Bioscience, Biotechnology, and Biochemistry 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Extraction and antioxidant capacity of mycosporine-like amino acids from red algae in Japan
Biosci Biotechnol Biochem. 2024 Apr 29:zbae051. doi: 10.1093/bbb/zbae051. Online ahead of print.ABSTRACTMycosporine-like amino acids (MAAs) are the natural UV absorbing compounds with antioxidant activity found in microalgae and macroalgae. We collected red algae Asparagopsis taxiformis, Meristotheca japonica, and Polysiphonia senticulosa from Nagasaki, where UV radiation is more intense than in Hokkaido, and investigated the effect of UV radiation on MAAs content. It was suggested that A. taxiformis and M. japonica contained shinorine and palythine, while UV absorbing compound in P. senticulosa could not be identified. Th...
Source: Bioscience, Biotechnology, and Biochemistry - April 29, 2024 Category: Biochemistry Authors: Ryuya Yamamoto Shigeru Toriumi Chikara Kawagoe Wataru Saburi Hideki Kishimura Yuya Kumagai Source Type: research
Synthesis, growth inhibitory activity against tumor cells and structure-activity relationship of CGK733 and its analogs
Biosci Biotechnol Biochem. 2024 Apr 27:zbae047. doi: 10.1093/bbb/zbae047. Online ahead of print.ABSTRACTCGK733 was reported as a compound that inhibited ATM/ATR kinase activities and blocked their checkpoint signaling pathways with great selectivity. However, this paper was subsequently retracted, and the truth about the activity of CGK733 remains unclear. We synthesized various analogs of CGK733 with a modification of the carboxylic acid moiety and/or the aniline derivative moiety to accumulate knowledge of the structure-activity relationship of this compound. Growth inhibitory activity of CGK733 and novel 35 analogs agai...
Source: Bioscience, Biotechnology, and Biochemistry - April 27, 2024 Category: Biochemistry Authors: Yuta Inagaki Kohki Hashimoto Shinnosuke Wakamori Ryo Katsuta Arata Yajima Daisuke Kaida Ken Ishigami Source Type: research
Synthesis, growth inhibitory activity against tumor cells and structure-activity relationship of CGK733 and its analogs
Biosci Biotechnol Biochem. 2024 Apr 27:zbae047. doi: 10.1093/bbb/zbae047. Online ahead of print.ABSTRACTCGK733 was reported as a compound that inhibited ATM/ATR kinase activities and blocked their checkpoint signaling pathways with great selectivity. However, this paper was subsequently retracted, and the truth about the activity of CGK733 remains unclear. We synthesized various analogs of CGK733 with a modification of the carboxylic acid moiety and/or the aniline derivative moiety to accumulate knowledge of the structure-activity relationship of this compound. Growth inhibitory activity of CGK733 and novel 35 analogs agai...
Source: Bioscience, Biotechnology, and Biochemistry - April 27, 2024 Category: Biochemistry Authors: Yuta Inagaki Kohki Hashimoto Shinnosuke Wakamori Ryo Katsuta Arata Yajima Daisuke Kaida Ken Ishigami Source Type: research
Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene
Biosci Biotechnol Biochem. 2024 Apr 25:zbae050. doi: 10.1093/bbb/zbae050. Online ahead of print.ABSTRACTWe found that the culture broth of fungi showed anti-fungal activity against multidrug-sensitive budding yeast. However, we could not identify the anti-fungal compound due to the small quantity. Therefore, we attempted to increase the productivity of the target compound by the introduction of a global secondary metabolism regulator, laeA to the strain, which led to the successful isolation of ten-folds greater amount of MS-347a (1) than Aspergillus sp. FKI-5362. Compound 1 was not effective against Candida albicans and t...
Source: Bioscience, Biotechnology, and Biochemistry - April 25, 2024 Category: Biochemistry Authors: Sota Honma Aoi Kimishima Atsushi Kimishima Masako Honsho Hiroki Kojima Toshiyuki Tokiwa Atsuka Nishitomi Satoshi Kato Naozumi Kondo Yasuko Araki Tadashi Takahashi Takumi Chinen Takeo Usui Shin-Ichi Fuji Kotaro Ito Yukihiro Asami Source Type: research
Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene
Biosci Biotechnol Biochem. 2024 Apr 25:zbae050. doi: 10.1093/bbb/zbae050. Online ahead of print.ABSTRACTWe found that the culture broth of fungi showed anti-fungal activity against multidrug-sensitive budding yeast. However, we could not identify the anti-fungal compound due to the small quantity. Therefore, we attempted to increase the productivity of the target compound by the introduction of a global secondary metabolism regulator, laeA to the strain, which led to the successful isolation of ten-folds greater amount of MS-347a (1) than Aspergillus sp. FKI-5362. Compound 1 was not effective against Candida albicans and t...
Source: Bioscience, Biotechnology, and Biochemistry - April 25, 2024 Category: Biochemistry Authors: Sota Honma Aoi Kimishima Atsushi Kimishima Masako Honsho Hiroki Kojima Toshiyuki Tokiwa Atsuka Nishitomi Satoshi Kato Naozumi Kondo Yasuko Araki Tadashi Takahashi Takumi Chinen Takeo Usui Shin-Ichi Fuji Kotaro Ito Yukihiro Asami Source Type: research
Synthesis of the A/D/E-ring Core Compounds of Maoecrystal V
Biosci Biotechnol Biochem. 2024 Apr 23:zbae049. doi: 10.1093/bbb/zbae049. Online ahead of print.ABSTRACTSynthesis of the A/D/E-ring core compounds of maoecrystal V was achieved. The key Diels-Alder reactions between tricyclic α-methylene lactones and Kitahara-Danishefsky dienes afforded the spirocyclic core compounds in a regioselective and stereoselective manner.PMID:38653727 | DOI:10.1093/bbb/zbae049 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - April 23, 2024 Category: Biochemistry Authors: Hiroki Asao Yasuharu Shimasaki Ayaka Sasaki Shunki Katayama Kousuke Ida Masaaki Kotake Eriko Sato Yuki Sato Taiki Ishimoto Minoru Izumi Christopher J Vavricka Kuwahara Shigefumi Hiromasa Kiyota Source Type: research
Synthesis of the A/D/E-ring Core Compounds of Maoecrystal V
Biosci Biotechnol Biochem. 2024 Apr 23:zbae049. doi: 10.1093/bbb/zbae049. Online ahead of print.ABSTRACTSynthesis of the A/D/E-ring core compounds of maoecrystal V was achieved. The key Diels-Alder reactions between tricyclic α-methylene lactones and Kitahara-Danishefsky dienes afforded the spirocyclic core compounds in a regioselective and stereoselective manner.PMID:38653727 | DOI:10.1093/bbb/zbae049 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - April 23, 2024 Category: Biochemistry Authors: Hiroki Asao Yasuharu Shimasaki Ayaka Sasaki Shunki Katayama Kousuke Ida Masaaki Kotake Eriko Sato Yuki Sato Taiki Ishimoto Minoru Izumi Christopher J Vavricka Kuwahara Shigefumi Hiromasa Kiyota Source Type: research
Synthesis of the A/D/E-ring Core Compounds of Maoecrystal V
Biosci Biotechnol Biochem. 2024 Apr 23:zbae049. doi: 10.1093/bbb/zbae049. Online ahead of print.ABSTRACTSynthesis of the A/D/E-ring core compounds of maoecrystal V was achieved. The key Diels-Alder reactions between tricyclic α-methylene lactones and Kitahara-Danishefsky dienes afforded the spirocyclic core compounds in a regioselective and stereoselective manner.PMID:38653727 | DOI:10.1093/bbb/zbae049 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - April 23, 2024 Category: Biochemistry Authors: Hiroki Asao Yasuharu Shimasaki Ayaka Sasaki Shunki Katayama Kousuke Ida Masaaki Kotake Eriko Sato Yuki Sato Taiki Ishimoto Minoru Izumi Christopher J Vavricka Kuwahara Shigefumi Hiromasa Kiyota Source Type: research
Chemical and biological study of flavonoid-related plant pigment: current findings and beyond
Biosci Biotechnol Biochem. 2024 Apr 17:zbae048. doi: 10.1093/bbb/zbae048. Online ahead of print.ABSTRACTFlavonoids are polyphenolic plant constituents. Anthocyanins are flavonoid pigments found in higher plants that show a wide variety of colors ranging from red through purple to blue. The blue color of the flowers is mostly attributed to anthocyanins. However, only a few types of anthocyanidin, chromophore of anthocyanin, exist in nature, and the extracted pigments are unstable with the color fading away. Therefore, the wide range and stable nature of colors in flowers has remained a mystery for more than a century. The m...
Source: Bioscience, Biotechnology, and Biochemistry - April 17, 2024 Category: Biochemistry Authors: Kumi Yoshida Source Type: research
Chemical and biological study of flavonoid-related plant pigment: current findings and beyond
Biosci Biotechnol Biochem. 2024 Apr 17:zbae048. doi: 10.1093/bbb/zbae048. Online ahead of print.ABSTRACTFlavonoids are polyphenolic plant constituents. Anthocyanins are flavonoid pigments found in higher plants that show a wide variety of colors ranging from red through purple to blue. The blue color of the flowers is mostly attributed to anthocyanins. However, only a few types of anthocyanidin, chromophore of anthocyanin, exist in nature, and the extracted pigments are unstable with the color fading away. Therefore, the wide range and stable nature of colors in flowers has remained a mystery for more than a century. The m...
Source: Bioscience, Biotechnology, and Biochemistry - April 17, 2024 Category: Biochemistry Authors: Kumi Yoshida Source Type: research
Deficiency of β-xylosidase activity in Aspergillus luchuensis mut. kawachii IFO 4308
In this study, we investigated a deleterious mutation in the β-xylosidase gene, xylA (AkxylA), in Aspergillus luchuensis mut. kawachii IFO 4308 by constructing an AkxylA disruptant and complementation strains of AkxylA and xylA derived from A. luchuensis RIB2604 (AlxylA), which does not harbor the mutation in xylA. Only the AlxylA complementation strain exhibited significantly higher growth and substantial β-xylosidase activity in medium containing xylan, accompanied by an increase in XylA expression. This resulted in lower xylobiose and higher xylose concentrations in the mash of barley shochu. These findings suggest th...
Source: Bioscience, Biotechnology, and Biochemistry - April 15, 2024 Category: Biochemistry Authors: Enkang Zhu Kentaro Hiramatsu Taiga Inoue Kazuki Mori Kosuke Tashiro Kiyotaka Fujita Takefumi Karashima Hideharu Takashita Kayu Okutsu Yumiko Yoshizaki Kazunori Takamine Hisanori Tamaki Taiki Futagami Source Type: research
Deficiency of β-xylosidase activity in Aspergillus luchuensis mut. kawachii IFO 4308
In this study, we investigated a deleterious mutation in the β-xylosidase gene, xylA (AkxylA), in Aspergillus luchuensis mut. kawachii IFO 4308 by constructing an AkxylA disruptant and complementation strains of AkxylA and xylA derived from A. luchuensis RIB2604 (AlxylA), which does not harbor the mutation in xylA. Only the AlxylA complementation strain exhibited significantly higher growth and substantial β-xylosidase activity in medium containing xylan, accompanied by an increase in XylA expression. This resulted in lower xylobiose and higher xylose concentrations in the mash of barley shochu. These findings suggest th...
Source: Bioscience, Biotechnology, and Biochemistry - April 15, 2024 Category: Biochemistry Authors: Enkang Zhu Kentaro Hiramatsu Taiga Inoue Kazuki Mori Kosuke Tashiro Kiyotaka Fujita Takefumi Karashima Hideharu Takashita Kayu Okutsu Yumiko Yoshizaki Kazunori Takamine Hisanori Tamaki Taiki Futagami Source Type: research
Phyllodulcin from the hexane fraction of Hydrangea macrophylla inhibits glucose-induced lipid accumulation and reactive oxygen species (ROS) generation in Caenorhabditis elegans
Biosci Biotechnol Biochem. 2024 Apr 10:zbae043. doi: 10.1093/bbb/zbae043. Online ahead of print.ABSTRACTWe confirmed that the hexane layer of Hydrangea macrophylla leaf extract (HLH) is rich in phyllodulcin (PD), an alternative sweetener through HPLC analysis. To investigate in vivo activity of HLH and its PD, acute toxicity and growth rate of Caenorhabditis elegans were tested and there are no clinical abnormalities at 125-500 μg/mL of HLH. HLH decreased the total lipid and TG contents dose-dependently glucose (GLU) induced obese worms. Also, HLH increased survival rates under oxidative and thermal stress and decreased b...
Source: Bioscience, Biotechnology, and Biochemistry - April 10, 2024 Category: Biochemistry Authors: Myogyeong Cho Harin Park Sang Hyun Lee Myojeong Kim Miran Jang Source Type: research
Sesquiterpenoids from the roots of Lindera glauca and their cytotoxicity activities
Biosci Biotechnol Biochem. 2024 Apr 10:zbae045. doi: 10.1093/bbb/zbae045. Online ahead of print.ABSTRACTThe chemical investigation of the roots of Lindera glauca guided the isolation and identification of three new sesquiterpenoids, namly glaucatotones J-L (1-3), and one known congener, (1β,5β)-1-hydroxyguaia-4(15),11(13)-dieno-12,5-lactone (4). The structures of new compounds were established based on comprehensive spectrographic methods, mainly including 1D & 2D NMR and HRESIMS analyses, and the absolute configurations were further confirmed by the comparison of experimental and calculated electronic circular dichr...
Source: Bioscience, Biotechnology, and Biochemistry - April 10, 2024 Category: Biochemistry Authors: Fanrong Zeng Xinyuan Pan Xiongyu Meng Qing Li Huaqiang Li Source Type: research
Phyllodulcin from the hexane fraction of Hydrangea macrophylla inhibits glucose-induced lipid accumulation and reactive oxygen species (ROS) generation in Caenorhabditis elegans
Biosci Biotechnol Biochem. 2024 Apr 10:zbae043. doi: 10.1093/bbb/zbae043. Online ahead of print.ABSTRACTWe confirmed that the hexane layer of Hydrangea macrophylla leaf extract (HLH) is rich in phyllodulcin (PD), an alternative sweetener through HPLC analysis. To investigate in vivo activity of HLH and its PD, acute toxicity and growth rate of Caenorhabditis elegans were tested and there are no clinical abnormalities at 125-500 μg/mL of HLH. HLH decreased the total lipid and TG contents dose-dependently glucose (GLU) induced obese worms. Also, HLH increased survival rates under oxidative and thermal stress and decreased b...
Source: Bioscience, Biotechnology, and Biochemistry - April 10, 2024 Category: Biochemistry Authors: Myogyeong Cho Harin Park Sang Hyun Lee Myojeong Kim Miran Jang Source Type: research
