Exercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting in FABP4/5 deficient mice
Skeletal muscle prefers carbohydrate use to fatty acid (FA) use as exercise intensity increases. In contrast, skeletal muscle minimizes glucose use and relies more on FA during fasting. In mice deficient for F... (Source: BMC Physiology)
Source: BMC Physiology - March 13, 2019 Category: Physiology Authors: Tatsuya Iso, Hikari Haruyama, Hiroaki Sunaga, Miki Matsui, Hiroki Matsui, Rina Tanaka, Yogi Umbarawan, Mas Rizky A. A. Syamsunarno, Tomoyuki Yokoyama and Masahiko Kurabayashi Tags: Research article Source Type: research
Deficiency of the BMP Type I receptor ALK3 partly protects mice from anemia of inflammation
Inflammatory stimuli induce the hepatic iron regulatory hormone hepcidin, which contributes to anaemia of inflammation (AI). Hepcidin expression is regulated by the bone morphogenetic protein (BMP) and the int... (Source: BMC Physiology)
Source: BMC Physiology - February 27, 2018 Category: Physiology Authors: Inka Gallitz, Niklas Lofruthe, Lisa Traeger, Nicole B äumer, Verena Hoerr, Cornelius Faber, Tanja Kuhlmann, Carsten Müller-Tidow and Andrea U. Steinbicker Tags: Research article Source Type: research
Claudin expression during early postnatal development of the murine cochlea
Claudins are major components of tight junctions, which form the paracellular barrier between the cochlear luminal and abluminal fluid compartments that supports the large transepithelial voltage difference an... (Source: BMC Physiology)
Source: BMC Physiology - January 25, 2018 Category: Physiology Authors: Takayuki Kudo, Philine Wangemann and Daniel C. Marcus Tags: Research article Source Type: research
Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator
Circadian rhythms of physiology and behavior are driven by a circadian clock located in the suprachiasmatic nucleus of the hypothalamus. This clock is synchronized to environmental day/night cycles by photic i... (Source: BMC Physiology)
Source: BMC Physiology - January 25, 2018 Category: Physiology Authors: Jessica A. Krizo, Linley E. Moreland, Ashutosh Rastogi, Xiang Mou, Rebecca A. Prosser and Eric M. Mintz Tags: Research article Source Type: research
Adiponectin is required for maintaining normal body temperature in a cold environment
Thermogenic impairment promotes obesity and insulin resistance. Adiponectin is an important regulator of energy homeostasis. While many beneficial metabolic effects of adiponectin resemble that of activated th... (Source: BMC Physiology)
Source: BMC Physiology - October 23, 2017 Category: Physiology Authors: Qiong Wei, Jong Han Lee, Hongying Wang, Odelia Y. N. Bongmba, Chia-Shan Wu, Geetali Pradhan, Zilin Sun, Lindsey Chew, Mandeep Bajaj, Lawrence Chan, Robert S. Chapkin, Miao-Hsueh Chen and Yuxiang Sun Tags: Research article Source Type: research
Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages
Previous studies show that androgens are involved in hypertrophy and excitability of cardiomyocytes and that their effects are mediated through their receptor. The aim of this study was to evaluate the presenc... (Source: BMC Physiology)
Source: BMC Physiology - August 14, 2017 Category: Physiology Authors: Enrique Pedernera, Mar ía José Gómora, Iván Meneses, Marlon De Ita and Carmen Méndez Tags: Research article Source Type: research
Disulfide high mobility group box-1 causes bladder pain through bladder Toll-like receptor 4
Bladder pain is a prominent symptom in several urological conditions (e.g. infection, painful bladder syndrome/interstitial cystitis, cancer). Understanding the mechanism of bladder pain is important, particul... (Source: BMC Physiology)
Source: BMC Physiology - May 25, 2017 Category: Physiology Authors: Fei Ma, Dimitrios E. Kouzoukas, Katherine L. Meyer-Siegler, Karin N. Westlund, David E. Hunt and Pedro L. Vera Source Type: research
Endothelial dysfunction in the pathogenesis of pre-eclampsia in Ghanaian women
Pre-eclampsia (PE) remains a disease of theories despite extensive research into its etiology. Alteration in the production of vascular endothelial growth factor (VEGF), a biomarker of endothelial dysfunction,... (Source: BMC Physiology)
Source: BMC Physiology - March 29, 2017 Category: Physiology Authors: Kwame Adu-Bonsaffoh, Daniel Ansong Antwi, Ben Gyan and Samuel Amenyi Obed Source Type: research
Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity
Obese individuals differ in their risk of developing metabolic and cardiovascular complications depending on fat distribution (subcutaneous versus visceral) and adipose tissue (AT) phenotype (hyperplasic versu... (Source: BMC Physiology)
Source: BMC Physiology - March 21, 2017 Category: Physiology Authors: Kathrin Landgraf, Susanne Schuster, Andrej Meusel, Antje Garten, Thomas Riemer, Dorit Schleinitz, Wieland Kiess and Antje K örner Source Type: research
Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age
Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and diet-i... (Source: BMC Physiology)
Source: BMC Physiology - March 17, 2017 Category: Physiology Authors: I. Webster, R. Salie, E. Marais, W.-J. Fan, G. Maarman, B. Huisamen and A. Lochner Source Type: research
Variation in branchial expression among insulin-like growth-factor binding proteins (igfbps) during Atlantic salmon smoltification and seawater exposure
In preparation for migration from freshwater to marine habitats, Atlantic salmon (Salmo salar L.) undergo smoltification, a transformation that includes the acquisition of hyposmoregulatory capacity. The growth h... (Source: BMC Physiology)
Source: BMC Physiology - January 18, 2017 Category: Physiology Authors: Jason P. Breves, Chelsea K. Fujimoto, Silas K. Phipps-Costin, Ingibj örg E. Einarsdottir, Björn Thrandur Björnsson and Stephen D. McCormick Source Type: research
