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Assessment of OATP transporter ‐mediated drug–drug interaction using physiologically‐based pharmacokinetic (PBPK) modeling – a case example
AbstractGDC ‐0810 was under development as an oral anti‐cancer drug for the treatment of estrogen receptor‐positive breast cancer as a single agent or in combination.In vitro data indicated that GDC ‐0810 is a potent inhibitor of OATP1B1/1B3. To assess clinical risk, a PBPK model was developed to predict the transporter drug–drug interaction (tDDI) between GDC‐0810 and pravastatin in human. The PBPK model was constructed in Simcyp® by integratingin vitro andin vivo data for GDC ‐0810. The prediction of human pharmacokinetics (PK) was verified using GDC‐0810 phase I clinical PK data. The Simcyp transporter ...
Source: Biopharmaceutics and Drug Disposition - November 20, 2018 Category: Drugs & Pharmacology Authors: Yuan Chen, Rui Zhu, Fang Ma, Jialin Mao, Eugene C. Chen, Edna F. Choo, Srikumar Sahasranaman, Lichuan Liu Tags: ORIGINAL PAPER Source Type: research

Effect of renal ischemia on urinary excretion of lithium in rats
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - November 5, 2018 Category: Drugs & Pharmacology Authors: Yuichi Uwai, Takato Suzuki, Ryota Kondo, Tatsuya Kawasaki, Tomohiro Nabekura Source Type: research

Effects of Generally Recognized as Safe (GRAS) and Dietary Compounds on Phenylephrine Metabolism in LS180 Human Intestinal Cells
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - October 28, 2018 Category: Drugs & Pharmacology Authors: Zhenxian Zhang, Phillip M. Gerk Source Type: research

The Impact of Low Temperature on Fraction Unbound for Plasma and Tissue
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - October 26, 2018 Category: Drugs & Pharmacology Authors: Sangwoo Ryu, Jonathan Novak, Roshan Patel, Phillip Yates, Li Di Source Type: research

CYP2J2 is the major enzyme in human liver microsomes responsible for hydroxylation of SYL ‐927, a novel and selective sphingosine 1‐phosphate receptor 1 (S1P1) agonist
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - October 26, 2018 Category: Drugs & Pharmacology Authors: Shu Yang, Jinping Hu, Yan Li, Zhigang Zhao Source Type: research

Assessment of OATP Transporter ‐Mediated Drug‐Drug Interaction using Physiologically‐Based Pharmacokinetic (PBPK) Modeling – A Case Example
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - October 18, 2018 Category: Drugs & Pharmacology Authors: Yuan Chen, Rui Zhu, Fang Ma, Jialin Mao, Eugene C. Chen, Edna Choo, Srikumar Sahasranaman, Lichuan Liu Source Type: research

Co ‐administration of Nuciferine reduces the concentration of metformin in liver via differential inhibition of hepatic drug transporter OCT1 and MATE1
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - October 8, 2018 Category: Drugs & Pharmacology Authors: Liping Li, Hongmei Lei, Wei Wang, Weijuan Du, Jingqun Yuan, Meijuan Tu, Hui Zhou, Su Zeng, Huidi Jiang Source Type: research

Issue Information
Biopharmaceutics&Drug Disposition,Volume 39, Issue 8, Page 369-370, September 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - September 27, 2018 Category: Drugs & Pharmacology Source Type: research

The role of organic anion ‐transporting polypeptides and formulation in the clearance and distribution of a novel Nav1.7 channel blocker
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - September 3, 2018 Category: Drugs & Pharmacology Authors: AndyPike , Neil J.Flanagan , R. IanStorer , Nigel A.Swain , ElaineTseng Source Type: research

CYP3A but not P ‐gp plays a relevant role in the in vivo intestinal and hepatic clearance of the delta‐specific phosphoinositide‐3 kinase inhibitor leniolisib
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - September 1, 2018 Category: Drugs & Pharmacology Authors: StefanDe Buck , KlausKucher , HisanoriHara , CathyGray , RalphWoessner Source Type: research

Issue Information
Biopharmaceutics&Drug Disposition,Volume 39, Issue 7, Page 319-320, July 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - August 24, 2018 Category: Drugs & Pharmacology Source Type: research

Quantification of in vivo gastric fluid volume in Bama miniature pigs in fasted state
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - August 18, 2018 Category: Drugs & Pharmacology Authors: HuiGuo , CuncaiWang , ZhenLiu , HuayongGu , YuwenLi , LiZhao , RanranHou , JiajiaZhu , HarveyHo , ZhihuiHao Source Type: research

Evaluation of renal excretion and pharmacokinetics of furosemide in rats after acute exposure to high altitude at 4300m
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - August 18, 2018 Category: Drugs & Pharmacology Authors: BingfengLuo , JingLi , TaoYang , WenbinLi , JuanhongZhang , ChangWang , AnpengZhao , RongWang Source Type: research

Metabolism of steroids by cytochrome P450 2C9 variants
Biopharmaceutics&Drug Disposition,Volume 0, Issue ja, -Not available-. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - August 11, 2018 Category: Drugs & Pharmacology Authors: TomohideUno , RyosukeNakano , RinaKitagawa , MaiOkada , KengoKanamaru , ShinjiTakenaka , YuichiUno , HiromasaImaishi Source Type: research

Issue Information
Biopharmaceutics&Drug Disposition,Volume 39, Issue 6, Page 281-282, June 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - July 30, 2018 Category: Drugs & Pharmacology Source Type: research