Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss
Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association... (Source: BMC Medicine)
Source: BMC Medicine - March 26, 2024 Category: Internal Medicine Authors: Sang-Hyuk Jung, Young Chan Lee, Manu Shivakumar, Jaeyoung Kim, Jae-Seung Yun, Woong-Yang Park, Hong-Hee Won and Dokyoon Kim Tags: Research article Source Type: research

A phase II study of belumosudil for chronic graft-versus-host disease in patients who failed at least one line of systemic therapy in China
Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhib... (Source: BMC Medicine)
Source: BMC Medicine - March 26, 2024 Category: Internal Medicine Authors: Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang and Ying Zhang Tags: Research article Source Type: research

SARS-CoV-2, influenza A/B and respiratory syncytial virus positivity and association with influenza-like illness and self-reported symptoms, over the 2022/23 winter season in the UK: a longitudinal surveillance cohort
Syndromic surveillance often relies on patients presenting to healthcare. Community cohorts, although more challenging to recruit, could provide additional population-wide insights, particularly with SARS-CoV-... (Source: BMC Medicine)
Source: BMC Medicine - March 26, 2024 Category: Internal Medicine Authors: Elisabeth Dietz, Emma Pritchard, Koen Pouwels, Muhammad Ehsaan, Joshua Blake, Charlotte Gaughan, Eric Haduli, Hugh Boothe, Karina-Doris Vihta, Tim Peto, Nicole Stoesser, Philippa Matthews, Nick Taylor, Ian Diamond, Ruth Studley, Emma Rourke & hellip; Tags: Research article Source Type: research

Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses
Childhood maltreatment is common globally and impacts morbidity, mortality, and well-being. Our understanding of its impact is constrained by key substantive and methodological limitations of extant research, ... (Source: BMC Medicine)
Source: BMC Medicine - March 25, 2024 Category: Internal Medicine Authors: Ana Lucia Espinosa Dice, Rebecca B. Lawn, Andrew Ratanatharathorn, Andrea L. Roberts, Christy A. Denckla, Ariel H. Kim, Pedro A. de la Rosa, Yiwen Zhu, Tyler J. VanderWeele and Karestan C. Koenen Tags: Research article Source Type: research

Association between inflammatory bowel disease and cancer risk: evidence triangulation from genetic correlation, Mendelian randomization, and colocalization analyses across East Asian and European populations
Inflammatory bowel disease (IBD), which includes Crohn ’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have bee... (Source: BMC Medicine)
Source: BMC Medicine - March 25, 2024 Category: Internal Medicine Authors: Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li and Youxin Wang Tags: Research article Source Type: research

Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer ’s disease
Synaptic dysfunction with reduced synaptic protein levels is a core feature of Alzheimer ’s disease (AD). Synaptic proteins play a central role in memory processing, learning, and AD pathogenesis. Evidence sugg... (Source: BMC Medicine)
Source: BMC Medicine - March 25, 2024 Category: Internal Medicine Authors: Huimin Cai, Yana Pang, Ziye Ren, Xiaofeng Fu and Longfei Jia Tags: Research article Source Type: research

Evaluation of a hospital-initiated tobacco dependence treatment service: uptake, smoking cessation, readmission and mortality
The National Health Service in England aims to implement tobacco dependency treatment services in all hospitals by 2024. We aimed to assess the uptake of a new service, adapted from the Ottawa Model of Smoking... (Source: BMC Medicine)
Source: BMC Medicine - March 25, 2024 Category: Internal Medicine Authors: John Robins, Irem Patel, Ann McNeill, John Moxham, Arran Woodhouse, Gareth Absalom, Buljana Shehu, Geraldine Bruce, Amy Dewar, Alanna Molloy, Stephanie Duckworth Porras, Michael Waring, Andrew Stock and Debbie Robson Tags: Research article Source Type: research

Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity
It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring... (Source: BMC Medicine)
Source: BMC Medicine - March 25, 2024 Category: Internal Medicine Authors: Aylin Rosberg, Harri Merisaari, John D. Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M. Rasmussen, Noora M. Scheinin, Linnea Karlsson, Hasse Karlsson and Jetro J. Tuulari Tags: Research article Source Type: research

Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort study
There is a growing population of children with in utero HIV exposure who are at risk of poor neurodevelopmental outcomes despite avoiding HIV infection. However, the underlying neurobiological pathways are not... (Source: BMC Medicine)
Source: BMC Medicine - March 22, 2024 Category: Internal Medicine Authors: Catherine J. Wedderburn, Shunmay Yeung, Sivenesi Subramoney, Jean-Paul Fouche, Shantanu H. Joshi, Katherine L. Narr, Andrea M. Rehman, Annerine Roos, Diana M. Gibb, Heather J. Zar, Dan J. Stein and Kirsten A. Donald Tags: Research article Source Type: research

Regional disparities and risk factors of mortality among patients at high risk of sudden cardiac death in emerging countries: a nonrandomized controlled trial
Comprehensive data on patients at high risk of sudden cardiac death (SCD) in emerging countries are lacking. The aim was to deepen our understanding of the SCD phenotype and identify risk factors for death amo... (Source: BMC Medicine)
Source: BMC Medicine - March 22, 2024 Category: Internal Medicine Authors: Shuang Zhao, Chi-Keong Ching, Dejia Huang, Yen-Bin Liu, Diego A. Rodriguez-Guerrero, Azlan Hussin, Young-Hoon Kim, Brian Van Dorn, Xiaohong Zhou, Balbir Singh and Shu Zhang Tags: Research article Source Type: research

Progress with the Learning Health System 2.0: a rapid review of Learning Health Systems ’ responses to pandemics and climate change
Pandemics and climate change each challenge health systems through increasing numbers and new types of patients. To adapt to these challenges, leading health systems have embraced a Learning Health System (LHS... (Source: BMC Medicine)
Source: BMC Medicine - March 22, 2024 Category: Internal Medicine Authors: Carolynn L. Smith, Georgia Fisher, Putu Novi Arfirsta Dharmayani, Shalini Wijekulasuriya, Louise A. Ellis, Samantha Spanos, Genevieve Dammery, Yvonne Zurynski and Jeffrey Braithwaite Tags: Research article Source Type: research

Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies
The impact of sodium intake on cardiovascular disease (CVD) health and mortality has been studied for decades, including the well-established association with blood pressure. However, non-linear patterns, dose... (Source: BMC Medicine)
Source: BMC Medicine - March 22, 2024 Category: Internal Medicine Authors: Lu Gan, Bin Zhao, Maki Inoue-Choi, Linda M. Liao, Barry I. Graubard, Stephanie J. Weinstein, Demetrius Albanes and Jiaqi Huang Tags: Research article Source Type: research

Sarcopenic obesity is part of obesity paradox in dementia development: evidence from a population-based cohort study
Sarcopenic obesity, a clinical and functional condition characterized by the coexistence of obesity and sarcopenia, has not been investigated in relation to dementia risk and its onset. (Source: BMC Medicine)
Source: BMC Medicine - March 22, 2024 Category: Internal Medicine Authors: Junhan Zhang, Xiaona Na, Zhihui Li, John S. Ji, Guowei Li, Haibing Yang, Yucheng Yang, Yuefeng Tan, Jian Zhang, Menglu Xi, Donghan Su, Huatang Zeng, Liqun Wu and Ai Zhao Tags: Research article Source Type: research

Incidence of new-onset hypertension before, during, and after the COVID-19 pandemic: a 7-year longitudinal cohort study in a large population
While the augmented incidence of diabetes after COVID-19 has been widely confirmed, controversial results are available on the risk of developing hypertension during the COVID-19 pandemic. (Source: BMC Medicine)
Source: BMC Medicine - March 19, 2024 Category: Internal Medicine Authors: Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Ugo Trama, Maria Virginia Manzi, Angela Lombardi, Roberto Piccinocchi, Paola Gallo, Giovanni Esposito, Gaetano Piccinocchi, Maria Lembo, Carmine Morisco, Francesco Rozza, Gaetano Santulli and Bruno Trima Tags: Research article Source Type: research

SARS-CoV-2 infection is detrimental to pregnancy outcomes after embryo transfer in IVF/ICSI: a prospective cohort study
To explore whether SARS-CoV-2 infection affects the pregnancy outcomes of assisted reproductive techniques (ART). (Source: BMC Medicine)
Source: BMC Medicine - March 18, 2024 Category: Internal Medicine Authors: Yuan Li, Qi Zhao, Shujuan Ma, Sha Tang, Guangxiu Lu, Ge Lin and Fei Gong Tags: Research article Source Type: research