Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01100. Online ahead of print.ABSTRACTAs the population ages, the prevalence of dysphagia among older adults is a growing concern. Age-related declines in physiological function, coupled with neurological disorders and structural changes in the pharynx associated with aging, can result in weakened tongue propulsion, a prolonged reaction time of the submental muscles, delayed closure of the laryngeal vestibule, and delayed opening of the upper esophageal sphincter (UES), increasing the risk of dysphagia. Dysphagia impacts the physical health of the elderly, leading to serious...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Kenji Karako Wei Tang Peipei Song Ying Xia Source Type: research
Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01062. Online ahead of print.ABSTRACTAntiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real-world s...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Fang Zhao Hongzhou Lu Source Type: research
Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia
In conclusion, the accumulation of lipid droplets and abnormal lipid metabolism may be critical mechanisms in the progression of AD in microglia carrying the APOE4 genotype.PMID:38631884 | DOI:10.5582/bst.2024.01092 (Source: BioScience Trends)
Source: BioScience Trends - April 17, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Ying Xia Source Type: research
Elevation of circulating DNAs of disease-associated cytokines in serum cell-free DNA from patients with alopecia areata
In this study, we aimed to investigate the clinical significance of cfDNA and the circulating DNAs of disease-associated cytokines in AA patients. Serum samples were obtained from 63 patients with AA and 32 healthy controls (HC). Using droplet digital polymerase chain reaction, circulating C-X-C motif chemokine ligand (CXCL) 9, CXCL10, CXCL11, C-X-C motif chemokine receptor 3, interferon (IFN)-γ, interleukin (IL) -7, IL-15, and Janus kinase (JAK) 2 were detectable in both HC and AA patients. Among the detectable DNAs, copies of circulating CXCL9, CXCL11, IL-15, IFN-γ, and JAK2 were significantly higher in AA patients tha...
Source: BioScience Trends - April 14, 2024 Category: Biomedical Science Authors: Soichiro Sawamura Tselmeg M Myangat Ikko Kajihara Katsunari Makino Jun Aoi Shinichi Masuguchi Satoshi Fukushima Source Type: research
A multidisciplinary collaborative diagnosis and rehabilitation program for dysphagia in general hospitals
This article summarizes common conditions causing dysphagia, clinical manifestations, complications, screening assessment, diagnosis, rehabilitation, and nutritional support related to dysphagia. It emphasizes the arrival at a multidisciplinary collaborative diagnosis and formulation of a rehabilitation management plan for dysphagia in general hospitals in order to provide strategic suggestions for establishing a multidisciplinary collaborative model for swallowing disorder management in general hospitals.PMID:38599879 | DOI:10.5582/bst.2024.01076 (Source: BioScience Trends)
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Dysphagia Research Team Juan Chen Lili Dai Min Guo Hui Huang Rongfen He Hui Jin Xin Jin Xiaoxiao Li Yumin Li Yonggang Liu Chao Wang Yukai Wang Li Wu Zhongcheng Xing Japan NCGM Cooperation Team Junko Fujitani Yasuo Sugiura Chihaya Hinohara Wei Tang Source Type: research
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance
In conclusion, our results demonstrate the potential of vitamin C as a potential therapeutic choice for RA.PMID:38599880 | DOI:10.5582/bst.2024.01037 (Source: BioScience Trends)
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Yanjie Zhang Sibin Zhen Hao Xu Songfang Sun Ziwei Wang Mian Li Liang Zou Yangyang Zhang Yan Zhao Yazhou Cui Jinxiang Han Source Type: research
NAD(P)H-quinone oxidoreductase 1 induces complicated effects on mitochondrial dysfunction and ferroptosis in an expression level-dependent manner
In this study, we examined how levels of NQO1 expression affects cell survival in response to toxic insults causing mitochondrial dysfunction and ferroptosis, and whether NQO1 has a potential as a biomarker in different stressed conditions. Following treatment with rotenone, overexpressed NQO1 in SH-SY5Y cells improved cell survival by reducing mitochondrial reductive stress via increased NAD+ supply without mitochondrial biogenesis. However, NQO1 overexpression boosted lipid peroxidation following treatment with RSL3 and erastin. A lipid droplet staining assay showed increased lipid droplets in cells overexpressing NQO1. ...
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Jaewang Lee Dong-Hoon Hyun Source Type: research
A multidisciplinary collaborative diagnosis and rehabilitation program for dysphagia in general hospitals
This article summarizes common conditions causing dysphagia, clinical manifestations, complications, screening assessment, diagnosis, rehabilitation, and nutritional support related to dysphagia. It emphasizes the arrival at a multidisciplinary collaborative diagnosis and formulation of a rehabilitation management plan for dysphagia in general hospitals in order to provide strategic suggestions for establishing a multidisciplinary collaborative model for swallowing disorder management in general hospitals.PMID:38599879 | DOI:10.5582/bst.2024.01076 (Source: BioScience Trends)
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Dysphagia Research Team Juan Chen Lili Dai Min Guo Hui Huang Rongfen He Hui Jin Xin Jin Xiaoxiao Li Yumin Li Yonggang Liu Chao Wang Yukai Wang Li Wu Zhongcheng Xing Japan NCGM Cooperation Team Junko Fujitani Yasuo Sugiura Chihaya Hinohara Wei Tang Source Type: research
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance
In conclusion, our results demonstrate the potential of vitamin C as a potential therapeutic choice for RA.PMID:38599880 | DOI:10.5582/bst.2024.01037 (Source: BioScience Trends)
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Yanjie Zhang Sibin Zhen Hao Xu Songfang Sun Ziwei Wang Mian Li Liang Zou Yangyang Zhang Yan Zhao Yazhou Cui Jinxiang Han Source Type: research
NAD(P)H-quinone oxidoreductase 1 induces complicated effects on mitochondrial dysfunction and ferroptosis in an expression level-dependent manner
In this study, we examined how levels of NQO1 expression affects cell survival in response to toxic insults causing mitochondrial dysfunction and ferroptosis, and whether NQO1 has a potential as a biomarker in different stressed conditions. Following treatment with rotenone, overexpressed NQO1 in SH-SY5Y cells improved cell survival by reducing mitochondrial reductive stress via increased NAD+ supply without mitochondrial biogenesis. However, NQO1 overexpression boosted lipid peroxidation following treatment with RSL3 and erastin. A lipid droplet staining assay showed increased lipid droplets in cells overexpressing NQO1. ...
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Jaewang Lee Dong-Hoon Hyun Source Type: research
A multidisciplinary collaborative diagnosis and rehabilitation program for dysphagia in general hospitals
This article summarizes common conditions causing dysphagia, clinical manifestations, complications, screening assessment, diagnosis, rehabilitation, and nutritional support related to dysphagia. It emphasizes the arrival at a multidisciplinary collaborative diagnosis and formulation of a rehabilitation management plan for dysphagia in general hospitals in order to provide strategic suggestions for establishing a multidisciplinary collaborative model for swallowing disorder management in general hospitals.PMID:38599879 | DOI:10.5582/bst.2024.01076 (Source: BioScience Trends)
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Dysphagia Research Team Juan Chen Lili Dai Min Guo Hui Huang Rongfen He Hui Jin Xin Jin Xiaoxiao Li Yumin Li Yonggang Liu Chao Wang Yukai Wang Li Wu Zhongcheng Xing Japan NCGM Cooperation Team Junko Fujitani Yasuo Sugiura Chihaya Hinohara Wei Tang Source Type: research
