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Diagnostic role of whole body bone scintigraphy in atypical skeletal tuberculosis resembling multiple metastases: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Scintigraphic bone scanning should be kept in mind when assessing bone pain in patients at a high risk of tuberculosis infection or reactivation. We present this unusual case of multifocal skeletal tuberculosis, and stress the related clinical and diagnostic points with the aim of stimulating a high index of suspicion that could facilitate early diagnosis and appropriate treatment. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Majid AssadiIraj NabipourMohammad EftekhariAbdolali EbrahimiSeyed-Reza AbotorabHooman SalimipourHamid JavadiKatayon VahdatReza GhasemikhahMohsen Saghari Source Type: journals

Ancestry-related assortative mating in latino populationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Assortative mating related to genetic ancestry persists in Latino populations to the current day, and has impacted on the genomic structure in these populations. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Neil RischShweta ChoudhryMarc ViaAnalabha BasuRonnie SebroCeleste EngKenneth BeckmanShannon ThyneRocio ChapelaJose Rodriguez-SantanaWilliam Rodriguez-CintronPedro AvilaElad ZivEsteban Gonzalez Burchard Source Type: journals

De novo 454 sequencing of barcoded BAC pools for comprehensive gene survey and genome analysis in the complex genome of barleyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The described multiplex 454 sequencing of barcoded BACs leads to sequence consensi highly representative for the clones. Assemblies are correct for the majority of contigs. Though the resolution of complex repetitive structures requires additional experimental efforts, our approach paves the way for a clone based strategy of sequencing the barley genome. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Burkhard SteuernagelStefan TaudienHeidrun GundlachMichael SeidelRuvini AriyadasaDaniela SchulteAndreas PetzoldMarius FelderAndreas GranerUwe ScholzKlaus MayerMatthias PlatzerNils Stein Source Type: journals

COMIT: Identification of noncoding motifs under selection in coding sequencesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the COMIT algorithm to detect functional noncoding motifs in coding regions using sequence conservation, explicitly separating nucleotide from amino acid effects. COMIT concurs with diverse experimental datasets, including splicing enhancers, silencers, replication motifs, and microRNA targets, and predicts many novel functional motifs. Intriguingly, COMIT scores are well-correlated to scores uncalibrated for amino acids, suggesting that nucleotide motifs often override peptide-level constraints. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Deniz KuralYang DingJiantao WuAlicia KorpiJeffrey Chuang Source Type: journals

Characterisation of microRNA expression in post-natal mouse mammary gland developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: MicroRNAs were expressed in likely co-regulated clusters during mammary gland development. Breast cancer-associated miRNAs were significantly enriched in these clusters. The mechanism and functional consequences of this miRNA co-regulation provide new avenues for research into mammary gland biology and generate candidates for functional validation. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Stefanie Avril-SassenLeonard GoldsteinJohn StinglCherie BlenkironJohn Le QuesneInmaculada SpiteriKonstantina KaragavriilidouChristine WatsonSimon TavareEric MiskaCarlos Caldas Source Type: journals

Searching for SNPs with cloud computingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As DNA sequencing outpaces improvements in computer speed, there is a critical need to accelerate tasks like alignment and SNP calling. Crossbow is a cloud-computing software tool that combines the aligner Bowtie and the SNP caller SOAPsnp. Executing in parallel using Hadoop, Crossbow analyzes data comprising 38-fold coverage of the human genome in three hours using a 320-CPU cluster rented from a cloud computing service for about $85. Crossbow is available from http://bowtie-bio.sf.net/crossbow. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Ben LangmeadMichael SchatzJimmy LinMihai PopSteven Salzberg Source Type: journals

Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: LGRs accounted for 25% of germline MMR mutations identified in 28 Slovakian HNPCC families. A high frequency of LGRs among the MSH2 mutations provides a rationale for a MLPA screening of the Slovakian HNPCC families prior scanning by DNA sequencing. LOH at part of the informative loci confined to the MLH1 or MSH2 gene (heterozygous LGR region, SNP, or microsatellite) is a novel finding and can be regarded as a partial LOH. The conversion begins within the gene, and the details of conversion tracts are discussed for each case. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Katarina ZavodnaTomas KrivulcikMaria Gerykova BujalkovaTomas SlamkaDavid MartinickyDenisa IlencikovaZdena Bartosova Source Type: journals

The modified two-by-one fixed orthodontic appliance for bodily movement of canine: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The design of this modified 2 by 1 appliance allows individualized bodily tooth movement of canine, it provides light and continuous force for physiological orthodontic movement with minimal root resorption. (Source: BioMed Central)
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Vicky TsuiHessa AlkhalHuie HouRicky WongA Bakr Rabie Source Type: journals

Cerebral fat embolism and the "starfield" pattern: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a patient with non-head trauma who demonstrated the classic "starfield" pattern on diffusion-weighted MRI imaging. (Source: BioMed Central)
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Amit AravapalliJames FoxChristos Lazaridis Source Type: journals

Prevalence and correlates of alcohol and other substance use disorders in young adulthood: A population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Alcohol use disorders are common in Finnish young adults, whereas other SUDs are less common than in many other developed countries. Our cross-sectional analyses suggested that the association between behavioral and affective factors and SUD was only partly accounted for by other correlates, such as early initiation of substance use and parental alcohol problems. In contrast, associations between many other factors and SUD were non-significant when adjusted for behavioral and affective factors. (Source: BioMed Central)
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Antti LatvalaAnnamari Tuulio-HenrikssonJonna PeralaSamuli SaarniTerhi Aalto-SetalaHillevi AroTellervo KorhonenSeppo KoskinenJouko LonnqvistJaakko KaprioJaana Suvisaari Source Type: journals

Make it better but don't change anythingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With massive amounts of data being generated in electronic format, there is a need in basic science laboratories to adopt new methods for tracking and analyzing data. An electronic laboratory notebook is not just a replacement for a paper lab notebook, it is a new method of storing and organizing data while maintaining the data entry flexibility and legal recording functions of paper notebooks. Paper notebooks are regarded as highly flexible since the user can configure it to store almost anything that can be written or physically pasted onto the pages. However, data retrieval and data sharing from paper notebooks are labo...
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Jerry Wright Source Type: journals

Expression of TNF-related apoptosis-inducing ligand (TRAIL) in keratinocytes mediates apoptotic cell death in allogenic T cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present study was to evaluate the aptitude of TRAIL gene expression for inducing apoptosis in co-cultivated T-cells. This should allow to prepare a strategy for the development of a durable, allogenic skin substitute based on the induction of an immune-privileged transplant. In order to counteract the significant potential of rejection in transplanted allogenic keratinocytes, we created a murine keratinocyte cell line which expressed TRAIL through stable gene transfer. The exogenic protein was localized on the cellular surface and was not found in soluble condition as sTRAIL. Contact to TRAIL expressin...
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Kerstin ReimersChristine RadtkeClaudia ChoiChristina AllmelingSusanne KallPaul KieferThomas MuhlbergerPeter Vogt Source Type: journals

An experimental loop design for the detection of constitutional chromosomal aberrations by array CGHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The loop design and the performance of the statistical analysis contribute to the quick adoption of array CGH as a routine diagnostic tool. They lower the detection limit of mosaicisms and improve the assignment of copy number variation for genetic association studies. (Source: BioMed Central)
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Joke AllemeerschSteven Van VoorenFemke HannesBart De MoorJoris Robert VermeeschYves Moreau Source Type: journals

Correction: Digital PCR provides sensitive and absolute calibration for high throughput sequencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After this article [1] appeared online, an error was called to our attention. The "universal probe" sequence UPL #149 in Table 6 appears with the 5' and 3' ends reversed. The correct sequence of this locked nucleic acid (LNA) probe is 5'-TCGCCGCC-3'. This typographical error does not affect any of the conclusions drawn in the article. (Source: BioMed Central)
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Richard WhitePaul BlaineyH FanStephen Quake Source Type: journals

Within but without: human rights and access to HIV prevention and treatment for internal migrantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Worldwide, far more people migrate within than across borders, and although internal migrants do not risk a loss of citizenship, they frequently confront significant social, financial and health consequences, as well as a loss of rights. The recent global financial crisis has exacerbated the vulnerability internal migrants face in realizing their rights to health care generally and to antiretroviral therapy in particular. For example, in countries such as China and Russia, internal migrants who lack official residence status are often ineligible to receive public health services and may be increasingly unable to afford pri...
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Katherine Wiltenburg TodrysJoseph Amon Source Type: journals

Complications of continuous renal replacement therapy in critically ill children: a prospective observational evaluation studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CRRT-related complications are common in children and some are potentially serious. The most common are hypotension at the time of connection and electrolyte disturbances. Strict control and continuous monitoring of the technique are therefore necessary in children on CRRT. (Source: BioMed Central)
Source: BioMed Central - November 19, 2009 Category: Journals (General) Authors: Maria SantiagoJesus Lopez-HerceJavier UrbanoMaria SolanaJimena Del CastilloYolanda BallesteroMarta BotranJose Bellon Source Type: journals

An acute urinary retention in an old man caused by a giant mullerian duct cyst: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of acute urinary retention in an old man caused by a giant Mullerian duct cyst.A 77-year-old man presented with of acute urinary retention. After bladder drainage, digital rectal examination found a large soft supraprostatic mass. Transrectal ultrasound and computed tomography scans revealed a large multilocular retrovesical cystic mass. The patient underwent open surgical resection of the cyst. Histologically, the cystic lesion was lined with stratified cubocolumnar cells, consistent with a Mullerian duct cyst.Acute urinary retention in the elderly is not always related to prostatic diseases. Oth...
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Mehdi JaidaneAdnen HidoussiAdel SlamaWissem HmidaNabil Ben SorbaFaouzi Mosbah Source Type: journals

Abscopal effect in a patient with chronic lymphocytic leukemia during radiation therapy: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a documented observation of Abscopal effect in a patient of Chronic Lymphocytic Leukemia during radiation therapy. (Source: BioMed Central)
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Preethi Bangalore LakshmangowdaLokesh ViswanathNaveen ThimmaiahLokanath DasappaSanjay Sudakar SupePramod Kallur Source Type: journals

Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Elastogenesis of elastic extracellular matrix (ECM) which was recognized as a major component of blood vessels has been believed for a long time to play only a passive role in the dynamic vascular changes of typical hypertension. Emilin1 gene participated in the transcription of ECM's formation and was recognized to modulate links TGF-beta maturation to blood pressure homeostasis in animal study. Recently relevant advances urge further researches to investigate the role of Emilin1 gene in regulating TGF-beta signals involved in elastogenesis and vascular cell defects of essential hypertension (EH). Methods: We ...
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Chong ShenXiangfeng LuYun LiQi ZhaoXiaoli LiuLiping HouLaiyuan WangShufeng ChenJianfeng HuangDongfeng Gu Source Type: journals

The isochore patterns of invertebrate genomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This work demonstrates not only that an isochore organization is present in all metazoan genomes analyzed, but also that the isochore families of invertebrates share GC levels with the corresponding families of vertebrates. (Source: BioMed Central)
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Rosalia CammaranoMaria CostantiniGiorgio Bernardi Source Type: journals

Social care and changes in occupational accidents and diseases - the situation in Eastern Europe in general and for skin diseases in particularEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Comparison of the social insurance systems and changes in occupational accidents and occupational diseases in 22 countries in Eastern Europe makes it clear that further effort is needed to develop registration and notification procedures. Only then will it be possible to analyse changes, to map successes and problems and perhaps to initiate necessary improvements. Standardisation of the documents must also be improved, to allow international comparisons between the systems. (Source: BioMed Central)
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Kathrin von HirschbergBjorn KahlerAlbert Nienhaus Source Type: journals

International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC Study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThe feasibility of the study is considered to be very high because of its similar design to the EURAS-OC study. All relevant methodological and logistical features of the study were successfully tested in the EURAS study.The chosen design minimizes the impact of referral and misclassification bias, healthy user effect and loss to follow-up. Overall, it is expected that the study design is robust enough to interpret hazard ratios of 1.5 or higher. (Source: BioMed Central)
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Juergen DingerKristina BardenheuerAnita Assmann Source Type: journals

Genomic and phenotypic variation in epidemic-spanning Salmonella enterica serovar Enteritidis isolatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The recent epidemic of S. Enteritidis infection in Uruguay has been driven by the introduction of closely related strains of phage type 4 lineage. Our results confirm previous reports demonstrating a high degree of genetic homogeneity among S. Enteritidis isolates. However, 10 of the regions of variability described here are for the first time reported as being variable in S. Enteritidis. In particular, the oldest pre-epidemic isolates carry phage-associated genetic regions not previously reported in S. Enteritidis. Overall, our results support the view that phages play a crucial role in the generation of gene...
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Laura BetancorLucia YimMaria FookesAraci MartinezNicholas ThomsonAlasdair IvensSarah PetersClare BryantGabriela AlgortaSamuel KariukiFelipe SchelottoDuncan MaskellGordon DouganJose Chabalgoity Source Type: journals

Expression profiling of repetitive elements by melting temperature analysis: variation in HERV-W gag expression across human individuals and tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Thus, regulated expression of non-coding regions of the human genome appears to include the HERV-W family of repetitive elements. Although it remains to be established whether such expression patterns represent leakage from transcription of functional regions or specific transcription, the current approach proves itself useful for studying detailed expression patterns of repetitive regions. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Christoffer NellakerFang LiFredrik UhrzanderJoanna TyrchaHakan Karlsson Source Type: journals

Self-healing photo-neuropathy and cervical spinal arthrosis in four sisters with brachioradial pruritusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. The role of sun and cervical spine disease has been discussed. This is a report on four sisters suffering from brachioradial pruritus recurring every summer. The sisters spent much time outdoors and exposed themselves extensively to the sun. They also had occupations requiring heavy lifting. Cervical radiographs indicated arthrosis. The density of sensory nerve fibers in the skin biopsies from the itchy skin of the arms, visualized by antibodies against a pan-neuronal marker, protein gene product 9.5, was reduced compared w...
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Joanna Wallengren Source Type: journals

Reverse genetics through random mutagenesis in Histoplasma capsulatumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This methodology improves our ability to isolate mutants in targeted genes, thereby facilitating the molecular genetic analysis of Histoplasma biology. The procedures described are widely applicable to many fungal systems and will be of particular interest to those for which homologous recombination techniques are inefficient or do not currently exist. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Brian YouseffJulie DoughertyChad Rappleye Source Type: journals

Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings indicate that phosphorylated PYK2 in SLE PBMCs may induce the expression of CD40L and CTLA4, and subsequently the cell proliferation. PYK2 signaling enhances the autoreactive lymphocyte activation and plays an important role in the pathogenesis of SLE. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Meiying WangHongsheng SunWei ZhangYuanchao Zhang Source Type: journals

Molecular testing for adult type Alport syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This test may be useful for presymptomatic and carrier testing in families with one of the mutations and in the diagnosis of unexplained hematuria or chronic kidney disease. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Genevieve Pont-KingdonKelli SumnerFriederike GedgeChris MillerJoyce DenisonMartin GregoryElaine Lyon Source Type: journals

Purification and characterization of cysteine protease from germinating cotyledons of horse gramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It appears that the newly synthesized protease is inactive, and activation takes place during germination. CPRHG has a broad substrate specificity and stability in pH, temperature, etc. therefore, this protease may turn out to be an efficient choice for the pharmaceutical, medicinal, food, and biotechnology industry. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Rajeswari JinkaVadde RamakrishnaSridhar RaoRamakrishna Rao Source Type: journals

Eurotatorian paraphyly: Revisiting phylogenetic relationships based on the complete mitochondrial genome sequence of Rotaria rotatoria (Bdelloidea: Rotifera: Syndermata)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Comparisons of inferred amino acid sequence and gene arrangement patterns with those of other metazoan mtDNAs (including those of acanthocephalan L. thecatus and monogonont B. plicatilis) support the hypothesis that Bdelloidea shares most common ancestry with Acanthocephala rather than with Monogononta. From this finding, we suggest that the obligatory asexuality of bdelloideans may have secondarily derived from some other preexisting condition in earlier lineage of rotifers. Providing a more complete assessment of phylogenetic relationships and inferring patterns of evolution of different types of life styles ...
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Gi-Sik MinJoong-Ki Park Source Type: journals

Community-acquired mastitis due to Mycobacterium abscessus: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Rapidly growing mycobacteria need to be included in the differential diagnosis of patients with chronic mastitis having pus discharge and who do not respond to broad-spectrum antibiotics. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Maria Bruna PasticciLuigi Maria LapalorciaGiacomo AntoniniAntonella MencacciRosanna MazzollaFranco Baldelli Source Type: journals

Performance of TB immunodiagnostic tests in Eurasian badgers (Meles meles) of different ages and the influence of duration of infection on serological sensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that serodiagnosis could be a valuable tool for detecting a higher proportion of badgers with the greatest probability of transmitting infection. The age category of the badger appeared to exert little influence on the performance of the serological tests. Although data were only available for the IFNgamma EIA in a small number of cubs, reduced sensitivity of the test in these individuals suggests a lower cut-off may be needed when testing younger animals. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Mark ChambersSue WaterhouseKonstantin LyashchenkoRichard DelahayRobin SayersR Glyn Hewinson Source Type: journals

The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results show that the residue Lysine69 plays a catalytic role and is not involved in substrate binding for the M. tuberculosis shikimate dehydrogenase. These efforts on M. tuberculosis shikimate dehydrogenase catalytic mechanism determination should help the rational design of specific inhibitors, aiming at the development of antitubercular drugs. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Valnes Rodrigues-JuniorArdala BredaDiogenes SantosLuiz Basso Source Type: journals

B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings indicate that both HERV-H Env and HERV-W Env are expressed in higher quantities on the surface of B cells and monocytes in patients with active MS, and that the expression of these proteins may be associated with exacerbation of the disease. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Tomasz BrudekTove ChristensenLars AagaardThor PetersenHans HansenAnne Moller-Larsen Source Type: journals

Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we investigated the association between MAP values of 70 mmHg or higher, vasopressor load, 28-day mortality and disease-related events in septic shock. Methods: This is a post hoc analysis of data of the control group of a multicenter trial and includes 290 septic shock patients in whom a mean MAP [greater than or equal to] 70 mmHg could be maintained during shock. Demographic and clinical data, MAP, vasopressor requirements during the shock period, disease-related events and 28-day mortality were documented. Logistic regression models adjusted for the geographic region of the study center, age, presence of c...
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Martin DunserEsko RuokonenVille PettilaHanno UlmerChristian TorgersenChristian SchmittingerStephan JakobJukka Takala Source Type: journals

CD10 expression in urothelial carcinoma of the bladderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: To date, only a few comparative IHC studies have assessed CD10 expression in urothelial carcinoma of the urinary bladder and this study represents the largest series. Our findings indicate that CD10 expression is strongly correlated with high tumor grade and stage in urothelial carcinoma of the bladder, and that CD10 may be associated with tumor progression in bladder cancer pathogenesis. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Burak BahadirKemal BehzatogluSibel BektasErol BozkurtSukru Ozdamar Source Type: journals

Experiences, attitudes and barriers towards research amongst junior faculty of Pakistani medical universitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The developing world has had limited quality research and in Pakistan, research is still in its infancy. We conducted a study to assess the proportion of junior faculty involved in research to highlight their attitude towards research, and identify the factors associated with their research involvement. Methods: A cross-sectional study was conducted in four medical universities/teaching hospitals in Pakistan, representing private and public sectors. A pre-tested, self-administered questionnaire was used to collect information from 176 junior faculty members of studied universities/hospitals. Logistic regression...
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Saniya SabzwariSamreen KauserAli Khuwaja Source Type: journals

Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have established a highly malignant HNSCC cell line, SASVO3, from primary tumors using three sequential rounds of xenotransplantation. SASVO3 possesses enhanced tumorigenic ability both in vitro and in vivo. Moreover, SASVO3 exhibits properties of cancer stem cells, including that increased the abilities of sphere-forming, the number of side population cells, the potential of transplanted tumor growth and elevated expression of the...
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Chi-Yuan ChenShih-Hwa ChiouChih-Yang HuangChia-Ing JanShu-Chun LinMing-Long TsaiJeng-Fan Lo Source Type: journals

Pulmonary fibrosis associated with psychotropic drug therapy: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Drug induced lung disease can be rapidly progressive and if drug exposure continues may result in respiratory failure and death. Prompt recognition is critical as drug withdrawal may result in marked resolution of disease. This case highlights sertraline and risperidone as drugs that may, in susceptible individuals, cause diffuse pulmonary fibrosis. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Clare ThorntonToby MaherDavid HansellAndrew NicholsonAthol Wells Source Type: journals

Unique challenges for appropriate management of a 16-year-old girl with superior mesenteric artery syndrome as a result of anorexia nervosa: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This case illustrates important points regarding the pathogenesis of superior mesenteric artery syndrome in the setting of anorexia, and it highlights the complexities that arise when managing an adolescent with both medical and psychiatric needs, as well as outlining a viable solution. While superior mesenteric artery syndrome is an uncommon cause of small bowel obstruction, the general pediatrician and child psychiatrist should be aware of this complication of anorexia nervosa. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Philip VerhoefAngelika Rampal Source Type: journals

Percutaneous nephrolithotomy in horseshoe Kidneys: is rigid nephroscopy sufficient tool for complete clearance? a case series studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Percutaneous nephrolithotomy is generally safe and successful in the management of stones in horseshoe kidneys. However, location of the stones in these patients is crucial to decide the proper tool for optimal stone clearance result. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Mohamed El GhoneimyAhmed KoderaAshraf EmranTamer OrbanAhmed ShabanMohamed El Gammal Source Type: journals

Residential mobility during pregnancy in the north of EnglandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Many epidemiological studies assign exposure to an individual's residence at a single time point, such as birth or death. This approach makes no allowance for migration and may result in exposure error, leading to reduced study power and biased risk estimates. Pregnancy outcomes are less susceptible to this bias, however data from North American populations indicate that pregnant women are a highly mobile group. We assessed mobility in pregnant women in the north of England using data from the Northern Congenital Abnormality Survey (NorCAS). Methods: Data were extracted from NorCAS for 1985 to 2003. Eligible ca...
Source: BioMed Central - November 15, 2009 Category: Journals (General) Authors: Susan HodgsonMark ShirleyMary BythellJudith Rankin Source Type: journals

Anastomotic leak management after a low anterior resection leading to recurrent abdominal compartment syndrome: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Abdominal compartment syndrome may present as a devastating complication of damage control laparotomy. Prompt recognition and goal-directed management are the cornerstones of treatment. (Source: BioMed Central)
Source: BioMed Central - November 14, 2009 Category: Journals (General) Authors: Kostas ToutouzasEleftheria KleidiPanagiotis DrimousisMargarita BallaMetaxia PapanikolaouAndreas LarentzakisDimitrios TheodorouStylianos Katsaragakis Source Type: journals

Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The bacterium Salmonella enterica includes a diversity of serotypes that cause disease in humans and different animal species. Some Salmonella serotypes show a broad host range, some are host restricted and exclusively associated with one particular host, and some are associated with one particular host species, but able to cause disease in other host species and are thus considered "host adapted". Five Salmonella genome sequences, representing a broad host range serotype (Typhimurium), two host restricted serotypes (Typhi [two genomes] and Paratyphi) and one host adapted serotype (Choleraesuis) were used to id...
Source: BioMed Central - November 14, 2009 Category: Journals (General) Authors: Yesim SoyerRenato OrsiLorraine Rodriguez-RiveraQi SunMartin Wiedmann Source Type: journals

Autosomal dominant pseudohypoaldosteronism type 1 with a novel splice site mutation in MR geneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions; mRNA analysis have been rarely conducted for PHA1 because kidney tissues are unavailable for this disease. However, we conducted RT-PCR analysis using mRNA extracted from urinary sediments. We could demonstrate that NMD does not fully function in kidney cells and that haploinsufficiency due to NMD with premature termination is not sufficient to give rise to the PHA1 phenotype at least in this mutation of our patient. Additional studies including mRNA analysis will be needed to identify the exact mechanism of the phenotype of PHA. (Source: BioMed Central)
Source: BioMed Central - November 14, 2009 Category: Journals (General) Authors: Kyoko KandaKandai NozuNaoki YokoyamaIchiro MoriokaAkihiro MiwaYuya HashimuraHiroshi KaitoKazumoto IijimaMasafumi Matsuo Source Type: journals

Exceptional epidemics: AIDS still deserves a global responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There has been a renewed debate over whether AIDS deserves an exceptional response. We argue that as AIDS is having differentiated impacts depending on the scale of the epidemic, and population groups impacted, and so responses must be tailored accordingly. AIDS is exceptional, but not everywhere. Exceptionalism developed as a Western reaction to a once poorly understood epidemic, but remains relevant in the current multi-dimensional global response. The attack on AIDS exceptionalism has arisen because of the amount of funding targeted to the disease and the belief that AIDS activists prioritize it above other health issue...
Source: BioMed Central - November 14, 2009 Category: Journals (General) Authors: Alan WhitesideJulia Smith Source Type: journals

Fibrin glue in the treatment of anal fistula: a systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In literature there are only two randomized controlled trials comparing the conventional surgical management versus the fibrin glue treatment in patients with anal fistulas. Although from our statistical analysis we cannot find any statistically significant result, the healing rate remains higher in patients who underwent the conventional surgical treatment (P =0,68), and the anal incontinence rate is very low in the fibrin glue treatment group (P =0,08). Anyway the limited collected data do not support the use of fibrin glue. Moreover, in our subgroup analysis the use of fibrin glue in combination with intra-...
Source: BioMed Central - November 14, 2009 Category: Journals (General) Authors: Roberto CirocchiEriberto FarinellaFrancesco La MuraLorenzo CattoriniBarbara RossettiDiego MilaniPatrizia RicciPiero CovarelliMarco CoccettaGiuseppe NoyaFrancesco Sciannameo Source Type: journals

False positive diagnosis of malignancy in a case of cryptogenic organising pneumonia presenting as a pulmonary mass with mediastinal nodes detected on fluorodeoxyglucose-positron emission tomography: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a lung mass positive on PET CT scan(Positron emission tomography-competerised tomgraphy), with the appearance of contralateral mediastinal involvement strongly suggestive of an inoperable lung carcinoma. The lung mass proved to be crytogenic organising pneumonia. While this has previously been shown to be PET CT positive, apparent mediastinal involvement simulating malignant spread has not been reported.A 50 year old Caucasian female patient presented with a history of unproductive cough, and was found to have a mass in the right upper lobe shown on chest X-ray and CT scanning. A subsequent PET CT scan ...
Source: BioMed Central - November 14, 2009 Category: Journals (General) Authors: Aravind PonnuswamyNeeraj MedirattaIain LyburnJames Finnerty Source Type: journals

Sutureless technique to support anastomosis during thoracic aorta replacementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Aortic replacement with the combination of ligation clips and a surgical sealant vs. sutures alone allows easy manipulations of the aorta and adaptation of the diameters, thus optimizing aortic operational timings and hemostasis. Moreover, it prevents blood loss and aortic wall trauma from multiple sutures. (Source: BioMed Central)
Source: BioMed Central - November 13, 2009 Category: Journals (General) Authors: Efstratios ApostolakisVassilios LeivaditisConstantinos Anagnostopoulos Source Type: journals

Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A single injection of simvastatin loaded in PEG-PLGA-PEG gel into rat tail discs had the potential to retard or regenerate the degenerative disc. (Source: BioMed Central)
Source: BioMed Central - November 13, 2009 Category: Journals (General) Authors: Huina ZhangLin WangJun Beom ParkPaul ParkVictor YangScott HollisterFrank La MarcaChia-Ying Lin Source Type: journals