Development of an UHPLC-MS/MS method to determine cutaneous biodistribution of cannabidiol after topical application of cannabidiol gel assisted by iontophoresis
This study aimed to establish a method for the determination of cannabidiol in skin samples by UHPLC-MS/MS. A BEH C18 (50.0 × 2.1 mm, 2.5 μm) column was used; the mobile phase consisted of acetonitrile-0.1% formic acid (70:30, v/v), the flow rate was 0.2 μl·min-1 and the column temperature was 30°C. Positive-ion mode with multiple reaction monitoring detection was used to quantify cannabidiol (m/z 315.1 → 193.1) while diphenhydramine (m/z 256.3 → 167.08) served as the internal standard. Good linearity was shown in the range of 1-200 ng·ml-1 for cannabidiol with correlation coefficients of >0.999. The LLOQ was ...
Source: Biomedical Chromatography : BMC - August 31, 2023 Category: Biomedical Science Authors: Dongzhu Kang Chenhui Wang Wenqian Liu Meiqing Yang Xiaohong Cheng Yong Chen Source Type: research
Development of an UHPLC-MS/MS method to determine cutaneous biodistribution of cannabidiol after topical application of cannabidiol gel assisted by iontophoresis
This study aimed to establish a method for the determination of cannabidiol in skin samples by UHPLC-MS/MS. A BEH C18 (50.0 × 2.1 mm, 2.5 μm) column was used; the mobile phase consisted of acetonitrile-0.1% formic acid (70:30, v/v), the flow rate was 0.2 μl·min-1 and the column temperature was 30°C. Positive-ion mode with multiple reaction monitoring detection was used to quantify cannabidiol (m/z 315.1 → 193.1) while diphenhydramine (m/z 256.3 → 167.08) served as the internal standard. Good linearity was shown in the range of 1-200 ng·ml-1 for cannabidiol with correlation coefficients of >0.999. The LLOQ was ...
Source: Biomedical Chromatography : BMC - August 31, 2023 Category: Biomedical Science Authors: Dongzhu Kang Chenhui Wang Wenqian Liu Meiqing Yang Xiaohong Cheng Yong Chen Source Type: research
Development of an UHPLC-MS/MS method to determine cutaneous biodistribution of cannabidiol after topical application of cannabidiol gel assisted by iontophoresis
This study aimed to establish a method for the determination of cannabidiol in skin samples by UHPLC-MS/MS. A BEH C18 (50.0 × 2.1 mm, 2.5 μm) column was used; the mobile phase consisted of acetonitrile-0.1% formic acid (70:30, v/v), the flow rate was 0.2 μl·min-1 and the column temperature was 30°C. Positive-ion mode with multiple reaction monitoring detection was used to quantify cannabidiol (m/z 315.1 → 193.1) while diphenhydramine (m/z 256.3 → 167.08) served as the internal standard. Good linearity was shown in the range of 1-200 ng·ml-1 for cannabidiol with correlation coefficients of >0.999. The LLOQ was ...
Source: Biomedical Chromatography : BMC - August 31, 2023 Category: Biomedical Science Authors: Dongzhu Kang Chenhui Wang Wenqian Liu Meiqing Yang Xiaohong Cheng Yong Chen Source Type: research
Development of an UHPLC-MS/MS method to determine cutaneous biodistribution of cannabidiol after topical application of cannabidiol gel assisted by iontophoresis
This study aimed to establish a method for the determination of cannabidiol in skin samples by UHPLC-MS/MS. A BEH C18 (50.0 × 2.1 mm, 2.5 μm) column was used; the mobile phase consisted of acetonitrile-0.1% formic acid (70:30, v/v), the flow rate was 0.2 μl·min-1 and the column temperature was 30°C. Positive-ion mode with multiple reaction monitoring detection was used to quantify cannabidiol (m/z 315.1 → 193.1) while diphenhydramine (m/z 256.3 → 167.08) served as the internal standard. Good linearity was shown in the range of 1-200 ng·ml-1 for cannabidiol with correlation coefficients of >0.999. The LLOQ was ...
Source: Biomedical Chromatography : BMC - August 31, 2023 Category: Biomedical Science Authors: Dongzhu Kang Chenhui Wang Wenqian Liu Meiqing Yang Xiaohong Cheng Yong Chen Source Type: research
Development of an UHPLC-MS/MS method to determine cutaneous biodistribution of cannabidiol after topical application of cannabidiol gel assisted by iontophoresis
This study aimed to establish a method for the determination of cannabidiol in skin samples by UHPLC-MS/MS. A BEH C18 (50.0 × 2.1 mm, 2.5 μm) column was used; the mobile phase consisted of acetonitrile-0.1% formic acid (70:30, v/v), the flow rate was 0.2 μl·min-1 and the column temperature was 30°C. Positive-ion mode with multiple reaction monitoring detection was used to quantify cannabidiol (m/z 315.1 → 193.1) while diphenhydramine (m/z 256.3 → 167.08) served as the internal standard. Good linearity was shown in the range of 1-200 ng·ml-1 for cannabidiol with correlation coefficients of >0.999. The LLOQ was ...
Source: Biomedical Chromatography : BMC - August 31, 2023 Category: Biomedical Science Authors: Dongzhu Kang Chenhui Wang Wenqian Liu Meiqing Yang Xiaohong Cheng Yong Chen Source Type: research
A Qualitative Analysis of First-Hand Accounts of Diphenhydramine Misuse Available on YouTube
. (Source: Journal of Psychoactive Drugs)
Source: Journal of Psychoactive Drugs - August 31, 2023 Category: Psychiatry & Psychology Authors: Haley Maria Dourron Heith Copes Agasthya Vedre-Kyanam Daniel D. Reyes Maggie Gossage Noah Wiles Sweat Peter S. Hendricks Source Type: research
A Case Report of Venezuelan Suntiger Tarantula (Psalmopoeus Irminia) Envenomation and Review of Tarantula Exposures
J Emerg Med. 2023 Jun 10:S0736-4679(23)00320-7. doi: 10.1016/j.jemermed.2023.05.022. Online ahead of print.ABSTRACTBACKGROUND: Tarantula envenomations are encountered infrequently but may increase with increased exotic animal ownership. This case report presents the first documented toxicity from a Venezuelan suntiger tarantula (VST), Psalmopoeus irminia, and provides a general framework for approaching patients with tarantula exposures.CASE REPORT: A 35-year-old man presented to an emergency department 4 h after experiencing a bite from his pet VST. He developed erythema, pain, and edema to the bite site on the left thena...
Source: Pain Physician - August 27, 2023 Category: Anesthesiology Authors: Mark Simon Christopher Hoyte Source Type: research
The impact of Verapamil for radial access in diagnostic cerebrovascular angiograms: A retrospective case-control study
CONCLUSION: Verapamil in the "cocktail" for wrist access diagnostic cerebral angiograms was associated with periprocedural hives, but not associated with a significant reduction in spasm compared to the non-Verapamil group. Our findings suggest that the administration of prophylactic Verapamil for these procedures may not be necessary.PMID:37574785 | DOI:10.1177/15910199231193932 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - August 14, 2023 Category: Radiology Authors: Dominic Romeo Mohamed M Salem Georgios S Sioutas Antonio Corral Tarbay Jinggang Jenny Ng Pakinam E Aboutaleb Visish M Srinivasan Bryan Pukenas Brian T Jankowitz Jan-Karl Burkhardt Source Type: research
Occurrence and risk assessment of pharmaceuticals in hospital wastewater in Costa Rica
Chemosphere. 2023 Aug 5:139746. doi: 10.1016/j.chemosphere.2023.139746. Online ahead of print.ABSTRACTThis work aims to determine the occurrence, hazard and prioritization of pharmaceuticals from hospital wastewater in Costa Rica through the monitoring of 70 compounds and assessing their environmental risk through a hazard quotient approach (HQ). Moreover, the quantification of selected antibiotic resistance genes (ARGs) was conducted for the first time in this matrix in this geographical location. Thirty-four pharmaceuticals were detected, being caffeine, 1,7-dimethylxanthine, acetaminophen, ibuprofen, naproxen, ciproflox...
Source: Chemosphere - August 7, 2023 Category: Chemistry Authors: Carlos E Rodr íguez-Rodríguez Didier Ram írez-Morales Mario Masis-Mora Jos é R Montiel-Mora Claudio Soto-Garita Emanuel Araya-Valverde Juan Carlos Cambronero-Heinrichs Alexandre S ànchez-Melsió Susana Brice ño-Guevara Michael Mendez-Rivera Jos é L Source Type: research
Occurrence and risk assessment of pharmaceuticals in hospital wastewater in Costa Rica
Chemosphere. 2023 Aug 5:139746. doi: 10.1016/j.chemosphere.2023.139746. Online ahead of print.ABSTRACTThis work aims to determine the occurrence, hazard and prioritization of pharmaceuticals from hospital wastewater in Costa Rica through the monitoring of 70 compounds and assessing their environmental risk through a hazard quotient approach (HQ). Moreover, the quantification of selected antibiotic resistance genes (ARGs) was conducted for the first time in this matrix in this geographical location. Thirty-four pharmaceuticals were detected, being caffeine, 1,7-dimethylxanthine, acetaminophen, ibuprofen, naproxen, ciproflox...
Source: Chemosphere - August 7, 2023 Category: Chemistry Authors: Carlos E Rodr íguez-Rodríguez Didier Ram írez-Morales Mario Masis-Mora Jos é R Montiel-Mora Claudio Soto-Garita Emanuel Araya-Valverde Juan Carlos Cambronero-Heinrichs Alexandre S ànchez-Melsió Susana Brice ño-Guevara Michael Mendez-Rivera Jos é L Source Type: research
Comment on: Are antimuscarinic effects common in hydroxyzine overdose? A cohort analysis of antimuscarinic effects in hydroxyzine and diphenhydramine poisoned patient
Volume 61, Issue 7, July 2023, Page 562-563 . (Source: Clinical Toxicology)
Source: Clinical Toxicology - August 3, 2023 Category: Toxicology Authors: Samantha S. Klein Joshua Bloom Marlis Gnirke Mary Ann Howland Source Type: research
Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
