Early life adversities are associated with lower expected value signaling in the adult brain
Early adverse experiences are assumed to affect fundamental processes of reward learning and decision-making. However, computational neuroimaging studies investigating these circuits in the context of adversity are sparse and limited to studies conducted in adolescent samples, leaving the long-term effects unexplored. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 16, 2024 Category: Psychiatry Authors: Seda Sacu, Magda Dubois, Frank H. Hezemans, Pascal-M. Aggensteiner, Maximilian Monninger, Daniel Brandeis, Tobias Banaschewski, Tobias U. Hauser, Nathalie E. Holz Tags: Archival Report Source Type: research
Erratum
to: “12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice,” by Di Meco et al. (Biol Psychiatry 2017; 81:92–100); https://doi.org/10.1016/j.biopsych.2016.05.023. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 15, 2024 Category: Psychiatry Tags: Erratum Source Type: research
Longitudinal trajectories of plasma polyunsaturated fatty acids and associations with psychosis-spectrum outcomes in early adulthood
Evidence supports associations between polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and psychosis. However, PUFA trajectories in the general population have not been characterised and associations with psychosis-spectrum outcomes in early adulthood are unknown. background (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 15, 2024 Category: Psychiatry Authors: David Mongan, Benjamin I. Perry, Colm Healy, Subash Raj Susai, Stan Zammit, Mary Cannon, David R. Cotter Tags: Archival Report Source Type: research
Early Infant Prefrontal Cortical Microstructure Predicts Present and Future Emotionality
High levels of infant negative emotionality (NE) and low positive emotionality (PE) predict future emotional and behavioral problems. The prefrontal cortex (PFC) supports emotional regulation, with each PFC subregion specializing in specific emotional processes. Neurite Orientation Dispersion and Density Imaging (NODDI) estimates microstructural integrity and myelination via the neurite density index (NDI) and dispersion via the orientation dispersion index (ODI), with potential to more accurately evaluate microstructural alterations in the developing brain. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 9, 2024 Category: Psychiatry Authors: Yicheng Zhang, Layla Banihashemi, Amelia Versace, Alyssa Samolyk, Megan Taylor, Gabrielle English, Vanessa J. Schmithorst, Vincent K. Lee, Richelle Stiffler, Haris Aslam, Ashok Panigrahy, Alison E. Hipwell, Mary L. Phillips Tags: Archival Report Source Type: research
Revisiting the Relative Contribution of Common and Rare Genetic Variants to Attention-Deficit/Hyperactivity Disorder Among Diverse Populations
Polygenic risk score (PRS) represents a groundbreaking advancement in personalized medicine, offering a nuanced and predictive tool for assessing an individual ’s susceptibility to polygenic diseases based on their genetic makeup by aggregating the small effects of many common variants. However, the application of PRS in neuropsychiatric disorders is limited due to the challenges in achieving clinical utility in general medical settings (1). Copy number variants (CNVs) are deletions or duplications of sections of DNA that often result in changes in gene dosage. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Authors: Yulin Dai, Brisa S. Fernandes, Zhongming Zhao Tags: Commentary Source Type: research
Current Complexities in Establishing Risk Factors for Attention-Deficit/Hyperactivity Disorder in Longitudinal Research
A long-term goal of psychiatric research is to understand the process by which psychiatric disorders develop over time and lead to impairing symptoms. Attention-deficit/hyperactivity disorder (ADHD), as defined in diagnostic manuals, is a prevalent neurodevelopmental disorder that often begins in childhood and includes persistent symptoms of hyperactivity, inattention, and impulsiveness. Longitudinal studies of ADHD trajectories support the notion that ADHD symptoms begin early in life but that patterns of symptoms vary across development (1,2). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Authors: Katherine N. Thompson Tags: Commentary Source Type: research
Neurodevelopmental Genetic Associations Across the Translational Space-Time Continuum
Genes encoding machinery for synaptic development and plasticity have been shown to play a role in the pathophysiology of neurodevelopmental psychiatric disorders such as schizophrenia and autism, although the precise mechanisms are poorly understood. As recent advances in genomics uncover more of these disease genes, it is critical to identify convergent molecular pathways to facilitate the development of broadly applicable therapeutics. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Authors: Mariam Alexandra Gachechiladze, Joseph D. Dougherty Tags: Commentary Source Type: research
Connecting Environmental and Genetic Explanations for Nonlinear Language Development in Infancy and Toddlerhood
Language development is not linear, regardless of the lens through which it is examined. Across both comprehension (i.e., receptive vocabulary) and production (i.e., expressive vocabulary, grammar), development is characterized by slow and gradual progress followed by sudden spurts. For example, comprehension is thought to improve drastically around 14 months of age; while infants exhibit knowledge of a few words prior to this time, their word recognition quickly improves after this point (1). Expressive vocabulary knowledge is also slow at first; typically developing infants go from knowing just a few words to knowing at ...
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Authors: Federica Bulgarelli Tags: Early Career Investigator Commentary Source Type: research
In This Issue
Volume 95, Number 9, May 1, 2024 (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Tags: In This Issue Source Type: research
Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Source Type: research
Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Source Type: research
Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Source Type: research
Guide for Authors
Biological Psychiatry, founded in 1969, is an official journal of the Society of Biological Psychiatry and the first in the Biological Psychiatry family of journals. Companion titles include Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society ’s purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, and behavior. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 8, 2024 Category: Psychiatry Source Type: research
Lost in translation: Challenges for translational research in the field of stress and cognition.
Exposure to an adverse environment often compromises an individual ’s well-being and poses long-term risk for mental and physical disorders. These adverse effects are thought to be mediated by a set of general (stressor non-specific) psychological, biological, and behavioral mechanisms, referred to as “stress” or the “stress-response”. The mechanistic/cau sative link between the stressors (environmental agents causing stress), the stress response, and changes taking place in the organism, has been a topic of vigorous investigations for physicians, psychologists, biologists, and social scientists for nearly a cent...
Source: Biological Psychiatry - April 4, 2024 Category: Psychiatry Authors: Israel Liberzon Tags: Commentary Source Type: research
SIRT1 coordinates transcriptional regulation of neural activity and modulates depression-like behaviors in the nucleus accumbens
Major depression and anxiety disorder are significant causes of disability and socio-economic burden. Despite the prevalence and considerable impact of these affective disorders, their pathophysiology remains elusive. Thus, there is an urgent need to develop novel therapeutics for these conditions. We evaluated the role of SIRT1 in regulating dysfunctional processes of reward by using chronic social defeat stress (CSDS) to induce depression- and anxiety-like behaviors. CSDS induces physiological and behavioral changes that recapitulate depression-like symptomatology and alters gene expression programs in the nucleus accumb...
Source: Biological Psychiatry - April 2, 2024 Category: Psychiatry Authors: Hee-Dae Kim, Jing Wei, Tanessa Call, Xiaokuang Ma, Nicole Teru Quintus, Alexander J. Summers, Samantha Carotenuto, Ross Johnson, Angel Nguyen, Yuehua Cui, Jin G. Park, Shenfeng Qiu, Deveroux Ferguson Tags: Archival Report Source Type: research
