Cell ‐Cycle‐Dependent Regulation of Cell Adhesions: Adhering to the Schedule
Cell ‐ECM adhesion changes biphasically as cells progress from G1 to S to G2. In mitosis, focal adhesions are replaced by αVβ5 integrin‐mediated reticular adhesions at the tips of retraction fibers. Focal adhesions disassemble during mitosis, but surprisingly little is known about how these structures respond to other phases of the cell cycle. Three recent papers reveal unexpected results as they examine adhesions through the cell cycle. A biphasic response is detected where focal adhesions grow during S phase before disassembly begins early in G2. In M phase, activated integrins at the tips of retraction fibers anch...
Source: BioEssays - November 28, 2018 Category: Molecular Biology Authors: Yitong Li, Keith Burridge Tags: Prospects & Overviews Source Type: research

BioEssays 12 ∕2018
Amphioxus represents the most basally divergent group in chordates and probably the best extant proxy to the ancestor of all chordates including vertebrates. The amphioxus, or lancelets, are benthic filter feeding marine animals and their interest as a model in research is due to their phylogenetic position and their anatomical and genetic stasis throughout their evolutionary history. In article number1800130, Hector Escriva reviews the discovery and development of amphioxus as a superb model organism in evolutionary and evolutionary ‐developmental biology. (Source: BioEssays)
Source: BioEssays - November 21, 2018 Category: Molecular Biology Tags: Back Cover Source Type: research

BioEssays 12 ∕2018
African trypanosomes cause human and veterinary disease throughout sub ‐Saharan Africa. The parasite cycles between the insect vector, tsetse flies, and the mammalian host, where they live free in the blood and extracellular spaces. Trypanosomes use a remarkable process of antigenic variation to survive in the face of the host adaptive immune response. Further detail s can be found in article number1800181 by James D. Bangs.Photo Credits:Trypanosome: Peter Bush, School of Dental Medicine, University at Buffalo AfricanCattle: Keith Matthews, Institute of Immunology and Infection Research, University of EdinburghPostprandi...
Source: BioEssays - November 21, 2018 Category: Molecular Biology Tags: Cover Picture Source Type: research

Corrigendum Referring to: Getting the Message? Native Reactive Electrophiles Pass Two Out of Three Thresholds to be Bona Fide Signaling Mediators
BioEssays, Volume 40, Issue 12, December 2018. (Source: BioEssays)
Source: BioEssays - November 21, 2018 Category: Molecular Biology Tags: Corrigendum Source Type: research

A Word of Heartfelt Thanks to Our Reviewers
BioEssays, Volume 40, Issue 12, December 2018. (Source: BioEssays)
Source: BioEssays - November 21, 2018 Category: Molecular Biology Tags: Acknowledgments Source Type: research

BioEssays 12 ∕2018
BioEssays, Volume 40, Issue 12, December 2018. (Source: BioEssays)
Source: BioEssays - November 21, 2018 Category: Molecular Biology Tags: Masthead Source Type: research

In Grateful Recognition of Our Editorial Board
BioEssays, Volume 40, Issue 12, December 2018. (Source: BioEssays)
Source: BioEssays - November 21, 2018 Category: Molecular Biology Tags: Editorial Source Type: research

On the State of Scientific English and How to Improve it − Part 12: Keeping it Simple When Under Time Pressure…
BioEssays, Volume 40, Issue 12, December 2018. (Source: BioEssays)
Source: BioEssays - November 21, 2018 Category: Molecular Biology Authors: Andrew Moore Tags: Editorial Source Type: research

Why the Submarine Alkaline Vent is the Most Reasonable Explanation for the Emergence of Life
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - November 15, 2018 Category: Molecular Biology Authors: Elbert Branscomb, Michael J. Russell Tags: Thoughts & Opinion Source Type: research

Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - November 2, 2018 Category: Molecular Biology Authors: Zachary T. Calamari, Jimmy Kuang ‐Hsien Hu, Ophir D. Klein Source Type: research

Evolution of Antigenic Variation in African Trypanosomes: Variant Surface Glycoprotein Expression, Structure, and Function
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - October 29, 2018 Category: Molecular Biology Authors: James D. Bangs Source Type: research

RNAs, Phase Separation, and Membrane ‐Less Organelles: Are Post‐Transcriptional Modifications Modulating Organelle Dynamics?
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - October 29, 2018 Category: Molecular Biology Authors: Aleksej Drino, Matthias R. Schaefer Source Type: research

Have Causal Claims About the Gut Microbiome Been Over ‐Hyped?
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - October 29, 2018 Category: Molecular Biology Authors: Pierrick Bourrat Source Type: research

Human Endogenous Formaldehyde as an Anticancer Metabolite: Its Oxidation Downregulation May Be a Means of Improving Therapy
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - October 29, 2018 Category: Molecular Biology Authors: Yuri L. Dorokhov, Ekaterina V. Sheshukova, Tatiana E. Bialik, Tatiana V. Komarova Source Type: research

BioEssays 11 ∕2018
BioEssays,Volume 40, Issue 11, November 2018. (Source: BioEssays)
Source: BioEssays - October 22, 2018 Category: Molecular Biology Source Type: research