with macrophage content within aortic atherosclerosis. This imaging approach might serve as a useful non-invasive imaging technique and potentially permit monitoring of relative changes in inflammation within the atherosclerotic lesion.
Source: BMC Medical Physics - May 25, 2006 Category: Physics Authors: Zhuangyu Zhang, Josef Machac, Gerard Helft, Stephen G Worthley, Cheuk Tang, Azfar G Zaman, Oswaldo J Rodriguez, Monte S Buchsbaum, Valentin Fuster and Juan J Badimon Source Type: journals