Evaluation of outpatient prescription patterns of COVID-19 drugs in Iran: comparison of real practice with local therapeutic recommendations
ConclusionIn this study, we showed frequent use of drugs with unproven efficacy in outpatient cases of Covid-19 mostly attributed to corticosteroids and antibiotics use. Our research highlights the discrepancy between recommendations for care and clinical practice and the need for strategy to bridge gaps in evidence-based informed decision-making. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - November 27, 2023 Category: Pharmaceuticals Source Type: research
Lifting the Shade on Pediatric Acute Care Delirium —an Underrecognized Problem
Dr. Hadley
Presenters: Nicholas Beam, MD, Jeri Kessenich, MD, Jillian Bybee, MD, and Brett Leingang, MD
Delirium is underrecognized in the pediatric acute care spaces, both in the intensive care unit and on the general medical floors. Studies have reported that the incidence of pediatric delirium is 20% to 65% of pediatric intensive care unit (PICU) patients and 10% to 40% of all hospitalized children.1 Delirium is defined in the DSM-5 as a disturbance in attention and alertness, with an abrupt change from baseline, which fluctuates, is not explained by pre-existing neurocognitive disorders, and has evidence of a cause.2 ...
Source: The Hospitalist - November 1, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Pediatrics PHM Coverage Source Type: research
Diphenhydramine/epinephrine
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2023 Category: Drugs & Pharmacology Source Type: research
Perioperative management of mastocytosis
ConclusionIntraoperative anaphylaxis can be the first presenting sign of mastocytosis. Patients with mastocytosis who received chronic antimediator therapy and/or preoperative prophylactic medications had an uneventful surgical course. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 1, 2023 Category: Anesthesiology Source Type: research
Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review
CONCLUSIONS: Although PHGS is a disease with a high worldwide prevalence, the lack of consensus about therapeutic management indicates gaps in existing evidence. Most of the proposed treatment consists in symptomatic drugs with empiric regimens which are ineffective for the viral replication. The main limit to realize randomized clinical trial is due to the rapid onset and remission of the disease. In fact, the diagnostic delay, estimated in 72 h, decreases the effectiveness of any antiviral drugs.CLINICAL RELEVANCE: Out of the five studies included in this systematic review, only one was able to provide some weak evidence...
Source: Herpes - September 21, 2023 Category: Infectious Diseases Authors: Noemi Coppola Tiziana Cantile Daniela Adamo Federica Canfora Stefania Baldares Francesco Riccitiello Gennaro Musella Michele Davide D Mignogna Stefania Leuci Source Type: research
Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review
CONCLUSIONS: Although PHGS is a disease with a high worldwide prevalence, the lack of consensus about therapeutic management indicates gaps in existing evidence. Most of the proposed treatment consists in symptomatic drugs with empiric regimens which are ineffective for the viral replication. The main limit to realize randomized clinical trial is due to the rapid onset and remission of the disease. In fact, the diagnostic delay, estimated in 72 h, decreases the effectiveness of any antiviral drugs.CLINICAL RELEVANCE: Out of the five studies included in this systematic review, only one was able to provide some weak evidence...
Source: Herpes - September 21, 2023 Category: Infectious Diseases Authors: Noemi Coppola Tiziana Cantile Daniela Adamo Federica Canfora Stefania Baldares Francesco Riccitiello Gennaro Musella Michele Davide D Mignogna Stefania Leuci Source Type: research
Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review
ConclusionsAlthough PHGS is a disease with a high worldwide prevalence, the lack of consensus about therapeutic management indicates gaps in existing evidence. Most of the proposed treatment consists in symptomatic drugs with empiric regimens which are ineffective for the viral replication. The main limit to realize randomized clinical trial is due to the rapid onset and remission of the disease. In fact, the diagnostic delay, estimated in 72 h, decreases the effectiveness of any antiviral drugs.Clinical relevanceOut of the five studies included in this systematic review, only one was able to provide some weak evidence t...
Source: Clinical Oral Investigations - September 21, 2023 Category: Dentistry Source Type: research
A case of diphenhydramine intoxication showing prolonged false positive tricyclic antidepressant in the urine assay
CONCLUSION: The present case suggests that diphenhydramine overdose may cause cerebellar ataxia and show prolonged cross-reactivity as TCA in the urine.PMID:37706054 | PMC:PMC10423011 | DOI:10.2478/abm-2023-0042 (Source: Biomed Res)
Source: Biomed Res - September 14, 2023 Category: Research Authors: Dongsun Kim Hyun Young Shin Bon D Ku Source Type: research
A case of diphenhydramine intoxication showing prolonged false positive tricyclic antidepressant in the urine assay
CONCLUSION: The present case suggests that diphenhydramine overdose may cause cerebellar ataxia and show prolonged cross-reactivity as TCA in the urine.PMID:37706054 | PMC:PMC10423011 | DOI:10.2478/abm-2023-0042 (Source: Biomed Res)
Source: Biomed Res - September 14, 2023 Category: Research Authors: Dongsun Kim Hyun Young Shin Bon D Ku Source Type: research
Percutaneous absorption and Skin accumulation of Lorazepam-Diphenhydramine- Haloperidol Carbopol gel in Porcine Ear Skin
In conclusion, the ABH Carbopol gel provides a promising alternative to the ABH PLO gel for treating CINV in hospice patients. Further studies are required to validate these findings in clinical settings.PMID:37700110 | DOI:10.1208/s12249-023-02608-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Rabin Neupane Sai H S Boddu Moawia M Al-Tabakha Shery Jacob R Jayachandra Babu Amit K Tiwari Source Type: research
Percutaneous absorption and Skin accumulation of Lorazepam-Diphenhydramine- Haloperidol Carbopol gel in Porcine Ear Skin
In conclusion, the ABH Carbopol gel provides a promising alternative to the ABH PLO gel for treating CINV in hospice patients. Further studies are required to validate these findings in clinical settings.PMID:37700110 | DOI:10.1208/s12249-023-02608-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Rabin Neupane Sai H S Boddu Moawia M Al-Tabakha Shery Jacob R Jayachandra Babu Amit K Tiwari Source Type: research
Percutaneous absorption and Skin accumulation of Lorazepam-Diphenhydramine- Haloperidol Carbopol gel in Porcine Ear Skin
In conclusion, the ABH Carbopol gel provides a promising alternative to the ABH PLO gel for treating CINV in hospice patients. Further studies are required to validate these findings in clinical settings.PMID:37700110 | DOI:10.1208/s12249-023-02608-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Rabin Neupane Sai H S Boddu Moawia M Al-Tabakha Shery Jacob R Jayachandra Babu Amit K Tiwari Source Type: research
Percutaneous absorption and Skin accumulation of Lorazepam-Diphenhydramine- Haloperidol Carbopol gel in Porcine Ear Skin
In conclusion, the ABH Carbopol gel provides a promising alternative to the ABH PLO gel for treating CINV in hospice patients. Further studies are required to validate these findings in clinical settings.PMID:37700110 | DOI:10.1208/s12249-023-02608-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Rabin Neupane Sai H S Boddu Moawia M Al-Tabakha Shery Jacob R Jayachandra Babu Amit K Tiwari Source Type: research
A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial
CONCLUSION: Chitosan-based doxepin nano-formulation might be a promising alternative for routine treatments of oral mucositis.PMID:37668810 | DOI:10.1007/s10787-023-01325-7 (Source: Cancer Control)
Source: Cancer Control - September 5, 2023 Category: Cancer & Oncology Authors: Nazafarin Samiraninezhad Mostafa Rezaee Ahmad Gholami Ali Amanati Maryam Mardani Source Type: research
