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The First Metal Complexes of 4,6-diamino-1-hydro- 5-hydroxy-pyrimidine-2-thione: Preparation, Physical and Spectroscopic Studies, and Preliminary Antimicrobial PropertiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The new complexes [M2O5L2(H2O)2]⋅H2O (M=Mo,1;M=W,2), [RuL2(H2O)2]⋅H2O (3), [ML3]⋅xH2O (M=Rh,x=2,4;M=Ir,x=1,5), [RhL2(PPh3)2](ClO4)⋅2H2O (6), [PdL2]⋅2H2O (7), [PdL(phen)]Cl⋅H2O (8), [Re⁡OL2(PPh3)]Cl (9) and [UO2L2] (10) are reported, where LH is 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione. The complexes were characterized by elemental analyses, physical techniques (molar conductivity, room-temperature magnetic susceptibility), and spectroscopic (IR, Raman, UV/VIS/ligand fi...
Source: Bioinorganic Chemistry and Applications - November 8, 2009 Category: Biochemistry Source Type: journals

Synthesis, Novel Crystal Structure, and β-Amyloid Binding Property of Re(I) (tricarbonyl)+ EHIDA AnalogueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A neutral compound Re(CO)3(L) (L: 2-((2-(2,6-diethylphenylamino)-2-oxoethyl)(2-ethoxy-2-oxoethyl)amino)acetic acid, an IDA analogue) has been synthesized and evaluated for in vitro imaging probes of β-amyloid (Aβ) aggregates. Results of X-ray measurement of Re(CO)3(L) demonstrated that the coordination mode of Re(CO)3(L) was different from that of classical Re/Tc(I) (tricarbonyl)-IDA analogues; the structure of Re(CO)3(L) was confirmed by means of infrared spectrum, HPLC-UV, TOF MS, and X-ray measurements (Cambridge Crystallographic Data Centre number is 732731): monoclinic P21/c, a=15.6636 (12) Å...
Source: Bioinorganic Chemistry and Applications - November 8, 2009 Category: Biochemistry Source Type: journals

Synthesis and Characterization of New Schiff Bases Derived from N (1)-Substituted Isatin with Dithiooxamide and Their Co(II), Ni(II), Cu(II), Pd(II), and Pt(IV) ComplexesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three new Schiff bases of N-substituted isatin LI, LII, and LIII = Schiff base of N-acetylisatin, N-benzylisatin, and N-benzoylisatin, respectively, and their metal complexes C1a,b=[Co2(LI)2Cl3]Cl, C2=[Ni(LI)2Cl2]0.4BuOH, C3=[CuLICl(H2O)]Cl⋅0.5BuOH, C4=[Pd(LI)2Cl]Cl, C5=[Pt(L1)2Cl2]Cl2⋅1.8EtOH.H2O, C6a=[CoLIICl]Cl⋅0.4H2O⋅0.3DMSO, C6b=[CoLIICl]Cl⋅0.3H2O⋅0.1BuOH, C7=[NiLIICl2], C8=[CuLII]Cl2⋅H2O , C9=[Pd(LII)2]Cl2, C10=[Pt(LII)2.5Cl]Cl3, C11a=[Co(LIII)]C12⋅H2O, C11b=[Co(LIII)]Cl2⋅0.2H2O, and C12=[Ni(LIII)2]Cl2, C13=[Ni(LIII)2]Cl2 were repor...
Source: Bioinorganic Chemistry and Applications - October 26, 2009 Category: Biochemistry Source Type: journals

Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and ApigeninEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL2(H2O)2]⋅nH2O (1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while...
Source: Bioinorganic Chemistry and Applications - October 9, 2009 Category: Biochemistry Source Type: journals

Fine Structures of 8-G-1-(p-YC6H4C ≡ CSe)C10H6 (G = H, Cl, and Br) in Crystals and Solutions: Ethynyl Influence and Y- and G-DependencesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fine structures of 8-G-1-(p-YC6H4C ≡ CSe)C10H6 [1 (G = H) and 2 (G = Cl): Y = H (a), OMe (b), Me (c), F (d), Cl (e), CN (f), and NO2 (g)] are determined by the X-ray analysis. Structures of 1, 2, and 3 (G = Br) are called A if each Se–Csp bond is perpendicular to the naphthyl plane, whereas they are B when the bond is placed on the plane. Structures are observed as A for 1a–c bearing Y of nonacceptors, whereas they are B for 1e–g with Y of strong acceptors. The change in the structures of 1e–g versus those of 1a–c is called Y-dependence in 1. The Y-dependence is very speci...
Source: Bioinorganic Chemistry and Applications - September 27, 2009 Category: Biochemistry Source Type: journals

Effect of Poly (Sodium 4-Styrene Sulfonate) on the Morphology of Hydroxyapatite ParticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nanorods hydroxyapatite, (HAP) Ca10(PO4)6(OH)2 is successfully prepared by water in oil microemulsion using, CaCL2 and H3PO4 (water phase), poly(sodium 4-styrene sulfonate) (PSSS) as template and cyclohexane as oil phase. The nano-structure of the product was studied by means of X-ray diffraction (XRD), Fourier transmission infrared spectrometer (FT-IR), scanning electron microscopy (SEM), and atomic force microscope (AFM). With this system, we could synthesize nano-particles of hydroxyapatite with high crystallinity and least agglomeration. (Source: Bioinorganic Chemistry and Applications)
Source: Bioinorganic Chemistry and Applications - September 16, 2009 Category: Biochemistry Source Type: journals

Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the BloodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The absorption efficiency of any drug in blood is of prime importance. Compounds having the general formula: Kn[M(FO)2(H2O)2]⋅xH2O, where (M=Cu(II) or Fe(III), n=2 or 1 , FO=folate anion, x=2 or 3 with respect), were prepared, and their absorption efficiency in rodent's blood was determined. The obtained compounds were characterized by elemental analysis, infrared as well as thermogravimetric analysis and polarization of light. The results suggest that the two folate complexes were formed in 1 : 2 molar ratio (metal : folic acid) which acted as a bidentate ligand through both carboxylic groups. Polarization of l...
Source: Bioinorganic Chemistry and Applications - September 6, 2009 Category: Biochemistry Source Type: journals

Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity: Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA ConstituentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The [Pd(DEEN)Cl2] and [Pt(DEEN)Cl2] complexes were synthesized and characterized where DEEN=N,N-diethylethylenediamine. The stoichiometry and stability of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents and dicarboxylic acids) and [Pd(DEEN)(H2O)2]2+ were investigated at 37∘C and 0.16 M ionic strength. The stability constant of the complexes formed in solution were determined and the binding centres of the ligands were assigned. The concentration distribution diagrams of the complexes were evaluated The equilibrium constants for the displacement of re...
Source: Bioinorganic Chemistry and Applications - August 17, 2009 Category: Biochemistry Source Type: journals

Divalent Cu, Cd, and Pb Biosorption in Mixed SolventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dead dried Chlorella vulgaris was studied in terms of its performance in binding divalent copper, cadmium, and lead ions from their aqueous or 50% v/v methanol, ethanol, and acetone solutions. The percentage uptake of cadmium ions exhibited a general decrease with decrease in dielectric constant values, while that of copper and lead ions showed a general decrease with increase in donor numbers. Uptake percentage becomes less sensitive to solvent properties the larger the atomic radius of the biosorbed ion, and uptake of copper was the most affected. FT-IR analyses revealed stability of the biomass in mixed solvents and...
Source: Bioinorganic Chemistry and Applications - August 13, 2009 Category: Biochemistry Source Type: journals

Analysis of One-Bond Se-Se Nuclear Couplings in Diselenides and 1,2-Diselenoles on the Basis of Molecular Orbital Theory: Torsional Angular Dependence, Electron Density Influence, and Origin in J1(Se, Se)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nuclear couplings for the Se-Se bonds, J1(Se, Se), are analyzed on the basis of the molecular orbital (MO) theory. The values are calculated by employing the triple ζ basis sets of the Slater type at the DFT level. J1(Se, Se) are calculated modeled by MeSeSeMe (1a), which shows the typical torsional angular dependence on ϕ(CMeSeSeCMe). The dependence explains well the observed J1(Se, Se)obsd of small values (≤64 Hz) for RSeSeR′ (1) (simple derivatives of 1a) and large values (330–380 Hz) observed for 4-substituted naphto[1,8-c,d]-1,2-diselenoles (2) which correspond to symperiplanar...
Source: Bioinorganic Chemistry and Applications - August 6, 2009 Category: Biochemistry Source Type: journals

Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal ComplexesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [M(eno)2(H2O)2]3H2O(M=CuII, NiII or MnII) and [M(eno)(H2O)2]Cl⋅4H2O (M=FeIII) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal com...
Source: Bioinorganic Chemistry and Applications - August 3, 2009 Category: Biochemistry Source Type: journals

Synthesis and Characterization of bis[(2-ethyl-5-methyl-imidazo-4-yl)methyl]Sulfide and Its Coordination Behavior toward Cu(II) as a Possible Approach of a Copper Site Type IEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The synthesis and characterization of a novel ligand, bis[(2-ethyl-5-methyl-imidazo-4-yl)methyl]sulfide (bemims), as well as a bemims-containing copper(II) coordination complex are described. In this complex, [Cu(bemims)X2] with X=NO3-, bemims acts as a tridentate ligand and two monodentate nitrate ions complete the coordination sphere. Both imidazole N atoms and the thioether S atom of bemims participate in coordination. The Cu(II) ion is five-coordinated with a slightly distorted square-pyramidal geometry (τ=.09). Electrochemical studies and spectroscopic data for this complex are compared with some blue copper pr...
Source: Bioinorganic Chemistry and Applications - July 6, 2009 Category: Biochemistry Source Type: journals

Sequestration of Alkyltin(IV) Compounds in Aqueous Solution: Formation, Stability, and Empirical Relationships for the Binding of Dimethyltin(IV) Cation by N- and O-Donor LigandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The sequestering ability of polyamines and aminoacids of biological and environmental relevance (namely, ethylenediamine, putrescine, spermine, a polyallylamine, a branched polyethyleneimine, aspartate, glycinate, lysinate) toward dimethyltin(IV) cation was evaluated. The stability of various dimethyltin(IV) / ligand species was determined in NaClaq at t=25∘C and at different ionic strengths (0.1≤I/mol L-1≤1.0), and the dependence of stability constants on this parameter was modeled by an Extended Debye-Hückel equation and by Specific ion Interaction Theory (SIT) approach. At I=0.1 mol L&#x...
Source: Bioinorganic Chemistry and Applications - July 6, 2009 Category: Biochemistry Source Type: journals

Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic AcidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H2O]Cl·3H2O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surrounded by two N atoms from hsm, two O atoms from the quinolone, and one apical water oxygen. Alteration of bacterial DNA structure and/or associated functions in vivo by [Cu(hsm)(nal)H2O]Cl·3H2O was demonstrated by the induction of a recA-lacZ fusion integrated at the amyE locus of a recombinant Bacillus subtilis s...
Source: Bioinorganic Chemistry and Applications - June 25, 2009 Category: Biochemistry Source Type: journals

DNA-Metallodrugs Interactions Signaled by Electrochemical Biosensors: An OverviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The interaction of drugs with DNA is an important aspect in pharmacology. In recent years, many important technological advances have been made to develop new techniques to monitor biorecognition and biointeraction on solid devices. The interaction between DNA and drugs can cause chemical and conformational modifications and, thus, variation of the electrochemical properties of nucleobases. The propensity of a given compound to interact with DNA is measured as a function of the decrease of guanine oxidation signal on a DNA electrochemical biosensor. Covalent binding at N7 of guanine, electrostatic interactions, and interca...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A series of metal complexes of Cu(II) and Ni(II) having the general composition [M(L)X2] with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro a...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

NMR Structure and CD Titration with Metal Cations of Human Prion α2-Helix-Related PeptidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 173–195 segment corresponding to the helix 2 of the C-globular prion protein domain could be one of several “spots” of intrinsic conformational flexibility. In fact, it possesses chameleon conformational behaviour and gathers several disease-associated point mutations. We have performed spectroscopic studies on the wild-type fragment 173–195 and on its D178N mutant dissolved in trifluoroethanol to mimic the in vivo system, both in the presence and in the absence of metal cations. NMR data showed that the structure of the D178N mutant is characterized by two short helices separated by a kink, whe...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Thermodynamic and Structural Characterization of the Copper(II) Complexes of Peptides Containing Both Histidyl and Aspartyl ResiduesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Terminally protected pentapeptides with 2 histidines (Ac-HHVGD-NH2 and Ac-HVGDH-NH2) and the terminally free peptides containing both internal aspartyl and C-terminal histidyl residues (FDAH and VIDAH) have been synthesized, and copper(II) complexes studied by potentiometric, UV-Vis, CD, and EPR spectroscopic techniques in solution. Both thermodynamic and spectroscopic data reveal that side chain donor atoms of aspartyl and histidyl residues have a significant contribution to the metal binding affinity of peptide molecules. In the case of terminally protected peptides, the role of the imidazole-N donor functions is...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Characterization of Copper(II) Interactions with Sinefungin, a Nucleoside Antibiotic: Combined Potentiometric, Spectroscopic and DFT StudiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interactions between sinefungin and copper(II) ions were investigated. Stoichiometry and stability constants of the metal-free system and two mononuclear complexes present in solution were determined on the basis of potentiometric data analysis. The results were compared to the Cu(II)-ornithine system due to structural similarities between both molecules. Combined spectroscopic and theoretical studies allowed for determination of coordination pattern for the Cu(II)-sinefungin complexes. At acidic pH, copper is bound in “glycine-like” coordination mode, identical with that of ornithine. This involves α...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Interaction of Imidazole Containing Hydroxamic Acids with Fe(III): Hydroxamate Versus Imidazole Coordination of the LigandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Solution equilibrium studies on Fe(III) complexes formed with imidazole-4-carbohydroxamic acid (Im-4-Cha), N-Me-imidazole-4-carbohydroxamic acid (N-Me-Im-4-Cha), imidazole-4-acetohydroxamic acid (Im-4-Aha), and histidinehydroxamic acid (Hisha) have been performed by using pH-potentiometry, UV-visible spectrophotometry, EPR, ESI-MS, and H1-NMR methods. All of the obtained results demonstrate that the imidazole moiety is able to play an important role very often in the interaction with Fe(III), even if this metal ion prefers the hydroxamate chelates very much. If the imidazole moiety is in α-position to the hydroxam...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis, X-Ray Structure, and Characterization of a Complex Containing the Hexakis(urea)cobalt(II) Cation and Lattice Urea MoleculesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 12: 1 reaction of urea (U) with CoI2 in EtOH yielded the “clathrate-coordination” compound [CoU6]I2·4U (1). The complex crystallizes in the monoclinic space group P21/c. The lattice constants are a = 9.844(4), b = 7.268(3), c = 24.12(1) Å, and β=98.12(1)∘. The crystal structure determination demonstrates the existence of octahedral [CoU6]2+ cations, I- counterions, and two different types (two U1 and two U2) of hydrogen-bonded, lattice urea molecules. The [CoU6]2+ cations and the U1 lattice molecules form two-dimensional hydrogen-bonded layers which are parallel to the ab plane. ...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis, Characterization, and Biological Activity of N1-Methyl-2-(1H-1,2,3-Benzotriazol-1-y1)-3-Oxobutan-ethioamide Complexes with Some Divalent Metal (II) IonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new series of Zn2+, Cu2+, Ni2+, and Co2+ complexes of N1-methyl-2-(1H-1,2,3-benzotriazol-1-yl)-3-oxobutanethioamide (MBOBT), HL, has been synthesized and characterized by different spectral and magnetic measurements and elemental analysis. IR spectral data indicates that (MBOBT) exists only in the thione form in the solid state while 13C NMR spectrum indicates its existence in thione and thiole tautomeric forms. The IR spectra of all complexes indicate that (MBOBT) acts as a monobasic bidentate ligand coordinating to the metal(II) ions via the keto-oxygen and thiolato-sulphur atoms. The electronic spectral studies sho...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in WaterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions. (Source: Bioinorganic Chemistry and Applications)
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri-n-Butyltin(IV) with 2-Thiobarbituric AcidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel tri-n-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [(n-Bu)3Sn(TBA)⋅H2O] (1) has been synthesized and characterized by elemental analysis and 119Sn-NMR and FT-IR spectroscopic techniques. The crystal structure of complex 1 has been determined by single crystal X-ray diffraction analysis at 120(2) K. The geometry around Sn(IV) is trigonal bipyramidal. Three n-butyl groups and one oxygen atom from a deprotonated 2-thiobarbituric ligand are bonded to the metal center. The geometry is completed with one oxygen from a water molecule. Compound 1 exhibits potent, in vitro, cytotoxi...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Cu(II) and Ni(II) Interactions with the Terminally Blocked Hexapeptide Ac-Leu-Ala-His-Tyr-Asn-Lys-amide Model of Histone H2B (80–85)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The N- and C-terminal blocked hexapeptide Ac-Leu-Ala-His-Tyr-Asn-Lys-amide (LAHYNK) representing the 80–85 fragment of histone H2B was synthesized and its interactions with Cu(II) and Ni(II) ions were studied by potentiometric, UV-Vis, CD, EPR, and NMR spectroscopic techniques in solution. Our data reveal that the imidazole N(3) nitrogen atom is the primary ligating group for both metal ions. Sequential amide groups deprotonation and subsequent coordination to metal ions indicated an {Nimidazole,3Namide} coordination mode above pH∼9, in all cases. In the case of Cu(II)-peptide system, the almost exclusive form...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in WeldersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we analyzed blood and urine samples from shipyard industry welders being exposed to different levels of Cr(VI) over a period of five months in order to assay in vivo the relation of ApoJ/CLU serum levels with Cr(VI). Our findings confirmed the previously reported in vitro data since reduction of Cr levels, after a worksite intervention, associated with lower levels of ApoJ/CLU serum levels. We concluded that the human ApoJ/CLU gene is responsive to the acute in vivo oxidative stress induced by heavy metals such as hexavalent chromium. (Source: Bioinorganic Chemistry and Applications)
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

The Crystal Water Affect in the Interaction between the Tenebrio Molitor Alpha-Amylase and Its InhibitorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Molecular dynamics simulation of the interaction between the Tenebrio molitor alpha-amylase and its inhibitor at different proportion of crystal water was carried out with OPLS force field by hyperchem 7.5 software. In the correlative study, the optimal temperature of wheat monomeric and dimeric protein inhibitors was from 273 K to 318 K. The the average temperature of experimentation is 289 K. (1) The optimal temperature of interaction between alpha-amylase and its inhibitors was 280 K without crystal water that was close to the results of experimentation. The forming of enzyme-water and inhibi...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of ApoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The antineoplastic potential of a stable monomeric Au(II) complex with hematoporphyrin IX (Hp), namely [Au(II)Hp-2H.(H2O)2], was investigated in a panel of tumor cell lines. The complex exhibits strong cytotoxicity, whereby the leukaemia- and lymphoma-derived cell lines are more sensitive, with IC50 values comparable to those of the reference anticancer drug cisplatin. In contrast, the solid tumor models are more sensitive to the platinum drug. A comparative assessment of both agents against the human kidney cell line 293T has shown that [Au(II)Hp-2H.(H2O)2] is less cytotoxic. The gold complex induces oligonucleosomal DNA ...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Methylated Trivalent Arsenic-Glutathione Complexes are More Stable than their Arsenite AnalogEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The trivalent arsenic glutathione complexes arsenic triglutathione, methylarsonous diglutathione, and dimethylarsinous glutathione are key intermediates in the mammalian metabolism of arsenite and possibly represent the arsenic species that are transported from the liver to the kidney for urinary excretion. Despite this, the comparative stability of the arsenic-sulfur bonds in these complexes has not been investigated under physiological conditions resembling hepatocyte cytosol. Using size-exclusion chromatography and a glutathione-containing phosphate buffered sa...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Pt(II) and Pd(II) Complexes with β-AlanineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A sequence of stages in the syntheses of isomeric bisamino acid complexes of Pt(II) with β-aminopropionic acid (β-alanine = β-AlaH) has been studied by the P195t NMR spectroscopy. The techniques have been developed of the synthesis of the cis- and trans-bischelates of Pt(II) and Pd(II) with β-alanine as well as of the halide complexes of trans-[M(β-AlaH)2Cl2] (M = Pt, Pd) and trans-K2[Pt(β-Ala)2I2] types. The NMR spectroscopy and IR spectroscopy (in the nuclei of P195t,C13,H1) and X-ray diffraction analysis have been used to examine the structures of the synthesized compounds. (Sou...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

The Mechanisms of Catalysis by Metallo β-LactamasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Class B β-lactamases or metallo-β-lactamases (MBLs) require zinc ions to catalyse the hydrolysis of β-lactam antibiotics such as penicillins, cephalosporins, carbapenems, and cephamycins. There are no clinically useful inhibitors against MBLs which are responsible for the resistance of some bacteria to antibiotics. There are two metal-ion binding sites that have different zinc ligands but the exact roles of the metal-ion remain controversial, and distinguishing between their relative importance is complex. The metal-ion can act as a Lewis acid by co-ordination to the β-lactam carbonyl oxygen to ...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Kinetics and Mechanism of the Reaction between Chromium(III) and 3,4-Dihydroxy-Phenyl-Propenoic Acid (Caffeic Acid) in Weak Acidic Aqueous SolutionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Our study of the complexation of 3,4-dihydroxy-phenyl-propenoic acid by chromium(III) could give information on the way that this metal ion is available to plants. The reaction between chromium(III) and 3,4-dihydroxy-phenyl-propenoic acid in weak acidic aqueous solutions has been shown to take place by at least three stages. The first stage corresponds to substitution (Id mechanism) of water molecule from the Cr(H2O)5OH2+ coordination sphere by a ligand molecule. A very rapid protonation equilibrium, which follows, favors the aqua species. The second and the third stages are chromium(III) and ligand concentration independe...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Complexes of Cu(II) Ions and Noncovalent Interactions in Systems with L-Aspartic Acid and Cytidine-5'-MonophosphateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interactions between aspartic acid (Asp) and cytidine-5-monophosphate (CMP) in metal-free systems as well as the coordination of Cu(II) ions with the above ligands were studied. The composition and overall stability constants of the species formed in those systems were determined by the potentiometric method, and the interaction centres in the ligands were identified by the spectral methods UV-Vis, EPR, NMR, and IR. In metal-free systems, the formation of adducts, in which each ligand has both positive and negative reaction centres, was established. The main reaction centres in Asp are the oxygen atoms of carboxyl groups a...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Biomimetic Modeling of Copper Complexes: A Study of Enantioselective Catalytic Oxidation on D-(+)-Catechin and L-(−)-Epicatechin with Copper ComplexesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The biomimetic catalytic oxidations of the dinuclear and trinuclear copper(II) complexes versus two catechols, namely, D-(+)-catechin and L-(−)-epicatechin to give the corresponding quinones are reported. The unstable quinones were trapped by the nucleophilic reagent, 3-methyl-2-benzothiazolinone hydrazone (MBTH), and have been calculated the molar absorptivities of the different quinones. The catalytic efficiency is moderate, as inferred by kinetic constants, but the complexes exhibit significant enantio-differentiating ability towards the catechols, albeit for the dinuclear complexes, this enantio-differen...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis and Antimicrobial Activity of Silver Citrate ComplexesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Formation of silver citrate/citric acid complexed solutions was investigated. Although, silver citrate is minimally soluble in water, it can successfully be dissolved in citric acid solutions. The maximum concentration of Ag(I) in solution is estimated at 23 to 25 g/L if the concentration of citric acid is at least 4 mol/L or higher. The dissolution of silver citrate in citric acid solutions was attributed to the formation of silver citrate complexes of a general formula [Ag3(C6H5O7)n+1]3n−. The silver citrate/citric acid solutions, containing more than about 13 g/L Ag+ ion, have exhibited a dec...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Biosorption of Uranium and Rare Earth Elements Using Biomass of AlgaeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to investigate the behavior of rare earth elements (REEs) and uranium (U) in marine organism, the concentrations of REEs and U in some brown algae samples taken on the coast of Niigata Prefecture were determined. In addition, laboratory model experiment to uptake these elements using living and dried algae (Undaria pinnatifida and Sargassum hemiphyllum) was also carried out to survey the uptake and bioaccumulation mechanism of REEs and U in algae. Consequently, the following matters have been mainly clarified. (1) The order of the concentration of REEs for each organ in Sargassum hemiphyllum is “main branch&...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell LinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The palladium(II) bis-chelate Pd (L1−3)2 and platinum(II) tetranuclear Pt4(L4)4 complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (1H,13C) spectroscopy. The complex Pd(L2)2 [HL2=m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a trans arrangement, while the complex Pt4(L4)4 [HL4=4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions t...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell LinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized. Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR, and UV-Visible spectroscopy. All complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra, and molar conductance measurements. The elemental analysis data suggest t...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Coordination Behavior of 3-Ethoxycarbonyltetronic Acid towards Cu(II) and Co(II) Metal IonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present the complexation reactions of 3-ethoxycarbonyl tetronic acids with acetates and chlorides of Cu(II) and Co(II). These complexes have been studied by means of EPR spectroscopy and magnetic susceptibility measurements. From the obtained results, a preliminary complexation mode of the ligand is proposed. (Source: Bioinorganic Chemistry and Applications)
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Reaction of Chromium(III) with 3,4-Dihydroxybenzoic Acid: Kinetics and Mechanism in Weak Acidic Aqueous SolutionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The interactions between chromium(III) and 3,4-dihydroxybenzoic acid (3,4-DHBA) were studied resulting in the formation of oxygen-bonded complexes upon substitution of water molecules in the chromium(III) coordination sphere. The experimental results show that the reaction takes place in at least three stages, involving various intermediates. The first stage was found to be linearly dependent on ligand concentration k1(obs)_=k0+k1(obs)[3,4-DHBA], and the corresponding activation parameters were calculated as follows: ΔH1(obs)≠=51.2±11.5 kJ mol−1, ΔS1(obs)≠=−9...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

The First Metal Complexes of 4,6-diamino-1-hydro- 5-hydroxy-pyrimidine-2-thione: Preparation, Physical and Spectroscopic Studies, and Preliminary Antimicrobial PropertiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The new complexes [M2O5L2(H2O)2]⋅H2O (M=Mo,1;M=W,2), [RuL2(H2O)2]⋅H2O (3), [ML3]⋅xH2O (M=Rh,x=2,4;M=Ir,x=1,5), [RhL2(PPh3)2](ClO4)⋅2H2O (6), [PdL2]⋅2H2O (7), [PdL(phen)]Cl⋅H2O (8), [Re⁡OL2(PPh3)]Cl (9) and [UO2L2] (10) are reported, where LH is 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione. The complexes were characterized by elemental analyses, physical techniques (molar conductivity, room-temperature magnetic susceptibility), and spectroscopic (IR, Raman, UV/VIS/ligand field, NMR, ma...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic AcidsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZA or p-H2BZA) of formulae [R2Sn(HL)2] (where H2L = o-H2BZA and R = Me- (1), n-Bu- (2)); [R3Sn(HL)] (where H2L = o-H2BZA and R = n-Bu- (3), Ph- (4) or H2L = p-H2BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZA or p-H2BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, H1, S119n-NMR, UV/Vis spectroscopy, and Mass spectro...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Zinc and Mercury Complexes of 2-Formylpyridine ThiosemicarbazoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A series of metal complexes of Zn(II) and Hg(II) having the general composition [M(L)2]X2 [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = Cl−, NO3 − and 1/2SO4 2−] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand an...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis and Evaluation of Novel Organogermanium Sesquioxides As Antitumor AgentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Five new organogermanium sesquioxides have been synthesized and characterized by elemental analysis and IR spectra. All the compounds were tested for antitumor activities against KB, HCT, and Bel cells in vitro. Compound 5 (γ-thiocarbamido propyl germanium sesquioxide) showed excellent antitumor activity, and its inhibition yield to KB, HCT, and Bel cells was 92.9%, 84.9%, and 70.9%, respectively. A rapid method was described for the labeling compound 5 with T99mc, and the optimum labeling conditions were investigated. The labeling yield is above 90% in pH 7.0, 20∘C, reaction time greater than...
Source: Bioinorganic Chemistry and Applications - June 10, 2009 Category: Biochemistry Source Type: journals

Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Zinc and Mercury Complexes of 2-Formylpyridine ThiosemicarbazoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A series of metal complexes of Zn(II) and Hg(II) having the general composition [M(L)2]X2 [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = Cl−, NO3 − and 1/2SO4 2−] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand an...
Source: Bioinorganic Chemistry and Applications - April 30, 2009 Category: Biochemistry Source Type: journals

Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic AcidsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZA or p-H2BZA) of formulae [R2Sn(HL)2] (where H2L = o-H2BZA and R = Me- (1), n-Bu- (2)); [R3Sn(HL)] (where H2L = o-H2BZA and R = n-Bu- (3), Ph- (4) or H2L = p-H2BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZA or p-H2BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, H1, S119n-NMR, UV/Vis spectroscopy, and Mass spectro...
Source: Bioinorganic Chemistry and Applications - April 18, 2009 Category: Biochemistry Source Type: journals

The First Metal Complexes of 4,6-diamino-1-hydro- 5-hydroxy-pyrimidine-2-thione: Preparation, Physical and Spectroscopic Studies, and Preliminary Antimicrobial PropertiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The new complexes [M2O5L2(H2O)2]⋅H2O (M=Mo,1;M=W,2), [RuL2(H2O)2]⋅H2O (3), [ML3]⋅xH2O (M=Rh,x=2,4;M=Ir,x=1,5), [RhL2(PPh3)2](ClO4)⋅2H2O (6), [PdL2]⋅2H2O (7), [PdL(phen)]Cl⋅H2O (8), [Re⁡OL2(PPh3)]Cl (9) and [UO2L2] (10) are reported, where LH is 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione. The complexes were characterized by elemental analyses, physical techniques (molar conductivity, room-temperature magnetic susceptibility), and spectroscopic (IR, Raman, UV/VIS/ligand field, NMR, ma...
Source: Bioinorganic Chemistry and Applications - March 29, 2009 Category: Biochemistry Source Type: journals

Reaction of Chromium(III) with 3,4-Dihydroxybenzoic Acid: Kinetics and Mechanism in Weak Acidic Aqueous SolutionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The interactions between chromium(III) and 3,4-dihydroxybenzoic acid (3,4-DHBA) were studied resulting in the formation of oxygen-bonded complexes upon substitution of water molecules in the chromium(III) coordination sphere. The experimental results show that the reaction takes place in at least three stages, involving various intermediates. The first stage was found to be linearly dependent on ligand concentration k1(obs)_=k0+k1(obs)[3,4-DHBA], and the corresponding activation parameters were calculated as follows: ΔH1(obs)≠=51.2±11.5 kJ mol−1, ΔS1(obs)≠=−9...
Source: Bioinorganic Chemistry and Applications - February 4, 2009 Category: Biochemistry Source Type: journals

Coordination Behavior of 3-Ethoxycarbonyltetronic Acid towards Cu(II) and Co(II) Metal IonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present the complexation reactions of 3-ethoxycarbonyl tetronic acids with acetates and chlorides of Cu(II) and Co(II). These complexes have been studied by means of EPR spectroscopy and magnetic susceptibility measurements. From the obtained results, a preliminary complexation mode of the ligand is proposed. (Source: Bioinorganic Chemistry and Applications)
Source: Bioinorganic Chemistry and Applications - February 3, 2009 Category: Biochemistry Source Type: journals