A Hematological and Histopathological Study on Diphenhydramine Nasal Nano-gel and Nano-emulgel for the Management of Allergic Rhinitis in Animal Model
In this study, we conducted experiment on New Zealand white male rabbits to prove our hypothesis that nasal diphenhydramine nano-gel and nano-emulgel can penetrate the nasal mucosa faster to show drug response and subside histaminic symptoms than market nasal spray (as reference). Blood samples from 48 New Zealand white male rabbits, under both experimental conditions (physiological and pathological) divided into four groups for each (n = 6) were investigated after inducing each dosage form intranasally. Hematologic parameters (WBCs, RBCs, HGB, PLTs, lymphocytes, monocytes, eosinophils, granulocyte counts) were analyzed in...
Source: AAPS PharmSciTech - February 9, 2023 Category: Drugs & Pharmacology Authors: Hina Javed Syed Nisar Hussain Shah Furqan Muhammad Iqbal Nida Javed Benish Saeed Source Type: research
A Hematological and Histopathological Study on Diphenhydramine Nasal Nano-gel and Nano-emulgel for the Management of Allergic Rhinitis in Animal Model
In this study, we conducted experiment on New Zealand white male rabbits to prove our hypothesis that nasal diphenhydramine nano-gel and nano-emulgel can penetrate the nasal mucosa faster to show drug response and subside histaminic symptoms than market nasal spray (as reference). Blood samples from 48 New Zealand white male rabbits, under both experimental conditions (physiological and pathological) divided into four groups for each (n = 6) were investigated after inducing each dosage form intranasally. Hematologic parameters (WBCs, RBCs, HGB, PLTs, lymphocytes, monocytes, eosinophils, granulocyte counts) were analyzed in...
Source: AAPS PharmSciTech - February 9, 2023 Category: Drugs & Pharmacology Authors: Hina Javed Syed Nisar Hussain Shah Furqan Muhammad Iqbal Nida Javed Benish Saeed Source Type: research
Diphenhydramine
(Source: Reactions Weekly)
Source: Reactions Weekly - February 1, 2023 Category: Drugs & Pharmacology Source Type: research
Oculogyric Crisis after Initiation of Aripiprazole: A Case Report of an Active Duty Service Member
CONCLUSION: Aripiprazole-induced acute dystonia, specifically OGC, is a rare potential adverse effect of aripiprazole. Risk factors include male gender, young age, use of typical antipsychotics, and initiation or uptitration of an antipsychotic. Even though atypical antipsychotics including aripiprazole are associated with lower risk for extrapyramidal symptoms, the possibility of oculogyric dystonia merits close monitoring especially in young, male, and drug naive patients. Anticholinergic agents such as diphenhydramine can treat symptoms of acute dystonia.PMID:36660180 | PMC:PMC9845035 | DOI:10.1155/2023/9440028 (Source:...
Source: Case Reports in Psychiatry - January 20, 2023 Category: Psychiatry Authors: Nicole L Hadler Yevin A Roh David A Nissan Source Type: research
Automatic Identification of Self-Reported COVID-19 Vaccine Information from Vaccine Adverse Events Reporting System
CONCLUSION: Some self-reported side effects such as syncope, arthralgia, and blood clotting need further clinical investigations. Our NLP application may help in extracting information from big free-text electronic datasets to help policy makers and other researchers with decision making.PMID:36623831 | DOI:10.1055/s-0042-1760248 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 9, 2023 Category: Information Technology Authors: Jay S Patel Sonya Zhan Zasim Siddiqui Bari Dzomba Huanmei Wu Source Type: research
Automatic Identification of Self-Reported COVID-19 Vaccine Information from Vaccine Adverse Events Reporting System
CONCLUSION: Some self-reported side effects such as syncope, arthralgia, and blood clotting need further clinical investigations. Our NLP application may help in extracting information from big free-text electronic datasets to help policy makers and other researchers with decision making.PMID:36623831 | DOI:10.1055/s-0042-1760248 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 9, 2023 Category: Information Technology Authors: Jay S Patel Sonya Zhan Zasim Siddiqui Bari Dzomba Huanmei Wu Source Type: research
