An all-in-one therapeutic platform for the treatment of resistant Helicobacter pylori infection
Biomaterials. 2024 Mar 21;308:122540. doi: 10.1016/j.biomaterials.2024.122540. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) infection is a major cause of gastric diseases. Currently, bismuth-based quadruple therapy is widely adopted for eradicating H. pylori infection. However, this first-line strategy faces several challenges such as drug resistance, intestinal dysbacteriosis, and patients' poor compliance. To overcome these problems, an all-in-one therapeutic platform (CLA-Bi-ZnO2@Lipo) that composed of liposomes loading clarithromycin (CLA), Bi, and ZnO2 hybrid nanoparticles was developed for eradicatin...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chao Sun Jia Huang Xiaoqian Guo Chenli Zhang Li Wei Ka Ioi Wong Ziyun Yang Gang Zhao Min Lu Weiyan Yao Source Type: research

Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots
Biomaterials. 2024 Mar 22;308:122547. doi: 10.1016/j.biomaterials.2024.122547. Online ahead of print.ABSTRACTUrinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC), often reoccur due to the formation of intracellular bacterial colonies (IBCs) and antibiotic resistance. Given the significance of YadC for UPEC infection in our previous study, we developed D-xylose-decorated ɛ-poly-L-lysine (εPL)-based carbon dots (D-xyl@εPLCDs) that can be traced, and employed multi-step approaches to elucidate the functional roles of D-xyl@εPLCDs in UPEC infection. Compared to undecorated particles, D-xyl@εPLCD...
Source: Biomaterials - March 27, 2024 Category: Materials Science Authors: Chunhui Miao Yajie Zhang Guowen Liu Jianming Yang Kaiyuan Yu Junqiang Lv Ran Liu Zhi Yao Yuanjie Niu Xiaojuan Wang Quan Wang Source Type: research

Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment
In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs) and developed ECM hydrogels from decellularized tissues (dECM) to assess the effects of RT-induced ECM changes on breast cancer cell behavior. Irradiated MFPs were characterized by increased ECM deposition and fiber density compared to unirradiated controls, which may provide a platform for cell invasion and proliferation. ECM component changes in collagens I, IV, and VI, and fibronectin were observed following irradiation in both MFPs and dECM hydrogels. Encapsulated TNBC cell proliferat...
Source: Biomaterials - March 26, 2024 Category: Materials Science Authors: Tian Zhu Steven M Alves Arianna Adamo Xiaona Wen Kevin C Corn Anastasia Shostak Shereena Johnson Nicholas D Shaub Shannon E Martello Benjamin C Hacker Antonio D'Amore Rizia Bardhan Marjan Rafat Source Type: research

Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment
In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs) and developed ECM hydrogels from decellularized tissues (dECM) to assess the effects of RT-induced ECM changes on breast cancer cell behavior. Irradiated MFPs were characterized by increased ECM deposition and fiber density compared to unirradiated controls, which may provide a platform for cell invasion and proliferation. ECM component changes in collagens I, IV, and VI, and fibronectin were observed following irradiation in both MFPs and dECM hydrogels. Encapsulated TNBC cell proliferat...
Source: Biomaterials - March 26, 2024 Category: Materials Science Authors: Tian Zhu Steven M Alves Arianna Adamo Xiaona Wen Kevin C Corn Anastasia Shostak Shereena Johnson Nicholas D Shaub Shannon E Martello Benjamin C Hacker Antonio D'Amore Rizia Bardhan Marjan Rafat Source Type: research

Progress in the development of piezoelectric biomaterials for tissue remodeling
Biomaterials. 2024 Mar 11;307:122528. doi: 10.1016/j.biomaterials.2024.122528. Online ahead of print.ABSTRACTPiezoelectric biomaterials have demonstrated significant potential in the past few decades to heal damaged tissue and restore cellular functionalities. Herein, we discuss the role of bioelectricity in tissue remodeling and explore ways to mimic such tissue-like properties in synthetic biomaterials. In the past decade, biomedical engineers have adopted emerging functional biomaterials-based tissue engineering approaches using innovative bioelectronic stimulation protocols based on dynamic stimuli to direct cellular a...
Source: Biomaterials - March 24, 2024 Category: Materials Science Authors: Amit Nain Srishti Chakraborty Snigdha Roy Barman Pratik Gavit Sushma Indrakumar Akhilesh Agrawal Zong-Hong Lin Kaushik Chatterjee Source Type: research

Membrane-anchoring selenophene viologens for antibacterial photodynamic therapy against periodontitis via restoring subgingival flora and alleviating inflammation
Biomaterials. 2024 Mar 21;307:122536. doi: 10.1016/j.biomaterials.2024.122536. Online ahead of print.ABSTRACTAntibacterial photodynamic therapy (aPDT) has emerged as a promising strategy for treating periodontitis. However, the weak binding of most photosensitizers to bacteria and the hypoxic environment of periodontal pockets severely hamper the therapeutic efficacy. Herein, two novel oxygen-independent photosensitizers are developed by introducing selenophene into viologens and modifying with hexane chains (HASeV) or quaternary ammonium chains (QASeV), which improve the adsorption to bacteria through anchoring to the neg...
Source: Biomaterials - March 24, 2024 Category: Materials Science Authors: Rui Ding Xu Liu Xiaodan Zhao Qi Sun Yilong Cheng Ang Li Dandan Pei Gang He Source Type: research

Progress in the development of piezoelectric biomaterials for tissue remodeling
Biomaterials. 2024 Mar 11;307:122528. doi: 10.1016/j.biomaterials.2024.122528. Online ahead of print.ABSTRACTPiezoelectric biomaterials have demonstrated significant potential in the past few decades to heal damaged tissue and restore cellular functionalities. Herein, we discuss the role of bioelectricity in tissue remodeling and explore ways to mimic such tissue-like properties in synthetic biomaterials. In the past decade, biomedical engineers have adopted emerging functional biomaterials-based tissue engineering approaches using innovative bioelectronic stimulation protocols based on dynamic stimuli to direct cellular a...
Source: Biomaterials - March 24, 2024 Category: Materials Science Authors: Amit Nain Srishti Chakraborty Snigdha Roy Barman Pratik Gavit Sushma Indrakumar Akhilesh Agrawal Zong-Hong Lin Kaushik Chatterjee Source Type: research

Membrane-anchoring selenophene viologens for antibacterial photodynamic therapy against periodontitis via restoring subgingival flora and alleviating inflammation
Biomaterials. 2024 Mar 21;307:122536. doi: 10.1016/j.biomaterials.2024.122536. Online ahead of print.ABSTRACTAntibacterial photodynamic therapy (aPDT) has emerged as a promising strategy for treating periodontitis. However, the weak binding of most photosensitizers to bacteria and the hypoxic environment of periodontal pockets severely hamper the therapeutic efficacy. Herein, two novel oxygen-independent photosensitizers are developed by introducing selenophene into viologens and modifying with hexane chains (HASeV) or quaternary ammonium chains (QASeV), which improve the adsorption to bacteria through anchoring to the neg...
Source: Biomaterials - March 24, 2024 Category: Materials Science Authors: Rui Ding Xu Liu Xiaodan Zhao Qi Sun Yilong Cheng Ang Li Dandan Pei Gang He Source Type: research

ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction
Biomaterials. 2024 Mar 16;307:122534. doi: 10.1016/j.biomaterials.2024.122534. Online ahead of print.ABSTRACTDespite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to in situ stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical microgels with a size of 150 μm were obtained. The MTK-TK-drug microgels efficiently converted the pro-inf...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Shuqin Wang Yuejun Yao Liang Song Zihe Zhai Shifen Li Zhaolong Wang Liyin Shen Yang Zhu Wenxing Liu Changyou Gao Source Type: research

Plant mucus-derived microgels: Blood-triggered gelation and strong hemostatic adhesion
Biomaterials. 2024 Mar 16;307:122535. doi: 10.1016/j.biomaterials.2024.122535. Online ahead of print.ABSTRACTArrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the mi...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Yu Huang Weichao Hu Kaige Xu Ruijue Dan Shali Tan Zhenzhen Shu Xin Li Hangzong Liu Chaoqiang Fan Malcolm Xing Shiming Yang Source Type: research

A neoteric antibacterial ceria-silver nanozyme for abiotic surfaces
Biomaterials. 2024 Mar 18;307:122527. doi: 10.1016/j.biomaterials.2024.122527. Online ahead of print.ABSTRACTCommunity-associated and hospital-acquired infections caused by bacteria continue to yield major global challenges to human health. Bacterial contamination on abiotic surfaces is largely spread via high-touch surfaces and contemporary standard disinfection practices show limited efficacy, resulting in unsatisfactory therapeutic outcomes. New strategies that offer non-specific and broad protection are urgently needed. Herein, we report our novel ceria-silver nanozyme engineered at a molar ratio of 5:1 and with a high...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Abinaya Sindu Pugazhendhi Craig J Neal Khoa Minh Ta Marco Molinari Udit Kumar Fei Wei Elayaraja Kolanthai Andrew Ady Christina Drake Megan Hughes Shibu Yooseph Sudipta Seal Melanie J Coathup Source Type: research

ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction
Biomaterials. 2024 Mar 16;307:122534. doi: 10.1016/j.biomaterials.2024.122534. Online ahead of print.ABSTRACTDespite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to in situ stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical microgels with a size of 150 μm were obtained. The MTK-TK-drug microgels efficiently converted the pro-inf...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Shuqin Wang Yuejun Yao Liang Song Zihe Zhai Shifen Li Zhaolong Wang Liyin Shen Yang Zhu Wenxing Liu Changyou Gao Source Type: research

Plant mucus-derived microgels: Blood-triggered gelation and strong hemostatic adhesion
Biomaterials. 2024 Mar 16;307:122535. doi: 10.1016/j.biomaterials.2024.122535. Online ahead of print.ABSTRACTArrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the mi...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Yu Huang Weichao Hu Kaige Xu Ruijue Dan Shali Tan Zhenzhen Shu Xin Li Hangzong Liu Chaoqiang Fan Malcolm Xing Shiming Yang Source Type: research

A neoteric antibacterial ceria-silver nanozyme for abiotic surfaces
Biomaterials. 2024 Mar 18;307:122527. doi: 10.1016/j.biomaterials.2024.122527. Online ahead of print.ABSTRACTCommunity-associated and hospital-acquired infections caused by bacteria continue to yield major global challenges to human health. Bacterial contamination on abiotic surfaces is largely spread via high-touch surfaces and contemporary standard disinfection practices show limited efficacy, resulting in unsatisfactory therapeutic outcomes. New strategies that offer non-specific and broad protection are urgently needed. Herein, we report our novel ceria-silver nanozyme engineered at a molar ratio of 5:1 and with a high...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Abinaya Sindu Pugazhendhi Craig J Neal Khoa Minh Ta Marco Molinari Udit Kumar Fei Wei Elayaraja Kolanthai Andrew Ady Christina Drake Megan Hughes Shibu Yooseph Sudipta Seal Melanie J Coathup Source Type: research

ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction
Biomaterials. 2024 Mar 16;307:122534. doi: 10.1016/j.biomaterials.2024.122534. Online ahead of print.ABSTRACTDespite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to in situ stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical microgels with a size of 150 μm were obtained. The MTK-TK-drug microgels efficiently converted the pro-inf...
Source: Biomaterials - March 22, 2024 Category: Materials Science Authors: Shuqin Wang Yuejun Yao Liang Song Zihe Zhai Shifen Li Zhaolong Wang Liyin Shen Yang Zhu Wenxing Liu Changyou Gao Source Type: research