OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1
Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC).... (Source: Biology Direct)
Source: Biology Direct - April 24, 2024 Category: Biology Authors: Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo and Qiuran Xu Tags: Research Source Type: research
Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging
Oocyte quality is critical for the mammalian reproduction due to its necessity on fertilization and early development. During aging, the declined oocytes showing with organelle dysfunction and oxidative stress... (Source: Biology Direct)
Source: Biology Direct - April 23, 2024 Category: Biology Authors: Lin-Lin Hu, Mei-Hua Liao, Ya-Xi Liu, Chun-Hua Xing, Lan-Lan Nong, Feng-Lian Yang and Shao-Chen Sun Tags: Research Source Type: research
Biomimetic peroxidase MOF-Fe promotes bone defect repair by inhibiting TfR2 and activating the BMP2 pathway
Large bone defects pose a clinical treatment challenge; inhibiting transferrin receptor 2 (TfR2), which is involved in iron metabolism, can promote osteogenesis. Iron-based metal-organic frameworks (MOF-Fe) pa... (Source: Biology Direct)
Source: Biology Direct - April 23, 2024 Category: Biology Authors: Yaxin Xue, Wei Xu, Danyang Zhao, Zijing Du, Hao Jiang, Hao Lv, Dong Zhang, Zhencheng Yu, Yi Cao and Dong Han Tags: Research Source Type: research
ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway
Osteosarcoma is a diverse and aggressive bone tumor. Driver genes regulating osteosarcoma initiation and progression remains incompletely defined. Zinc finger protein 692 (ZNF692), a kind of Kr üppel C2H2 zinc ... (Source: Biology Direct)
Source: Biology Direct - April 22, 2024 Category: Biology Authors: Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu and Weichun Guo Tags: Research Source Type: research
Correction: Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway
(Source: Biology Direct)
Source: Biology Direct - April 18, 2024 Category: Biology Authors: Du Shen and Shaosan Kang Tags: Correction Source Type: research
Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity
Ischemic stroke is a sudden and acute disease characterized by neuronal death, increment of reactive gliosis (reactive microglia and astrocytes), and a severe inflammatory process. Neuroinflammation is an earl... (Source: Biology Direct)
Source: Biology Direct - April 6, 2024 Category: Biology Authors: Mario Villa-Gonz ález, Marina Rubio, Gerardo Martín-López, Paula R. Mallavibarrena, Laura Vallés-Saiz, Denis Vivien, Francisco Wandosell and Maria José Pérez-Álvarez Tags: Research Source Type: research
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p
Circular RNAs (circRNAs) are a class of highly multifunctional single-stranded RNAs that play crucial roles in cancer progression, including osteosarcoma (OS). Circ_0002669, generated from the dedicator of cyt... (Source: Biology Direct)
Source: Biology Direct - April 3, 2024 Category: Biology Authors: Ying Zhang, Yizhou Zhan, Zhaoyong Liu, Huancheng Guo, Dongchen Liu and Chuangzhen Chen Tags: Research Source Type: research
LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4
Pancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be associated with Pancreatic Ductal Adenocarcinoma stemness characteristics but ... (Source: Biology Direct)
Source: Biology Direct - March 19, 2024 Category: Biology Authors: Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou and Chuanzhao Zhang Tags: Research Source Type: research
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling
This study seeks to investigate the impacts of Lactobacillus reuteri (L. reuteri) on hepatic ischemia-reperfusion (I/R) injury and uncover the mechanisms involved. (Source: Biology Direct)
Source: Biology Direct - March 18, 2024 Category: Biology Authors: Leiyi Zhang, Xiaoxiang Gong, Juan Tan, Rongsen Zhang, Mingxia Li, Cong Liu, Chenhao Wu and Xiaojing Li Tags: Research Source Type: research
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance
Neutral/alkaline invertases (N/AINVs) play a crucial role in plant growth, development, and stress response, by irreversibly hydrolyzing sucrose into glucose and fructose. However, research on cotton in this a... (Source: Biology Direct)
Source: Biology Direct - March 14, 2024 Category: Biology Authors: Kaikai Qiao, Qingtao Zeng, Jiaoyan Lv, Lingling Chen, Juxin Hao, Ding Wang, Qifeng Ma and Shuli Fan Tags: Research Source Type: research
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway
Mammalian enabled (MENA) protein is a member of the enabled/vasodilator stimulated phosphoprotein (Ena/VASP) protein family, which regulates cytoplasmic actin network assembly. It plays a significant role in b... (Source: Biology Direct)
Source: Biology Direct - March 8, 2024 Category: Biology Authors: Lifang He, Chuanghong She, Sen Jiang, Zhaochang Qi, Zihao Deng, Likeng Ji, Yukun Cui and Jundong Wu Tags: Research Source Type: research
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma
This study explored the role of circLRIG1 in the development and progression of bladder carcinoma a... (Source: Biology Direct)
Source: Biology Direct - March 7, 2024 Category: Biology Authors: Shiliang Cheng, Chunguang Li, Lu Liu, Xinli Liu, Meng Li, Jinhua Zhuo, Jue Wang, Wen Zheng and Zhongmin Wang Tags: Research Source Type: research
PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA
Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Current therapeutic effect is far from satisfaction. Hence, identifying susceptible genes and potential targets is necessary ... (Source: Biology Direct)
Source: Biology Direct - March 1, 2024 Category: Biology Authors: Zhiwei Chang, Yongxu Jia, Ming Gao, Lijie Song, Weijie Zhang, Ruihua Zhao, Dandan Yu, Xiaolei Liu, Jing Li and Yanru Qin Tags: Research Source Type: research
Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway
STAM Binding Protein Like 1 (STAMBPL1), functions as a deubiquitinase (DUB) and plays a significant role in various types of cancers. However, its effect as a DUB participating in the HCC tumorigenesis and pro... (Source: Biology Direct)
Source: Biology Direct - February 28, 2024 Category: Biology Authors: Zhihuai Wang, Yinjie Zhang, Yuhang Shen, Haiyang Zhou, Yuan Gao, Chunfu Zhu and Xihu Qin Tags: Research Source Type: research
Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway
Bladder cancer (BC) is the fourth and tenth most common malignancy in men and women worldwide, respectively. The complexity of the molecular biological mechanism behind BC is a major contributor to the lack of... (Source: Biology Direct)
Source: Biology Direct - February 26, 2024 Category: Biology Authors: Du Shen and Shaosan Kang Tags: Research Source Type: research
