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561 records returned

Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Schizophrenia is a complex neuropsychiatric disorder whose etiology involves a mixture of genetic and environmental factors. By virtue of this complexity, schizophrenia is a field of research in which a number of key technologies converge: in particular, identification of putative susceptibility genes through association studies in clinical populations leads to investigation of the behavioural roles of these genes by targeted manipulation in mice and their phenotypic characterisation ('gene-driven' approach); in a complementary manner, identification of putative pathophysiological processes and therapeutic pathways lea...
Source: Behavioural Brain Research - September 4, 2009 Category: Neurology Authors: Desbonnet L, Waddington JL, Tuathaigh CM Tags: Behav Brain Res Source Type: journals

Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Animal models are critical for the study of psychiatric disorders since they allow the use of invasive methods that cannot be used for ethical reasons in humans. Currently there are three general models of schizophrenia; (i) those produced with acute pharmacological intervention (i.e. MK-801, ketamine, PCP and amphetamine), (ii) genetic models (i.e. mutant DISC-1, D(2)-R over expression) and (iii) developmental disruption models (i.e. MAM, neonatal ventral hippocampal lesion, isolation rearing, maternal infection). Here we review evidence for the validity of gestational (day 17) MAM administration as a developmental di...
Source: Behavioural Brain Research - September 2, 2009 Category: Neurology Authors: Lodge DJ, Grace AA Tags: Behav Brain Res Source Type: journals

Evaluation of NMDA receptor models of schizophrenia: divergences in the behavioral effects of sub-chronic PCP and MK-801.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hypothesis of hypo-functionality of NMDA receptors in schizophrenia originates from the observation that administration of the NMDA antagonist phencyclidine (PCP) induces psychotic states that closely resemble schizophrenic symptoms and that persist after drug discontinuation. A large number of animal studies have used PCP and the NMDA antagonist dizocilpine (MK-801) almost interchangeably to model schizophrenia. However, PCP interacts with pharmacological targets other than NMDA receptors that are not affected by MK-801. In addition, although acute administration of either compound produces similar effects in anim...
Source: Behavioural Brain Research - September 2, 2009 Category: Neurology Authors: Seillier A, Giuffrida A Tags: Behav Brain Res Source Type: journals

Structure learning in action.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
'Learning to learn' phenomena have been widely investigated in cognition, perception and more recently also in action. During concept learning tasks, for example, it has been suggested that characteristic features are abstracted from a set of examples with the consequence that learning of similar tasks is facilitated-a process termed 'learning to learn'. From a computational point of view such an extraction of invariants can be regarded as learning of an underlying structure. Here we review the evidence for structure learning as a 'learning to learn' mechanism, especially in sensorimotor control where the motor system ...
Source: Behavioural Brain Research - August 27, 2009 Category: Neurology Authors: Braun DA, Mehring C, Wolpert DM Tags: Behav Brain Res Source Type: journals

Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pdeb(rd1).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Ts65Dn mouse is the most studied and complete aneuploid model of Down syndrome (DS) widely available. As a model for human trisomy 21, these mice display many attractive features, including performance deficits in different behavioral tasks, alterations in synaptic plasticity and adult neurogenesis, motor dysfunction, and age-dependent cholinergic neurodegeneration. Currently, Ts65Dn mice are maintained on a genetic background that leads to blindness in about 25% of their offspring, because it segregates for the retinal degeneration 1 (Pde6b(rd1)) mutation of C3H/HeSnJ. This means that 25% of the mice have to be di...
Source: Behavioural Brain Research - August 27, 2009 Category: Neurology Authors: Costa AC, Stasko MR, Schmidt C, Davisson MT Tags: Behav Brain Res Source Type: journals

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gene-environment interaction may play a role in the etiology of schizophrenia. Transgenic mice expressing dominant-negative DISC1 (DN-DISC1 mice) show some histological and behavioral endophenotypes relevant to schizophrenia. Viral infection during neurodevelopment provides a major environmental risk for schizophrenia. Neonatal injection of polyriboinosinic-polyribocytidylic acid (polyI:C), which mimics innate immune responses elicited by viral infection, leads to schizophrenia-like behavioral alteration in mice after puberty. To study how gene-environmental interaction during neurodevelopment results in phenotypic cha...
Source: Behavioural Brain Research - August 26, 2009 Category: Neurology Authors: Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, Yamada K Tags: Behav Brain Res Source Type: journals

DCP-LA neutralizes mutant amyloid beta peptide-induced impairment of long-term potentiation and spatial learning.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Long-term potentiation (LTP) was monitored from the CA1 region of the intact rat hippocampus by delivering high frequency stimulation (HFS) to the Schaffer collateral commissural pathway. Intraventricular injection with mutant amyloid beta(1-42) peptide lacking glutamate-22 (Abeta(1-42)E22Delta), favoring oligomerization, 10 min prior to HFS, inhibited expression of LTP, with the potency more than wild-type amyloid beta(1-42) peptide. Intraperitoneal injection with the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) 70 min prior to HFS neutralized mutant Abeta(1-42)E22Delt...
Source: Behavioural Brain Research - August 26, 2009 Category: Neurology Authors: Nagata T, Tominaga T, Mori H, Yaguchi T, Nishizaki T Tags: Behav Brain Res Source Type: journals

Hand Shaping in the Rat: Conserved Release and Collection vs. Flexible Manipulation In Overground Walking, Ladder Rung Walking, Cylinder Exploration, and Skilled Reaching.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hand shaping in terrestrial mammals is adapted to many functions including walking, climbing, exploration, and skilled manipulation. Nevertheless, hand shaping is not well described in the rat (Rattus norvegicus) although the species is used to study the evolution of movement, the neural control of movement, and to model impairments that can result from brain injury. In the present study, rat hand movements were examined in standardized tests of overground walking, horizontal or inclined ladder rung walking, exploring a vertical wall of a cylinder, and skilled reaching for food. Behavior was filmed with high-speed (250...
Source: Behavioural Brain Research - August 26, 2009 Category: Neurology Authors: Whishaw IQ, Travis SG, Koppe SW, Sacrey LA, Gholamrezaei G, Gorny B Tags: Behav Brain Res Source Type: journals

Effects of maternal hyperleptinaemia during lactation on short-term memory/learning, anxiety-like and novelty-seeking behavioural traits of adult male rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present study was to evaluate whether maternal hyperleptinaemia programs anxiety-like and novelty-seeking behaviors as well as short-term memory/learning in adult male Wistar rats. During the first 10 days of lactation dams were s.c. injected with either murine leptin (LEP) or saline (CON). Adult LEP offspring displayed less anxiety-like behavior and had better memory performance than CON ones, indicating that maternal hyperleptinaemia has specific long lasting behavioral effects at adulthood. PMID: 19716850 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 26, 2009 Category: Neurology Authors: Fraga-Marques MC, Moura EG, Silva JO, Neto SC, Pereira-Toste F, Passos MC, Lisboa PC, Manhães AC Tags: Behav Brain Res Source Type: journals

Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
3-nitropropionic acid (3-NP) is a well known experimental model to study Huntington's disease (HD) and associated neuropsychiatric problems. Present study has been designed to explore the protective effects of hesperidin, naringin, and their nitric oxide mechanism (if any) against 3-nitropropionic acid induced neurotoxicity in rats. Systemic 3-nitropropionic acid (10mg/kg) treatment for 14 days in rats significantly induced HD like symptoms in rats as indicated by reduced locomotor activity, body weight, grip strength, oxidative defense and mitochondrial complex enzymes (complex -I, II, and IV) activities in striatum. ...
Source: Behavioural Brain Research - August 25, 2009 Category: Neurology Authors: Kumar P, Kumar A Tags: Behav Brain Res Source Type: journals

A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Young chicks were trained on a weakly reinforced variant of a single-trial discrimination avoidance task which fails to consolidate the long-term memory stage. The ryanodine receptor (RyR) agonist 4-chloro-m-cresol (500muM, i.c.) promoted high retention persistently until at least 24 hr post-training when administered between the time of training and 20min post-training. The consolidation of the long-term memory stage by RyR activation implicates intracellular calcium release in triggering long-term memory. PMID: 19716384 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 25, 2009 Category: Neurology Authors: Baker KD, Edwards TM, Rickard NS Tags: Behav Brain Res Source Type: journals

Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we examined the effects of cocaine and diazepam on reward-facilitation and response rate in C57BL/6J mice, the most frequently used mouse line to study genetic modifications. Both cocaine and diazepam potentiated the rewarding effects of lateral hypothalamic brain stimulation in a dose-dependent manner and increased the rate of responding. Interestingly, the maximum decrease in ICSS thresholds was comparable for both drugs, suggesting a similar ability to affect reward and motivation despite different effects on brain reward systems. PMID: 19716385 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 25, 2009 Category: Neurology Authors: Straub CJ, Carlezon WA, Rudolph U Tags: Behav Brain Res Source Type: journals

Activity-related behaviors in the hole-board predict nicotine consumption in C57B6 mice prenatally exposed to nicotine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hole-board behaviors of adolescent C57B/6 mice that had been exposed to nicotine during gestation and suckling were evaluated on postnatal days 34-36. Rearing on all three trials significantly predicted higher nicotine intake on a two bottle choice test administered from days 37-42. For head pokes, there was a weak trend for lower head poking in the first trial to be predictive of higher nicotine intake. Locomotor activity only predicted higher nicotine consumption on the third trial. These results show that hole-board behaviors predict subsequent nicotine intake in mice exposed to nicotine prenatally, especially after...
Source: Behavioural Brain Research - August 24, 2009 Category: Neurology Authors: Gyekis J, Foreman JE, Anthony K, Klein LC, Vandenbergh DJ Tags: Behav Brain Res Source Type: journals

Population level "flipperedness" in the eastern Pacific leatherback turtle.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Limb preference is a behavioral indicator of lateralized brain function that was recently elucidated experimentally in lower vertebrates. We assessed natural spontaneous limb use of nesting eastern Pacific leatherback turtles by recording which hindlimb flipper was extended overtop the cloaca to cover the egg chamber during oviposition. We found a population-level right bias in 1,889 observations of 361 individuals. This is the first report of a limb preference in Testudinata. PMID: 19712702 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 23, 2009 Category: Neurology Authors: Sieg AE, Zandonà E, Izzo VM, Paladino FV, Spotila JR Tags: Behav Brain Res Source Type: journals

Differential dorsolateral prefrontal cortex activation during a verbal n-back task according to sensory modality.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Functional neuroimaging studies carried out on healthy volunteers while performing different n-back tasks have shown a common pattern of bilateral frontoparietal activation, especially of the dorsolateral prefrontal cortex (DLPFC). Our objective was to use functional magnetic resonance imaging (fMRI) to compare the pattern of brain activation while performing two similar n-back tasks which differed in their presentation modality. Thirteen healthy volunteers completed a verbal 2-back task presenting auditory stimuli, and a similar 2-back task presenting visual stimuli. A conjunction analysis showed bilateral activation ...
Source: Behavioural Brain Research - August 23, 2009 Category: Neurology Authors: Rodriguez-Jimenez R, Avila C, Garcia-Navarro C, Bagney A, Aragon AM, Ventura-Campos N, Martinez-Gras I, Forn C, Ponce G, Rubio G, Jimenez-Arriero MA, Palomo T Tags: Behav Brain Res Source Type: journals

Lower risk taking and exploratory behavior in alcohol-preferring sP rats than in alcohol non-preferring sNP rats in the multivariate concentric square field (MCSF) test.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, alcohol-naïve adult Sardinian alcohol-preferring (sP) and non-preferring (sNP) rats were tested in the multivariate concentric square field (MCSF) test. The MCSF test has an ethoexperimental approach and measures general activity, exploration, risk assessment, risk taking, and shelter seeking in laboratory rodents. The multivariate design enables behavioral profiling in one and the same test situation. Age-matched male Wistar rats were included as a control group. Five weeks after the first MCSF trial, a repeated testing was done to explore differences in acquired experience. The results revealed distin...
Source: Behavioural Brain Research - August 20, 2009 Category: Neurology Authors: Roman E, Colombo G Tags: Behav Brain Res Source Type: journals

Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vitamin C (ascorbate) has important antioxidant functions that can help protect against oxidative stress in the brain and damage associated with neurodegenerative disorders such as Alzheimer's disease. When administered parenterally ascorbate can bypass saturable uptake mechanisms in the gut and thus higher tissue concentrations can be achieved than by oral administration. In the present study we show that ascorbate (125mg/kg) administered intraperitoneally (i.p.) 1-hour before testing, partially attenuated scopolamine-induced (1mg/kg i.p.) cognitive deficits in Morris water maze performance in young mice. Cumulative s...
Source: Behavioural Brain Research - August 20, 2009 Category: Neurology Authors: Harrison FE, Hosseini AH, Dawes SM, Weaver S, May JM Tags: Behav Brain Res Source Type: journals

Consequences of extinction training on associative and non-associative fear in a mouse model of Posttraumatic Stress Disorder (PTSD).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A common approach to the clinical treatment of Posttraumatic Stress Disorder (PTSD) has focused on the facilitation of Pavlovian fear extinction through cognitive behavioral therapy that involves both safe exposure to the trauma-related cues and subsequent changes in conditioned stimulus - unconditioned stimulus (CS-US) contingency expectations. PTSD symptoms can be tracked back to pathologically modified associative fear, hyperarousal and a time-dependent fear generalization. We have used a mouse model of PTSD that is based on a brief exposure to an inescapable foot shock in order to investigate the influence of early...
Source: Behavioural Brain Research - August 20, 2009 Category: Neurology Authors: Golub Y, Mauch CP, Dahlhoff M, Wotjak CT Tags: Behav Brain Res Source Type: journals

Neonatal oxytocin alters subsequent estrogen receptor alpha protein expression and estrogen sensitivity in the female rat.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In most species, the effects of oxytocin (OT) on female reproductive behavior are dependent upon estrogen, which increases both OT and OT receptor expression. It is also becoming apparent that OT neurotransmission can influence estrogen signaling, especially during development, as neonatal OT manipulations in prairie voles alter ERalpha expression and estrogen-dependent behaviors. We tested the hypothesis that OT developmentally programs ERalpha expression and estrogen sensitivity in female Sprague-Dawley rats, a species previously used to establish the estrogen-dependence of OT signaling in adulthood. OT treatment for...
Source: Behavioural Brain Research - August 20, 2009 Category: Neurology Authors: Perry AN, Paramadilok A, Cushing BS Tags: Behav Brain Res Source Type: journals

Slope-based Encoding of a Goal Location is Unaffected by Hippocampal Lesions in Homing Pigeons (Columba livia).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using the same procedures as Nardi and Bingman [Nardi D, Bingman VP. Pigeon (Columba livia) encoding of a goal-location: The relative importance of shape geometry and slope. J Comp Psychol, 2009; 123(2): 204-216.], bilateral hippocampal lesions were found to have no detectable effect on the capacity of homing pigeons to use the slope of an inclined surface to encode a goal location. Hippocampal lesioned pigeons, like controls, also preferentially relied on slope over geometry when the two sources of information were set in conflict. As such, slope resembles visual features as a source of goal recognition information th...
Source: Behavioural Brain Research - August 20, 2009 Category: Neurology Authors: Nardi D, Bingman VP Tags: Behav Brain Res Source Type: journals

Fornix transected macaques make fewer perseverative errors than controls during the early stages of learning conditional visuospatial discriminations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies with macaque monkeys have found rapid learning to be impaired in both spatial (visuospatial) and non-spatial (visuomotor) associative learning tasks after fornix transection. In order to test theories that posit a general role for the fornix in associative learning, we investigated whether monkeys with fornix transection would also be impaired in the rapid acquisition of visuovisual conditional associations. We trained monkeys, postoperatively, on three sets of conditional stimulus-stimulus concurrent associations. Fornix transection did not impair learning of these associations, even in the early stag...
Source: Behavioural Brain Research - August 18, 2009 Category: Neurology Authors: Kwok SC, Buckley MJ Tags: Behav Brain Res Source Type: journals

In sexually naive anestrous ewes, male odour is unable to induce a complete activation of olfactory systems.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exposure of anestrous females to a ram or his odour induces rapid secretion of LH that can lead to ovulation. This response is mediated by the main olfactory system (MOS) in sexually experienced ewes. The accessory olfactory system (AOS) has a minor, but unclear, role in this response. In sexually naive ewes, male odour is less effective than in experienced ewes, but the neural pathway involved is not known. In our experiment, we investigated the brain regions activated by the male or his odour in young and sexually naive anestrous ewes using immunohistochemistry for Fos alone, Fos double-labeled with Gonadotropin-Rele...
Source: Behavioural Brain Research - August 16, 2009 Category: Neurology Authors: Chanvallon A, Fabre-Nys C Tags: Behav Brain Res Source Type: journals

Serial and Parallel Processing in the Primate Auditory Cortex Revisited.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over a decade ago it was proposed that the primate auditory cortex is organized in a serial and parallel manner in which there is a dorsal stream processing spatial information and a ventral stream processing non-spatial information. This organization is similar to the "what" / "where" processing of the primate visual cortex. This review will examine several key studies, primarily electrophysiological, that have tested this hypothesis. We also review several human imaging studies that have attempted to define these processing streams in the human auditory cortex. While there is good evidence that spatial information is...
Source: Behavioural Brain Research - August 13, 2009 Category: Neurology Authors: Recanzone GH, Cohen YE Tags: Behav Brain Res Source Type: journals

Resilience against predator stress and dendritic morphology of amygdala neurons.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Individual differences in coping response lie at the core of vulnerability to conditions like post traumatic stress disorder (PTSD). Like humans, not all animals exposed to severe stress show lasting change in affect. Predator stress is a traumatic experience inducing long-lasting fear, but not in all rodents. Thus, individual variation may be a cross species factor driving responsiveness to stressful events. The present study investigated neurobiological bases of variation in coping with severe stress. The amygdala was studied because it modulates fear and its function is affected by stress. Moreover, stress-induced p...
Source: Behavioural Brain Research - August 13, 2009 Category: Neurology Authors: Mitra R, Adamec R, Sapolsky R Tags: Behav Brain Res Source Type: journals

Chronic Prenatal Caffeine Exposure Impairs Novel Object Recognition and Radial Arm Maze Behaviors in Adult Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we demonstrate that chronic prenatal exposure to a moderate dose of caffeine disrupts novel object recognition and radial arm maze behaviors in adult male and female rats. Pregnant dams were administered either tap water or 75mg/L caffeinated tap water throughout gestation. Oral self-administration in the drinking water led to an approximate maternal intake of 10mg/kg/day, equivalent to 2-3 cups of coffee/day in humans based on a metabolic body weight conversion. In adulthood, the offspring underwent testing on novel object recognition, radial arm maze, and Morris water maze tasks. Prenatal caffeine exposur...
Source: Behavioural Brain Research - August 13, 2009 Category: Neurology Authors: Soellner DE, Grandys T, Nuñez JL Tags: Behav Brain Res Source Type: journals

Prefrontal function associated with impaired emotion recognition in patients with multiple sclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multiple sclerosis (MS) is associated with the occurrence of white matter plaques in the central nervous system. These are frequently located in areas interconnecting areas associated with the processing of emotions. Although recent behavioral studies indicated social and affective disturbances in many of these patients, functional studies investigating specific emotional recognition in MS are lacking. We used functional magnetic resonance imaging (fMRI) and lesion mapping in MS-patients to investigate correlates between these measures and emotional facial recognition. Eleven patients whose affective ability was impair...
Source: Behavioural Brain Research - August 13, 2009 Category: Neurology Authors: Krause M, Wendt J, Dressel A, Berneiser J, Kessler C, Hamm AO, Lotze M Tags: Behav Brain Res Source Type: journals

Effects of treadmill training on motor performance and extracellular glutamate level in striatum in rats with or without transient middle cerebral artery occlusion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glutamate transmission is essential for learning and memory. Several studies have shown that exercise can up-regulate the expression of brain-derived neurotrophic factor (BDNF) in normal brain, thus enhancing glutamate release through the synaptic-associated protein synapsin I in vitro. The aim of this study was to investigate the effects of treadmill training on the release of these factors in the striatum and on the motor function in both normal and brain-ischemic rats. Rats were randomly assigned to normal and brain-ischemic groups. Those in the brain-ischemic group underwent middle cerebral artery occlusion (MCAO) ...
Source: Behavioural Brain Research - August 13, 2009 Category: Neurology Authors: Chang HC, Yang YR, Wang SG, Wang RY Tags: Behav Brain Res Source Type: journals

The usefulness of the operant conditioning to assess long-lasting deficits following transient focal ischemia in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined a number of short and long term sensorimotor, behavioural and cognitive consequences of an experimental ischemia induced by a 60-minute right middle cerebral artery occlusion (MCAO) in 129S2 mice. During fourteen days after surgery, a classical sensorimotor assessment was conducted using hanging wire test, negative geotaxis test, grip strength test, accelerated rotarod test and locomotor activity-meter. In order to provide a technique for the assessment of more resistant consequences of ischemia on fine psychomotor control, the peak procedure (a modified version of the operant fixed-interval sche...
Source: Behavioural Brain Research - August 13, 2009 Category: Neurology Authors: Ferrara A, Bejaoui SE, Seyen S, Tirelli E, Plumier JC Tags: Behav Brain Res Source Type: journals

Perseveration Related To Frontal Lesion In Mice Using The Olfactory H-Maze.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The delayed reaction paradigm, consisting to discover two different rules consecutively (delayed alternation and non-alternation task) followed by a delayed reversal task, is a specific marker for the functioning of primate prefrontal cortex. Although several works in rodents report the use of operant delayed alternation tasks, in none of the studies mice with lesion of the prefrontal cortex were used in this paradigm. In the current study, mouse experiments were conducted using a new, totally automated device, the olfactory H-maze. Here, we show that unilateral lesion of the dorsomedial prefrontal cortex in mice induc...
Source: Behavioural Brain Research - August 12, 2009 Category: Neurology Authors: Del'guidice T, Nivet E, Escoffier G, Baril N, Caverni JP, Roman FS Tags: Behav Brain Res Source Type: journals

Cytoskeletal alterations in rat hippocampus following chronic unpredictable mild stress and re-exposure to acute and chronic unpredictable mild stress.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The intrinsic dynamic instability of the cytoskeletal microtubular system is essential for neuronal development and organization. The modulation of microtubule dynamics depends on the phosphorylation of neuronal microtubule-associated proteins (MAPs). Chronic unpredicted mild stress (CUMS) affects hippocampal structure and function in the rat. The aim of the present work was to investigate the possible alteration of cytoskeleton in the hippocampus of rats exposed to CUMS and re-exposed to CUMS to mimic depression and the recurrence of depression of human. We investigated the effects of CUMS, fluoxetine and re-exposure ...
Source: Behavioural Brain Research - August 11, 2009 Category: Neurology Authors: Yang C, Wang G, Wang H, Liu Z, Wang X Tags: Behav Brain Res Source Type: journals

Involvement of the Serotonergic System in the Anxiolytic-like Effect Caused by m-Trifluoromethyl-diphenyl Diselenide in Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The organoselenium compound diphenyl diselenide (PhSe)(2) has shown interesting antioxidant and neuroprotective activities. On the other hand, this compound has also presented some toxic effects. m-Trifluoromethyl-diphenyl diselenide (m-CF(3)-C(6)H(4)Se)(2), a structural analog of (PhSe)(2), has proven to be antipsychotic and antioxidant in mice. The present study was designed to investigate the anxiolytic-like effect of (m-CF(3)-C(6)H(4)Se)(2) in female mice, employing light/dark box and elevated plus-maze (EPM) tests. The involvement of 5-hydroxytryptamine (5-HT) receptors and monoamine oxidase (MAO) activity in the ...
Source: Behavioural Brain Research - August 11, 2009 Category: Neurology Authors: Brüning CA, Prigol M, Roehrs JA, Nogueira CW, Zeni G Tags: Behav Brain Res Source Type: journals

Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study thus provides a model for the development and application of both pharmacologic and cell-based therapies to offset the effects of neurobehavioral teratogens. PMID: 19682500 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 10, 2009 Category: Neurology Authors: Billauer-Haimovitch H, Slotkin TA, Dotan S, Langford R, Pinkas A, Yanai J Tags: Behav Brain Res Source Type: journals

Early life programming of fear conditioning and extinction in adult male rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The early rearing environment programs corticolimbic function and neuroendocrine stress reactivity in adulthood. Although early environmental programming of innate fear has been previously examined, its impact on fear learning and memory later in life remains poorly understood. Here we examined the role of the early rearing environment in programming fear conditioning and extinction in adult male rats. Pups were subjected to maternal separation (MS; 360min), brief handling (H; 15min), or animal facility rearing (AFR) on post-natal days 2-14. As adults, animals were tested in a three-day fear learning and memory paradig...
Source: Behavioural Brain Research - August 10, 2009 Category: Neurology Authors: Stevenson CW, Spicer CH, Mason R, Marsden CA Tags: Behav Brain Res Source Type: journals

Is there "neural efficiency" during the processing of visuo-spatial information in male humans? an eeg study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IS THERE "NEURAL EFFICIENCY" DURING THE PROCESSING OF VISUO-SPATIAL INFORMATION IN MALE HUMANS? AN EEG STUDY. Behav Brain Res. 2009 Aug 6; Authors: Capotosto P, Perrucci MG, Brunetti M, Del Gratta C, Doppelmayr M, Grabner RH, Klimesch W, Neubauer A, Neuper C, Pfurtscheller G, Romani GL, Babiloni C More intelligent persons (high IQ) typically present a higher cortical activity during tasks requiring the encoding of visuo-spatial information, namely higher alpha (about 10Hz) event-related desynchronization (ERD; Doppelmayr et al. 2005a). The opposite is true ("neural efficiency") during the retrieval of the encod...
Source: Behavioural Brain Research - August 5, 2009 Category: Neurology Authors: Capotosto P, Perrucci MG, Brunetti M, Del Gratta C, Doppelmayr M, Grabner RH, Klimesch W, Neubauer A, Neuper C, Pfurtscheller G, Romani GL, Babiloni C Tags: Behav Brain Res Source Type: journals

Relationships between Prepulse Inhibition and Cognition are Mediated by Attentional Processes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prepulse inhibition (PPI) is suggested to reflect a basic inhibitory mechanism which regulates sensory input to the brain, preventing sensory overload and cognitive fragmentation. However, studies directly investigating the relationship between PPI and cognition have produced inconsistent findings; this is likely to be due to the use of uninstructed PPI tasks, and limitations with the methods for measurement of PPI and startle. Therefore, the current study examined the relationship between cognitive performance and attentional modulation of PPI, using novel methods for the measurement of PPI. PPI was measured in 44 pat...
Source: Behavioural Brain Research - August 5, 2009 Category: Neurology Authors: Scholes KE, Martin-Iverson MT Tags: Behav Brain Res Source Type: journals

Small platform sleep deprivation selectively increases the average duration of rapid eye movement sleep episodes during sleep rebound.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The single platform-on-water method is extensively used for depriving rapid eye movement sleep (REMS). Detailed comparison of sleep-wake architecture, recorded during the rebound period after spending three days on either a small or large platform, could separate the effects of REMS deficit from other stress factors caused by the procedure. A further aim of the study was to find the most characteristic REMS parameter of the rebound originating from REMS deficit. Rats were kept on a small or large platform for 72hours. Their frontoparietal electroencephalogram, electromyogram and motility were recorded during the 24h re...
Source: Behavioural Brain Research - August 5, 2009 Category: Neurology Authors: Kitka T, Katai Z, Pap D, Molnar E, Bagdy G Tags: Behav Brain Res Source Type: journals

Chronic Administration Of Risperidone To Healthy Rats: A Behavioural And Morphological Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Taking into account that most of the experimental research into the effects of antipsychotic drugs has mainly focused on behavioural aspects, the aim of the present work is to investigate the effects of a chronic therapeutic dose of risperidone (1mg/Kg/day during 140 days) on both behavioural and morphological aspects in healthy rats. The behavioural results revealed only minor modifications in prepulse inhibition, showing the risperidone-treated group higher values at 70 days of treatment with respect to the vehicle group. Moreover, in the open-field test, this group showed a greater incidence of grooming. In the acti...
Source: Behavioural Brain Research - August 5, 2009 Category: Neurology Authors: Castellano O, Moscoso A, Riolobos AS, Carro J, Arji M, Molina V, López DE, Sancho C Tags: Behav Brain Res Source Type: journals

Nitric oxide modulation of methylphenidate-induced disruption of prepulse inhibition in Swiss mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, methylphenidate induced a dose dependent PPI disruption in Swiss mice modulated by NO/sGC/cGMP and dopamine. The results corroborate the hypothesis of dopamine and NO interacting to modulate sensorimotor gating through central nervous system. It may be useful to understand methylphenidate and other psychostimulants effects. PMID: 19665495 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 5, 2009 Category: Neurology Authors: Issy AC, Salum C, Del Bel EA Tags: Behav Brain Res Source Type: journals

Age Differences in Visual Path Integration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrated age-related deficits in the ability to perform visual return-to-origin tasks and suggests one way in which elderly navigation performance may be compromised. PMID: 19665496 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 5, 2009 Category: Neurology Authors: Mahmood O, Adamo D, Briceno E, Moffat SD Tags: Behav Brain Res Source Type: journals

Depression-like and anxiety-like behavioural aftermaths of impact accelerated traumatic brain injury in rats: A model of comorbid depression and anxiety?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the aforesaid behavioural anomalies observed in TBI rats are analogous to comorbid anxiety and depression in humans. These findings substantiate the TBI rats as a candidate model of comorbid anxiety and depression. PMID: 19660499 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 2, 2009 Category: Neurology Authors: Pandey DK, Yadav SK, Mahesh R Tags: Behav Brain Res Source Type: journals

Conditioned place preference but not rewarding self-stimulation after electrical activation of the external lateral parabrachial nucleus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this experiment was to examine the rewarding effect of electrical stimulation of the external lateral parabrachial nucleus (LPBe) and of the lateral hypothalamus (LH) in concurrent Conditioned Place Preference (cCPP) and Brain Self-Stimulation Rewarding tasks. As expected, LH-stimulated animals readily learned cCPP tasks and developed self-stimulation behaviours following the rate-frequency procedure. As previously demonstrated, stimulation of the parabrachial complex generated rewarding or aversive behaviours in cCPP procedures. However, stimulation of this subnucleus induced consistent cCPP behaviours bu...
Source: Behavioural Brain Research - August 2, 2009 Category: Neurology Authors: Maria JS, Filomena M, Amadeo P Tags: Behav Brain Res Source Type: journals

Topiramate and phenytoin anti-immobility effect in the mice forced swimming test is reversed by veratrine: implication for bipolar depression treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topiramate and phenytoin possess mood stabilizing properties. The mechanism of action of anticonvulsants used in the treatment of bipolar depression is complex and still not completely elucidated. Na(+) channels are present at distinct sites in neurons, where they sub serve different functions and play distinct roles. The fact that most of the anticonvulsants used in the treatment of bipolar disorders are blockers of voltage-gated Na channels has determined our interest in evaluating the role of ion channels in bipolar disorders. Objectives: The scope of this study was to determinate if sodium channels are important fo...
Source: Behavioural Brain Research - August 2, 2009 Category: Neurology Authors: Bourin M, Chenu F, Hascoët M Tags: Behav Brain Res Source Type: journals

The Development of Skilled Walking in the Rat.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study presents a qualitative analysis of the developmental progression of skilled movement in the rat by using a skilled walking task. A new rung bridge task was used to expose rat pups to a novel environment in order to reveal their potential capabilities. Ten rat pups were filmed daily from postnatal day 7 through postnatal day 30 as they explored the rung bridge task. Discrete changes in skilled and non-skilled walking in fore- and hind limbs were evaluated by scoring seven categories and 24 subcategories of motor behaviour, including limb flexion and extension, coordination, posture, sensorimotor responses, distal...
Source: Behavioural Brain Research - August 2, 2009 Category: Neurology Authors: Shriner AM, Drever FR, Metz GA Tags: Behav Brain Res Source Type: journals

Behavioral phenotyping of Neuroepeptide S receptor knockout mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Central administration of Neuropeptide S (NPS) in rodents induces arousal and prolonged wakefulness as well as anxiolytic-like effects. NPS has also been implicated in modulation of cognitive functions and energy homeostasis. Here we present a comprehensive phenotypical analysis of mice carrying a targeted mutation in the NPS receptor (NPSR) gene. NPSR knockout mice were found to exhibit reduced exploratory activity when challenged with a novel environment, which might indicate attenuated arousal. We also observed attenuated late peak wheel running activity in NPSR knockout mice, representing reduced activity during th...
Source: Behavioural Brain Research - July 27, 2009 Category: Neurology Authors: Duangdao DM, Clark SD, Okamura N, Reinscheid RK Tags: Behav Brain Res Source Type: journals

Neonatal ventral hippocampal lesions disrupt set-shifting ability in adult rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Set-shifting in a T-maze task was assessed in rats with a neonatal ventral hippocampal lesion (NVHL), a proposed animal model of schizophrenia. NVHL animals tested as adults were impaired in shifting to a new rule; an increase in perseverative errors suggested that this impairment stemmed from an inability to suppress the previously learned strategy. The NVHL animals' performance is reminiscent of humans with prefrontal damage and patients with schizophrenia. PMID: 19646488 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 27, 2009 Category: Neurology Authors: Brady AM Tags: Behav Brain Res Source Type: journals

The effects of foraging role and genotype on light and sucrose responsiveness in honey bees (Apis mellifera L.).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In honey bees, the sensory system can be measured by touching sugar water to the antennae, eliciting the extension of the proboscis. The proboscis extension response (PER) [6,13] is closely associated with complex behavioral traits involving foraging and learning [30-32,34-36,43-49]. Bees specializing in pollen foraging are more responsive to low concentrations of sucrose solution and, as a consequence, perform better in associative learning assays [4,43,46-48]. An important unanswered question is whether sensory-motor differences between pollen and nectar specialists are restricted to the gustatory modality or whether...
Source: Behavioural Brain Research - July 26, 2009 Category: Neurology Authors: Tsuruda JM, Page RE Tags: Behav Brain Res Source Type: journals

Effects of unilateral amygdala dopamine depletion on behaviour in the elevated plus maze: Role of sex, hemisphere and retesting.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined behaviour in the elevated plus maze over two consecutive days, and plasma adrenocorticotropic hormone (ACTH) levels in response to a separate 30minute restraint stress. Overall, females showed significantly more exploration of open arms of the plus maze than males, while not differing in general activity reflected in closed arm entries. Significant sex x hemisphere interactions were observed for all measures related to open arm exploration, as right amygdala DA depletion produced an anxiolytic effect in males, increasing open arm exploration, but reduced this behaviour in females. Moreover, open arm exploration...
Source: Behavioural Brain Research - July 26, 2009 Category: Neurology Authors: Sullivan RM, Duchesne A, Hussain D, Waldron J, Laplante F Tags: Behav Brain Res Source Type: journals

Diurnal rhythm and stress regulate, dendritic architecture and spine density of pyramidal neurons in the rat infralimbic cortex.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The medial prefrontal cortex (mPFC) participates in several higher-order cognitive functions and is involved in the regulation of the stress response. The infralimbic cortex (ILC), the most ventral part of the mPFC, receives a strong afferent input from the master circadian pacemaker, the suprachiasmatic nucleus. This fact raises the possibility that, similarly to stress, the diurnal rhythm may affect structural plasticity of neurons in the ILC. Here we investigated, whether diurnal changes in combination with immobilization stress have any impact on the dendritic morphology of layer III pyramidal neurons in the ILC. P...
Source: Behavioural Brain Research - July 26, 2009 Category: Neurology Authors: Perez-Cruz C, Simon M, Flügge G, Fuchs E, Czéh B Tags: Behav Brain Res Source Type: journals

Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: Behavioral and Biochemical Evidence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three decades after the coining of the term chronic fatigue syndrome, the diagnosis of this illness is still symptom based and the aetiology remains elusive. Chronic fatigue syndrome pathogenesis seems to be multifactorial and the possible involvement of immune system is supported. The present study was designed to evaluate the effects of the epigallocatechin gallate in a mouse model of immunologically-induced chronic fatigue. On 19th day, after lipopolysaccharide/Brucella abortus administration, the mice showed significant increase in immobility period, post swim fatigue and thermal hyperalgesia. Behavioral deficits w...
Source: Behavioural Brain Research - July 26, 2009 Category: Neurology Authors: Sachdeva AK, Kuhad A, Tiwari V, Chopra K Tags: Behav Brain Res Source Type: journals

Medial Prefrontal Administration of MK-801 Impairs T-maze Discrimination Reversal Learning in Weanling Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several executive functions rely on the medial prefrontal cortex (mPFC) in the rat. Aspiration and neurotoxic lesions of the mPFC impair reversal learning in adult rats [1,16, 34, 55]. Systemic administration of MK-801, an NMDA receptor antagonist, impairs T-maze reversal learning in weanling rats but the role of mPFC NMDA receptor antagonism in this effect is not known in either adult or young animals. This set of studies showed that mPFC NMDA receptors are specifically involved in T-maze discrimination reversal in weanling rats. In Experiment 1, 26-day-old rats (P26) demonstrated a dose-dependent impairment following...
Source: Behavioural Brain Research - July 26, 2009 Category: Neurology Authors: Watson DJ, Stanton ME Tags: Behav Brain Res Source Type: journals