Alterations in the brain serotonin system and serotonin-regulated behavior during aging in zebrafish males and females
Behav Brain Res. 2024 Apr 15:115000. doi: 10.1016/j.bbr.2024.115000. Online ahead of print.ABSTRACTThe brain serotonin (5-HT) system performs a neurotrophic function and supports the plasticity of the nervous system, while its age-related changes can increase the risk of senile neurodegeneration. Zebrafish brain is highly resistant to damage and neurodegeneration due to its high regeneration potential and it is a promising model object in searching for molecular factors preventing age-related neurodegeneration. In the present study alterations in 5-HT-related behavior in the home tank and the novel tank diving test, as wel...
Source: Behavioural Brain Research - April 17, 2024 Category: Neurology Authors: Valentina S Evsiukova Ivan E Sorokin Peter A Kulikov Alexander V Kulikov Source Type: research
Neural responses to gaming content on social media in young adults
Behav Brain Res. 2024 Apr 15:115004. doi: 10.1016/j.bbr.2024.115004. Online ahead of print.ABSTRACTExcessive gaming can impair both mental and physical health, drawing widespread public and clinical attention, especially among young generations. People are now more exposed to gaming-related content on social media than before, and this exposure may have a significant impact on their behavior. However, the neural mechanisms underlying this effect remain unexplored. Using functional magnetic resonance imaging (fMRI), this study aimed to investigate the neural activity induced by gaming-related content on social media among y...
Source: Behavioural Brain Research - April 17, 2024 Category: Neurology Authors: Yuka Fujimoto Junya Fujino Daisuke Matsuyoshi Daisuke Jitoku Nanase Kobayashi Chenyu Qian Shoko Okuzumi Shisei Tei Takehiro Tamura Takefumi Ueno Makiko Yamada Hidehiko Takahashi Source Type: research
EEG complexity in emotion conflict task in individuals with psychiatric disorders
This study highlights the significance of investigating EEG complexity and its potential applications in the transdiagnostic exploration of impulsivity in psychiatric disorders.PMID:38621461 | DOI:10.1016/j.bbr.2024.114997 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 15, 2024 Category: Neurology Authors: Chao Gu Tina Chou Alik S Widge Darin D Dougherty Source Type: research
EEG complexity in emotion conflict task in individuals with psychiatric disorders
This study highlights the significance of investigating EEG complexity and its potential applications in the transdiagnostic exploration of impulsivity in psychiatric disorders.PMID:38621461 | DOI:10.1016/j.bbr.2024.114997 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 15, 2024 Category: Neurology Authors: Chao Gu Tina Chou Alik S Widge Darin D Dougherty Source Type: research
Prelimbic Cortex-Nucleus Accumbens Core Projection Positively Regulates Itch and Itch-Related Aversion
In this study, rat models of acute neck and cheek itch were established by subcutaneous injection of 5-HT, compound 48/80, or chloroquine. Immunofluorescence experiments determined that the number of c-Fos-immunopositive neurons in the Prl increased during acute itch. Chemogenetic inhibition of Prl glutamatergic neurons or Prl-NAcC glutamatergic projections can inhibit both histaminergic and nonhistaminergic itch-scratching behaviors and rectify the itch-related conditioned place aversion (CPA) behavior associated with nonhistaminergic itch. The Prl-NAcC projection may play an important role in the positive regulation of i...
Source: Behavioural Brain Research - April 14, 2024 Category: Neurology Authors: Jun-Hui Long Pu-Jun Wang Li Xuan Yao Juan Guang-Yan Wu Jun-Fei Teng Jian-Feng Sui Ya-Min Li Liu Yang Hong-Li Li Shu-Lei Liu Source Type: research
Prelimbic Cortex-Nucleus Accumbens Core Projection Positively Regulates Itch and Itch-Related Aversion
In this study, rat models of acute neck and cheek itch were established by subcutaneous injection of 5-HT, compound 48/80, or chloroquine. Immunofluorescence experiments determined that the number of c-Fos-immunopositive neurons in the Prl increased during acute itch. Chemogenetic inhibition of Prl glutamatergic neurons or Prl-NAcC glutamatergic projections can inhibit both histaminergic and nonhistaminergic itch-scratching behaviors and rectify the itch-related conditioned place aversion (CPA) behavior associated with nonhistaminergic itch. The Prl-NAcC projection may play an important role in the positive regulation of i...
Source: Behavioural Brain Research - April 14, 2024 Category: Neurology Authors: Jun-Hui Long Pu-Jun Wang Li Xuan Yao Juan Guang-Yan Wu Jun-Fei Teng Jian-Feng Sui Ya-Min Li Liu Yang Hong-Li Li Shu-Lei Liu Source Type: research
Increased Sensitivity in Detection of Deficits Following Two Commonly Used Animal Models of Stroke
Behav Brain Res. 2024 Apr 11:114991. doi: 10.1016/j.bbr.2024.114991. Online ahead of print.ABSTRACTStroke is a leading cause of death and disability in the United States. Most strokes are ischemic, resulting in both cognitive and motor impairments. Animal models of ischemic stroke such as the distal medial cerebral artery occlusion (dMCAO) and photothrombotic stroke (PTS) procedures have become invaluable tools, with their own advantages and disadvantages. The dMCAO model is clinically relevant as it occludes the artery most affected in humans, but yields variability in the infarct location as well as the behavioral and co...
Source: Behavioural Brain Research - April 13, 2024 Category: Neurology Authors: Kimberly Prescott Taitum O Cothren John T Holsten Christopher J Evonko Elan C Doyle Faith E Bullock Paul T Marron Julia G Staton Laura S Hatvany Justin W Flack Stacie L Beuschel David A MacQueen Todd C Peterson Source Type: research
Serotonin transporter knockdown relieves depression-like behavior and ethanol-induced CPP in mice after chronic social defeat stress
Behav Brain Res. 2024 Apr 13;466:114998. doi: 10.1016/j.bbr.2024.114998. Online ahead of print.ABSTRACTPatients with stress-triggered major depression disorders (MDD) can often seek comfort or temporary relief through alcohol consumption, as they may turn to it as a means of self-medication or coping with overwhelming emotions. The use of alcohol as a coping mechanism for stressful events can escalate, fostering a cycle where the temporary relief it provides from depression can deepen into alcohol dependence, exacerbating both conditions. Although, the specific mechanisms involved in stress-triggered alcohol dependence and...
Source: Behavioural Brain Research - April 13, 2024 Category: Neurology Authors: Amine Bahi Source Type: research
Serotonin transporter knockdown relieves depression-like behavior and ethanol-induced CPP in mice after chronic social defeat stress
Behav Brain Res. 2024 Apr 11:114998. doi: 10.1016/j.bbr.2024.114998. Online ahead of print.ABSTRACTPatients with stress-triggered major depression disorders (MDD) can often seek comfort or temporary relief through alcohol consumption, as they may turn to it as a means of self-medication or coping with overwhelming emotions. The use of alcohol as a coping mechanism for stressful events can escalate, fostering a cycle where the temporary relief it provides from depression can deepen into alcohol dependence, exacerbating both conditions. Although, the specific mechanisms involved in stress-triggered alcohol dependence and MDD...
Source: Behavioural Brain Research - April 13, 2024 Category: Neurology Authors: Amine Bahi Source Type: research
Increased Sensitivity in Detection of Deficits Following Two Commonly Used Animal Models of Stroke
Behav Brain Res. 2024 Apr 11:114991. doi: 10.1016/j.bbr.2024.114991. Online ahead of print.ABSTRACTStroke is a leading cause of death and disability in the United States. Most strokes are ischemic, resulting in both cognitive and motor impairments. Animal models of ischemic stroke such as the distal medial cerebral artery occlusion (dMCAO) and photothrombotic stroke (PTS) procedures have become invaluable tools, with their own advantages and disadvantages. The dMCAO model is clinically relevant as it occludes the artery most affected in humans, but yields variability in the infarct location as well as the behavioral and co...
Source: Behavioural Brain Research - April 13, 2024 Category: Neurology Authors: Kimberly Prescott Taitum O Cothren John T Holsten Christopher J Evonko Elan C Doyle Faith E Bullock Paul T Marron Julia G Staton Laura S Hatvany Justin W Flack Stacie L Beuschel David A MacQueen Todd C Peterson Source Type: research
Effort-cost decision-making associated with negative symptoms in schizophrenia and bipolar disorder
Behav Brain Res. 2024 Apr 10:114996. doi: 10.1016/j.bbr.2024.114996. Online ahead of print.ABSTRACTMotivational deficits and reduced goal-directed behavior for external rewards have long been considered an important features of negative symptoms in patients with schizophrenia (SCZ). Negative symptoms have also a high prevalence in bipolar disorder (BP). We used a transdiagnostic approach in order to examine association between negative symptoms and effort allocation for monetary rewards. 41 patients with SCZ and 34 patients with BP were enrolled in the study along with 41 healthy controls (HC). Effort-Expenditure for Rewar...
Source: Behavioural Brain Research - April 12, 2024 Category: Neurology Authors: Serhan Is ıklı Asl ıhan Bilge Bektaş Şule Temel Murat Atabay Bilgesu Deniz Arkal ı Ba şak Bağcı Adem Bayrakc ı Miriam Sebold Nabi Zorlu Source Type: research
Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i.p), on the behavioural and cortisol level of unpredictable chronic stress (UCS) zebrafish model. Based on the findings from the behavioural study, the cortisol levels in the zebrafish body after treatment with the two most effective compounds were measured using enzyme-linked immunosorbent assay (ELISA). Furthermore, a molecular docking study was conducted to predict the inhibitory impact of the triterpenoid c...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Zaynab Mando Huda Mando Adlin Afzan Khozirah Shaari Zurina Hassan Mohamad Nurul Azmi Fauziahanim Zakaria Source Type: research
Structural Characteristics of Amygdala Subregions in Type 2 Diabetes Mellitus
This study aims to explore the microstructural alterations of the amygdala in T2DM and to investigate the relationship between the alterations and depressive symptoms. Fifty T2DM and 50 healthy controls were included. Firstly, the volumes of subcortical regions and subregions of amygdala were calculated by FreeSurfer. Covariance analysis (ANCOVA) was conducted between the two groups with covariates of age, sex, and estimated total intracranial volume to explore the differences in volume of subcortical regions and subregions of amygdala. Furthermore, the structural covariance within the amygdala subregions was performed. Mo...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Wenbin Qiu Xiaomei Yue Haoming Huang Limin Ge Weiye Lu Zidong Cao Yawen Rao Xin Tan Yan Wang Jinjian Wu Yuna Chen Shijun Qiu Gang Li Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i.p), on the behavioural and cortisol level of unpredictable chronic stress (UCS) zebrafish model. Based on the findings from the behavioural study, the cortisol levels in the zebrafish body after treatment with the two most effective compounds were measured using enzyme-linked immunosorbent assay (ELISA). Furthermore, a molecular docking study was conducted to predict the inhibitory impact of the triterpenoid c...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Zaynab Mando Huda Mando Adlin Afzan Khozirah Shaari Zurina Hassan Mohamad Nurul Azmi Fauziahanim Zakaria Source Type: research
