Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10104-y. Online ahead of print.ABSTRACTPolyalthia longifolia is well-known for its abundance of polyphenol content and traditional medicinal uses. Previous research has demonstrated that the methanolic extract of P. longifolia leaves (PLME, 1 mg/mL) possesses anti-aging properties in Saccharomyces cerevisiae BY611 yeast cells. Building on these findings, this study delves deeper into the potential antiaging mechanism of PLME, by analyzing the transcriptional responses of BY611 cells treated with PLME using RNA-sequencing (RNA-seq) technology. The RNA-seq analysis results...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Manisekaran Hemagirri Yeng Chen Subash C B Gopinath Mohd Adnan Mitesh Patel Sreenivasan Sasidharan Source Type: research
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10104-y. Online ahead of print.ABSTRACTPolyalthia longifolia is well-known for its abundance of polyphenol content and traditional medicinal uses. Previous research has demonstrated that the methanolic extract of P. longifolia leaves (PLME, 1 mg/mL) possesses anti-aging properties in Saccharomyces cerevisiae BY611 yeast cells. Building on these findings, this study delves deeper into the potential antiaging mechanism of PLME, by analyzing the transcriptional responses of BY611 cells treated with PLME using RNA-sequencing (RNA-seq) technology. The RNA-seq analysis results...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Manisekaran Hemagirri Yeng Chen Subash C B Gopinath Mohd Adnan Mitesh Patel Sreenivasan Sasidharan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Telomeres and aging: on and off the planet!
Biogerontology. 2024 Apr;25(2):313-327. doi: 10.1007/s10522-024-10098-7. Epub 2024 Apr 6.ABSTRACTImproving human healthspan in our rapidly aging population has never been more imperative. Telomeres, protective "caps" at the ends of linear chromosomes, are essential for maintaining genome stability of eukaryotic genomes. Due to their physical location and the "end-replication problem" first envisioned by Dr. Alexey Olovnikov, telomeres shorten with cell division, the implications of which are remarkably profound. Telomeres are hallmarks and molecular drivers of aging, as well as fundamental integrating components of the cum...
Source: Biogerontology - April 6, 2024 Category: Geriatrics Authors: Christopher E Mason Maria A Sierra Henry J Feng Susan M Bailey Source Type: research
Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet
In this study, we explored the impact of trans fatty acid (TFA) consumption on the overall health and lifespan of male Drosophila melanogaster under an isocaloric high-sugar and high-fat diet. Our results indicate that TFA intake results in a shortened lifespan, elevated body weight, and increased triglyceride levels in flies fed a high-sugar and high-fat diet with equivalent caloric intake. Additionally, TFA exposure induces oxidative stress, locomotor deficits, and damage to the intestinal barrier in flies. Collectively, chronic TFA consumption expedites the aging process and reduces the lifespan of male Drosophila melan...
Source: Biogerontology - April 6, 2024 Category: Geriatrics Authors: Qianhua Yuan Mengliu Luo Yutong Xie Wanhan Song Ya Wang Dazhang Deng Shuyan Chen Honghui Guo Source Type: research
Telomeres and aging: on and off the planet!
Biogerontology. 2024 Apr;25(2):313-327. doi: 10.1007/s10522-024-10098-7. Epub 2024 Apr 6.ABSTRACTImproving human healthspan in our rapidly aging population has never been more imperative. Telomeres, protective "caps" at the ends of linear chromosomes, are essential for maintaining genome stability of eukaryotic genomes. Due to their physical location and the "end-replication problem" first envisioned by Dr. Alexey Olovnikov, telomeres shorten with cell division, the implications of which are remarkably profound. Telomeres are hallmarks and molecular drivers of aging, as well as fundamental integrating components of the cum...
Source: Biogerontology - April 6, 2024 Category: Geriatrics Authors: Christopher E Mason Maria A Sierra Henry J Feng Susan M Bailey Source Type: research
