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Comparing unilateral and bilateral upper limb training: The ULTRA-stroke program designEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionULTRA-stroke is a 3-year translational research program which aims (1) to assess the relative effectiveness of the three interventions, on a group level but also as a function of patient characteristics, and (2) to delineate the functional and neurophysiological changes that are induced by those interventions.The outcome on the ARAT together with information about changes in the associated mechanisms will provide a better understanding of how specific therapies influence neurobiological changes, and which post-stroke conditions lend themselves to specific treatments.The ULTRA-stroke program is registered at the N...
Source: BMC Neurology - November 6, 2009 Category: Neurology Authors: A. (Lex) van DeldenC. (Lieke) PeperJaap HarlaarAndreas DaffertshoferNienke ZijpKirsten NienhuysPeter KoppeGert KwakkelPeter Beek Source Type: journals

Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this NMO case report we wanted to emphasize the extensiveness of inflammatory spinal cord changes in our patient, from C2 level to conus. In the conclusion it is important to say that accurate, early diagnosis and distinction from MS is critical to facilitate initiation of immunosuppressive therapy for attack prevention. (Source: BMC Neurology)
Source: BMC Neurology - October 22, 2009 Category: Neurology Authors: Zeljka Petelin GadzeSanja HajnsekSilvio BasicDavor SporisGoran PavlisaSibila Nankovic Source Type: journals

Systematic review of pharmacological treatments in fragile X syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Currently there is no robust evidence to support recommendations on pharmacological treatments in patients with FXS in general or in those with an additional diagnosis of ADHD or autism. (Source: BMC Neurology)
Source: BMC Neurology - October 12, 2009 Category: Neurology Authors: Jose-Ramon RuedaJavier BallesterosMaria-Isabel Tejada Source Type: journals

Neutralizing antibodies explain the poor clinical response to Interferon beta in a small proportion of patients with Multiple Sclerosis: a retrospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Neutralizing antibodies (NAbs) against Interferon beta (IFNbeta) are reported to be associated with poor clinical response to therapy in multiple sclerosis (MS) patients. We aimed to quantify the contribution of NAbs to the sub-optimal response of IFNbeta treatment. Methods: We studied the prevalence of NAbs in MS patients grouped according to their clinical response to IFNbeta during the treatment period. Patients were classified as: group A, developing [greater than or equal to]1 relapse after the first 6 months of therapy; group B, exhibiting confirmed disability progression after the first 6 months of thera...
Source: BMC Neurology - October 12, 2009 Category: Neurology Authors: Emilia SbardellaValentina TomassiniClaudio GasperiniFrancesca BellomiLuca Ausili CefaroVincenzo Brescia MorraGuido AntonelliCarlo Pozzilli Source Type: journals

Oxidative stress and S-100B protein in children with bacterial meningitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Bacterial meningitis is often associated with cerebral compromise which may be responsible for neurological sequelae in nearly half of the survivors. Little is known about the mechanisms of CNS involvement in bacterial meningitis. Several studies have provided substantial evidence for the key role of nitric oxide (NO) and reactive oxygen species in the complex pathophysiology of bacterial meningitis. Methods: In the present study, serum and CSF levels of NO, lipid peroxide (LPO) (mediators for oxidative stress and lipid peroxidation); total thiol, superoxide dismutase (SOD) (antioxidant mediators) and S-100B pr...
Source: BMC Neurology - October 7, 2009 Category: Neurology Authors: Sherifa HamedEnas HamedMadeha Zakhary Source Type: journals

Upper limbs dysmetria caused by cervical spinal cord injury: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Sudden onset of upper limbs dysmetria is a sign of dysfunction in cerebellum and its associated pathway. However, lesion in spinal cord can also cause cerebellar signs such as dysmetria. (Source: BMC Neurology)
Source: BMC Neurology - September 23, 2009 Category: Neurology Authors: Hsun-Chang LinChun-Hung ChenGim-Thean KhorPoyin Huang Source Type: journals

Determinants of participation restriction among community dwelling stroke survivors: A path analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Identification of stroke survivors at risk of high levels of participation restriction, depressive symptoms and low self-esteem will assist health professionals to devise appropriate rehabilitation interventions that target improving both physical and psychosocial functioning. (Source: BMC Neurology)
Source: BMC Neurology - September 6, 2009 Category: Neurology Authors: Janita ChauDavid ThompsonSheila TwinnAnne ChangJean Woo Source Type: journals

Population normative data for the 10/66 Dementia Research Group cognitive test battery from Latin America, India and China: a cross-sectional surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cognitive assessment is a basic element for dementia diagnosis. Age- and education-specific norms are required for this purpose, while the effect of gender can probably be ignored. The basis of cultural effects is poorly understood, but our findings serve to emphasise that normative data may not be safely generalised from one population to another with quite different characteristics. The minimal effects of region on COGSCORE and WLR are reassuring with respect to the cross-cultural validity of the 10/66 dementia diagnosis, which uses only these elements of the 10/66 battery. (Source: BMC Neurology)
Source: BMC Neurology - August 25, 2009 Category: Neurology Authors: Ana SosaEmiliano AlbaneseMartin PrinceDaisy AcostaCleusa FerriMariella GuerraYueqin HuangK JacobJuan Llibre de RodriguezAquiles SalasFang YangCiro GaonaA JoteeshwaranGuillermina RodriguezGabriela Rojas de la TorreJoseph WilliamsRobert Stewart Source Type: journals

Quality of Life as an outcome in Alzheimer's disease and other dementias - obstacles and goalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionOutcome model variables such as quality of life (QoL) or health care resource utilization require the patient to appraise their own well-being or third parties to set preferences. In Alzheimer's disease and other dementias the evaluation process performed by the patient is subject to the disease process itself because over progress of the disease neuroanatomical structures are affected that mediate evaluation processes.SummaryPublished research and methodological considerations thus lead to the conclusion that current QoL-instruments, which have been useful in other contexts, are ill-suited and insufficiently val...
Source: BMC Neurology - August 24, 2009 Category: Neurology Authors: Matthias RiepeThomas MittendorfHans ForstlLutz FrolichMartin HauptReiner LeidlChristoph VauthMatthias Graf von der Schulenburg Source Type: journals

Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although no active hit has been identified, the present study demonstrates the feasibility of using a cell-based approach to HTS for FRDA. Furthermore, it highlights the difficulty in the development of a stable frataxin-deficient cell model, an essential condition for productive HTS in the future. (Source: BMC Neurology)
Source: BMC Neurology - August 23, 2009 Category: Neurology Authors: Nadege CalmelsHerve SeznecPascal VillaLaurence ReutenauerMarcel HibertJacques HaiechPierre RustinMichel KoenigHelene Puccio Source Type: journals

Protocol for the saMS trial (supportive adjustment for multiple sclerosis): A randomized controlled trial comparing cognitive behavioral therapy to supportive listening for adjustment to multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThis trial is distinctive in its aims in that it aids adjustment to MS in a broad sense. It is not a treatment specifically for depression. Use of nurses as therapists makes the interventions potentially viable in terms of being rolled out in the NHS. The trial benefits from incorporating patient input in the development and evaluation stages. The trial will provide important information about the efficacy, cost-effectiveness and acceptability of the interventions as well as mechanisms of psychosocial adjustment.Trial registration: Current Controlled Trials ISRCTN91377356 (Source: BMC Neurology)
Source: BMC Neurology - August 22, 2009 Category: Neurology Authors: Rona Moss-MorrisLaura DennisonLucy YardleySabine LandauSuzanne RochePaul McCroneTrudie Chalder Source Type: journals

Clinical presentation and diffusion weighted MRI of acute cerebral infarction. The Bergen Stroke StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: No large study has compared the yield of diffusion-weighted imaging (DWI) with clinical examination in order to differentiate lacunar stroke from other stroke subtypes. This differentiation is important for guiding further investigations and treatment. Methods: Consecutive patients admitted with cerebral infarction were classified according to the Oxfordshire Community Stroke Project scale. Based on DWI and CT stroke was classified as lacunar (LI) and non-lacunar (NLI). Acute ischemic lesion (Source: BMC Neurology)
Source: BMC Neurology - August 17, 2009 Category: Neurology Authors: Halvor NaessJan BroggerTitto IdiculaUlrike Waje-AndreassenGunnar MoenLars Thomassen Source Type: journals

Clinical presentation and diffusion weighted MRI of acute cerebral infarction. The Bergen Stroke Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: No large study has compared the yield of diffusion-weighted imaging (DWI) with clinical examination in order to differentiate lacunar stroke from other stroke subtypes. This differentiation is important for guiding further investigations and treatment. Methods: Consecutive patients admitted with cerebral infarction were classified according to the Oxfordshire Community Stroke Project scale. Based on DWI and CT stroke was classified as lacunar (LI) and non-lacunar (NLI). Acute ischemic lesion (Source: BMC Neurology)
Source: BMC Neurology - August 17, 2009 Category: Neurology Authors: Halvor NaessJan BroggerTitto IdiculaUlrike Waje-AndreassenGunnar MoenLars Thomassen Source Type: journals

Cost-effectiveness of a structured progressive task-oriented circuit class training programme to enhance walking competency after stroke: The protocol of the FIT-Stroke trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is registered in the Dutch Trial Register as NTR1534. (Source: BMC Neurology)
Source: BMC Neurology - August 12, 2009 Category: Neurology Authors: Ingrid van de PortLotte WeversHanneke RoelseLenneke van KatsEline LindemanGert Kwakkel Source Type: journals

Fluorodeoxyglucose-Positron Emission Tomography in the differential diagnosis of early-onset dementia: a prospective, community-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The high specificity of FDG-PET suggests this technique might help in the diagnosis of frontotemporal dementia and other forms of early-onset dementia. (Source: BMC Neurology)
Source: BMC Neurology - August 11, 2009 Category: Neurology Authors: Peter PanegyresJeffrey RogersMichael McCarthyAndrew CampbellJing Wu Source Type: journals

Can cognitive enhancers reduce the risk of falls in older people with Mild Cognitive Impairment? A protocol for a randomised controlled double blind trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study may contribute to a new approach to prevent and treat fall risk in seniors in early stages of dementia.Trial Registration: The protocol for this study is registered with the Clinical Trials Registry, identifier number: NCT00934531 (www.clinicaltrials.gov) (Source: BMC Neurology)
Source: BMC Neurology - August 11, 2009 Category: Neurology Authors: Manuel Montero-OdassoJennie WellsMichael BorrieMark Speechley Source Type: journals

Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Alleles of these 5 functional polymorphisms of MMPs seem not to be associated with structural alterations in the blood vessel wall of sCAD patients. However, this does not exclude a pathogenetic role for MMPs in sCAD via secondary factors such as cytokines that are able to induce these enzymes in cervical blood vessel walls. (Source: BMC Neurology)
Source: BMC Neurology - August 8, 2009 Category: Neurology Authors: Armin BussKatrin PechSusanne RoelverBrunhilde BloemekeChristoph KlotzschSebastian Breuer Source Type: journals

Scleroderma linearis: hemiatrophia faciei progressiva (Parry-Romberg syndrom) without any changes in CNS and linear scleroderma "en coup de sabre" with CNS tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We described typical cases of a rare diseases, hemifacial atrophy and "en coup de sabre" scleroderma. In the patient diagnosed with Parry-Romberg syndrome, with Borrelia burgdoferi infection and with minor neurological symptoms, despite a four-year case history, there was a lack of proper diagnosis and treatment.In the second patient only skin changes without any neurological symptoms could be observed and only a precise neurological diagnosis revealed the presence of CNS tumor. (Source: BMC Neurology)
Source: BMC Neurology - July 26, 2009 Category: Neurology Authors: Beata Bergler-CzopAnna Lis-SwietyLigia Brzezinska-Wcislo Source Type: journals

Optimal cut-off criteria for duplex ultrasound for the diagnosis of restenosis in stented carotid arteries: review and protocol for a diagnostic studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionTo address the deficiencies of the existing studies, we propose a prospective cohort study nested within the International Carotid Stenting Study (ICSS), an international multi-centre trial in which over 1,700 patients have been randomised between stenting and CEA. In this cohort we will enrol a minimum of 300 patients treated with a stent. All patients undergo regular DUS examination at the yearly follow-up visit according to the ICSS protocol. To avoid verification bias, an additional computed tomography angiography (CTA) will be performed as a reference test in all consecutive patients, regardless the degree o...
Source: BMC Neurology - July 21, 2009 Category: Neurology Authors: Paul NederkoornMartin Brown Source Type: journals

An analysis of Methylenetetrahydrofolate reductase and Glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study shows no major gene effect of either the MTHFR or GSTO-1 genes as a modifier of ischemic stroke volume. However, given the relatively small sample size, a minor gene effect is not excluded by this investigation. (Source: BMC Neurology)
Source: BMC Neurology - July 21, 2009 Category: Neurology Authors: Leema Reddy PeddareddygariAna Virginia DutraMark LevenstienSouvik SenRaji Grewal Source Type: journals

Exercise intervention to prevent falls and enhance mobility in community dwellers after stroke: a protocol for a randomised controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to establish and evaluate community-based sustainable exercise programs for stroke survivors. We will determine the effects of the exercise programs in preventing falls and enhancing mobility among people following stroke. This program, if found to be effective, has the potential to be implemented within existing community services.Trial registration: The protocol for this study is registered with the Australian New Zealand Clinical Trials Registry ACTRN12606000479505. (Source: BMC Neurology)
Source: BMC Neurology - July 21, 2009 Category: Neurology Authors: Catherine DeanChris RisselMichelle SharkeyCatherine SherringtonRobert CummingRuth BarkerStephen LordSandra O'RourkeCatherine Kirkham Source Type: journals

Retrospective analysis of treatment outcome in 315 patients with oligodendroglial brain tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Although chemotherapy with procarbazine, lomustine and vincristine (PCV) is considered to be well tolerated, side effects frequently lead to dose reduction or even discontinuation of treatment of oligodenrdroglial brain tumors. Methods: The primary objective of the analysis was to retrospectively compare progression-free survival (PFS) after PCV vs. PC chemotherapy (without vincristine to avoid side effects). Patients were retrospectively identified from an database containing our patients between 1990 and 2003. For the selected cases, all histopathology reports were re-evaluated by a local neuropathologist. Ba...
Source: BMC Neurology - July 15, 2009 Category: Neurology Authors: Jan VesperErika GrafJohannes TilgnerMichael TrippelChristian WilleGuido NikkhahChristoph Ostertag Source Type: journals

Getting the balance right: A randomised controlled trial of physiotherapy and exercise interventions for ambulatory people with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionData analysis will analyse change in each group, and the differences between groups. Sub group analysis may be performed if sufficient numbers are recruited.Trial registration number: ISRCTN77610415 (Source: BMC Neurology)
Source: BMC Neurology - July 15, 2009 Category: Neurology Authors: Susan CooteMaria GarrettNeasa HoganAidan LarkinJean Saunders Source Type: journals

NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NG2 and phosphacan were both present in the evolving astroglial scar and, therefore, might play an important role in the blockade of successful CNS regeneration. Neurocan and versican, however, were located at the lesion epicentre, associated with Schwann cell myelin on regenerating peripheral nerve fibres, a distribution that was unlikely to contribute to failed CNS axon regeneration. The present data points to the importance of such correlative investigations for demonstrating the clinical relevance of experimental data. (Source: BMC Neurology)
Source: BMC Neurology - July 14, 2009 Category: Neurology Authors: Armin BussKatrin PechByron KakulasDidier MartinJean SchoenenJohannes NothGary Brook Source Type: journals

Infarction in the territory of the anterior cerebral artery: clinical study of 51 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cardioembolism is the main cause of brain infarction in the territory of the ACA. Several clinical features are more frequent in stroke patients with ACA infarction than in patients with ischaemic stroke due to infarction in the MCA and PCA territories. (Source: BMC Neurology)
Source: BMC Neurology - July 8, 2009 Category: Neurology Authors: Adria ArboixLuis Garcia-ErolesNuria SellaresAgnes RagaMontserrat OliveresJoan Massons Source Type: journals

Co-morbidities of vertiginous diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In general, we did not detect an increased prevalence of the co-morbidities diabetes mellitus, arterial hypertension, migraine, other headache and obesity compared to the general population. There was an increased prevalence of psychiatric co-morbidity in patients with PPV. (Source: BMC Neurology)
Source: BMC Neurology - July 6, 2009 Category: Neurology Authors: Jan-Christian WarninghoffOtmar BayerUta FerrariAndreas Straube Source Type: journals

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case seriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These observations suggest that B-lymphocytes are involved in CFS pathogenesis for a subset of patients. Benefit for all CFS symptoms, the delayed symptom relief following B-cell depletion, the kinetics of relapses, and the effect also from methotrexate treatment, provide suggestive evidence that B-cells play a significant role in the ongoing clinical features, and that CFS may be amenable to therapeutic interventions aimed at modifying B-cell number and function. More systematic investigations of this therapeutic strategy, and of its biological basis, are now needed. (Source: BMC Neurology)
Source: BMC Neurology - June 30, 2009 Category: Neurology Authors: Oystein FlugeOlav Mella Source Type: journals

SPEM Dysfunction and General Schizotypy as Measured by the SSQ: A Controlled StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study provides additional evidence that SPEM dysfunction is associated with schizotypic features that precede the onset of schizophrenia and is already observable in general population subjects that show these features. (Source: BMC Neurology)
Source: BMC Neurology - June 28, 2009 Category: Neurology Authors: Dirk van KampenJan Berend Deijen Source Type: journals

Pontine infarction with pure motor hemiparesis or hemiplegia: A prospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The pontine infarction may present as PMH or hemiplegia with more frequency of nonvertiginous dizziness, a progressive course and diabetes mellitus. MRI can confirm the infarct location on the basal pons at early stage after stroke onset. (Source: BMC Neurology)
Source: BMC Neurology - June 15, 2009 Category: Neurology Authors: Li LingLiangfu ZhuJinsheng ZengSongjie LiaoSuping ZhangJian YuZhiyun Yang Source Type: journals

Psychosocial Outcomes in StrokE: the POISE observational stroke study protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThe study is designed to identify targets for rehabilitation-, social- and medical-intervention strategies that promote and maintain healthy ageing in people with cardiovascular and mental health conditions, two of the seven Australian national health priority areas. This will rectify the paucity of information internationally around optimal clinical practice and social policy in this area. (Source: BMC Neurology)
Source: BMC Neurology - June 12, 2009 Category: Neurology Authors: Maree HackettNick GlozierStephen JanRichard Lindley Source Type: journals

Dopamine Agonists and their risk to induce psychotic episodes in Parkinson's disease: a case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The analysis indicates that dementia and concomitant medication are factors in PD associated with psychotic symptoms. Furthermore, different dopaminergic drugs showed markedly different associations with psychotic symptoms (Source: BMC Neurology)
Source: BMC Neurology - June 10, 2009 Category: Neurology Authors: Daniel EckerAlexander UnrathJan KassubekMichael Sabolek Source Type: journals

Correlates of degree of nerve involvement in early Bell's palsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The degree of nerve involvement in early Bell's palsy correlates positively with age and negatively with corticosteroid use. (Source: BMC Neurology)
Source: BMC Neurology - June 7, 2009 Category: Neurology Authors: Ru-Lan HsiehChia-Wei WuLing-Yi WangWen-Chung Lee Source Type: journals

Markers of cerebral damage during delirium in elderly patients with hip fractureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: S100B protein and Neuron Specific Enolase (NSE) can increase due to brain cell damage and/or increased permeability of the blood-brain-barrier. Elevation of these proteins has been shown after various neurological diseases with cognitive dysfunction. Delirium is characterized by temporal cognitive deficits and is an important risk factor for dementia. The aim of this study was to compare the level of S100B and NSE of patients before, during and after delirium with patients without delirium and investigate the possible associations with different subtypes of delirium. Methods: The study population were patients ...
Source: BMC Neurology - May 27, 2009 Category: Neurology Authors: Barbara van MunsterCatharina KorseSophia de RooijJohannes BonfrerAeilko ZwindermanJohanna Korevaar Source Type: journals

Identification of potential neuromotor mechanisms of manual therapy in patients with musculoskeletal disablement: rationale and description of a clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study is designed to identify potential neuromotor changes associated with manual therapy procedures directed to the appendicular skeleton, compare the relative effect of treatment speed on potential neuromotor effects of manual therapy procedures, and determine the behavioral relevance of potential neuromotor effects of manual therapy procedures. (Source: BMC Neurology)
Source: BMC Neurology - May 21, 2009 Category: Neurology Authors: Beth FisherTodd DavenportKornelia KuligAllan Wu Source Type: journals

Admission C – reactive protein after acute ischemic stroke is associated with stroke severity and mortality: The 'Bergen stroke study'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Admission CRP is associated with stroke severity and long-term mortality when measured at least 24 hours after onset. There is a crude association between high CRP and short-term functional outcome which is likely secondary to stroke severity. CRP is an independent predictor of long-term mortality after ischemic stroke. (Source: BMC Neurology)
Source: BMC Neurology - April 28, 2009 Category: Neurology Authors: Titto T Idicula, Jan Brogger, Halvor Naess, Ulrike Waje-Andreassen and Lars Thomassen Source Type: journals

Estimating the probability of stroke in Korean hypertensive patients visiting tertiary hospitals using a risk profile from the framingham studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Aggressive interventions are mandated to reduce blood pressure and alleviate the high risk of stroke in hypertensive patients. (Source: BMC Neurology)
Source: BMC Neurology - April 22, 2009 Category: Neurology Authors: Cheol Ung Choi and Chang Gyu Park Source Type: journals

Awareness of benign paroxysmal positional vertigo in central IsraelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results show that BPPV is still an under-recognized entity. (Source: BMC Neurology)
Source: BMC Neurology - April 22, 2009 Category: Neurology Authors: Lea Pollak Source Type: journals

Moyamoya disease: A clinical spectrum literature review and case series from a tertiary care hospital in PakistanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Physicians when dealing with childhood strokes and characteristic deficits in adult population should consider Moyamoya disease. Key words Moyamoya, Stroke, Cerebrovascular (Source: BMC Neurology)
Source: BMC Neurology - April 15, 2009 Category: Neurology Authors: Sana Shoukat, Ahmed Itrat, Ather M Taqui, Moazzam Zaidi and Ayeesha K Kamal Source Type: journals

The FLASSH study: protocol for a randomised controlled trial evaluating falls prevention after stroke and two sub-studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThe results of the FLASSH project will inform falls prevention practice for stroke survivors. If the falls prevention program is shown to be effective, low cost strategies to prevent falls can be implemented for those at risk around the time of discharge from rehabilitation, thus improving safety and quality of life for stroke survivors. The two sub-studies will contribute to the overall understanding and management of falls risk in stroke survivors.Trial registrationThis trial is registered with the Australian and New Zealand Clinical Trials Registry (ACTRN012607000398404). (Source: BMC Neurology)
Source: BMC Neurology - March 31, 2009 Category: Neurology Authors: Frances A Batchelor, Keith D Hill, Shylie F Mackintosh, Catherine M Said and Craig H Whitehead Source Type: journals

Significant difference between three observers in the assessment of intraepidermal nerve fiber density in skin biopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The determination of Intraepidermal Nerve Fiber Density (IENFD) in skin biopsy is a useful method for the evaluation of different types of peripheral neuropathies. To allow a dependable use of the method it is necessary to determine interobserver reliability. Previous studies dealing with this topic used limited suitable statistical methods. Methods: In the present study three observers determined the IENFD and estimated the staining quality of the basement membrane for an adequate quantity of 120 skin biopsies (stained with indirect immunofluorescence technique) from 68 patients. More adequate statistical met...
Source: BMC Neurology - March 31, 2009 Category: Neurology Authors: Sigrid Wopking, Andrea Scherens, Ida S Haussleiter, Helmut Richter, Julia Schuning, Sabrina Klauenberg and Christoph Maier Source Type: journals

The FLASSH study: protocol for a randomised controlled trial evaluating falls prevention after stroke and two sub-studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThe results of the FLASSH project will inform falls prevention practice for stroke survivors. If the falls prevention program is shown to be effective, low cost strategies to prevent falls can be implemented for those at risk around the time of discharge from rehabilitation, thus improving safety and quality of life for stroke survivors. The two sub-studies will contribute to the overall understanding and management of falls risk in stroke survivors. Trial registration This trial is registered with the Australian and New Zealand Clinical Trials Registry (ACTRN012607000398404). (Source: BMC Neurology)
Source: BMC Neurology - March 31, 2009 Category: Neurology Authors: Frances A Batchelor, Keith D Hill, Shylie F Mackintosh, Catherine M Said and Craig H Whitehead Source Type: journals

The size of the treatment effect: do patients and proxies agree?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Although the results need to be further explored in larger samples, these results do point towards possible use of proxy respondents to assess patient perceived treatment change at the group level. (Source: BMC Neurology)
Source: BMC Neurology - March 25, 2009 Category: Neurology Authors: Femke AH van der Linden, Jolijn J Kragt, Jeremy C Hobart, Martin Klein, Alan J Thompson, Henk M van der Ploeg, Chris H Polman and Bernard MJ Uitdehaag Source Type: journals

Study design and methods of the Ansan Geriatric Study (AGE study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionHere, we report the design and sampling participants, measurement tools, and characteristics of the AGE study. This cohort study will allow a detailed study of the longitudinal comprehensive data on health information of elderly Koreans, thereby contributing to policy formulation and planning of health, welfare management, and other social services in Korea. (Source: BMC Neurology)
Source: BMC Neurology - February 24, 2009 Category: Neurology Authors: Changsu Han, Sangmee Ahn Jo, Nan Hee Kim, Inho Jo and Moon Ho Park Source Type: journals

Cardiac rehabilitation adapted to transient ischaemic attack and stroke (CRAFTS): a randomised controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionApplication of the Cardiac Rehabilitation paradigm to patients with ischaemic stroke or TIA has not been explored despite the obvious overlap in aetiology. It is hoped the anticipated improvement in vascular risk factors and fitness resulting from such a programme will enhance health and social gain in this population. Trial Registration: Current Controlled Trials ISCTRN90272638 (Source: BMC Neurology)
Source: BMC Neurology - February 23, 2009 Category: Neurology Authors: Olive C Lennon and Catherine Blake Source Type: journals

Improving community ambulation after stroke: the AMBULATE trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study has obtained ethical approval from the relevant Human Research Ethics Committees.DiscussionBy improving stroke survivors' walking ability, it is likely also to improve their general wellbeing by promoting better health and greater community participation. Furthermore, if stroke survivors can reach a point where their walking and community participation is self-sustaining, this will reduce the burden of care on family and friends as well as the economic burden on the health system. Given the major demographic shift in developed nations involving significant growth in the aged population, this research will make a...
Source: BMC Neurology - February 11, 2009 Category: Neurology Authors: Louise Ada, Catherine M Dean, Richard I Lindley and Gemma Lloyd Source Type: journals

Meta-analysis of duloxetine vs. pregabalin and gabapentin in the treatment of diabetic peripheral neuropathic painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: From the few available studies suitable for indirect comparison, DLX shows comparable efficacy and tolerability to GBP and PGB in DPNP. Duloxetine provides an important treatment option for this disabling condition. (Source: BMC Neurology)
Source: BMC Neurology - February 10, 2009 Category: Neurology Authors: Sibilia Quilici, Jeremy Chancellor, Mickael Lothgren, Dominique Simon, Gerard Said, Trong Kim Le, Ana Garcia-Cebrian and Brigitta Monz Source Type: journals

Changes in cognitive domains during three years in patients with Alzheimers disease treated with donepezilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The course of illness in the three domains was heterogeneous among the patients. We were not able to identify any clinically relevant correlates of this heterogeneity. As an aid we constructed three algorithms corresponding to the cognitive domains, which can be used to characterize patients initially, identify rapid decliners and follow the course of the disease. (Source: BMC Neurology)
Source: BMC Neurology - February 10, 2009 Category: Neurology Authors: Cecilia M Persson, Asa K Wallin, Sten Levander and Lennart Minthon Source Type: journals

A clinical registry of dementia based on the principle of epidemiological surveillanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The ReDeGi is a viable epidemiological surveillance device that provides information about the clinical and demographic characteristics of patients diagnosed with dementia in a defined geographical area. (Source: BMC Neurology)
Source: BMC Neurology - January 28, 2009 Category: Neurology Authors: Josep Garre-Olmo, Margarita Flaque, Jordi Gich, Teresa Osuna Pulido, Josefina Turbau, Natalia Vallmajo, Marta Vinas, Secundi Lopez-Pousa and Registry of Dementia of Girona Study Group (ReDeGi Group) Source Type: journals