Effects of Tyr555 and Trp678 on the processivity of cellobiohydrolase A from Ruminiclostridium thermocellum: A simulation study
AbstractCellobiohydrolase A fromRuminiclostridium thermocellum (Cbh9A) is a processive exoglucanase from family 9 and is an important cellobiohydrolase that hydrolyzes cello ‐oligosaccharide into cellobiose. Residues Tyr555 and Trp678 considerably affect catalytic activity, but their mechanisms are still unknown. To investigate how the Tyr555 and Trp678 affect the processivity of Cbh9A, conventional molecular dynamics, steered molecular dynamics, and free energy calcu lation were performed to simulate the processive process of wild type (WT)‐Cbh9A, Y555S mutant, and W678G mutant. Analysis of simulation results suggests...
Source: Biopolymers - November 28, 2018 Category: Biochemistry Authors: Fei Han,
Ye Liu,
Jingwen E,
Shanshan Guan,
Weiwei Han,
Yaming Shan,
Song Wang,
Hao Zhang Tags: ORIGINAL ARTICLE Source Type: research
Cover Image
In celebration of his 65th birthday, this issue ofBiopolymers is dedicated to the scientific career and research achievements of Prof. Vincenzo Pavone. The cover highlights his contributions to the field of peptide and protein design. Vincenzo pioneered the use of non ‐coded amino acids as molecular tools to freeze peptides into defined and functional three‐dimensional structures. He built a wide range of bioactive peptides, and peptide‐based metalloprotein models. Included are (L‐Pro‐Aib)4 in a novel helical structure, the b ‐bend ribbon; MEN10627, a potent anti‐inflammatory peptide; and Mimochrome IV, a min...
Source: Biopolymers - November 5, 2018 Category: Biochemistry Tags: COVER IMAGE Source Type: research
Issue Information
Biopolymers, Volume 109, Issue 10, October 2018. (Source: Biopolymers)
Source: Biopolymers - November 5, 2018 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Vincenzo Pavone: Friend, mentor and inspiring scientist
Biopolymers, Volume 109, Issue 10, October 2018. (Source: Biopolymers)
Source: Biopolymers - November 5, 2018 Category: Biochemistry Authors: Flavia Nastri,
Ornella Maglio,
Angela Lombardi Tags: EDITORIAL Source Type: research
Amino acid modifications for conformationally constraining naturally occurring and engineered peptide backbones: Insights from the Protein Data Bank
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - October 25, 2018 Category: Biochemistry Authors: Luigi Di Costanzo,
Shuchismita Dutta,
Stephen K. Burley Source Type: research
Issue Information
Biopolymers,Volume 109, Issue 9, September 2018. (Source: Biopolymers)
Source: Biopolymers - October 17, 2018 Category: Biochemistry Source Type: research
The effects of fluorescent labels on A β42 aggregation detected by fluorescence correlation spectroscopy
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - October 12, 2018 Category: Biochemistry Authors: Yanpeng Zheng,
Lingwan Xu,
Jingfa Yang,
Xianglei Peng,
He Wang,
Na Yu,
Ying Hua,
Jiang Zhao,
Jinsheng He,
Tao Hong Source Type: research
Association of κ‐carrageenan subjected to deep alkaline hydrolysis
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - September 30, 2018 Category: Biochemistry Authors: Ekaterina R. Gasilova,
Galina P. Aleksandrova,
Elena N. Vlasova,
Vadim A. Baigildin Source Type: research
Discovery of the first self ‐assembling peptide, study of peptide dynamic behaviors, and G protein‐coupled receptors using an Aviv circular dichroism spectropolarimeter
Biopolymers,Volume 109, Issue 8, August 2018. (Source: Biopolymers)
Source: Biopolymers - September 30, 2018 Category: Biochemistry Authors: Shuguang Zhang Source Type: research
Cover Image
Biopolymers,Volume 109, Issue 8, August 2018. (Source: Biopolymers)
Source: Biopolymers - September 30, 2018 Category: Biochemistry Source Type: research
Issue Information
Biopolymers,Volume 109, Issue 8, August 2018. (Source: Biopolymers)
Source: Biopolymers - September 30, 2018 Category: Biochemistry Source Type: research
Jack Aviv: An incredible, generous and humble human being
Biopolymers,Volume 109, Issue 8, August 2018. (Source: Biopolymers)
Source: Biopolymers - September 30, 2018 Category: Biochemistry Authors: Shuguang Zhang Source Type: research
Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - September 11, 2018 Category: Biochemistry Authors: Marco
Chino
,
Shao ‐Qing
Zhang
,
Fabio
Pirro
,
Linda
Leone
,
Ornella
Maglio
,
Angela
Lombardi
,
William F.
DeGrado Source Type: research
Storage stability of electrospun pure gelatin stabilized with EDC/Sulfo ‐NHS
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - September 7, 2018 Category: Biochemistry Authors: Zahra
Ghassemi
,
Gymama
Slaughter Source Type: research
Rational design of a hexameric protein assembly stabilized by metal chelation
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - September 6, 2018 Category: Biochemistry Authors: Rafael
Alcala ‐Torano
,
Mathieu
Walther
,
Dayn J.
Sommer
,
Chad K.
Park
,
Giovanna
Ghirlanda Source Type: research
