Biomechanics and Modeling in Mechanobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Determining a musculoskeletal system's pre-stretched state using continuum-mechanical forward modelling and joint range optimization
Biomech Model Mechanobiol. 2024 Apr 15. doi: 10.1007/s10237-024-01821-x. Online ahead of print.ABSTRACTThe subject-specific range of motion (RoM) of a musculoskeletal joint system is balanced by pre-tension levels of individual muscles, which affects their contraction capability. Such an inherent pre-tension or pre-stretch of muscles is not measureable with in vivo experiments. Using a 3D continuum mechanical forward simulation approach for motion analysis of the musculoskeletal system of the forearm with 3 flexor and 2 extensor muscles, we developed an optimization process to determine the muscle fibre pre-stretches for a...
Source: Biomechanics and Modeling in Mechanobiology - April 15, 2024 Category: Biomedical Science Authors: Okan Avci Oliver R öhrle Source Type: research

Determining a musculoskeletal system's pre-stretched state using continuum-mechanical forward modelling and joint range optimization
Biomech Model Mechanobiol. 2024 Apr 15. doi: 10.1007/s10237-024-01821-x. Online ahead of print.ABSTRACTThe subject-specific range of motion (RoM) of a musculoskeletal joint system is balanced by pre-tension levels of individual muscles, which affects their contraction capability. Such an inherent pre-tension or pre-stretch of muscles is not measureable with in vivo experiments. Using a 3D continuum mechanical forward simulation approach for motion analysis of the musculoskeletal system of the forearm with 3 flexor and 2 extensor muscles, we developed an optimization process to determine the muscle fibre pre-stretches for a...
Source: Biomechanics and Modeling in Mechanobiology - April 15, 2024 Category: Biomedical Science Authors: Okan Avci Oliver R öhrle Source Type: research

The mechanical effects of chemical stimuli on neurospheres
Biomech Model Mechanobiol. 2024 Apr 13. doi: 10.1007/s10237-024-01841-7. Online ahead of print.ABSTRACTThe formulation of more accurate models to describe tissue mechanics necessitates the availability of tools and instruments that can precisely measure the mechanical response of tissues to physical loads and other stimuli. In this regard, neuroscience has trailed other life sciences owing to the unavailability of representative live tissue models and deficiency of experimentation tools. We previously addressed both challenges by employing a novel instrument called the cantilevered-capillary force apparatus (CCFA) to eluci...
Source: Biomechanics and Modeling in Mechanobiology - April 13, 2024 Category: Biomedical Science Authors: Yun-Han Huang Roza Vaez Ghaemi James Cheon Vikramaditya G Yadav John M Frostad Source Type: research

The mechanical effects of chemical stimuli on neurospheres
Biomech Model Mechanobiol. 2024 Apr 13. doi: 10.1007/s10237-024-01841-7. Online ahead of print.ABSTRACTThe formulation of more accurate models to describe tissue mechanics necessitates the availability of tools and instruments that can precisely measure the mechanical response of tissues to physical loads and other stimuli. In this regard, neuroscience has trailed other life sciences owing to the unavailability of representative live tissue models and deficiency of experimentation tools. We previously addressed both challenges by employing a novel instrument called the cantilevered-capillary force apparatus (CCFA) to eluci...
Source: Biomechanics and Modeling in Mechanobiology - April 13, 2024 Category: Biomedical Science Authors: Yun-Han Huang Roza Vaez Ghaemi James Cheon Vikramaditya G Yadav John M Frostad Source Type: research

A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow
We present a novel continuum model for VWF dynamics in flow based on a modified viscoelastic fluid model that incorporates a single constitutive relation to describe the propensity of VWF to unfold as a function of the scalar shear rate. Using experimental data of VWF unfolding in pure shear flow, we fix the parameters for VWF's unfolding propensity and the maximum VWF length, so that the protein is half unfolded at a shear rate of approximately 5000 s - 1 . We then use the theoretical model to predict VWF's behaviour in two complex flows where experimental data are challenging to obtain: pure elongational flow and ste...
Source: Biomechanics and Modeling in Mechanobiology - April 9, 2024 Category: Biomedical Science Authors: E F Yeo J M Oliver N Korin S L Waters Source Type: research

A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow
We present a novel continuum model for VWF dynamics in flow based on a modified viscoelastic fluid model that incorporates a single constitutive relation to describe the propensity of VWF to unfold as a function of the scalar shear rate. Using experimental data of VWF unfolding in pure shear flow, we fix the parameters for VWF's unfolding propensity and the maximum VWF length, so that the protein is half unfolded at a shear rate of approximately 5000 s - 1 . We then use the theoretical model to predict VWF's behaviour in two complex flows where experimental data are challenging to obtain: pure elongational flow and ste...
Source: Biomechanics and Modeling in Mechanobiology - April 9, 2024 Category: Biomedical Science Authors: E F Yeo J M Oliver N Korin S L Waters Source Type: research

A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow
We present a novel continuum model for VWF dynamics in flow based on a modified viscoelastic fluid model that incorporates a single constitutive relation to describe the propensity of VWF to unfold as a function of the scalar shear rate. Using experimental data of VWF unfolding in pure shear flow, we fix the parameters for VWF's unfolding propensity and the maximum VWF length, so that the protein is half unfolded at a shear rate of approximately 5000 s - 1 . We then use the theoretical model to predict VWF's behaviour in two complex flows where experimental data are challenging to obtain: pure elongational flow and ste...
Source: Biomechanics and Modeling in Mechanobiology - April 9, 2024 Category: Biomedical Science Authors: E F Yeo J M Oliver N Korin S L Waters Source Type: research

A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow
We present a novel continuum model for VWF dynamics in flow based on a modified viscoelastic fluid model that incorporates a single constitutive relation to describe the propensity of VWF to unfold as a function of the scalar shear rate. Using experimental data of VWF unfolding in pure shear flow, we fix the parameters for VWF's unfolding propensity and the maximum VWF length, so that the protein is half unfolded at a shear rate of approximately 5000 s - 1 . We then use the theoretical model to predict VWF's behaviour in two complex flows where experimental data are challenging to obtain: pure elongational flow and ste...
Source: Biomechanics and Modeling in Mechanobiology - April 9, 2024 Category: Biomedical Science Authors: E F Yeo J M Oliver N Korin S L Waters Source Type: research

Treatment for middle cerebral artery bifurcation aneurysms: in silico comparison of the novel Contour device and conventional flow-diverters
In this study, two in silico MCA bifurcation aneurysm models were treated by specific Contour devices and flow-diverters using fast-deployment algorithms. Computational fluid dynamic simulations were used to examine the performance and efficiency of deployed devices. Hemodynamic parameters, including aneurysm inflow and wall shear stress, were compared among each Contour device, conventional flow-diverter, and untreated condition. Our results show that the placement of devices can effectively reduce the risk of aneurysm rupture, while the deployment of a Contour device causes more flow reduction than using flow-diverters (...
Source: Biomechanics and Modeling in Mechanobiology - April 8, 2024 Category: Biomedical Science Authors: Mengzhe Lyu Ryo Torii Ce Liang Thomas W Peach Pervinder Bhogal Levansri Makalanda Qiaoqiao Li Yiannis Ventikos Duanduan Chen Source Type: research

Biventricular finite element modeling of the fetal heart in health and during critical aortic stenosis
Biomech Model Mechanobiol. 2024 Apr 8. doi: 10.1007/s10237-024-01842-6. Online ahead of print.ABSTRACTFinite Element simulations are a robust way of investigating cardiac biomechanics. To date, it has only been performed with the left ventricle (LV) alone for fetal hearts, even though results are likely different with biventricular (BiV) simulations. In this research, we conduct BiV simulations of the fetal heart based on 4D echocardiography images to show that it can capture the biomechanics of the normal healthy fetal heart, as well as those of fetal aortic stenosis better than the LV alone simulations. We found that per...
Source: Biomechanics and Modeling in Mechanobiology - April 8, 2024 Category: Biomedical Science Authors: Meifeng Ren Wei Xuan Chan Laura Green Martin L Buist Choon Hwai Yap Source Type: research

Treatment for middle cerebral artery bifurcation aneurysms: in silico comparison of the novel Contour device and conventional flow-diverters
In this study, two in silico MCA bifurcation aneurysm models were treated by specific Contour devices and flow-diverters using fast-deployment algorithms. Computational fluid dynamic simulations were used to examine the performance and efficiency of deployed devices. Hemodynamic parameters, including aneurysm inflow and wall shear stress, were compared among each Contour device, conventional flow-diverter, and untreated condition. Our results show that the placement of devices can effectively reduce the risk of aneurysm rupture, while the deployment of a Contour device causes more flow reduction than using flow-diverters (...
Source: Biomechanics and Modeling in Mechanobiology - April 8, 2024 Category: Biomedical Science Authors: Mengzhe Lyu Ryo Torii Ce Liang Thomas W Peach Pervinder Bhogal Levansri Makalanda Qiaoqiao Li Yiannis Ventikos Duanduan Chen Source Type: research

Acoustic emission applied to stochastic modeling of microdamage in compact bone
This study investigates the fracture of human complete ribs subjected to bending and using acoustic emission (AE) for microfailure detection. As the strain increases, the number of AE signals per unit of time rises until, beyond a certain threshold, an avalanche of signals occurs, indicating the aggregation of numerous microfailures into a macroscopic fracture. Since microfailures appear randomly throughout the bending test, and given the lack of a deterministic law and the random nature of microfailures during the bending test, we opted to develop a stochastic model to account for their occurrence within the irregular and...
Source: Biomechanics and Modeling in Mechanobiology - March 30, 2024 Category: Biomedical Science Authors: D S ánchez-Molina S Garc ía-Vilana Source Type: research

Acoustic emission applied to stochastic modeling of microdamage in compact bone
This study investigates the fracture of human complete ribs subjected to bending and using acoustic emission (AE) for microfailure detection. As the strain increases, the number of AE signals per unit of time rises until, beyond a certain threshold, an avalanche of signals occurs, indicating the aggregation of numerous microfailures into a macroscopic fracture. Since microfailures appear randomly throughout the bending test, and given the lack of a deterministic law and the random nature of microfailures during the bending test, we opted to develop a stochastic model to account for their occurrence within the irregular and...
Source: Biomechanics and Modeling in Mechanobiology - March 30, 2024 Category: Biomedical Science Authors: D S ánchez-Molina S Garc ía-Vilana Source Type: research

Acoustic emission applied to stochastic modeling of microdamage in compact bone
This study investigates the fracture of human complete ribs subjected to bending and using acoustic emission (AE) for microfailure detection. As the strain increases, the number of AE signals per unit of time rises until, beyond a certain threshold, an avalanche of signals occurs, indicating the aggregation of numerous microfailures into a macroscopic fracture. Since microfailures appear randomly throughout the bending test, and given the lack of a deterministic law and the random nature of microfailures during the bending test, we opted to develop a stochastic model to account for their occurrence within the irregular and...
Source: Biomechanics and Modeling in Mechanobiology - March 30, 2024 Category: Biomedical Science Authors: D S ánchez-Molina S Garc ía-Vilana Source Type: research

Acoustic emission applied to stochastic modeling of microdamage in compact bone
This study investigates the fracture of human complete ribs subjected to bending and using acoustic emission (AE) for microfailure detection. As the strain increases, the number of AE signals per unit of time rises until, beyond a certain threshold, an avalanche of signals occurs, indicating the aggregation of numerous microfailures into a macroscopic fracture. Since microfailures appear randomly throughout the bending test, and given the lack of a deterministic law and the random nature of microfailures during the bending test, we opted to develop a stochastic model to account for their occurrence within the irregular and...
Source: Biomechanics and Modeling in Mechanobiology - March 30, 2024 Category: Biomedical Science Authors: D S ánchez-Molina S Garc ía-Vilana Source Type: research