Willingness and preferences for long-acting injectable PrEP among US men who have sex with men: a discrete choice experiment
Conclusions
A large proportion of MSM expressed a preference for LA-PrEP over daily oral pills. Most respondents chose LA-PrEP regardless of cost, clinic time, side effects or protection level; however, preferences varied by sociodemographics. These varied groups likely require tailored intervention strategies to achieve maximum LA-PrEP uptake and persistence. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Cole, S. W., Glick, J. L., Campoamor, N. B., Sanchez, T. H., Sarkar, S., Vannappagari, V., Rinehart, A., Rawlings, K., Sullivan, P. S., Bridges, J. F. P. Tags: Open access HIV/AIDS Source Type: research
Estimating the incidence of COVID-19, influenza and respiratory syncytial virus infection in three regions of Queensland, Australia, winter 2022: findings from a novel longitudinal testing-based sentinel surveillance programme
Conclusion
This testing-based surveillance programme could estimate disease trends and be a useful tool in settings where testing is less common or accessible. Difficulties with recruitment meant the study was underpowered. The frontline sentinel nature of workplaces meant participants were not representative of the general population but were high-risk groups providing early warning of disease. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: May, F., Ginige, S., Firman, E., Li, Y. S., Soonarane, Y. K., Smoll, N., Hunter, I., Pery, B., Macfarlane, B., Bladen, T., Allen, T., Green, T., Walker, J., Slinko, V., Stickley, M., Khandaker, G., Anuradha, S., Wattiaux, A. Tags: Open access, Public health, COVID-19 Source Type: research
Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial
Introduction
Cancer-related cognitive impairment is common among people diagnosed with and treated for cancer. This can be a distressing and disabling side effect for impacted individuals. Interventions to mitigate cognitive dysfunction are available, but, to date, most have been trialled in samples that are largely or exclusively composed of people with solid tumours. Intervention strategies to support cognitive functioning are needed, but there is a paucity of research in this area. The main aim of this study is to test the feasibility and acceptability of methods and procedures intended for use in a definitive trial of ...
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Gates, P., Green, H. J., Gough, K., Dhillon, H., Vardy, J. L., Dickinson, M., Guarnera, J., Krishnasamy, M., Livingston, P. M., White, V., Ugalde, A., Caeyenberghs, K. Tags: Open access, Haematology (incl blood transfusion) Source Type: research
Remote neuropsychological assessment of patients with neurological disorders and injuries--a study protocol for a cross-sectional case-control validation study
This study protocol describes a cross-sectional study aimed at validating the newly developed digitalized neuropsychological test battery Mindmore Remote in patients with neurological disorders and injuries. Diagnoses comprise traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis, brain tumour and epilepsy. 50 patients in each patient group will be included. In addition, 50 healthy controls will be recruited. All participants will undergo both testing with Mindmore Remote at home and traditional neuropsychological assessment face-to-face in a randomised order. The primary outcome is the association ...
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Berginström, N., Andersson, L. Tags: Open access, Neurology Source Type: research
Association of the Controlling Nutritional Status (CONUT) score with all-cause and cause-specific mortality in patients with diabetic kidney disease: evidence from the NHANES 2009-2018
Conclusion
Moderate and severe malnutrition was associated with greater risks of all-cause death, diabetes-related death and nephropathy-related death than normal nutritional status in DKD. Close monitoring of immuno-nutritional status in patients with DKD may help prognosis management and improvement. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Zhang, H., Liu, N., Dang, H. Tags: Open access, Renal medicine Source Type: research
Association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) incidence and recurrence: a systematic review and meta-analysis
Conclusion
Results of this systematic review and meta-analysis demonstrated a negative correlation between serum vitamin D and BPPV incidence, while any relationship between serum vitamin D and BPPV recurrence remained uncertain. Risk of bias analysis revealed evidence of variable quality. There were insufficient data available to evaluate seasonal relationships between serum vitamin D and BPPV. Given the potential for this as a confounding factor, future research should aim to investigate this further.
PROSPERO registration number
CRD42021271840. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Wood, H., Kluk, K., BinKhamis, G. Tags: Open access, Ear, nose and throat/otolaryngology Source Type: research
Qualitative interview study of rheumatology patients experiences of COVID-19 shielding to explore the physical and psychological impact and identify associated support needs
Conclusion
Patients are dealing with lasting physical and mental effects from shielding and consequences of delayed healthcare. Health professionals need time and resources to ask about patients’ well-being, identify their health needs and refer/signpost to appropriate sources of support. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Silverthorne, C. A., Jones, B., Brooke, M., Coates, L. C., Orme, J., Robson, J. C., Tillett, W., Dures, E. Tags: Open access, Qualitative research, COVID-19 Source Type: research
Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial
Introduction
Sepsis remains the major cause of death among hospitalised patients in intensive care. While targeting sepsis-causing pathogens with source control or antimicrobials has had a dramatic impact on morbidity and mortality of sepsis patients, this strategy remains insufficient for about one-third of the affected individuals who succumb. Pharmacological targeting of mechanisms that reduce sepsis-defining organ dysfunction may be beneficial. When given at low doses, the anthracycline epirubicin promotes tissue damage control and lessens the severity of sepsis independently of the host–pathogen load by conferri...
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Thomas-Rüddel, D., Bauer, M., Moita, L. F., Helbig, C., Schlattmann, P., Ehler, J., Rahmel, T., Meybohm, P., Gründling, M., Schenk, H., Köcher, T., Brunkhorst, F. M., Gräler, M., Heger, A.-J., Weis, S., EPOS-1 study group, Tags: Open access, Intensive care Source Type: research
'God protects us from death through faith and science: a qualitative study on the role of faith leaders in combating the COVID-19 pandemic and in building COVID-19 vaccine trust in Addis Ababa, Ethiopia
Conclusions
This research showed that faith leaders played crucial roles in encouraging vaccine use but were limited in their persuasion power because of intense rumours and misinformation. Empowering faith leaders with the latest vaccine evidence needs to be prioritised in the future. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Yibeltal, K., Workneh, F., Melesse, H., Wolde, H., Kidane, W. T., Berhane, Y., Herzig van Wees, S. Tags: Open access, Public health, COVID-19 Source Type: research
Correction for 'multicentre, open-label, randomised, controlled trial to compare early intervention with calcimimetics and conventional therapy in preventing coronary artery calcification in patients with secondary hyperparathyroidism (UPCOMING): a study protocol
This article has been corrected since it was published online. The authors wish to add a statement about the sharing of data for this trial, in line with BMJ Open’s policy on data sharing.
The jRCT registry (the registry where information for this trial is listed) provides a section on data sharing, which is titled "Plan to share IPD" (individual participant data), and the authors had already filled out this section when initially registering the study. The jRCT system only makes this section publicly available after the study is complete. Data generated from our study and any other necessary materials will be made a...
Source: BMJ Open - April 19, 2024 Category: General Medicine Tags: Open access Correction Source Type: research
Mixed Methods EvAluation of the high-volume low-complexity Surgical hUb pRogrammE (MEASURE): a mixed methods study protocol
This study will evaluate the impact of HVLC surgical hubs on productivity, patient care and the workforce.
Methods and analysis
This 4-year project consists of six interlinked work packages (WPs) and is informed by the Consolidated Framework for Implementation Research. WP1: Mapping current and future HVLC provision in England through document analysis, quantitative data sets (eg, Hospital Episodes Statistics) and interviews with national service leaders. WP2: Exploring the effects of HVLC hubs on key performance outcomes, primarily the volume of low-complexity patients treated, using quasi-experimental methods. WP3: Expl...
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Scantlebury, A., Sivey, P., Anteneh, Z., Ayres, B., Bloor, K., Castelli, A., Castro-Avila, A. C., Davies, F., Davies, S., Glerum-Brooks, K., Gutacker, N., Lampard, P., Rangan, A., Saad, A., Street, A., Wen, J., Adamson, J. Tags: Open access, Surgery Source Type: research
Protocol for the development of a core outcome set and reporting guidelines for locoregional treatment in neoadjuvant systemic breast cancer treatment trials: the PRECEDENT project
Introduction
Neoadjuvant systemic anticancer therapy (neoSACT) is increasingly used in the treatment of early breast cancer. Response to therapy is prognostic and allows locoregional and adjuvant systemic treatments to be tailored to minimise morbidity and optimise oncological outcomes and quality of life. Accurate information about locoregional treatments following neoSACT is vital to allow the translation of downstaging benefits into practice and facilitate meaningful interpretation of oncological outcomes, particularly locoregional recurrence. Reporting of locoregional treatments in neoSACT studies, however, is currentl...
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Potter, S., Avery, K., Ahmed, R., de Boniface, J., Chatterjee, S., Dodwell, D., Dubsky, P., Iwata, H., Jiang, M., Lee, H.-B., MacKenzie, M., Poulakaki, F., Richardson, A. L., Sepulveda, K., Spillane, A., Thompson, A. M., Werutsky, G., Wright, J. L., Zdenk Tags: Open access, Oncology Source Type: research
Prevalence and perceptions of flavour capsule cigarettes among adults who smoke in Brazil, Japan, Republic of Korea, Malaysia and Mexico: findings from the ITC surveys
Conclusion
Our study documented the high prevalence of FCCs in some countries, pointing to the need to develop and implement regulatory strategies to control these attractive products. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Kyriakos, C. N., Erinoso, O., Driezen, P., Thrasher, J. F., Katanoda, K., Quah, A. C. K., Tabuchi, T., Perez, C. d. A., Seo, H. G., Kim, S. Y., Nordin, A. S. A., Hairi, F. M., Fong, G. T., Filippidis, F. T. Tags: Open access, Smoking and tobacco Source Type: research
Moral distress measurement in animal care workers: a systematic review
Conclusion
This is the first systematic review focused on moral distress measurement in animal care workers. It shows that moral distress is rarely measured using standardised and evidence-based methods and that such methods should be developed and validated in the context of animal care.
PROSPERO registration number
CRD42023422259. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Baysal, Y., Goy, N., Hartnack, S., Guseva Canu, I. Tags: Open access, Qualitative research Source Type: research
Effects of combined cognitive and resistance training on physical and cognitive performance and psychosocial well-being of older adults >=65: study protocol for a randomised controlled trial
This study aims to investigate the impact of three distinct interventions: cognitive training, resistance training and a combination of both, compared with an inactive control group, on cognitive performance, mobility and quality of life in adults aged ≥65 years.
Methods and analysis
This trial will investigate healthy older adults aged ≥65 years living independently without cognitive impairments. Participants will be randomly assigned to one of four groups: (1) cognitive training, (2) resistance training, (3) combined cognitive and resistance training, and (4) control group (n=136 participants with 34 participants ...
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Aminirakan, D., Losekamm, B., Wollesen, B. Tags: Open access, Sports and exercise medicine Source Type: research
