Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice
In conclusion, dapagliflozin can potentially promote WAT browning in HFD induced obese mice via improving lipogenesis and angiogenesis in WAT.PMID:38504370 | PMC:PMC10949628 | DOI:10.1186/s40360-024-00747-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 20, 2024 Category: Drugs & Pharmacology Authors: Lin Xiang Min Liu Guangda Xiang Ling Yue Junxia Zhang Xiaoli Xu Jing Dong Source Type: research

Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice
In conclusion, dapagliflozin can potentially promote WAT browning in HFD induced obese mice via improving lipogenesis and angiogenesis in WAT.PMID:38504370 | DOI:10.1186/s40360-024-00747-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 20, 2024 Category: Drugs & Pharmacology Authors: Lin Xiang Min Liu Guangda Xiang Ling Yue Junxia Zhang Xiaoli Xu Jing Dong Source Type: research

Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan
CONCLUSION: This study indicates that diuretics could raise the risk of CKD in diabetic patients, but when used in combination with SGLT2i, they continue to offer protection against CKD.PMID:38443996 | PMC:PMC10913410 | DOI:10.1186/s40360-024-00745-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Han-Jie Lin Pin-Yang Shih Stella Chin-Shaw Tsai Wu-Lung Chuang Tsai-Ling Hsieh Heng-Jun Lin Teng-Shun Yu Fuu-Jen Tsai Chiu-Ying Chen Kuang-Hsi Chang Source Type: research

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
CONCLUSION: We utilized a miniaturized tumor-immune model to enable time and cost-effective evaluation of a broad panel of drugs in an immuno-oncology setting in vitro. Using this approach, immunomodulatory effects exerted by TKIs and statins were identified.PMID:38444002 | PMC:PMC10913607 | DOI:10.1186/s40360-024-00746-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Tove Selvin Malin Berglund Lena Lenhammar Magnus Lindskog Malin Jarvius Rolf Larsson Peter Nygren M årten Fryknäs Claes R Andersson Source Type: research

Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan
CONCLUSION: This study indicates that diuretics could raise the risk of CKD in diabetic patients, but when used in combination with SGLT2i, they continue to offer protection against CKD.PMID:38443996 | PMC:PMC10913410 | DOI:10.1186/s40360-024-00745-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Han-Jie Lin Pin-Yang Shih Stella Chin-Shaw Tsai Wu-Lung Chuang Tsai-Ling Hsieh Heng-Jun Lin Teng-Shun Yu Fuu-Jen Tsai Chiu-Ying Chen Kuang-Hsi Chang Source Type: research

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
CONCLUSION: We utilized a miniaturized tumor-immune model to enable time and cost-effective evaluation of a broad panel of drugs in an immuno-oncology setting in vitro. Using this approach, immunomodulatory effects exerted by TKIs and statins were identified.PMID:38444002 | PMC:PMC10913607 | DOI:10.1186/s40360-024-00746-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Tove Selvin Malin Berglund Lena Lenhammar Magnus Lindskog Malin Jarvius Rolf Larsson Peter Nygren M årten Fryknäs Claes R Andersson Source Type: research

Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan
CONCLUSION: This study indicates that diuretics could raise the risk of CKD in diabetic patients, but when used in combination with SGLT2i, they continue to offer protection against CKD.PMID:38443996 | PMC:PMC10913410 | DOI:10.1186/s40360-024-00745-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Han-Jie Lin Pin-Yang Shih Stella Chin-Shaw Tsai Wu-Lung Chuang Tsai-Ling Hsieh Heng-Jun Lin Teng-Shun Yu Fuu-Jen Tsai Chiu-Ying Chen Kuang-Hsi Chang Source Type: research

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
CONCLUSION: We utilized a miniaturized tumor-immune model to enable time and cost-effective evaluation of a broad panel of drugs in an immuno-oncology setting in vitro. Using this approach, immunomodulatory effects exerted by TKIs and statins were identified.PMID:38444002 | PMC:PMC10913607 | DOI:10.1186/s40360-024-00746-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Tove Selvin Malin Berglund Lena Lenhammar Magnus Lindskog Malin Jarvius Rolf Larsson Peter Nygren M årten Fryknäs Claes R Andersson Source Type: research

Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan
CONCLUSION: This study indicates that diuretics could raise the risk of CKD in diabetic patients, but when used in combination with SGLT2i, they continue to offer protection against CKD.PMID:38443996 | PMC:PMC10913410 | DOI:10.1186/s40360-024-00745-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Han-Jie Lin Pin-Yang Shih Stella Chin-Shaw Tsai Wu-Lung Chuang Tsai-Ling Hsieh Heng-Jun Lin Teng-Shun Yu Fuu-Jen Tsai Chiu-Ying Chen Kuang-Hsi Chang Source Type: research

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
CONCLUSION: We utilized a miniaturized tumor-immune model to enable time and cost-effective evaluation of a broad panel of drugs in an immuno-oncology setting in vitro. Using this approach, immunomodulatory effects exerted by TKIs and statins were identified.PMID:38444002 | PMC:PMC10913607 | DOI:10.1186/s40360-024-00746-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Tove Selvin Malin Berglund Lena Lenhammar Magnus Lindskog Malin Jarvius Rolf Larsson Peter Nygren M årten Fryknäs Claes R Andersson Source Type: research

Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan
CONCLUSION: This study indicates that diuretics could raise the risk of CKD in diabetic patients, but when used in combination with SGLT2i, they continue to offer protection against CKD.PMID:38443996 | PMC:PMC10913410 | DOI:10.1186/s40360-024-00745-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 5, 2024 Category: Drugs & Pharmacology Authors: Han-Jie Lin Pin-Yang Shih Stella Chin-Shaw Tsai Wu-Lung Chuang Tsai-Ling Hsieh Heng-Jun Lin Teng-Shun Yu Fuu-Jen Tsai Chiu-Ying Chen Kuang-Hsi Chang Source Type: research