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Effect of cyclosporine on drug transport and pharmacokinetics of nifedipine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nifedipine (NFP) is an anti-hypersensitive drug and a well-known substrate of cytochrome P450 3A4 (CYP3A4), while cyclosporine (CSP) is a potent p-glycoprotein (P-gp) inhibitor. P-gp is a drug transporter, which determines the absorption and bioavailability of many drugs that are substrates for P-gp. Drugs that induce or inhibit P-gp may have a profound effect on the absorption and pharmacokinetics (PK) of drugs transported by P-gp within the body, possibly compromising their bioavailability. But the role of P-gp in the NFP efflux and its impact on PK profile is not known. Hence in our present study we attempted to inv...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 25, 2009 Category: Drugs & Pharmacology Authors: Dorababu M, Nishimura A, Prabha T, Naruhashi K, Sugioka N, Takada K, Shibata N Tags: Biomed Pharmacother Source Type: journals

Biological activities of sulfated polysaccharides from tropical seaweeds.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sulfated polysaccharides from 11 species of tropical marine algae (one edible specie of Rhodophyta, six species of Phaeophyta and four species of Chlorophyta) collected from Natal city coast (Northeast of Brazil) were evaluated for their anticoagulant, antioxidant and antiproliverative in vitro activities. In the activated partial thromboplastin time (APTT) test, which evaluates the intrinsic coagulation pathway, seven seaweeds presented anticoagulant activity. Dictyota cervicornis showed the highest activity, prolonging the coagulation time to double the baseline value in the APTT with only 0.01mg/100mul of plasma, 1....
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 8, 2009 Category: Drugs & Pharmacology Authors: Costa LS, Fidelis GP, Cordeiro SL, Oliveira RM, Sabry DA, Câmara RB, Nobre LT, Costa MS, Almeida-Lima J, Farias EH, Leite EL, Rocha HA Tags: Biomed Pharmacother Source Type: journals

Bone morphometry and differences in bone fluorine containing compounds in rats treated with NaF and MFP.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sodium fluoride (NaF) and sodium monofluorophosphate (MFP) are drugs used to increase bone mass. They have been considered equivalent but the results of the treatments were not always coincident. Most studies have been carried out in osteoporotic women or ovariectomized rats pointing to the result in bone mass rather than at the mechanism of action. Convincing evidence indicates that pharmacokinetic of NaF is different from MFP. While only fluoride is found in bones and plasma of rats treated with NaF, in MFP-treated rats, there are also fluorine (F) bound to plasma alpha-macroglobulin and bone covalently bound F. A si...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 8, 2009 Category: Drugs & Pharmacology Authors: Brun LR, Pera LI, Rigalli A Tags: Biomed Pharmacother Source Type: journals

Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF, TNF-alpha and TGF-beta1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While compelling evidence indicates beneficial effects of statins on inflammatory processes, besides their cholesterol-lowering activities, the actions on angiogenesis are less clear-cut. Our aim was to investigate the effects of atorvastatin on key components of inflammatory angiogenesis in the murine sponge model. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were implanted in Swiss mice. Atorvastatin (0.6, 3mg/kg/day) was given orally for 8 days in drinking water. The implants collected at day 9 postimplantation were processed for the assessement of hemoglobin, myeloperoxidase ...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 8, 2009 Category: Drugs & Pharmacology Authors: Araújo FA, Rocha MA, Mendes JB, Andrade SP Tags: Biomed Pharmacother Source Type: journals

Anticancer activity of fungal taxol derived from Botryodiplodia theobromae Pat., an endophytic fungus, against 7, 12 dimethyl benz(a)anthracene (DMBA)-induced mammary gland carcinogenesis in Sprague dawley rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast cancer is the second most prevalent cancer worldwide and their incidence increases gradually. Taxol (paclitaxel), a potent anticancer drug, is naturally isolated from the bark of the Pacific yew. Taxol is widely used in the treatment of ovarian, lung and breast cancer. The increased demand for taxol, coupled with its limited availability from the protected Pacific yew, has had researchers scrambling for alternate sources. The purpose of the present study is to investigate chemopreventive effect of fungal taxol derived from a novel endophytic fungus Botryodiplodia theobromae Pat., isolated from a medicinal plant ...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 3, 2009 Category: Drugs & Pharmacology Authors: Pandi M, Manikandan R, Muthumary J Tags: Biomed Pharmacother Source Type: journals

Assisting the diagnosis of Graves' hyperthyroidism with Bayesian-type and SOM-type neural networks by making use of a set of three routine tests and their correlation with free T4.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, the amount of female sample data was increased and routine test data (14 parameters) from 120 subjects with a known diagnosis (35 patients with Graves' hyperthyroidism and 85 healthy volunteers) were adopted as training data, before 171 individuals who had also undergone the same routine tests at the Tohoku University Hospital were screened by the network for Graves' hyperthyroidism. The present re-examination of the screening method showed its high screening ability with the set of parameters used (low serum creatinine was added to the established measures of elevated alkaline phosphatase and low total cho...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 3, 2009 Category: Drugs & Pharmacology Authors: Sato W, Hoshi K, Kawakami J, Sato K, Sugawara A, Saito Y, Yoshida K Tags: Biomed Pharmacother Source Type: journals

Advanced glycation endproducts increase EPC apoptosis and decrease nitric oxide release via MAPK pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: AGE can promote EPC apoptosis and decrease NO release via MAPK pathways. PMID: 19766439 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 3, 2009 Category: Drugs & Pharmacology Authors: Shen C, Li Q, Zhang YC, Ma G, Feng Y, Zhu Q, Dai Q, Chen Z, Yao Y, Chen L, Jiang Y, Liu N Tags: Biomed Pharmacother Source Type: journals

Tamoxifen epigenetically modulates CXCL12 expression in MCF-7 breast cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The CXCL12 chemokine binds to the CXCR4 receptor and contributes to survival, proliferation, and migration of malignant cells. Recent reports indicate that breast cancer cells lacking expression of CXCL12 but exhibiting CXCR4 can metastasize to target organs that secrete CXCL12. We observed that Tamoxifen (Tam), similarly to 5-dAzaC, results in significantly increased levels of CXCL12 transcript and protein in MCF-7 breast cancer cells. Bisulfite sequencing suggests that Tam, similarly to 5-dAzaC, may increase CXCL12 expression via reduction in methylation of cytosine in the cytosine-guanosine (CpG) dinucleotide island...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 2, 2009 Category: Drugs & Pharmacology Authors: Pietkiewicz PP, Lutkowska A, Lianeri M, Jagodzinski PP Tags: Biomed Pharmacother Source Type: journals

Effect of citrus pectin on malignant cell proliferation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect of citrus pectin (CP) on the proliferative capacity of four malignant cell lines was examined. Various dose of CP inhibited the proliferation of two-colon carcinoma and an erythroleukemia cell lines. Raji cells were not affected at all. The three lines affected by CP are known to express galectins which are pivotal for cell growth and metastasis, while Raji cells, whose proliferation was not affected by CP, are deficient of this betagalactoside. It is possible that the antiproliferative effect of CP on the malignant cells may be due at least in part to its ability to inhibit galectin expression. PMID: 19...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 2, 2009 Category: Drugs & Pharmacology Authors: Bergman M, Djaldetti M, Salman H, Bessler H Tags: Biomed Pharmacother Source Type: journals

Gene expression of the invasive phenotype of TNF-alpha-treated MCF-7 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: TNF-alpha can enhance the invasive capacity of MCF-7 cells by affecting the expression of a group of genes that have roles in various steps of metastasis. Mechanistic insights into the role of TNF-alpha in tumor cell metastasis are discussed. PMID: 19564093 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - June 13, 2009 Category: Drugs & Pharmacology Authors: Yin Y, Chen X, Shu Y Tags: Biomed Pharmacother Source Type: journals

JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was aimed to identify the signalling pathway of TNF-alpha in VEGF expression regulation in breast cancer cell line MCF7. Using luciferase reporter assays, we demonstrated that TNF-alpha significantly increased activator protein-1 (AP-1) transcriptional activity in the MCF7 cells. The expression of the AP-1 family members c-Jun, c-Fos and JunB and phosphorylation levels of c-Jun were upregulated by TNF-alpha, whereas other AP-1 family members Fra-1, Fra-2, and JunD were unaffected. The activation of AP-1 was associated with the formation of p-c-Jun-c-Jun and p-c-Jun-JunB homodimers. Furthermore, the phosphorylati...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - June 9, 2009 Category: Drugs & Pharmacology Authors: Yin Y, Wang S, Sun Y, Matt Y, Colburn NH, Shu Y, Han X Tags: Biomed Pharmacother Source Type: journals

Role of cilostazol in alleviating cardiovascular complications induced in experimental rats through regulation of type 1 plasminogen activator inhibitor and transforming growth factor-beta(1) overexpression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the effect of cilostazol for alleviating CVC through manipulation of transforming growth factor-beta(1) and type 1 plasminogen activator inhibitor as well as their relation to cAMP was also studied. This was achieved in rats through administration of l-NAME (0.1mg/ml) for two weeks, and then followed by i.p. single dose of streptozotocin (65mg/kg). Rats were classified to three groups; normal rats, control diabetic hypertensive rats and the third group were treated with cilostazol (1.8mg daily, orally) for six weeks. Cilostazol improved serum cAMP level and increased plasma NO concentration leading to d...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - March 12, 2009 Category: Drugs & Pharmacology Authors: Mohamed RH Tags: Biomed Pharmacother Source Type: journals

Inhibition of renin-angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent evidence indicates that renin-angiotensin system (RAS) plays an important role in the pathogenesis of atherosclerosis. It was reported that inhibition of RAS with angiotensin II type 1 receptor blockers (ARBs) or angiotensin converting enzyme inhibitors (ACEIs) is effective in prevention of atherosclerosis. Here, we investigated the effects of an ARB or/and an ACEI on atherosclerosis development and periadventitial inflammation in apolipoprotein E (ApoE)-deficient mice. RT-PCR revealed that major RAS components were expressed in periaortic tissue. Ang II infusion significantly increased accumulation of bone marr...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - March 10, 2009 Category: Drugs & Pharmacology Authors: Fukuda D, Enomoto S, Nagai R, Sata M Tags: Biomed Pharmacother Source Type: journals

WITHDRWAN: Effects of hormone replacement therapy with oral vitamin C and E on plasma thyroid hormone levels in postmenopausal women with Type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. PMID: 19261432 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - March 2, 2009 Category: Drugs & Pharmacology Authors: Naziroğlu M, Simşek M Tags: Biomed Pharmacother Source Type: journals

HCV positivity rate in the seronegative blood donors in China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19246175 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - February 10, 2009 Category: Drugs & Pharmacology Authors: Yang Z, Yu YX, Qiu Y, Han YX, Jiang JD Tags: Biomed Pharmacother Source Type: journals

Association analysis of CD40 gene polymorphism with acute coronary syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our results suggested that the CD40 gene (-1C/T) polymorphism was associated with ACS in Chinese people. The -1C allele gene carriers had a higher expression of CD40 and an increased risk of suffering from ACS. PMID: 19246174 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - February 10, 2009 Category: Drugs & Pharmacology Authors: Yan J, Wang C, Du R, Liu P, Chen G Tags: Biomed Pharmacother Source Type: journals

Effect of serum lipids on the pharmacokinetics of atazanavir in hyperlipidemic rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, although the protein binding rate and AUC were significantly increased, the pharmacokinetics of ATV might be tolerated in HL. PMID: 19246173 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - February 10, 2009 Category: Drugs & Pharmacology Authors: Fukushima K, Shibata M, Mizuhara K, Aoyama H, Uchisako R, Kobuchi S, Sugioka N, Takada K Tags: Biomed Pharmacother Source Type: journals

Proliferation and gene expression of osteoblasts cultured in DMEM containing the ionic products of dicalcium silicate coating.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The medium containing ionic products of dicalcium silicate (Ca(2)SiO(4)) for culturing the osteoblast-like cells (MG63) were prepared by immersing the plasma sprayed Ca(2)SiO(4) coatings in DMEM solution for 24h. The normal DMEM was also used to culture the MG63 cells as the control group. The results obtained from this work showed that the proliferation of MG63 cell was more significant in the group containing ionic products of Ca(2)SiO(4) coatings than in the control group. The cell cycle distribution indicated that the decreased G(0)/G(1) phase and increased S phase occurred in the cells cultured in the DMEM contain...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - February 8, 2009 Category: Drugs & Pharmacology Authors: Sun J, Li J, Liu X, Wei L, Wang G, Meng F Tags: Biomed Pharmacother Source Type: journals

Antidiabetic effect of orally administered conophylline-containing plant extract on streptozotocin-treated and Goto-Kakizaki rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conophylline, a vinca alkaloid from Ervatamia microphylla, is known to induce the differentiation of pancreatic precursor cells to insulin-producing cells. In the present research we examined the antidiabetic effects of this alkaloid in vivo by oral administration. Crude conophylline preparations were prepared from the leaves of Tabernaemontana divaricata collected in Okinawa Prefecture, Japan. Conophylline was orally absorbed and showed an increase in its plasma level in both normal and streptozotocin-induced diabetic Sprague-Dawley rats. The plasma conophylline concentration reached its maximum from 1.5 to 3h after a...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - February 4, 2009 Category: Drugs & Pharmacology Authors: Fujii M, Takei I, Umezawa K Tags: Biomed Pharmacother Source Type: journals

Gene expression, cytoskeletal changes and extracellular matrix synthesis in human osteoblasts treated with cyclosporin A.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyclosporin A (CyA) is an immunosuppressive agent used to prevent allograft rejection, but unfortunately it causes adverse effects such as bone diseases, osteoporosis and osteomalacia. These pathologies involve an imbalance between synthesis, degradation and mineralization of extracellular matrix. CyA can modify extracellular matrix components such as glycosaminoglycans (GAG) and collagen fibers. In addition, normal cell activity is dependent on cell morphology and substrate cell attachment. We treated normal human osteoblasts with CyA and analyzed: (i) gene expression by a microarray method; (ii) extracellular GAG and...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - December 27, 2008 Category: Drugs & Pharmacology Authors: Vertemati M, Minola E, Dolci C, Stabellini G, Pezzetti F, Moscheni C, Calastrini C, Bramerio M, Palmieri A, Vizzotto L Tags: Biomed Pharmacother Source Type: journals

Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to investigate the effects of cyclosporine A (CsA) on a multidrug resistance cultured cell line, and its effect on complete remission in patients with acute myeloid leukemia (AML). A multidrug resistant K562/ADM cell line and drug-sensitive K562 cell line was used. The intracellular concentration of daunorubicin and the accumulation of Rhodamine 123 (Rh123) in the K562/ADM and K562 cells were evaluated. Clinical effects of CsA were also studied in 65 patients with AML. In the K562/ADM cells, the 50% of inhibition concentration (IC50) of daunorubicin only group was 23.0+/-5.2mumol/L, which was greate...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - December 6, 2008 Category: Drugs & Pharmacology Authors: Li GY, Liu JZ, Zhang B, Wang LX, Wang CB, Chen SG Tags: Biomed Pharmacother Source Type: journals

Down-regulation of CXCR4 expression by tamoxifen is associated with DNA methyltransferase 3B up-regulation in MCF-7 breast cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The CXCR4 chemokine receptor is a seven transmembrane G protein-coupled receptor present on the surface of various cells including cancer cells. The CXCR4 receptor contributes to the induction of several intracellular signalling pathways that enhance survival, proliferation, and migration of malignant cells. We observed that tamoxifen (Tam) reduced the CXCR4 transcript and protein levels in MCF-7 breast cancer cells. However, we did not see a Tam effect on CXCR4 transcript and protein levels in MCF-7(LVMT3B) cells with RNA interference-mediated knockdown of DNMT3B. We also observed that Tam significantly increased, for...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - November 6, 2008 Category: Drugs & Pharmacology Authors: Kubarek L, Kozłowska A, Przybylski M, Lianeri M, Jagodzinski PP Tags: Biomed Pharmacother Source Type: journals

Effect of carvedilol on pulse pressure and left ventricular hypertrophy in spontaneously hypertensive rats with adriamycin nephropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, carvedilol alone, but more strongly in combination with captopril, significantly reduced blood pressure, PP, LVH, renal blood vessel changes and chronic renal failure progression. PMID: 19013753 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 31, 2008 Category: Drugs & Pharmacology Authors: Jovanovic D, Jovovic D, Mihailovic-Stanojevic N, Miloradovic Z, Naumovic R, Dimitrijevic J, Maksic N, Djukanovic L Tags: Biomed Pharmacother Source Type: journals

Anti-Trichomonas vaginalis activity of synthetic lipophilic diamine and amino alcohol derivatives.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report in this work the preparation and the in vitro anti-trichomonads activity of two diamines 1 and 2, and three different lipophilic amino alcohol derivatives 3, 4 and 5. These compounds were tested for in vitro activity against two isolates of Trichomonas vaginalis and displayed inhibition of the parasite growth. Five concentrations of each compound were tested. The butanediamine derivative 1, at a final concentration of 5.85muM, presented a cytotoxic effect against 47% of T. vaginalis trophozoites. Furthermore, the cytotoxicity of 1 did not present statistically significant difference when compared to metronidazole...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 31, 2008 Category: Drugs & Pharmacology Authors: Giordani RB, De Almeida MV, Fernandes E, França da Costa C, De Carli GA, Tasca T, Zuanazzi JA Tags: Biomed Pharmacother Source Type: journals

Screening of potential prodrugs on cells derived from Dupuytren's disease patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dupuytren's disease (DD) is a fibroproliferative disorder, the cure for which is still limited to surgical excision of the affected fascia, often leading to high recurrence rates. Due to this fact, non-surgical treatments are being investigated, among them those targeting molecular processes of proliferation and differentiation in Dupuytren's cell cultures. Drugs with antiproliferative action may be valuable in DD treatment. Through characterization of changes on DD-specific cells, we, therefore, decided to test the therapeutic potential of new cytostatic drugs for DD treatment and/or for reduction of post-operative re...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 31, 2008 Category: Drugs & Pharmacology Authors: Kraljevic Pavelic S, Bratulic S, Hock K, Jurisic D, Hranjec M, Karminski-Zamola G, Zinic B, Bujak M, Pavelic K Tags: Biomed Pharmacother Source Type: journals

A clinical study on the premedication of paclitaxel liposome in the treatment of solid tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our recommendations for the premedication of Lipusu in the treatment of solid tumors are: (1) methylprednisolone 40mg, administered intravenously 30min before Lipusu, and granisetron 30min before chemotherapy, (2) dexamethasone 2.25-3mg taken orally 12h and 2h before Lipusu, and granisetron 30min before chemotherapy. PMID: 19019625 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 31, 2008 Category: Drugs & Pharmacology Authors: Zhang Q, Huang XE, Gao LL Tags: Biomed Pharmacother Source Type: journals

Comparison of collagen versus adenosine diphosphate in detecting antiplatelet effect in patients with coronary artery disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, collagen may prove useful to study the effect of aspirin and ADP may be appropriate for assessing the inhibitory effect of clopidogrel. PMID: 19019624 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 31, 2008 Category: Drugs & Pharmacology Authors: Li J, Jian Z, Huang L, Guo H, Huang J, Qian D, Fu W, Li A, Song Y Tags: Biomed Pharmacother Source Type: journals

CD137 enhances cytotoxicity of CD3(+)CD56(+) cells and their capacities to induce CD4(+) Th1 responses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CD137 (4-1BB) is a TNFR superfamily member that mediates the costimulatory signal resulting in T cells and NK cells proliferation and cytokines production, but the effects of CD137 signaling on CD3(+)CD56(+) cell subpopulation have not been well-documented. The aim of this study was to investigate the effects of CD137 signaling on regulation of CD3(+)CD56(+) cell function. Anti-CD137 mAb or mouse IgG1 isotype control was added to CIK cell culture to determine the effects of proliferation and anti-tumor effects on CD3(+)CD56(+) cells. We observed that anti-CD137 mAb could dramatically promote proliferation of CIK cells....
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 31, 2008 Category: Drugs & Pharmacology Authors: Zhu BQ, Song-Wen J, Yong-Qian S Tags: Biomed Pharmacother Source Type: journals

Heparinoids algal and their anticoagulant, hemorrhagic activities and platelet aggregation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the activity of anticoagulant in activated partial thromboplastin time (APTT) and prothrombin time (PT) tests was assessed in the fucoidan (TF), from seaweed Fucus vesiculosus, partially desulfated fucoidans (PDF), desulfated fucoidans (DF) and purified fractions F1, F2 and F3 in acetone. Studies were also conducted to assess these polysaccharides for platelet aggregation and hemorrhagic activity. The APTT test showed high activity at 5mug (>/=240s) for TF, F1 and F2 (P<0.001). PT test showed high anticoagulant activity at 50mug (>/=120s) for F1 (P<0.001). Fraction F3, with low MW (15.2kDa) and s...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 26, 2008 Category: Drugs & Pharmacology Authors: Carvalho G de Azevedo T, Bezerra ME, Santos MD, Souza LA, Marques CT, Benevides NM, Leite EL Tags: Biomed Pharmacother Source Type: journals

Does estrogen receptor gene polymorphism play a role in Parkinson's disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we found no significant differences in the genotype or allele frequencies between patients with Parkinson's disease and healthy subjects. These findings suggest that the estrogen receptor gene polymorphism may not play a key role in the pathogenesis PD in Chinese patients. PMID: 18980828 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: Li XL, Cheng WD, Li J, Zheng YF, Guo CJ, Sun SG, Wang LX Tags: Biomed Pharmacother Source Type: journals

Interleukin 1 receptor antagonist inhibits normal hematopoiesis and reduces lethality and bone marrow toxicity of 5-fluouracil in mouse.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
5-Fluouracil (5-Fu) targeting of cycling hematopoietic cells results in bone marrow (BM) suppression. Interleukin 1 receptor antagonist (IL-1Ra) is a cytokine that competitively blocks the binding of interleukin 1 (IL-1) to its receptor. Unlike the supporting role of IL-1 less is known for the role of IL-1Ra in hematopoiesis. Here, we demonstrate that IL-1Ra expression in BM cells and in circulation was elevated temporarily during 5-Fu-induced myelosuppression. Exogenous IL-1Ra administered to normal mice reversibly inhibited cycling status of BM cells, and reduced the numbers of BM cells including colony-forming proge...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: Zhang J, Xiang D, Zhu S, Mao W, Lu H, Wu M, Wang Q, Yu Y, Herbst KD, Han W Tags: Biomed Pharmacother Source Type: journals

Inhibition of MAP kinases and down regulation of TNF-alpha, IL-beta and COX-2 genes by the crude extracts from marine bacteria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Crude ethyl acetate extracts from marine bacterial isolates Staphylococcus arlettae KP2 (GenBank accession No. EU594442) and Planococcus maritimus KP8 (GenBank accession No. EU594443) isolated from Andaman seas were studied for their anti-inflammatory effect by lymphocyte proliferation assay (LPA) employing peripheral blood mononuclear cells (PBMCs). The crude extracts from both the bacteria down regulated the synthesis of inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and cyclooxygenase-2 (COX-2), besides markedly inhibiting p38 mitogen activated protein (MAP) kina...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: Krishnaveni M, Jayachandran S Tags: Biomed Pharmacother Source Type: journals

The property of methylated APC gene promotor and its influence on lung cancer cell line.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous findings have suggested that methylation of the APC gene may be associated with some tumors including lung cancer. To explore the pattern of APC methylation and the effect of APC gene methylation on its protein expression in lung cancer cell lines, we investigated APC promotor methylation by methylation specific PCR (MSP) and bisulfite sequencing and analyzed the APC protein levels by western blot in three lung cancer cell lines. Monoallelic methylation and 20 methylated CpGs in CpG island near the open reading frame (ORF) of the APC gene were found in the NCI-H460 cell line, and were stablely inherited within...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: Pan S, Zhang L, Gao L, Gu B, Wang F, Xu J, Shu Y, Yang D, Chen Z Tags: Biomed Pharmacother Source Type: journals

The metabolic syndrome, an epidemic among HIV-infected patients on HAART.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: MS seems an inevitable consequence of long-term successful HAART. PMID: 18996676 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: Jevtović D, Dragović G, Salemović D, Ranin J, Djurković-Djaković O Tags: Biomed Pharmacother Source Type: journals

Cerebrolysin and morphine decrease glutathione and 5-hydroxyindole acetic acid levels in fasted rat brain.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Results suggest that cerebrolysin as well as morphine induced changes in cellular regulation and biochemical responses to oxidative stress induced by moderate hypoglycaemia in brain. PMID: 18993027 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: Calderón Guzmán D, Osnaya Brizuela N, García Álvarez R, Hernández García E, Barragán Mejía G, Juárez Olguín H Tags: Biomed Pharmacother Source Type: journals

Tamoxifen inhibits proliferation and induces apoptosis in human hepatocellular carcinoma cell line HepG2 via down-regulation of survivin expression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the tamoxifen decreasing cell proliferation and induction of apoptosis of HepG2 cells depends on drug concentration, which is due to cytostatic and cytocide effects, the latter may be mediated by a down-regulation of survivin expression. PMID: 18993026 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: Guo R, Huang Z, Shu Y, Jin S, Ge H Tags: Biomed Pharmacother Source Type: journals

Racemic Etodolac is cytotoxic and cytostatic for B-cell precursor acute lymphoblastic leukemia cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several epidemiological studies have provided evidence that administration of nonsteroidal anti-inflammatory drugs (NSAIDs) could have a prophylactic effect against some cancers such as sporadic colorectal cancer and leukemia. Indeed, various NSAIDs have been shown to induce apoptosis in malignant cells. We evaluated the effect of racemic Etodolac on proliferation and cell survival in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells. Etodolac decreased survival of Nalm-16 and Nalm-6 BCP-ALL cell lines and also decreased cell proliferation in Nalm-16 cell line. Ours findings indicate, for the first time to ...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: de Souza Thiago L, Sobral da Costa E, Lopes DV, Borojevic R Tags: Biomed Pharmacother Source Type: journals

Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Phospholipase C gamma-1 (PLCgamma1) phosphorylation is a key step in intracellular signal transduction in T cells. We used Hut-78 T lymphoma cells to demonstrate the effect of apicidin on cellular levels of the PLCgamma1 molecule. Using reverse-transcription, real-time quantitative PCR and Western blot analysis, we observed that apicidin reduced the PLCgamma1 transcript and protein contents in Hut-78 T lymphoma cells. Our results indicate that protein synthesis appears to be crucial in the apicidin decrease of PLCgamma1 mRNA steadiness. Moreover, we determined that apicidin reduces the half-life of PLCgamma1 mRNAs from...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 23, 2008 Category: Drugs & Pharmacology Authors: Dębicki S, Jagodzinski PP Tags: Biomed Pharmacother Source Type: journals

Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the direct effect of PSK on B cells and discovered that PSK was able to enhance IgM production in the human B cell line BALL-1. Furthermore, BALL-1 was shown to have the characteristic features of B-1a cells, which are independently involved in the primary immune response. These results show that there is a possibility that PSK directly acts on B cells and simultaneously enhances both humoral immunity and cellular immunity. PMID: 18848763 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 9, 2008 Category: Drugs & Pharmacology Authors: Maruyama S, Taiki Akasaka , Yamada K, Tachibana H Tags: Biomed Pharmacother Source Type: journals

NK cell-mediated lysis is essential to kill Epstein-Barr virus transformed lymphoblastoid B cells when using rituximab.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rituximab is a humanized chimeric monoclonal antibody, targeted against the pan B cell marker CD20. It is frequently used to treat a variety of B cell lymphomas and immunosuppression associated lymphoproliferations such as posttransplant lymphoproliferative disorder (PTLD). The response rate of rituximab treatment is 65%, but the exact in vivo mechanism of action is not yet fully understood, although antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and direct induction of apoptosis have been suggested as effector mechanism. Rituximab may affect different types of lymphomas ...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 30, 2008 Category: Drugs & Pharmacology Authors: Markasz L, Vanherberghen B, Flaberg E, Otvös R, Stuber G, Gustafsson Jernberg A, Olah E, Skribek H, Szekely L Tags: Biomed Pharmacother Source Type: journals

Decreased immune response in alexithymic women: A cross-sectional study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study further demonstrates that alexithymic women have altered immune function, with a predominance of depressed cell-mediated immunity and a skewed Th1/Th2 ratio towards Th2 response. PMID: 18824323 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 26, 2008 Category: Drugs & Pharmacology Authors: Guilbaud O, Curt F, Perrin C, Chaouat G, Berthoz S, Dugré-Le Bigre C, Wallier J, Strebler M, Touitou C, Jeammet P, Corcos M Tags: Biomed Pharmacother Source Type: journals

Vascular endothelial dysfunction: A tug of war in diabetic nephropathy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vascular endothelium regulates vascular tone and maintains free flow of blood in vessels. Vascular endothelial dysfunction (VED) results in reduced activation of endothelial nitric oxide synthase (eNOS), reduced generation and bioavailability of nitric oxide (NO) and increased production of reactive oxygen species (ROS). The eNOS uncoupling in VED leads to eNOS mediated production of ROS that further damage the endothelial cells by upregulating the proinflammatory mediators and adhesion molecules. VED has been associated in the pathogenesis of hypertension, atherosclerosis, coronary artery diseases, diabetes mellitus a...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 25, 2008 Category: Drugs & Pharmacology Authors: Balakumar P, Chakkarwar VA, Krishan P, Singh M Tags: Biomed Pharmacother Source Type: journals

Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the dose-limiting toxicities of cisplatin is nephrotoxicity. Renal toxicity is localized to quiescent proximal tubule cells, where the formation of DNA-adducts cannot account for the dose-limiting toxicity. Our earlier results have shown that a glutathione conjugate of cisplatin is metabolized to a nephrotoxicant via gamma-glutamyl transpeptidase (GGT) and a cysteine S-conjugate beta-lyase. The present study was designed to evaluate the potential role of glutathione S-transferase Pi (GSTP) in the initial steps of the bioactivation of cisplatin. Wild-type mice and mice deficient in both murine GSTP genes (GstP1/P...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 7, 2008 Category: Drugs & Pharmacology Authors: Townsend DM, Tew KD, He L, King JB, Hanigan MH Tags: Biomed Pharmacother Source Type: journals

Development of an antisense RNA delivery system using conjugates of the MS2 bacteriophage capsids and HIV-1 TAT cell penetrating peptide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we utilized the heterobifunctional crosslinker, sulfosuccinimidyl-4-(p-maleimidophenyl)-butyrate (sulfo-SMPB), to conjugate the human immunodeficiency virus-1 (HIV-1) Tat peptide and MS2 VLPs; the antisense RNA against the 5'-untranslated region (UTR) and the internal ribosome entry site (IRES) of the hepatitis C virus (HCV) was packaged into these particles by using a two-plasmid coexpression system. The MS2 VLPs conjugated with the Tat peptide were then transferred into Huh-7 cells containing an HCV reporter system. The packaged antisense RNA showed an inhibitory effect on the translation of HCV. This pape...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 7, 2008 Category: Drugs & Pharmacology Authors: Wei B, Wei Y, Zhang K, Wang J, Xu R, Zhan S, Lin G, Wang W, Liu M, Wang L, Zhang R, Li J Tags: Biomed Pharmacother Source Type: journals

Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the effects of berberine on the SDF-1-induced HL-60 cells, primary acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs) migration. Transwell migration chambers (8mum) were used to assess the role of berberine on leukemic cell migration; Flow cytometry was used to analyze the role of berberine on the CXCR4 expression; SDF-1 protein level secreted by bone marrow stromal cells (BMSCs) was evaluated by ELISA. Results demonstrated that berberine could partly inhibit SDF-1-induced AML cells as well as LSCs migration. Berberine could reduce SDF-1 protein level secreted by BMSCs in the m...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - September 4, 2008 Category: Drugs & Pharmacology Authors: Li H, Guo L, Jie S, Liu W, Zhu J, Du W, Fan L, Wang X, Fu B, Huang S Tags: Biomed Pharmacother Source Type: journals

Paeoniflorin suppress NF-kappaB activation through modulation of IkappaBalpha and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Paeoniflorin can inhibit NF-kappaB activity of SGC-7901 cells, and enhance 5-fluorouracil-induced apoptosis of gastric carcinoma cells. PMID: 18809274 [PubMed - as supplied by publisher]
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - August 31, 2008 Category: Drugs & Pharmacology Authors: Wu H, Li W, Wang T, Shu Y, Liu P Tags: Biomed Pharmacother Source Type: journals

Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the effects of platycodon D on the production of reactive oxygen species (ROS) and evaluated the association of these effects with apoptotic tumor cell death using a human leukemic U937 cell line. The results of this study demonstrate that platycodon D mediates ROS production, and that this mediation is followed by a decrease in mitochondrial membrane potential (MMP, DeltaPsi(m)), activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase (PARP). Both the cytotoxic effects and apoptotic characteristics induced by platycodon D treatment were significantly inhibited by z-DEVD-fmk, a casp...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - August 30, 2008 Category: Drugs & Pharmacology Authors: Shin DY, Kim GY, Li W, Choi BT, Kim ND, Kang HS, Choi YH Tags: Biomed Pharmacother Source Type: journals

A new model of pharmacovigilance? A pilot study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This multicenter study tested the actuation of a new model of pharmacovigilance, focused on three pharmacological wide-used categories (non-steroidal anti-inflammatory drugs, NSAID, oral anticoagulants, and antihypertensive drugs). Besides the traditional way of pharmacovigilance, an active investigation was performed, using a phone-structured interview. Patients discharged from the participating hospitals were included into the study, if their prescribed therapy included some of the above drugs and after informed consent. Three hundred subjects were interviewed, 100 for each pharmacological category. For a period of s...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - August 28, 2008 Category: Drugs & Pharmacology Authors: Zancan A, Locatelli C, Ramella F, Tatoni P, Bacis G, Vecchio S, Manzo L Tags: Biomed Pharmacother Source Type: journals

Right ventricular beneficial effects of beta adrenergic receptor kinase inhibitor (betaARKct) gene transfer in a rat model of severe pressure overload.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heart failure is associated with abnormalities in betaAR cascade regulation, calcium cycling, expression of inflammatory mediators and apoptosis. Adenoviral mediated gene transfer of betaARKct has beneficial indirect effects on these pathologic processes upon the left ventricular myocardium. The concomitant biochemical changes that occur in the right ventricle have not been well characterized. Sprague-Dawley rats underwent aortic banding and were followed by echocardiography. After a decrease in fractional shortening of 25% from baseline, intracoronary injection of adenoviral-betaARKct (n=14) or adenoviral-beta-galacto...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - August 28, 2008 Category: Drugs & Pharmacology Authors: Molina EJ, Gupta D, Palma J, Gaughan JP, Macha M Tags: Biomed Pharmacother Source Type: journals

Reversal effect of resveratrol on multidrug resistance in KBv200 cell line.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A multidrug-resistant clone of human oral epidermoid carcinoma KB cells was isolated by stepwise selection on exposure to increasing doses of vincristine. The final clone, KBv200, obtained after ethylmethane sulfonate mutagenesis showed 156-fold higher resistance to vincristine than KB cells. The cells were also cross-resistant to paclitaxel and adriamycin. The aim of this study was to explore the reversal effect and potential mechanism of resveratrol on KBv200 cells. MTT assay was used to investigate the reversal index of resveratrol to vincristine, adriamycin and paclitaxel. Cell apoptosis was measured by flow cytome...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - August 28, 2008 Category: Drugs & Pharmacology Authors: Quan F, Pan C, Ma Q, Zhang S, Yan L Tags: Biomed Pharmacother Source Type: journals

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