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Construction of self-enhanced luminescence probes based on Ti 3 C 2 reducibility for ultrasensitive PNK analysis
This study not only provided insights for addressing the issue of ECL luminescence efficiency in Au NCs but also presented novel concepts for ECL self-enhancement strategies.PMID:38608494 | DOI:10.1016/j.bios.2024.116236 (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - April 12, 2024 Category: Biotechnology Authors: Zhihao Wei Huixin Zhang Feifei Zhang Jianfei Xia Qingyang Meng Hongjie Huang Zonghua Wang Source Type: research

Controllable detection threshold achieved through the toehold switch system in a mercury ion whole-cell biosensor
This study confirms the feasibility and performance of biosensor with controllable detection threshold, providing a new detection method and new ideas for expanding the detection range of biosensors while ensuring rapid and convenient measurements without compromising sensitivity.PMID:38608495 | DOI:10.1016/j.bios.2024.116283 (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - April 12, 2024 Category: Biotechnology Authors: Qinglong Zhang Zixiang Wei Xiaoqiang Jia Source Type: research

An enzyme-free sensing platform for miRNA detection and in situ imaging in clinical samples based on DNAzyme cleavage-triggered catalytic hairpin assembly
Biosens Bioelectron. 2024 Apr 9;256:116279. doi: 10.1016/j.bios.2024.116279. Online ahead of print.ABSTRACTMicroRNA (miRNA) is demonstrated to be associated with the occurrence and development of various diseases including cancer. Currently, most miRNA detection methods are confined to in vitro detection and cannot obtain information on the temporal and spatial expression of miRNA in relevant tissues and cells. In this work, we established a novel enzyme-free method that can be applied to both in vitro detection and in situ imaging of miRNA by integrating DNAzyme and catalytic hairpin assembly (CHA) circuits. This develope...
Source: Biosensors and Bioelectronics - April 12, 2024 Category: Biotechnology Authors: Hechen Wang Minzhe Shen Xudan Shen Jiatong Liu Wenwen Huang Xianfeng Jiang Hui Liu Su Zeng Kewang Nan Sheng Cai Source Type: research

An enzymatically activated AND-gate DNA logic circuit for tumor cells recognition via multi-microRNAs detection
Biosens Bioelectron. 2024 Apr 7;256:116278. doi: 10.1016/j.bios.2024.116278. Online ahead of print.ABSTRACTThe DNA-based logic circuit, constructed to mimic biochemical reaction networks, is highly significant in detecting biomarkers at the molecular level. The differences in the expression levels of microRNAs (miRNAs) within different types of cells provide hope for distinguishing cell subtypes. However, reliance on a single miRNA often leads to unreliable results. Herein, we constructed an enzyme-triggered cascade logic circuit based on the AND gate, which is capable of generating corresponding fluorescence signals in th...
Source: Biosensors and Bioelectronics - April 12, 2024 Category: Biotechnology Authors: Hanrong Yan Guojun Cao Jin Wang Xu Zhu Shuqing Dong Yuqi Huang Minghao Chao Yuting Li Fenglei Gao Lei Hua Source Type: research

Perovskite hydroxide-based laccase mimics with controllable activity for environmental remediation and biosensing
Biosens Bioelectron. 2024 Apr 7;256:116275. doi: 10.1016/j.bios.2024.116275. Online ahead of print.ABSTRACTConstructing relatively inexpensive nanomaterials to simulate the catalytic performance of laccase is of great significance in recent years. Although research on improving laccase-like activity by regulating ligands of copper (amino acids or small organic molecules, etc.) have achieved remarkable success. There are few reports on improving laccase-like activity by adjusting the composition of metal Cu. Here, we used perovskite hydroxide AB(OH)6 as a model to evaluate the relationship between Cu based alloys and their ...
Source: Biosensors and Bioelectronics - April 11, 2024 Category: Biotechnology Authors: Yufeng Liu Jing Zhang Shuai Cui Hui Wei Dongzhi Yang Source Type: research

An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids
Biosens Bioelectron. 2024 Apr 9;256:116280. doi: 10.1016/j.bios.2024.116280. Online ahead of print.ABSTRACTMonitoring biomarkers in human interstitial fluids (ISF) using microneedle sensors has been extensively studied. However, most of the previous studies were limited to simple in vitro demonstrations and lacked system integration and analytical performance. Here we report a miniaturized, high-precision, fully integrated wearable electrochemical microneedle sensing device that works with a customized smartphone application to wirelessly and in real-time monitor glucose in human ISF. A microneedle array fabrication method...
Source: Biosensors and Bioelectronics - April 11, 2024 Category: Biotechnology Authors: Yong Yang Can Sheng Fang Dong Sheng Liu Source Type: research

Highly sensitive and selective demethylase FTO detection using a DNAzyme-mediated CRISPR/Cas12a signal cascade amplification electrochemiluminescence biosensor with C-CN/PCN V heterojunction as emitter
In this study, an electrochemiluminescence (ECL) biosensor for the detection of demethylase FTO was developed based on DNAzyme-mediated CRISPR/Cas12a signal cascade amplification system and carboxylated carbon nitride nanosheets/phosphorus-doped nitrogen-vacancy modified carbon nitride nanosheets (C-CN/PCNV) heterojunction as the emitter. The biosensor was constructed by modifying the C-CN/PCNV heterojunction and a ferrocene-tagged probe (ssDNA-Fc) on a glassy carbon electrode. The presence of FTO removes the m6A modification on the catalytic core of DNAzyme, restoring its cleavage activity and generating activator DNA. Th...
Source: Biosensors and Bioelectronics - April 10, 2024 Category: Biotechnology Authors: Hong Li Shuai Qiao Heng Zhang Yanxia Qiao Jin Liu Yan Li Source Type: research

A photoelectrochemical biosensor based on self-calibration platform of carbon-rich plasmonic probe with near-infrared driving signal amplification
Biosens Bioelectron. 2024 Apr 7;256:116274. doi: 10.1016/j.bios.2024.116274. Online ahead of print.ABSTRACTExploring the photochemical (PEC) method induced by low-energy light source makes great significance to achieve high stability and accurate analysis. A sensing platform driven by near-infrared (NIR) light was designed by making the biochemically encoded carbon rich plasmonic hybrid (CPH) probe, the peptide@C-Mo2C. The inherent plasmonic effect of C-Mo2C CPH can directly absorb NIR light, thus starting effective electronic-hole pairs separation. Moreover, the photothermal effect of C-Mo2C CPH also promoted the reaction...
Source: Biosensors and Bioelectronics - April 10, 2024 Category: Biotechnology Authors: Yanjie Chen Yitian Huang Shupei Zhang Lihong Gao Hong Dai Source Type: research

Coreactant-free aggregation-induced electrochemiluminescence system based on the novel zinc-luminol metal-organic gel for ultrasensitive detection of PiRNA-823
Biosens Bioelectron. 2024 Apr 4;255:116263. doi: 10.1016/j.bios.2024.116263. Online ahead of print.ABSTRACTAggregation-induced electrochemiluminescence (AIECL) technology has aroused widespread interest due to the significant improve in ECL response by solving the problems of aggregation-caused quenching and poor water solubility of the luminophore. However, the existing AIECL emitters still suffer from low ECL efficiency, additional coreactants and complex synthesis steps, which greatly limit their applications. Herein, luminol, as a kind of AIE molecule, was assembled with Zn2+ nodes to obtain a novel microflower-like Zi...
Source: Biosensors and Bioelectronics - April 9, 2024 Category: Biotechnology Authors: Congyi Hu Liping Cao Xinjie Wu Gaoxu Chen Yuanfang Li Jian Wang Chengzhi Huang Lei Zhan Source Type: research

Hepatocellular carcinoma biomarkers screening based on hydrogel photonic barcodes with tyramine deposition amplified ELISA
Biosens Bioelectron. 2024 Apr 4;255:116270. doi: 10.1016/j.bios.2024.116270. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC), as one of the most lethal cancers, significantly impacts human health. Attempts in this area tends to develop novel technologies with sensitive and multiplexed detection properties for early diagnosis. Here, we present novel hydrogel photonic crystal (PhC) barcodes with tyramine deposition amplified enzyme-linked immunosorbent assay (ELISA) for highly sensitive and multiplexed HCC biomarker screening. Because of the abundant amino groups of acrylic acid (AA) component, the constructed h...
Source: Biosensors and Bioelectronics - April 8, 2024 Category: Biotechnology Authors: Wenjing Xue Li Wang Kexin Yi Lingyu Sun Haozhen Ren Feika Bian Source Type: research

Metabolism-triggered sensor array aided by machine learning for rapid identification of pathogens
Biosens Bioelectron. 2024 Apr 6;255:116264. doi: 10.1016/j.bios.2024.116264. Online ahead of print.ABSTRACTChemical-nose strategy has achieved certain success in the discrimination and identification of pathogens. However, this strategy usually relies on non-specific interactions, which are prone to be significantly disturbed by the change of environment thus limiting its practical usefulness. Herein, we present a novel chemical-nose sensing approach leveraging the difference in the dynamic metabolic variation during peptidoglycan metabolism among different species for rapid pathogen discrimination. Pathogens were first te...
Source: Biosensors and Bioelectronics - April 8, 2024 Category: Biotechnology Authors: Xin Wang Huida Li Chengxin Wu Jianyu Yang Jianhua Wang Ting Yang Source Type: research