Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection
This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n = 30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the sa...
Source: Behavioural Neurology - April 3, 2024 Category: Neurology Authors: Fatima Salloum Mohamad Farran Houssam Shaib Abdo Jurjus Roni Sleiman Mahmoud I Khalil Source Type: research
Amyotrophic Lateral Sclerosis and Pain: A Narrative Review from Pain Assessment to Therapy
Behav Neurol. 2024 Mar 16;2024:1228194. doi: 10.1155/2024/1228194. eCollection 2024.ABSTRACTAmyotrophic lateral sclerosis (ALS) is the most frequent neurodegenerative disease of the motor system that affects upper and lower motor neurons, leading to progressive muscle weakness, spasticity, atrophy, and respiratory failure, with a life expectancy of 2-5 years after symptom onset. In addition to motor symptoms, patients with ALS have a multitude of nonmotor symptoms; in fact, it is currently considered a multisystem disease. The purpose of our narrative review is to evaluate the different types of pain, the correlation betwe...
Source: Behavioural Neurology - March 25, 2024 Category: Neurology Authors: Vincenzo Pota Pasquale Sansone Sara De Sarno Caterina Aurilio Francesco Coppolino Manlio Barbarisi Francesco Barbato Marco Fiore Gianluigi Cosenza Maria Beatrice Passavanti Maria Caterina Pace Source Type: research
Amyotrophic Lateral Sclerosis and Pain: A Narrative Review from Pain Assessment to Therapy
Behav Neurol. 2024 Mar 16;2024:1228194. doi: 10.1155/2024/1228194. eCollection 2024.ABSTRACTAmyotrophic lateral sclerosis (ALS) is the most frequent neurodegenerative disease of the motor system that affects upper and lower motor neurons, leading to progressive muscle weakness, spasticity, atrophy, and respiratory failure, with a life expectancy of 2-5 years after symptom onset. In addition to motor symptoms, patients with ALS have a multitude of nonmotor symptoms; in fact, it is currently considered a multisystem disease. The purpose of our narrative review is to evaluate the different types of pain, the correlation betwe...
Source: Behavioural Neurology - March 25, 2024 Category: Neurology Authors: Vincenzo Pota Pasquale Sansone Sara De Sarno Caterina Aurilio Francesco Coppolino Manlio Barbarisi Francesco Barbato Marco Fiore Gianluigi Cosenza Maria Beatrice Passavanti Maria Caterina Pace Source Type: research
Amyotrophic Lateral Sclerosis and Pain: A Narrative Review from Pain Assessment to Therapy
Behav Neurol. 2024 Mar 16;2024:1228194. doi: 10.1155/2024/1228194. eCollection 2024.ABSTRACTAmyotrophic lateral sclerosis (ALS) is the most frequent neurodegenerative disease of the motor system that affects upper and lower motor neurons, leading to progressive muscle weakness, spasticity, atrophy, and respiratory failure, with a life expectancy of 2-5 years after symptom onset. In addition to motor symptoms, patients with ALS have a multitude of nonmotor symptoms; in fact, it is currently considered a multisystem disease. The purpose of our narrative review is to evaluate the different types of pain, the correlation betwe...
Source: Behavioural Neurology - March 25, 2024 Category: Neurology Authors: Vincenzo Pota Pasquale Sansone Sara De Sarno Caterina Aurilio Francesco Coppolino Manlio Barbarisi Francesco Barbato Marco Fiore Gianluigi Cosenza Maria Beatrice Passavanti Maria Caterina Pace Source Type: research
Amyotrophic Lateral Sclerosis and Pain: A Narrative Review from Pain Assessment to Therapy
Behav Neurol. 2024 Mar 16;2024:1228194. doi: 10.1155/2024/1228194. eCollection 2024.ABSTRACTAmyotrophic lateral sclerosis (ALS) is the most frequent neurodegenerative disease of the motor system that affects upper and lower motor neurons, leading to progressive muscle weakness, spasticity, atrophy, and respiratory failure, with a life expectancy of 2-5 years after symptom onset. In addition to motor symptoms, patients with ALS have a multitude of nonmotor symptoms; in fact, it is currently considered a multisystem disease. The purpose of our narrative review is to evaluate the different types of pain, the correlation betwe...
Source: Behavioural Neurology - March 25, 2024 Category: Neurology Authors: Vincenzo Pota Pasquale Sansone Sara De Sarno Caterina Aurilio Francesco Coppolino Manlio Barbarisi Francesco Barbato Marco Fiore Gianluigi Cosenza Maria Beatrice Passavanti Maria Caterina Pace Source Type: research
