Molecular Regulation of NLRP3 Inflammasome Activation During Parasitic Infection
Biosci Rep. 2024 Apr 16:BSR20231918. doi: 10.1042/BSR20231918. Online ahead of print.ABSTRACTParasitic diseases are a serious global health concern, causing many common and severe infections, including Chagas disease, leishmaniasis,and schistosomiasis. The NLRP3 inflammasome belongs to the NLR (nucleotide-binding domain leucine-rich-repeat-containing proteins) family, which are cytosolic proteins playing key roles in the detection of pathogens. NLRP3 inflammasomes are activated in immune responses to Plasmodium,Leishmania, Toxoplasma gondii, Entamoeba histolytica,Trypanosoma cruzi and other parasites. The role of NLRP3 is ...
Source: Bioscience Reports - April 16, 2024 Category: Biomedical Science Authors: Rasha Alonaizan Source Type: research
Molecular Regulation of NLRP3 Inflammasome Activation During Parasitic Infection
Biosci Rep. 2024 Apr 16:BSR20231918. doi: 10.1042/BSR20231918. Online ahead of print.ABSTRACTParasitic diseases are a serious global health concern, causing many common and severe infections, including Chagas disease, leishmaniasis,and schistosomiasis. The NLRP3 inflammasome belongs to the NLR (nucleotide-binding domain leucine-rich-repeat-containing proteins) family, which are cytosolic proteins playing key roles in the detection of pathogens. NLRP3 inflammasomes are activated in immune responses to Plasmodium,Leishmania, Toxoplasma gondii, Entamoeba histolytica,Trypanosoma cruzi and other parasites. The role of NLRP3 is ...
Source: Bioscience Reports - April 16, 2024 Category: Biomedical Science Authors: Rasha Alonaizan Source Type: research
Expression of Concern: MiR-302e attenuates allergic inflammation in vitro model by targeting RelA
Biosci Rep. 2024 Apr 24;44(4):BSR-2018-0025_EOC. doi: 10.1042/BSR-2018-0025_EOC.NO ABSTRACTPMID:38606536 | PMC:PMC11016530 | DOI:10.1042/BSR-2018-0025_EOC (Source: Bioscience Reports)
Source: Bioscience Reports - April 12, 2024 Category: Biomedical Science Source Type: research
Me31B, A Key Repressor in Germline Regulation and Beyond
This article endeavors to comprehensively review historic and recent research on Me31B, distill the major findings, discern generalizable patterns in Me31B's functions across different research contexts, and provide insights into its fundamental role and mechanism of action. The primary focus of this article centers on elucidating the role of Drosophila Me31B within the germline, while concurrently delving into pertinent research on its orthologs within other species and cellular systems.PMID:38606619 | DOI:10.1042/BSR20231769 (Source: Bioscience Reports)
Source: Bioscience Reports - April 12, 2024 Category: Biomedical Science Authors: Ming Gao Source Type: research
Expression of Concern: MiR-302e attenuates allergic inflammation in vitro model by targeting RelA
Biosci Rep. 2024 Apr 24;44(4):BSR-2018-0025_EOC. doi: 10.1042/BSR-2018-0025_EOC.NO ABSTRACTPMID:38606536 | DOI:10.1042/BSR-2018-0025_EOC (Source: Bioscience Reports)
Source: Bioscience Reports - April 12, 2024 Category: Biomedical Science Source Type: research
Me31B, A Key Repressor in Germline Regulation and Beyond
This article endeavors to comprehensively review historic and recent research on Me31B, distill the major findings, discern generalizable patterns in Me31B's functions across different research contexts, and provide insights into its fundamental role and mechanism of action. The primary focus of this article centers on elucidating the role of Drosophila Me31B within the germline, while concurrently delving into pertinent research on its orthologs within other species and cellular systems.PMID:38606619 | DOI:10.1042/BSR20231769 (Source: Bioscience Reports)
Source: Bioscience Reports - April 12, 2024 Category: Biomedical Science Authors: Ming Gao Source Type: research
Spectroscopic Analysis of the Bacterially Expressed Head Domain of Rotavirus VP6
Biosci Rep. 2024 Apr 9:BSR20232178. doi: 10.1042/BSR20232178. Online ahead of print.ABSTRACTThe rotavirus capsid protein VP6 forms the middle of three protein layers and is responsible for many critical steps in the viral life cycle. VP6 as a structural protein can be used in various applications including as a subunit vaccine component. The head domain of VP6 (VP6H) contains key sequences that allow the protein to trimerize and that represent epitopes that are recognized by human antibodies in the viral particle. The domain is rich in beta-sheet secondary structures. Here VP6H was solubilised from bacterial inclusion bodi...
Source: Bioscience Reports - April 9, 2024 Category: Biomedical Science Authors: Milaan Simone Strachan Tshepo Mashapa Samantha Gildenhuys Source Type: research
Spectroscopic Analysis of the Bacterially Expressed Head Domain of Rotavirus VP6
Biosci Rep. 2024 Apr 9:BSR20232178. doi: 10.1042/BSR20232178. Online ahead of print.ABSTRACTThe rotavirus capsid protein VP6 forms the middle of three protein layers and is responsible for many critical steps in the viral life cycle. VP6 as a structural protein can be used in various applications including as a subunit vaccine component. The head domain of VP6 (VP6H) contains key sequences that allow the protein to trimerize and that represent epitopes that are recognized by human antibodies in the viral particle. The domain is rich in beta-sheet secondary structures. Here VP6H was solubilised from bacterial inclusion bodi...
Source: Bioscience Reports - April 9, 2024 Category: Biomedical Science Authors: Milaan Simone Strachan Tshepo Mashapa Samantha Gildenhuys Source Type: research
Spectroscopic Analysis of the Bacterially Expressed Head Domain of Rotavirus VP6
Biosci Rep. 2024 Apr 9:BSR20232178. doi: 10.1042/BSR20232178. Online ahead of print.ABSTRACTThe rotavirus capsid protein VP6 forms the middle of three protein layers and is responsible for many critical steps in the viral life cycle. VP6 as a structural protein can be used in various applications including as a subunit vaccine component. The head domain of VP6 (VP6H) contains key sequences that allow the protein to trimerize and that represent epitopes that are recognized by human antibodies in the viral particle. The domain is rich in beta-sheet secondary structures. Here VP6H was solubilised from bacterial inclusion bodi...
Source: Bioscience Reports - April 9, 2024 Category: Biomedical Science Authors: Milaan Simone Strachan Tshepo Mashapa Samantha Gildenhuys Source Type: research
Anorexigenic neuropeptides as anti-obesity and neuroprotective agents
The objective of this review was to explore anorexigenic neuropeptides produced and acting within the brain, emphasizing their potential not only for the treatment of obesity but also for the treatment of neurodegenerative disorders.PMID:38577975 | DOI:10.1042/BSR20231385 (Source: Bioscience Reports)
Source: Bioscience Reports - April 5, 2024 Category: Biomedical Science Authors: Veronika Strnadov á Andrea Pa česová Vil ém Charvát Zuzana Šmotková Blanka Zelezna Jaroslav Kunes Lenka Maletinska Source Type: research
Anorexigenic neuropeptides as anti-obesity and neuroprotective agents
The objective of this review was to explore anorexigenic neuropeptides produced and acting within the brain, emphasizing their potential not only for the treatment of obesity but also for the treatment of neurodegenerative disorders.PMID:38577975 | DOI:10.1042/BSR20231385 (Source: Bioscience Reports)
Source: Bioscience Reports - April 5, 2024 Category: Biomedical Science Authors: Veronika Strnadov á Andrea Pa česová Vil ém Charvát Zuzana Šmotková Blanka Zelezna Jaroslav Kunes Lenka Maletinska Source Type: research
Anorexigenic neuropeptides as anti-obesity and neuroprotective agents
The objective of this review was to explore anorexigenic neuropeptides produced and acting within the brain, emphasizing their potential not only for the treatment of obesity but also for the treatment of neurodegenerative disorders.PMID:38577975 | DOI:10.1042/BSR20231385 (Source: Bioscience Reports)
Source: Bioscience Reports - April 5, 2024 Category: Biomedical Science Authors: Veronika Strnadov á Andrea Pa česová Vil ém Charvát Zuzana Šmotková Blanka Zelezna Jaroslav Kunes Lenka Maletinska Source Type: research
Anorexigenic neuropeptides as anti-obesity and neuroprotective agents
The objective of this review was to explore anorexigenic neuropeptides produced and acting within the brain, emphasizing their potential not only for the treatment of obesity but also for the treatment of neurodegenerative disorders.PMID:38577975 | DOI:10.1042/BSR20231385 (Source: Bioscience Reports)
Source: Bioscience Reports - April 5, 2024 Category: Biomedical Science Authors: Veronika Strnadov á Andrea Pa česová Vil ém Charvát Zuzana Šmotková Blanka Zelezna Jaroslav Kunes Lenka Maletinska Source Type: research
Chloride ions in health and disease
Biosci Rep. 2024 Apr 4:BSR20240029. doi: 10.1042/BSR20240029. Online ahead of print.ABSTRACTChloride is a key anion involved in cellular physiology by regulating its homeostasis and rheostatic processes. Changes in cellular Cl- concentration result in differential regulation of cellular functions such as transcription and translation, post-translation modifications, cell cycle and proliferation, cell volume, and pH levels. In intracellular compartments, Cl- modulates the function of lysosomes, mitochondria, endosomes, phagosomes, the nucleus, and the endoplasmic reticulum. In extracellular fluid (ECF), Cl- is present in bl...
Source: Bioscience Reports - April 4, 2024 Category: Biomedical Science Authors: Satish K Raut Kulwinder Singh Shridhar Sanghvi Veronica Loyo-Celis Liyah Varghese Ekam R Singh Shubha Gururaja Rao Harpreet Singh Source Type: research
Metabolic Reprogramming of the Retinal Pigment Epithelium by Cytokines Associated with Age-related Macular Degeneration
In this study, we investigate the effects of four cytokines associated with AMD, TNFα, TGF-β2, IL-6, and IL-1β, as well as a cocktail containing all four cytokines, on RPE metabolism using ARPE-19 cells, primary human RPE cells, and ex vivo rat eyecups. Strikingly, we found cytokine-specific changes in numerous metabolic markers including lactate production, glucose consumption, extracellular acidification rate, and oxygen consumption rate accompanied by increases in total mitochondrial volume and ATP production. Together, all four cytokines, could potently override the constitutive suppression of glycolysis in the RPE,...
Source: Bioscience Reports - April 3, 2024 Category: Biomedical Science Authors: David S Hansman Yuefang Ma Daniel Thomas Justine R Smith Robert J Casson Daniel Peet Source Type: research
