Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Associations among environmental exposure to trace elements and biomarkers of early kidney damage in the pediatric population
Conclusions. Among the explored metals, exposure to Cu and iodine impairs renal function. In contrast, Se may manifest as a beneficial metal. Interactions of Mo-Se and Mo-Iodine seem to alter the expression of NGAL; Mo-Cu for CLU; Mo-Cu, Mo-Se, and Mo-iodine for Cys-C and a-1MG; and Mo-Cu and Mo-iodine for KIM-1; were noticed. Our study could suggest that trace element interactions were associated with early kidney damage biomarkers.PMID:38642266 | DOI:10.1007/s10534-024-00603-3 (Source: Biometals)
Source: Biometals - April 20, 2024 Category: Biochemistry Authors: Manolo Ortega-Romero Elodia Rojas-Lima Juan Carlos Rubio-Guti érrez Octavio Gamaliel Aztatzi-Aguilar Juana Narv áez-Morales Mariela Esparza-Garc ía Ángel Barrera-Hernández Miguel Ángel Mejia Pablo Mendez-Hern ández Mara Medeiros Olivier Christophe Source Type: research
Cadmium toxicity promotes hormonal imbalance and induces the expression of genes involved in systemic resistances in barley
Biometals. 2024 Apr 14. doi: 10.1007/s10534-024-00597-y. Online ahead of print.ABSTRACTCadmium (Cd) is a widely distributed pollutant that adversely affects plants' metabolism and productivity. Phytohormones play a vital role in the acclimation of plants to metal stress. On the other hand, phytohormones trigger systemic resistances, including systemic acquired resistance (SAR) and induced systemic resistance (ISR), in plants in response to biotic interactions. The present study aimed to investigate the possible induction of SAR and ISR pathways in relation to the hormonal alteration of barley seedlings in response to Cd st...
Source: Biometals - April 13, 2024 Category: Biochemistry Authors: Fatemeh Alzahra Neyshabouri Ali Akbar Ghotbi-Ravandi Zeinab Shariatmadari Masoud Tohidfar Source Type: research
Cadmium toxicity promotes hormonal imbalance and induces the expression of genes involved in systemic resistances in barley
Biometals. 2024 Apr 14. doi: 10.1007/s10534-024-00597-y. Online ahead of print.ABSTRACTCadmium (Cd) is a widely distributed pollutant that adversely affects plants' metabolism and productivity. Phytohormones play a vital role in the acclimation of plants to metal stress. On the other hand, phytohormones trigger systemic resistances, including systemic acquired resistance (SAR) and induced systemic resistance (ISR), in plants in response to biotic interactions. The present study aimed to investigate the possible induction of SAR and ISR pathways in relation to the hormonal alteration of barley seedlings in response to Cd st...
Source: Biometals - April 13, 2024 Category: Biochemistry Authors: Fatemeh Alzahra Neyshabouri Ali Akbar Ghotbi-Ravandi Zeinab Shariatmadari Masoud Tohidfar Source Type: research
Cadmium toxicity promotes hormonal imbalance and induces the expression of genes involved in systemic resistances in barley
Biometals. 2024 Apr 14. doi: 10.1007/s10534-024-00597-y. Online ahead of print.ABSTRACTCadmium (Cd) is a widely distributed pollutant that adversely affects plants' metabolism and productivity. Phytohormones play a vital role in the acclimation of plants to metal stress. On the other hand, phytohormones trigger systemic resistances, including systemic acquired resistance (SAR) and induced systemic resistance (ISR), in plants in response to biotic interactions. The present study aimed to investigate the possible induction of SAR and ISR pathways in relation to the hormonal alteration of barley seedlings in response to Cd st...
Source: Biometals - April 13, 2024 Category: Biochemistry Authors: Fatemeh Alzahra Neyshabouri Ali Akbar Ghotbi-Ravandi Zeinab Shariatmadari Masoud Tohidfar Source Type: research
Cadmium toxicity promotes hormonal imbalance and induces the expression of genes involved in systemic resistances in barley
Biometals. 2024 Apr 14. doi: 10.1007/s10534-024-00597-y. Online ahead of print.ABSTRACTCadmium (Cd) is a widely distributed pollutant that adversely affects plants' metabolism and productivity. Phytohormones play a vital role in the acclimation of plants to metal stress. On the other hand, phytohormones trigger systemic resistances, including systemic acquired resistance (SAR) and induced systemic resistance (ISR), in plants in response to biotic interactions. The present study aimed to investigate the possible induction of SAR and ISR pathways in relation to the hormonal alteration of barley seedlings in response to Cd st...
Source: Biometals - April 13, 2024 Category: Biochemistry Authors: Fatemeh Alzahra Neyshabouri Ali Akbar Ghotbi-Ravandi Zeinab Shariatmadari Masoud Tohidfar Source Type: research
Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex
Biometals. 2024 Apr 9. doi: 10.1007/s10534-024-00598-x. Online ahead of print.ABSTRACTSchiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with a plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of the MTT a...
Source: Biometals - April 9, 2024 Category: Biochemistry Authors: Samira Jahangiry Maryam Lashanizadegan Pouneh Sadat Pourhosseini Mansoureh Zahedi-Tabrizi Source Type: research
Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex
Biometals. 2024 Apr 9. doi: 10.1007/s10534-024-00598-x. Online ahead of print.ABSTRACTSchiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with a plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of the MTT a...
Source: Biometals - April 9, 2024 Category: Biochemistry Authors: Samira Jahangiry Maryam Lashanizadegan Pouneh Sadat Pourhosseini Mansoureh Zahedi-Tabrizi Source Type: research
Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex
Biometals. 2024 Apr 9. doi: 10.1007/s10534-024-00598-x. Online ahead of print.ABSTRACTSchiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with a plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of the MTT a...
Source: Biometals - April 9, 2024 Category: Biochemistry Authors: Samira Jahangiry Maryam Lashanizadegan Pouneh Sadat Pourhosseini Mansoureh Zahedi-Tabrizi Source Type: research
Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex
Biometals. 2024 Apr 9. doi: 10.1007/s10534-024-00598-x. Online ahead of print.ABSTRACTSchiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with a plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of the MTT a...
Source: Biometals - April 9, 2024 Category: Biochemistry Authors: Samira Jahangiry Maryam Lashanizadegan Pouneh Sadat Pourhosseini Mansoureh Zahedi-Tabrizi Source Type: research
Coordination chemistry suggests that independently observed benefits of metformin and Zn < sup > 2+ < /sup > against COVID-19 are not independent
Biometals. 2024 Apr 5. doi: 10.1007/s10534-024-00590-5. Online ahead of print.ABSTRACTIndependent trials indicate that either oral Zn2+ or metformin can separately improve COVID-19 outcomes by approximately 40%. Coordination chemistry predicts a mechanistic relationship and therapeutic synergy. Zn2+ deficit is a known risk factor for both COVID-19 and non-infectious inflammation. Most dietary Zn2+ is not absorbed. Metformin is a naked ligand that presumably increases intestinal Zn2+ bioavailability and active absorption by cation transporters known to transport metformin. Intracellular Zn2+ provides a natural buffer of man...
Source: Biometals - April 5, 2024 Category: Biochemistry Authors: Thomas D Lockwood Source Type: research
Coordination chemistry suggests that independently observed benefits of metformin and Zn < sup > 2+ < /sup > against COVID-19 are not independent
Biometals. 2024 Apr 5. doi: 10.1007/s10534-024-00590-5. Online ahead of print.ABSTRACTIndependent trials indicate that either oral Zn2+ or metformin can separately improve COVID-19 outcomes by approximately 40%. Coordination chemistry predicts a mechanistic relationship and therapeutic synergy. Zn2+ deficit is a known risk factor for both COVID-19 and non-infectious inflammation. Most dietary Zn2+ is not absorbed. Metformin is a naked ligand that presumably increases intestinal Zn2+ bioavailability and active absorption by cation transporters known to transport metformin. Intracellular Zn2+ provides a natural buffer of man...
Source: Biometals - April 5, 2024 Category: Biochemistry Authors: Thomas D Lockwood Source Type: research
Coordination chemistry suggests that independently observed benefits of metformin and Zn < sup > 2+ < /sup > against COVID-19 are not independent
Biometals. 2024 Apr 5. doi: 10.1007/s10534-024-00590-5. Online ahead of print.ABSTRACTIndependent trials indicate that either oral Zn2+ or metformin can separately improve COVID-19 outcomes by approximately 40%. Coordination chemistry predicts a mechanistic relationship and therapeutic synergy. Zn2+ deficit is a known risk factor for both COVID-19 and non-infectious inflammation. Most dietary Zn2+ is not absorbed. Metformin is a naked ligand that presumably increases intestinal Zn2+ bioavailability and active absorption by cation transporters known to transport metformin. Intracellular Zn2+ provides a natural buffer of man...
Source: Biometals - April 5, 2024 Category: Biochemistry Authors: Thomas D Lockwood Source Type: research
Coordination chemistry suggests that independently observed benefits of metformin and Zn < sup > 2+ < /sup > against COVID-19 are not independent
Biometals. 2024 Apr 5. doi: 10.1007/s10534-024-00590-5. Online ahead of print.ABSTRACTIndependent trials indicate that either oral Zn2+ or metformin can separately improve COVID-19 outcomes by approximately 40%. Coordination chemistry predicts a mechanistic relationship and therapeutic synergy. Zn2+ deficit is a known risk factor for both COVID-19 and non-infectious inflammation. Most dietary Zn2+ is not absorbed. Metformin is a naked ligand that presumably increases intestinal Zn2+ bioavailability and active absorption by cation transporters known to transport metformin. Intracellular Zn2+ provides a natural buffer of man...
Source: Biometals - April 5, 2024 Category: Biochemistry Authors: Thomas D Lockwood Source Type: research
