BMC Neuroscience - Latest articlesThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5

250 records returned

The choroid plexus response to a repeated peripheral inflammatory stimulusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These observations contribute to a better understanding of the brain response to peripheral inflammation and pave the way to study their impact on the progression of several disorders of the central nervous system in which inflammation is known to be implicated. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - November 18, 2009 Category: Neuroscience Authors: Fernanda MarquesJoao SousaGiovanni CoppolaDaniel GeschwindNuno SousaJoana PalhaMargarida Correia-Neves Source Type: journals

Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found that PEA-15 null mice have spatial learning disabilities that are similar to those of mice where ERK or RSK2 function is impaired. We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - November 16, 2009 Category: Neuroscience Authors: Joe RamosDavid TownsendDawn PiarulliStefan KolataKenneth LightGregory HaleLouis Matzel Source Type: journals

Status epilepticus affects the gigantocellular network of the pontine reticular formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We argue that the observed slow oscillation corresponds to the late periodic epileptiform discharge phase of status epilepticus, and that the PRF may be involved in the progression of status epilepticus. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - November 13, 2009 Category: Neuroscience Authors: Peter BaracskayViola KiglicsKatalin KekesiGabor JuhaszAndras Czurko Source Type: journals

Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone levelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: PKCI/HINT1 KO mice displayed a phenotype of behavioral and endocrine features which indicate changes of mood function, including anxiolytic-like and anti-depressant like behaviors, in conjunction with an elevated corticosterone level in plasma. These results suggest that the PKCI/HINT 1 gene could be important for the mood regulation function in the CNS. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - November 13, 2009 Category: Neuroscience Authors: Elisabeth BarbierJia Bei Wang Source Type: journals

A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - October 29, 2009 Category: Neuroscience Authors: Qian-Quan Sun Source Type: journals

Progranulin is expressed within motor neurons and promotes neuronal cell survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Neurons are among the most long-lived cells in the body and are subject to low levels of toxic challenges throughout life. We have demonstrated that progranulin is abundantly expressed in motor neurons and is cytoprotective over prolonged periods when over-expressed in a neuronal cell line. This work highlights the importance of progranulin as neuroprotective growth factor and may represent a therapeutic target for neurodegenerative diseases including motor neuron disease. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - October 27, 2009 Category: Neuroscience Authors: Cara RyanDavid BaranowskiBabykumari ChitramuthuSuneil MalikZhi LiMingju CaoSandra MinottiHeather DurhamDenis KayChristopher ShawHugh BennettAndrew Bateman Source Type: journals

Hypothalamic FTO is associated with the regulation of energy intake not feeding rewardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that FTO mRNA is present mainly in sites related to hunger/satiation control; changes in hypothalamic FTO expression are associated with cues related to energy intake rather than feeding reward. In line with that, neurons involved in feeding termination express FTO. Interestingly, baseline FTO expression appears linked not only with energy intake but also energy metabolism. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - October 27, 2009 Category: Neuroscience Authors: Pawel OlszewskiRobert FredrikssonAgnieszka OlszewskaOlga StephanssonJohan AlsioKatarzyna RadomskaAllen LevineHelgi Schioth Source Type: journals

Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study investigating the influence and mechanisms of CSPGs on the differentiation and migration of NPCs should help us to understand the basic biology of NPCs during CNS development and provide new insights into developing new strategies for the treatment of the neurological disorders in the CNS. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - October 20, 2009 Category: Neuroscience Authors: Wenli GuSaili FuYanxia WangYing LiHezuo LuXiaoming XuPeihua Lu Source Type: journals

Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study advises our community to proceed with caution to use the minimally invasive intravenous delivery of low dose minocycline in order to afford neuroprotection that is safe for stroke. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - October 5, 2009 Category: Neuroscience Authors: Noriyuki MatsukawaTakao YasuharaKoichi HaraLin XuMina MakiGuolong YuYuji KanekoKosei OjikaDavid HessCesar Borlongan Source Type: journals

A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that increased mEPSC frequency persists well beyond the 2 hour transcription-independent phase of plasticity in this model. This long-lasting mEPSC upregulation is transcription-dependent and requires ongoing action potential activity during the initial 2 hour period but not thereafter. Thus mEPSC upregulation may underlie the long term, transcription-dependent persistence of action potential bursting. This provides mechanistic insight to link gene candidates already identified by gene chip analysis to long lasting plasticity in this in vitro model. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 28, 2009 Category: Neuroscience Authors: J. Simon WiegertFrank HofmannHilmar BadingC. Peter Bengtson Source Type: journals

Chronic NMDA administration to rats increases brain pro-apoptotic factors while decreasing anti-Apoptotic factors and causes cell deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This alteration in the balance between pro- and anti-apoptotic factors by chronic NMDA receptor activation in this animal model may contribute to neuronal loss, and further suggests that the model can be used to examine multiple processes involved in excitotoxicity. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 27, 2009 Category: Neuroscience Authors: Hyung-Wook KimYunyoung ChangMei ChenStanley RapoportJagadeesh Rao Source Type: journals

Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Neural progenitors were produced from murine ES cells by a novel method that induced neuroectoderm cells by a combination of nonadherent conditions and serum starvation, in contrast to the embryoid body method in which neuroectoderm cells must be selected after formation of all three germ layers. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 23, 2009 Category: Neuroscience Authors: Huawei LiHong LiuC CorralesJessica RisnerJeff ForresterJeffrey HoltStefan HellerAlbert Edge Source Type: journals

Expressed sequence tag analysis of adult human optic nerve for NEIBank: Identification of cell type and tissue markersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that the new cDNA library is a faithful representation of human ON and EST data provide an initial overview of gene expression patterns in this tissue. The data provide clues for tissue-specific and species-specific properties of human ON that will help in design of therapeutic models. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 23, 2009 Category: Neuroscience Authors: Steven BernsteinYan GuoKatherine PetersonGraeme Wistow Source Type: journals

Vestibular effects on cerebral blood flowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we tested the hypothesis that stimulation of the vestibular system, specifically the otoliths organs, would result in changes in cerebral blood flow. Results: To test our hypothesis, we stimulated the vestibular organs of 25 healthy subjects by pitch tilt (stimulates both canals and otoliths) and by translation on a centrifuge (stimulates otoliths and not the canals) at five frequencies: 0.5, 0.25, 0.125 and 0.0625 Hz for 80 sec and 0.03125 Hz for 160 sec. Changes in cerebral flow velocity (by transcranial Doppler) and blood pressure (by Finapres) were similar during both stimuli and dependent on frequency o...
Source: BMC Neuroscience - Latest articles - September 22, 2009 Category: Neuroscience Authors: Jorge SerradorTodd SchlegelF Owen BlackScott Wood Source Type: journals

A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We have found that a secretory phospholipase (nPLA) purified from snake venom could reduce infarct volume in rodent stroke model. nPLA, has also been found to reduce neuronal cell death, apoptosis and promote cell survival in in-vitro ischemic conditions. In all conditions, the protective effects could be seen at sub-lethal concentrations of the protein. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 22, 2009 Category: Neuroscience Authors: Arunmozhiarasi ArmugamCharmian CherKaiYing LimDawn KohDavid HowellsKandiah Jeyaseelan Source Type: journals

Imaging short- and long-term training success in chronic aphasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results show for the first time that treatment-induced language recovery in the chronic stage after stroke is a dynamic process. Initially, brain regions involved in memory encoding, attention, and multimodal integration mediated treatment success. In contrast, long-term treatment success was predicted mainly by activity increases in the so-called 'classical' language regions. The results suggest that besides perilesional and homologue language-associated regions, functional integrity of domain-unspecific memory structures may be a prerequisite for successful (intensive) language interventions. (Source: BM...
Source: BMC Neuroscience - Latest articles - September 21, 2009 Category: Neuroscience Authors: Ricarda MenkeMarcus MeinzerHarald KugelMichael DeppeAnnette BaumgartnerHagen SchiffbauerMarion ThomasKira KramerHubertus LohmannAgnes FloelStefan KnechtCaterina Breitenstein Source Type: journals

Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Transplantation of NSCs genetically modified to differentiate into an oligodendrocytic lineage may be an effective strategy to improve functional outcomes following spinal cord trauma. The present study suggests that molecular factors governing cell fate decisions can be manipulated to enhance reparative potential of the cell-based therapy. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 21, 2009 Category: Neuroscience Authors: Dong HwangByung KimEun KimSeung LeeIn JooHaeyoung Suh-KimSeonghyang SohnSeung Kim Source Type: journals

Information in small neuronal ensemble activity in the hippocampal CA1 during delayed non-matching to sample performance in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results show that the spatiotemporal patterns of spiking activity among cells in the small neuronal ensemble contain much information that is specifically useful for the stimulus comparison. Small neuronal networks in the hippocampal CA1 might therefore act as a comparator during recognition memory tasks. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 14, 2009 Category: Neuroscience Authors: Susumu TakahashiYoshio Sakurai Source Type: journals

The role of left and right hemispheres in the comprehension of idiomatic language: an electrical neuroimaging studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data indicate bilateral involvement of both hemispheres in idiom comprehension, including the right MTG after 350 ms and the right medial frontal gyrus in the time windows 270-300 and 500-780 ms. In addition, the activation of left and right limbic regions (400-450 ms) suggests that they have a role in the emotional connotation of colourful idiomatic language. The data support the view that there is direct access to the idiomatic meaning of figurative language, not dependent on the suppression of its literal meaning, for which the LIFG was previously thought to be responsible. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 14, 2009 Category: Neuroscience Authors: Alice ProverbioNicola CrottiAlberto ZaniRoberta Adorni Source Type: journals

Age-related delay in information accrual for faces: Evidence from a parametric, single-trial EEG approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Using a component-free ERP analysis that provides a precise timing of the visual system sensitivity to image structure, the current study demonstrates that older observers accumulate face information more slowly than younger subjects. Additionally, the N170 appears to be less face-sensitive in older observers. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 8, 2009 Category: Neuroscience Authors: Guillaume RousseletJesse HuskCyril PernetCarl GasparPatrick BennettAllison Sekuler Source Type: journals

Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that BNIP3 and EndoG play important roles in hippocampal neuronal apoptosis following ischemia, and mitochondrial BNIP3 is a signal protein upstream of EndoG that can induce neuronal death. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 7, 2009 Category: Neuroscience Authors: Shen-Ting ZhaoMing ChenShu-Ji LiMing-Hai ZhangBo-Xing LiManas DasJonathan BeanJi-Ming KongXin-Hong ZhuTian-Ming Gao Source Type: journals

Ontogeny of ATP hydrolysis and isoform expression of the Plasma Membrane Ca2+-ATPase in mouse brainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results show an upregulation of PMCA activity and PMCA isoforms expression during brain development in mouse, with specific localizations mainly in cerebellum. Overall, our findings support a close relationship between the ontogeny of PMCA isoforms and specific requirements of Ca2+ during development of different brain areas. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 6, 2009 Category: Neuroscience Authors: Daniel MarcosM. Rosario SepulvedaMaria BerrocalAna Mata Source Type: journals

Regulation of cerebrospinal fluid production by caffeine consumptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results of this study show that long-term consumption of caffeine can induce ventriculomegaly, which is mediated in part by increased production of CSF. Moreover, we also showed that adenosine receptor signaling can regulate the production of CSF by controlling the expression of Na+, K+-ATPase and CBF. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 2, 2009 Category: Neuroscience Authors: Myoung-Eun HanHak-Jin KimYoung-Suk LeeDong-Hyun KimJoo-Taek ChoiChul-Sik PanSik YoonSun-Yong BaekBong-Seon KimJae-Bong KimSae-Ock Oh Source Type: journals

Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstrokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study indicates that HSP72 overexpression appears to be critical to the development of thermotolerance and protection from heat-induced hypothalamic ischemic and oxidative damage. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 2, 2009 Category: Neuroscience Authors: Zhih-Cherng ChenWen-Shian WuMao-Tsun LinChuan-Chih Hsu Source Type: journals

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study further validates Drosophila as a valuable model for preclinical testing of drugs with therapeutic potential for neurodegenerative diseases. The lower cost and amenability to high throughput testing make Drosophila PD models effective in vivo tools for screening novel therapeutic compounds. If our findings can be further validated in mammalian PD models, they would implicate drugs combining antioxidant and anti-inflammatory properties as strong therapeutic candidates for mechanism-based PD treatment. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 31, 2009 Category: Neuroscience Authors: Katharina FaustStephan GehrkeYufeng YangLichuan YangFlint BealBingwei Lu Source Type: journals

Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest that the deficiency of neither COX-1 nor COX-2 is sufficient to alter cognitive outcomes following TBI in mice. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 30, 2009 Category: Neuroscience Authors: Matthew KelsoStephen ScheffJames PaulyCharles Loftin Source Type: journals

Labelling and targeted ablation of specific bipolar cell types in the zebrafish retinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This report shows that enhancer trapping can be applied to label distinct morphological types of bipolar cells in the zebrafish retina. The genetic labelling of these cells yielded co-expression of a modified Gal4 transcription activator and the fluorescent marker eGFP. Our work also demonstrates the potential utility of the Gal4-UAS system for induction of other transgenes, including a bacterial nitroreductase fusion gene, which can facilitate analysis of bipolar cell differentiation and how the retina recovers from specific ablation of these cells. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 26, 2009 Category: Neuroscience Authors: Xiao-Feng ZhaoStaale EllingsenAnders Fjose Source Type: journals

Preliminary evidence that both blue and red light can induce alertness at nightEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results support previous findings that alertness may be mediated by the circadian system, but it does not seem to be the only light-sensitive pathway that can affect alertness at night. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 26, 2009 Category: Neuroscience Authors: Mariana FigueiroAndrew BiermanBarbara PlitnickMark Rea Source Type: journals

Automated threshold detection for auditory brainstem responses: comparison with visual estimation in a stem cell transplantation studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In summary, the automated detection method avoids the subjectivity of visual analysis and offers a rapid, easily accessible (http://axograph.com/source/abr.html) approach to measure hearing threshold levels in auditory brainstem response. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 25, 2009 Category: Neuroscience Authors: Sofie BogaertsJohn ClementsJeremy SullivanSharon Oleskevich Source Type: journals

Neurological and neurobehavioral assessment of experimental subarachnoid HemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 50% of humans with aneurysmal subarachnoid hemorrhage (SAH) die and many survivors have neurological and neurocognitive dysfunction. Animal studies usually focused on cerebral vasospasm and sometimes neuronal injury. The difference in endpoints may contribute to lack of translation of treatments effective in animals to humans. We reviewed prior animal studies of SAH to determine what neurological and neurobehavioral endpoints had been used, whether they differentiated between appropriate controls and animals with SAH, whether treatment effects were reported and whether they correlated with vasospasm. Only a few studi...
Source: BMC Neuroscience - Latest articles - August 24, 2009 Category: Neuroscience Authors: Hyojin JeonJinglu AiMohamed SabriAsma TariqXueyuan ShangGang ChenR Loch Macdonald Source Type: journals

Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Overall, results of the present study demonstrate that idiopathic scoliosis patients have an alteration in cognitive integration of vestibular signals. It is possible that severe spine deformity developed partly due to impaired vestibular information travelling from the cerebellum to the vestibular cortical network or alteration in the cortical mechanisms processing the vestibular signals. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 24, 2009 Category: Neuroscience Authors: Martin SimoneauVincent LamotheEmilie HutinPierre MercierNormand TeasdaleJean Blouin Source Type: journals

Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the hippocampus, DGKbeta is expressed in both projection neurons and interneurons and is accumulated at the perisynapse of dendritic spines in asymmetrical synapses. Transfection experiments suggest that DGKbeta may be involved in the molecular machineries of dendrite outgrowth and spinogenesis through its kinase activity. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 18, 2009 Category: Neuroscience Authors: Yasukazu HozumiMasahiko WatanabeKoichi OtaniKaoru Goto Source Type: journals

From upright to upside-down presentation: A spatio-temporal ERP study of the parametric effect of rotation on face and house processingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our N170 findings provide support for both the quantitative and qualitative accounts for face rotation effects. Although the qualitative explanation predicted the curvilinear shape of N170 modulations by face misrotations, topographical and source modeling findings suggest that the same brain regions, and thus the same mechanisms, are probably at work when processing upright and rotated faces. Taken collectively, our results indicate that the same processing mechanisms may be involved across the whole range of face orientations, but would operate in a non-linear fashion. Finally, the response tuning of the N170...
Source: BMC Neuroscience - Latest articles - August 18, 2009 Category: Neuroscience Authors: Boutheina JemelJulie CoutyaCaroline LangerSylvain Roy Source Type: journals

Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data support a regulatory role for miRNAs during the transition from neuronal progenitors into the earliest differentiating cortical neurons. In addition, by supplying a robust data set in which miRNA and mRNA profiles originate from the same purified cell type, this empirical study may facilitate the development of new algorithms to integrate various "-omics" data sets. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 18, 2009 Category: Neuroscience Authors: Joseph NielsenPierre LauDragan MaricJeffery BarkerLynn Hudson Source Type: journals

Presynaptic action of neurotensin on dopamine release through inhibition of D2 receptor functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Taken together, these data suggest that NT enhances DA release principally by inhibiting the function of terminal D2 autoreceptors and not by more direct mechanisms such as facilitation of terminal calcium influx. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 13, 2009 Category: Neuroscience Authors: Charbel FawazPhilippe MartelDamiana LeoLouis-Eric Trudeau Source Type: journals

Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The reduced severity of autoimmune encephalomyelitis in AQP4 deficiency suggests AQP4 as a novel determinant in autoimmune inflammatory diseases of the central nervous system and hence a potential drug target. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 5, 2009 Category: Neuroscience Authors: Lihua LiHua ZhangA Verkman Source Type: journals

General and specific responsiveness of the amygdala during explicit emotion recognition in females and malesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Applying high-resolution fMRI while subjects were performing an explicit emotion recognition task revealed bilateral amygdala activation to all emotions and neutral expressions presented. This mechanism seems to operate similarly in healthy females and males and for both in-group and out-group ethnicities. Our results support the assumption that an intact amygdala response is fundamental in the processing of these salient stimuli due the amygdala's relevance detecting function. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 3, 2009 Category: Neuroscience Authors: Birgit DerntlUte HabelChristian WindischbergerSimon RobinsonIlse Kryspin-ExnerRuben GurEwald Moser Source Type: journals

Hypoxia-induced transcription of dopamine D3 and D4 receptors in human neuroblastoma and astrocytoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In light of the relatively delayed transcriptional activation of the DRD3 and DRD4 genes, we propose that slow-reacting hypoxia sensitive transcription factors might be involved in the transactivation of DRD3 and DRD4 promoters in hypoxia. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - August 3, 2009 Category: Neuroscience Authors: Melinda BenceEva KereszturiViktor MozesMaria Sasvari-SzekelyGergely Keszler Source Type: journals

Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crushEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Differential responses to optic nerve crush between two widely used strains of mice were used to define molecular networks associated with ganglion cell death and reactive gliosis. These results form the basis for our continuing interest in the modifiers of retinal injury. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 29, 2009 Category: Neuroscience Authors: Justin TempletonMohamed NassrFelix Vazquez-ChonaNatalie Freeman-AndersonWilliam OrrRobert WilliamsEldon Geisert Source Type: journals

Syntactic learning by mere exposure - An ERP study in adult learnersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The presence of the P600 suggests that native speakers applied a grammatical rule. In contrast, non-native speakers appeared to use a lexical form-based processing strategy. Thus, the processing mechanisms acquired in the language learning task were only partly comparable to those applied by competent native speakers. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 28, 2009 Category: Neuroscience Authors: Jutta MuellerRegine ObereckerAngela Friederici Source Type: journals

Paraquat induces oxidative stress, neuronal loss in substantia nigra region And parkinsonism in adult rats: Neuroprotection and amelioration of symptoms by water-soluble formulation of Coenzyme Q10Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data confirmed that paraquat-induced neurotoxicity represents a convenient rat model of Parkinsonian neurodegeneration suitable for mechanistic and neuroprotective studies. This is the first preclinical evaluation of a water-soluble coenzyme Q10 formulation showing the evidence of prophylactic neuroprotection at clinically relevant doses. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 26, 2009 Category: Neuroscience Authors: Mallika Somayajulu-NituJagdeep SandhuJerome CohenT. s. SridharMarianna SikorskaHenryk Borowy-BorowskiAnca MateiSiyaram Pandey Source Type: journals

c-MycERTAM Transgene Silencing in a Genetically Modified Human Neural Stem Cell Line Implanted into MCAo Rodent BrainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In conclusion the results confirm that CTX0E03 cells downregulated c-mycERTAM transgene expression both in vitro following EGF, bFGF and 4-OHT withdrawal and in vivo following implantation in MCAo rat brain. The silencing of the c-mycERTAM transgene in vivo provides an additional safety feature of CTX0E03 cells for potential clinical application. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 20, 2009 Category: Neuroscience Authors: Lara StevanatoRandolph CortelingPaul StroemerAndrew HopeJulie HewardErik MiljanJohn Sinden Source Type: journals

Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest that differential neural circuit abnormalities may be present in the left and right auditory cortices in schizophrenia. In addition, they provide further support for the hypothesis that hallucinations are related to cortical hyperexcitability, which is manifested by an increased propensity for high-frequency synchronization in modality-specific cortical areas. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 19, 2009 Category: Neuroscience Authors: Kevin SpencerMargaret NiznikiewiczPaul NestorMartha ShentonRobert McCarley Source Type: journals

Imaging cortical activity following affective stimulation with a high temporal and spatial resolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It can be shown that stimulation with affective pictures lead to an enhanced activity in occipital region as compared to neutral pictures. However, the focus of differentiation is not stable over time but shifts into temporal and parietal regions within four seconds of stimulation. Thus, it can be crucial to carefully choose regions of interests and time intervals when analyzing the affective modulation of cortical activity. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 16, 2009 Category: Neuroscience Authors: Julian KeilHannah AdenauerClaudia CataniFrank Neuner Source Type: journals

A toolbox for the fast information analysis of multiple-site LFP, EEG and spike train recordingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The new toolbox presented here implements fast and data-robust computations of the most relevant quantities used in information theoretic analysis of neural data. The toolbox can be easily used within Matlab, the environment used by most neuroscience laboratories for the acquisition, preprocessing and plotting of neural data. It can therefore significantly enlarge the domain of application of information theory to neuroscience, and lead to new discoveries about the neural code. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 15, 2009 Category: Neuroscience Authors: Cesare MagriKevin WhittingstallVanessa SinghNikos LogothetisStefano Panzeri Source Type: journals

Neither in vivo MRI nor behavioural assessment indicate a therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study highlights the need for a thorough experimental design to test novel neuroprotective compounds in experimental stroke investigations incorporating: a positive reference compound, different models of focal ischaemia, varying the duration of ischaemia, and objective in vivo assessments within a single study. This procedure will help us to minimise the translation of less efficacious compounds. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 15, 2009 Category: Neuroscience Authors: Maria AshiotiJohn BeechAndrew LoweMichel BernanosAndrew McCrearyMichel ModoSteve Williams Source Type: journals

The formation of acetylcholine receptor clusters visualized with quantum dotsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Single-molecular tracking using QDs has provided direct evidence that the clustering of AChRs in muscle cells in response to synaptogenic stimuli is achieved by two distinct cellular processes: the Brownian motion of receptors in the membrane and their trapping and immobilization at the synaptic specialization. This study also provides a clearer picture of the "trap" that it is not a uniformly sticky area but consists of discrete foci at which AChRs are immobilized. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 15, 2009 Category: Neuroscience Authors: Lin GengHailong ZhangH. Benjamin Peng Source Type: journals

Estrous cycle influences the expression of neuronal nitric oxide synthase in the hypothalamus and limbic system of female miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: : These data demonstrate that, in mice, the expression of nNOS in some hypothalamic regions involved in the control of reproduction and characterized by a large number of estrogen receptors is under the control of gonadal hormones and may vary according to the rapid variations of hormonal levels that take place during the estrous cycle. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - July 14, 2009 Category: Neuroscience Authors: Monica SicaMariangela MartiniCarla Viglietti-PanzicaGianCarlo Panzica Source Type: journals