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Proceedings of the International Symposium on Nanotoxicity Assessment and Biomedical Environmental Application of Fine Particles and Nanotubes (Part 2). June 16-17, 2008. Hokkaido, Japan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19714791 [PubMed - indexed for MEDLINE] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - August 31, 2009 Category: Materials Science Tags: Biomed Mater Eng Source Type: journals

Studies of Paramecium caudatum by means of scanning electron microscope and projection X-ray microscope.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Samples of Paramecium caudatum are observed by means of a scanning electron microscope (SEM) and a projection X-ray microscope (XRM) with computer tomography (CT) function. The samples are fixed with two kinds of fixatives, glutaraldehyde and osmium-tetra oxide acid. After the fixation and replacement procedure with t-buthyl alcohol, the samples followed by a freeze drying, well retain their structures. Surface structures, cilia and microfibrillar systems including infraciliary lattice structures, are clearly depicted by SEM observation. On the other hand, XRM images give quite different information, namely, in the cas...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Yada K, Abe T, Haga N Tags: Biomed Mater Eng Source Type: journals

Low-voltage and high-voltage TEM observations on MWCNTs of rat in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study, we focused on the optimal conditions for observation of morphology and atomic structure of carbon nanotube (CNT) in vivo by transmission electron microscopy (TEM). Either low-voltage or high-voltage TEMs was chosen for the high-contrast or high-resolution imaging of subcutaneous tissue and the multi-wall CNT (MWCNT). The morphology and structure of each cell organelle were well recognized using the low-voltage TEM at 75 kV. Individual MWCNTs forming the cluster were also visible by the low-voltage TEM. On the contrary, the high-voltage TEM image at 1250 kV shows poor contrast on both the cell orga...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Sakaguchi N, Watari F, Yokoyama A, Nodasaka Y, Ichinose H Tags: Biomed Mater Eng Source Type: journals

Development of a second-generation radiofrequency ablation using sintered MgFe2O4 needles and alternating magnetic field for human cancer therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Magnetic metal particles are known to induce heat energy under an alternating magnetic field (AMF). We developed a local tumor-heating device incorporating an MgFe2O4 needle for the purpose of mild ablation for cancer treatment. A needle made from sintered MgFe2O4 particles was embedded in the hepatic or breast tumors. Tumors were then heated by the energy dissipated from the needle exposed to an AMF. We sequentially evaluated histological changes, cellular activity of tumors, and the extent of thermal effect using nicotinamide adenine dinucleotide (NADH) diaphorase and terminal deoxynucleotidyl tranferase-mediated dig...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Watanabe Y, Sato K, Yukumi S, Yoshida M, Yamamoto Y, Doi T, Sugishita H, Naohara T, Maehara T, Aono H, Kawachi K Tags: Biomed Mater Eng Source Type: journals

Poly-L-arginine-hydroxyapatite nanoparticle complexes translocate through lipidbilayer membranes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Certain molecules, which are able to directly translocate across phospholipid bilayer membranes (cell or endosormal membrane), can be useful as carriers (vectors) for drags (especially polymeric drags). We have studied the translocationability of the hydroxyapatite nanoparticle-poly-L-arginine complex through the negatively charged phospholipid bilayer membranes by using several instruments. It was confirmed by means of a confocal laser scanning microscopy (CLSM) not only the fact that the complex can translocate through the membranes but also the fact that the complexes were still retained in the inner water layer of ...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Ueno S, Shimabayashi S Tags: Biomed Mater Eng Source Type: journals

Development of a novel cement by conversion of hopeite in set zinc phosphate cement into biocompatible apatite.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, calcium nitrate solutions of various concentrations were used for the conversion of hopeite crystals into CP. The products after the solution treatment were analyzed by X-ray diffractometry (XRD), Fourier transform infrared spectrometry (FTIR), and scanning electron microscope (SEM) observation. These results indicated that the converted scholzite crystals could be partially detected. Several types of set zinc phosphate cement with different P/L ratios were arranged. The surface products of the set cement after the solution treatment were analyzed by XRD. However, the crystal phase such as hopeite was not de...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Horiuchi S, Asaoka K, Tanaka E Tags: Biomed Mater Eng Source Type: journals

Fabrication of porous chitosan/hydroxyapatite nanocomposites: Their mechanical and biological properties.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We fabricated novel chitosan/hydroxyapatite (HAp) nanocomposites with porous structure by the co-precipitation and porogen leaching method. SEM observation confirmed that the porous chitosan/HAp nanocomposites with 60.6% and 87.1% porosity showed the interconnective pores with pore diameters in the range of 100-200 mum. The composites were found to be mechanically flexible and could be easily formed into any desired shape. The mechanical strength was enhanced by the heat treatment with saturated steam, which was ascribed to the formation of hydrogen bonds between chitosan molecules. The composites subcutaneously implan...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Kashiwazaki H, Kishiya Y, Matsuda A, Yamaguchi K, Iizuka T, Tanaka J, Inoue N Tags: Biomed Mater Eng Source Type: journals

BMP-2 release and dose-response studies in hydroxyapatite and beta-tricalcium phosphate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study is to compare in vivo retention of BMP-2 and bone induction in HAp (porosity: 60-80%, pore size: 100-600 mum, sintering temperature: 800 degrees C, surface area: 1 m2/g) and beta-TCP (porosity: 75%, pore size: 100-400 mum, sintering temperature: 1050 degrees C, surface area: 4 m2/g). We estimated the in vivo release profile of 125I-labeled BMP-2 and bone induction of hard tissues histologically. The amount of BMP-2 remaining in the beta-TCP at 1 day after implantation was 49.6%, while the amount was 34.0% in the HAp. Furthermore, the HAp and beta-TCP containing 0.0, 0.05, 0.1, 0.3, 0.5, 1.0, 5...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Tazaki J, Murata M, Akazawa T, Yamamoto M, Ito K, Arisue M, Shibata T, Tabata Y Tags: Biomed Mater Eng Source Type: journals

Adhesion of human osteoblast-like cells (Saos-2) to carbon nanotube sheets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated adhesion of osteoblast-like cells to single-walled carbon nanotube (SWNT) and multi-walled carbon nanotube (MWNT) sheets and compared these adhesions with that on a cell culture polystyrene dish by using a cell adhesion test and a scanning electron microscope. The MWNT sheets exhibited faster adhesion of cells at an initial stage than SWNT sheets and cell culture polystyrene dish. The number of attached cells on the MWNT sheets seemed to be greater than on SWNT sheets and cell culture polystyrene. Moreover, the MWNT sheets exhibited both high speed and good capacity for cell adhesion. However...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Akasaka T, Yokoyama A, Matsuoka M, Hashimoto T, Abe S, Uo M, Watari F Tags: Biomed Mater Eng Source Type: journals

Improvement in cell proliferation on silicone rubber by carbon nanotube coating.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, a coating of carbon nanotubes (CNTs) was applied to silicone rubber to improve its cellular adhesiveness. Scanning electron micrograph of this coating revealed that CNTs had formed a densely packed meshwork; the Ra values and protein adsorption capacity were enhanced. Although the contact angle did not change after coating, it decreased after immersion into a culture medium. After cultivation for 6 d, while Saos-2 cells were hardly observed on untreated silicone, the cells proliferated on CNT-coated silicone. Thus, CNT coating might be a simple and effective solution to problems associated with silicone impl...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Matsuoka M, Akasaka T, Hashimoto T, Totsuka Y, Watari F Tags: Biomed Mater Eng Source Type: journals

Assessment of the nanostructure of acid-base resistant zone by the application of all-in-one adhesive systems: Super dentin formation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An acid-base resistant zone (ABRZ) has been shown to be created under a hybrid layer in a self-etching adhesive system at the adhesive/dentin interface. The purpose of this study was to assess the nanostructure of the ABRZ by applying all-in-one adhesive systems. Human premolar dentin was treated with one of two all-in-one adhesive systems; Clearfil Tri-S Bond and G-Bond according to the manufacturers' instructions. After placement of a resin composite, the bonded interface was vertically sectioned and subjected to an acid-base challenge. Following this, the nanostructure of the ABRZ was examined by SEM and TEM. The SE...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Nikaido T, Weerasinghe DD, Waidyasekera K, Inoue G, Foxton RM, Tagami J Tags: Biomed Mater Eng Source Type: journals

A novel prosthetic resin composite containing fine enamel particles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Finely powdered enamel was used to develop a prosthetic resin composite that has good mechanical properties and no potential to abrade opposing tooth structure. Bovine teeth were ground into powder and then the enamel particles were separated from the powder by centrifugation in bromoform-ethanol solution. The resin matrix consisted of UDMA (60 mole %) and Tri-EDMA (40 mole %). Camphorquinone (0.5 mass %) was added to the monomer as a photo-initiator. Fillers were incorporated directly into the resin matrix in amounts of 80 or 85 mass %. The flexural strength and Vickers hardness (Hv) were measured. The average flexura...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Endo K, Ohno H Tags: Biomed Mater Eng Source Type: journals

Modification of the dentin surface by using carbon nanotubes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the changes induced in the surfaces of tooth slices by the application of a coating of CNTs by observing CNT-coated tooth slices both macroscopically as well as under a scanning electron microscope. Further, we investigated the effect of CNT coating on the tensile bond strength of dentin adhesives. CNTs adhered easily to the tooth surfaces when tooth slices were suspended in a CNT-dispersed solution. Interestingly, it was observed that CNTs selectively adhered to the surfaces of dentin and cementum, possibly by adhering to their exposed collagen fibers. In addition, the CNT coating did not af...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Akasaka T, Nakata K, Uo M, Watari F Tags: Biomed Mater Eng Source Type: journals

Formaldehyde reduction with scallop shell powders fired at high temperatures: Identification of the effective ingredient.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The volatile organic compound (VOC) reduction activity of scallop shell powders fired at 300, 600 and 900 degrees C was examined using formaldehyde (HCHO). Raw shells as well as fired shells immediately after firing at several temperatures, except for 600 degrees C, were found to gradually remove HCHO from the air. In the case of shell powders stored for 3 months after firing, the HCHO reduction activity of the powder fired at 900 degrees C was obviously improved, with the HCHO concentrations rapidly reaching zero within 20 min. It has been found by X-ray diffraction measurements that shell powder stored for 3 months a...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Takada T, Furusaki A, Tanaka Y Tags: Biomed Mater Eng Source Type: journals

Effects of heat treatment on the bioactivity of surface-modified titanium in calcium solution.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to determine the effects of heat treatment on the bioactivity of hydrothermal-modified titanium in CaO solution for improved bioactivity by immersion in simulated body fluid (SBF). The hydrothermal treatment of titanium in CaO solution was performed at 121 degrees C at 0.2 MPa for 1 h in an autoclave followed by 1 h heat treatments at 200, 400, 600 and 800 degrees C simultaneously. The bioactivity of titanium was evaluated by hydroxyapatite precipitation during immersion in SBF. Surface microstructure changes after the heat treatments and immersion in SBF were determined by X-ray diffracto...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Sultana R, Hamada K, Ichikawa T, Asaoka K Tags: Biomed Mater Eng Source Type: journals

Effect of temperature on crystallinity of carbonate apatite foam prepared from alpha-tricalcium phosphate by hydrothermal treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect of temperature on crystallinity of carbonate apatite (CAp) foam prepared from alpha-tricalcium phosphate (alpha-TCP) foam by hydrothermal treatment was investigated in the present study. The alpha-TCP foams were prepared through a conventional sintering method using polyurethane foam as template. Then, the resultant alpha-TCP foams were hydrothermally treated with Na2CO3 aqueous solution at 100 degrees C, 150 degrees C and 200 degrees C for 72 h. After hydrothermal treatment, the cancellous bone-like macroporous structure of the alpha-TCP foams was maintained. However, microscopic morphology of the foams' fr...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Takeuchi A, Munar ML, Wakae H, Maruta M, Matsuya S, Tsuru K, Ishikawa K Tags: Biomed Mater Eng Source Type: journals

Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized. PMID: 19581716 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Abe S, Kida I, Esaki M, Akasaka T, Uo M, Hosono T, Sato Y, Jeyadevan B, Kuboki Y, Morita M, Tohji K, Watari F Tags: Biomed Mater Eng Source Type: journals

In vivo internal diffusion of several inorganic microparticles through oral administration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We observed the internal diffusion behavior of inorganic micro/nano particles through oral administration. By oral exposure, the fed particles were absorbed through the digestive system then reached some organs after internal diffusion in the body. For example, TiO2 particles fed to mice were detected in the lung, liver, and spleen after 10 days of feeding. Whereas, the absorption efficiency was extremely low compared with intravenous injection. In a comparison of the simple amount of administration, oral exposure required 102 times or more amount by intravenous injection for detection by an X-ray scanning analytical m...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Abe S, Koyama C, Esaki M, Akasaka T, Uo M, Kuboki Y, Morita M, Watari F Tags: Biomed Mater Eng Source Type: journals

Microstructures and biological influence of environmental exposure of asbestos.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Asbestos minerals are thin fiber type of minerals and honorably said as "the minerals of the miracle" because of their valuable natures even in the strategic field. On the other hand, the relation between asbestos exposure and diseases such as lung cancer and malignant mesothelioma was proved around 1970 by epidemiology and an animal experiment in relation to their microstructures. Here, microstructures of chrysotile asbestos, a mainstream of asbestos substances, are shown. It is also shown that in what kinds of environment people are exposed to asbestos and what kinds of biological or epidemical things happen after as...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Yada K, Kohyama N Tags: Biomed Mater Eng Source Type: journals

Calcium phosphate nanoparticles for the transfection of cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transfection is a widely used method in molecular biology for the introduction of foreign nucleic acids (DNA or RNA) into eukaryotic cells that permits to control intracellular processes, i.e. the induction or inhibition of protein expression. Nucleic acids alone cannot penetrate the cell membrane, therefore special carriers like cationic polymers or inorganic nanoparticles are required. Single-shell and multi-shell calcium phosphate nanoparticles were prepared and functionalized with DNA and siRNA. Thereby, the expression of enhanced green fluorescing protein (EGFP) can be induced (by using pcDNA3-EGFP) or silenced (b...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Kovtun A, Heumann R, Epple M Tags: Biomed Mater Eng Source Type: journals

Improved bond performance of a dental adhesive system using nano-technology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since adhesive technology was introduced into dental field, metal-based restoration has been gradually replaced by metal-free restoration. Using the adhesive technology, minimum invasive technique has been possible in daily clinical practice as well as esthetic tooth-colored restorations have become very popular all over the world.One of the current issues of the dental adhesive is durability of bond between tooth structure and adhesive resin. Several approaches to overcome the issues have been carried out. Self-etching approach is believed to create durable bond because demineralization of superficial tooth surface is...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Nagano F, Selimovic D, Noda M, Ikeda T, Tanaka T, Miyamoto Y, Koshiro K, Sano H Tags: Biomed Mater Eng Source Type: journals

Research on the societal impacts of nanotechnology: A preliminary comparison of USA, Europe and Japan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We initiate some comparisons between Japan, Europe and USA on how far there is governmental support for the ethical, legal, social and environmental dimensions of nanotechnology development. It is evident that in the USA and Europe nanotechnology is now firmly embedded in the consideration of ELSI. Yet Japan has not yet adequately recognized the importance of these dimensions. The history of bioethics in Japan is short. In Europe, as early as 2004, a nanotechnology report by the UK's Royal Society referred to the possibility of some nanotubes and fibres having asbestos-like toxicity. The negative history of asbestos in...
Source: Bio-Medical Materials and Engineering - July 8, 2009 Category: Materials Science Authors: Matsuda M, Hunt G Tags: Biomed Mater Eng Source Type: journals

Introduction to the special issue.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19458439 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Tags: Biomed Mater Eng Source Type: journals

Interaction of collagen triple-helix with carbon nanotubes: Geometric property of rod-like molecules.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The interactions between carbon nanotubes and important biomolecules, above all collagen molecules, have not been studied in detail. This situation is partly due to the fact that CNT are solid entities, while most of the biomolecules can be prepared in solution. We used turbidity as a means of evaluating the interaction between CNT and collagen molecules. To a stable suspension of CNT (10 ppm in 0.1% Triton), collagen solution was added to obtain a final concentration of 25 ppm. The degree of aggregation was evaluated by measuring the turbidity of the suspension at 660 nm. It was found that native collagen induced dist...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Kuboki Y, Terada M, Kitagawa Y, Abe S, Uo M, Watari F Tags: Biomed Mater Eng Source Type: journals

Multiwalled carbon nanotube monoliths prepared by spark plasma sintering (SPS) and their mechanical properties.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three types of multiwalled carbon nanotube (MWCNT) monoliths without any binders were obtained by spark plasma sintering (SPS) treatment at 2000 degrees C under 80 MPa sintering pressure. Three MWCNTs with different diameters: thin (slashed circle20-30 nm, CNT Co., Ltd., Korea), thick (slashed circle100 nm, Nano Carbon Technologies Co., Ltd., Japan) and spherical thin (slashed circle20-30 nm, granulated diameter = 1-3 microm, Shimizu Corporation, Japan) were employed for SPS. SEM observation confirmed that these materials maintained the nanosized tube microstructure of raw CNT powder after SPS treatment. The densest mo...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Uo M, Hasegawa T, Akasaka T, Tanaka I, Munekane F, Omori M, Kimura H, Nakatomi R, Soga K, Kogo Y, Watari F Tags: Biomed Mater Eng Source Type: journals

Development of an in vitro screening method for safety evaluation of nanomaterials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the role of particle size in cytotoxicity tests of nanomaterials (NMs), we exposed Chinese hamster cells to polystyrene (PS) spheres with defined diameters ranging from 0.1 to 9.2 microm. We found that the 4.45-microm PS particles were most cytotoxic while sizes 0.1 and 0.2 microm showed no cytotoxicity up to 1000 microg/ml. In the chromosome aberration test, the 4.45-microm PS particles induced polyploidy in a mass concentration-dependent manner in 24- and 48-h treatments. The 5.26-microm PS particles induced polyploidy only at 1000 microg/ml for 48 h. Next, we performed the cytotoxicity test with as-grown...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Matsuoka A, Onfelt A, Matsuda Y, Nakaoka R, Haishima Y, Yudasaka M, Iijima S, Tsuchiya T Tags: Biomed Mater Eng Source Type: journals

In-situ observation of silver nanoparticle ink at high temperature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In-situ TEM (transmission electron microscopy) of silver nanoparticle ink at high temperature was carried out. Into a carbon film tube coating the spiral tungsten filament which was attached to the TEM specimen holder, a silver nanoparticle ink was injected. After evaporation, silver nanoparticles with an aggregated structure could be observed. The temperature of the tungsten wire can be controlled by DC current supplied by dry batteries. Fusion of smaller nanoparticles was observed at a higher temperature and some particles were incorporated to larger particles. This technique can be generally used to consider the sin...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Yonezawa T Tags: Biomed Mater Eng Source Type: journals

Arrays of carbon nanofibers as a platform for biosensing at the molecular level and for tissue engineering and implantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arrays of Carbon nanofibers (CNFs) harness the advantages of individual CNF as well the collective property of assemblies, which made them promising materials in biosensing and tissue engineering or implantation. Here, we report two studies to explore the applications of vertically aligned CNFs. First, a nanoelectrode array (NEA) based on vertically aligned CNFs embedded in SiO(2) is used for ultrasensitive DNA detection. Oligonucleotide probes are selectively functionalized at the open ends of the CNFs and specifically hybridized with oligonucleotide targets. The guanine groups are employed as the signal moieties in t...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Koehne JE, Chen H, Cassell A, Liu GY, Li J, Meyyappan M Tags: Biomed Mater Eng Source Type: journals

Multiwalled carbon nanotube coating on titanium.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carbon nanotubes (CNTs) have excellent chemical durability, mechanical strength and electrical properties. Therefore, there is interest in CNTs for not only electrical and mechanical applications, but also biological and medical applications. We coated titanium, a common material for dental implants, with multiwalled carbon nanotubes (MWCNTs). First, titanium was aminated and covered with collagen. Then, the carboxylated MWCNTs were coated onto the collagen attached to the titanium plate. The collagen-coated titanium plate had a homogeneous MWCNT coating, which showed strong attachment to the titanium surface as a thin...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Terada M, Abe S, Akasaka T, Uo M, Kitagawa Y, Watari F Tags: Biomed Mater Eng Source Type: journals

Assessment of allergic hypersensitivity to dental materials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study indicates that dentists and dental researchers should be concerned about the allergenic potential of dental metal materials. PMID: 19458446 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Hosoki M, Bando E, Asaoka K, Takeuchi H, Nishigawa K Tags: Biomed Mater Eng Source Type: journals

Gene expression analyses of human macrophage phagocytizing sub-micro titanium particles by allergy DNA chip (Genopal).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to examine gene expressions of macrophage phagocytizing sub-micro Ti particles by a DNA chip. Human monocytic cell line THP-1 was differentiated into macrophages by culturing for two days in medium supplemented with 200 nM phorbol ester (PMA). The macrophages were then cultured in four media: medium without PMA (control); medium with suspended sub-micro Ti particles (0.5 wt%); medium with 1.0 microg/ml lipopolysaccharide (LPS); and medium with LPS and Ti particles. After 6 hours' culture, total RNA were extracted and gene expressions were evaluated by DNA allergy chip with 205 allergy and ...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Taira M, Nezu T, Sasaki M, Kimura S, Kagiya T, Harada H, Narushima T, Araki Y Tags: Biomed Mater Eng Source Type: journals

Injectable biphasic calcium phosphate bioceramic: The HYDROS concept.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new biphasic calcium phosphate ceramic material has been developed in our laboratory. It is composed of 60% of hydroxyapatite and 40% of beta-tricalcium phosphate, based on three granulometries (submicron, round microporous 80-200 mum and macro microporous 0.5-1 mm particles) and hydrated with water leading the formation of a putty filler for bone repair. Biocompatibility and osteogenicity were tested by filling femoral epiphyses critical size bone defect and lumbar muscles in rabbit. After 3, 6 and 12 weeks of implantation, explants were treated for histology. Results revealed the biocompatibility of the material an...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Baroth S, Bourges X, Goyenvalle E, Aguado E, Daculsi G Tags: Biomed Mater Eng Source Type: journals

Influence of heat treatment on morphological changes of nano-structured titanium oxide formed by anodic oxidation of titanium in acidic fluoride solution.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
TiO(2) nanotube array (TN) on titanium plate was fabricated by using an electrochemical method. The crystal structure and surface morphology of TN array was examined by X-ray diffraction (XRD) and Field Emission Scanning Electronic Microscopy (FE-SEM), respectively. The stability of the nanotube structure and crystal phase transition was studied at different temperatures in dry oxygen ambient. The as-deposited films were found to be amorphous. The tubes crystallized in the anatase phase at a temperature of 450 degrees C. Anatase crystallites formed inside the tubes walls was transformed completely to rutile at 500 degr...
Source: Bio-Medical Materials and Engineering - June 27, 2009 Category: Materials Science Authors: Neupane MP, Park IS, Lee MH, Bae TS, Watari F Tags: Biomed Mater Eng Source Type: journals

Producing MSC according GMP: Process and controls.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065017 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Sensebé L, Bourin P Tags: Biomed Mater Eng Source Type: journals

Engineering the 3D microenvironment of embryonic stem cells undergoing differentiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065018 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: McDevitt TC, Carpenedo RL, Sargent CY, Berguig GY, Marklein RA, Seaman S Tags: Biomed Mater Eng Source Type: journals

Molecular and phenotypical characterization of human amniotic fluid cells and their differentiation potential.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065019 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Montemurro T, Bossolasco P, Cova L, Zangrossi S, Calzarossa C, Buiatiotis S, Soligo D, Silani V, Lambertenghi Deliliers G, Rebulla P, Lazzari L Tags: Biomed Mater Eng Source Type: journals

Does adipose tissue cultured with collagen matrix and preadipocytes give comparable results to the standard technique in plastic surgery?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This experimental study showed that adipose tissue engineering is feasible and gives comparable results to fat grafting. It allows a better understanding of the sequence of events following the transfer of adipose tissue. It provides not only volume but also undeniable stimulation, leading to significant thickening of the extracellular matrix. PMID: 19065020 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Mojallal A, Lequeux C, Auxenfans C, Braye F, Damour O Tags: Biomed Mater Eng Source Type: journals

Influence of negative pressure when harvesting adipose tissue on cell yield of the stromal-vascular fraction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adipose tissue is the standard autologous filling material used in plastic surgery today. At the same time it is also a source of mesenchymal stem cells, situated in the Stromal-Vascular Fraction (SVF) and easy to obtain in large quantities. The method of harvesting adipose tissue is an important stage for cell survival. So far, comparative studies on harvesting techniques have only concerned MTT cell viability of mature adipocytes. The aim of our study was to determine the influence of pressure on the yield of SVF cells in relation to the syringe aspiration technique which is the standard technique in plastic surgery....
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Mojallal A, Auxenfans C, Lequeux C, Braye F, Damour O Tags: Biomed Mater Eng Source Type: journals

Polyelectrolyte multilayer films: Effect of the initial anchoring layer on the cell growth.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, PAH-(PSS-PAH)(3) polyelectrolyte multilayer film seems to constitute an excellent material for MSC seeding. PMID: 19065022 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Moby V, Kadi A, de Isla N, Stoltz JF, Menu P Tags: Biomed Mater Eng Source Type: journals

Cyclic stretching promotes collagen synthesis and affects F-actin distribution in rat mesenchymal stem cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies have shown effects of mechanical environment on bone marrow mesenchymal stem cells (BMSC). In order to examine how BMSC and their cytoskeleton respond to mechanical stimulation, we investigated their collagen synthesis and F-actin expression. Rat BMSC were harvested from adult rats and cultured to passage 4. Then the cells were seeded onto a silicone membrane loaded with an uniaxial cyclic stretching (10%, 1 Hz) during 3, 6, 12, 24 and 36 h. The levels of collagen type I and III before and after stretching were analyzed by immunocytochemistry, and the F-actin in cytoplasm was observed by confocal microsc...
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Zhang L, Tran N, Chen HQ, Wang X Tags: Biomed Mater Eng Source Type: journals

Mechanobiology, chondrocyte and cartilage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065024 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Huselstein C, Netter P, de Isla N, Wang Y, Gillet P, Decot V, Muller S, Bensoussan D, Stoltz JF Tags: Biomed Mater Eng Source Type: journals

Osteoblast: A cell under compression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065025 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Sanchez C, Gabay O, Henrotin YE, Berenbaum F Tags: Biomed Mater Eng Source Type: journals

Recombinant human collagens as scaffold materials for chondrocyte cultures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065026 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Tiitu V, Pulkkinen HJ, Valonen P, Kiviranta O, Kiekara T, Kiviranta I, Lammi MJ Tags: Biomed Mater Eng Source Type: journals

Three-dimensional sprayed active biological gels and cells for tissue engineering application.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here that it is possible (i) to build an alginate gel by alternate spraying of alginate and Ca(2+); (ii) to spray active alginate gel and cells; (iii) to build layer-by-layer an active reservoir under and on the top of this sprayed gel and cells; (iv) to follow the activity of these sprayed cells with time; (v) to propose a three-dimensional sprayed structure for tissue engineering application. PMID: 19065027 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Facca S, Gillet P, Stoltz JF, Netter P, Mainard D, Voegel JC, Benkirane-Jessel N Tags: Biomed Mater Eng Source Type: journals

Functionalization of biomaterials for joint implant application.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065028 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Hélary G, Poussard L, Zreiqat H, Migonney V Tags: Biomed Mater Eng Source Type: journals

Osteogenic differentiation of amniotic fluid stem cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065029 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Peister A, Porter BD, Kolambkar YM, Hutmacher DW, Guldberg RE Tags: Biomed Mater Eng Source Type: journals

In vivo rat knee cartilage volume measurement using quantitative high resolution MRI (7 T): Feasibility and reproducibility.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: the image quality obtained at 7 Teslas with our dedicated coil allowed segmentation of the cartilage compartments with good reproducibility. This study demonstrated that MRI is a useful technology to provide a non-invasive and reliable assessment of rat knee cartilage volume. PMID: 19065030 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Goebel JC, Bolbos R, Pinzano A, Schaeffer M, Rengle A, Galois L, Etienne S, Netter P, Loeuille D, Beuf O, Gillet P Tags: Biomed Mater Eng Source Type: journals

Local induction of heat shock protein 70 (Hsp70) by proteasome inhibition confers chondroprotection during surgically induced osteoarthritis in the rat knee.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Intra-articular induction of Hsp70 by MG132 could be a safe and interesting tool in chondrocytes protection from cellular injuries and thus might be a novel chondroprotective modality in rat OA. PMID: 19065031 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Etienne S, Gaborit N, Henrionnet C, Pinzano A, Galois L, Netter P, Gillet P, Grossin L Tags: Biomed Mater Eng Source Type: journals

Quantitative dynamic contrast enhanced MRI of experimental synovitis in the rabbit knee: Comparison of macromolecular blood pool agents vs. Gadolinium-DOTA.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to assess 2 Gd-based macromolecular intravascular contrast agents (P792, rapid clearance blood pool agent (rBPA) and P717, slow clearance blood pool agent (sBPA)) compared to Gd-DOTA (representative extracellular non specific agent) in MR imaging of knee rabbit experimental synovitis. Quantitative dynamic contrast enhanced MRI (qDCE-MRI) after intravascular injection of a low molecular weight contrast agent of 0.56 kDa (Gd-DOTA) and 2 high-molecular-weight contrast agents of 6.47 kDa (P792) and 52 kDa (P717) was performed in rabbits with carrageenan-induced synovitis of the right knee. P79...
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Watrin-Pinzano A, Loeuille D, Goebel JC, Lapicque F, Walter F, Robert P, Netter P, Corot C, Gillet P, Blum A Tags: Biomed Mater Eng Source Type: journals

An integrated experimental-computational approach for the study of engineered cartilage constructs subjected to combined regimens of hydrostatic pressure and interstitial perfusion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19065033 [PubMed - in process] (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - December 11, 2008 Category: Materials Science Authors: Moretti M, Freed LE, Padera RF, Laganà K, Boschetti F, Raimondi MT Tags: Biomed Mater Eng Source Type: journals