Is obesity changing the phenotype of bipolar disorder from predominately euphoric toward mixed presentations?
Bipolar Disorders, EarlyView. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 28, 2018 Category: Psychiatry Authors: Roger S. McIntyre Tags: DEBATE Source Type: research

The Morbidity of Subthreshold Pediatric Bipolar Disorder: A Systematic Literature Review and Meta ‐Analysis
ConclusionsSubthreshold pediatric BP disorder is an identifiable morbid condition associated with significant functional impairment including psychiatric comorbidities and high rates of suicidality.This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 27, 2018 Category: Psychiatry Authors: Carrie A. H. Vaudreuil, Stephen V. Faraone, Maura Di Salvo, Janet R. Wozniak, Rebecca A. Wolenski, Nicholas W. Carrellas, Joseph Biederman Tags: Review Source Type: research

Differences between unipolar mania and bipolar ‐I disorder: Evidence from nine epidemiological studies
ConclusionsThe significant differences found in gender and comorbidity between mania and BP ‐I suggest that unipolar mania, despite its low prevalence, should be established as a separate diagnosis both for clinical and research purposes. In clinical settings, the rarer occurrence of suicide attempts, anxiety and drug use disorders among individuals with unipolar mania may facilitate suc cessful treatment of the disorder and lead to a more favorable course than that of BP‐I disorder.This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 26, 2018 Category: Psychiatry Authors: J. Angst, W. R össler, V. Ajdacic‐Gross, F. Angst, H‐U. Wittchen, R. Lieb, K. Beesdo‐Baum, E. Asselmann, K. R. Merikangas, L. Cui, L. H. Andrade, M. C. Viana, F. Lamers, B. W. J .H. Penninx, T. de Azevedo Cardoso, K. Jansen, L. Dias Tags: Original Article Source Type: research

What is early intervention in bipolar disorder? – Recommendation of a pragmatic way focusing on early intervention in patients with newly diagnosed bipolar disorder. Commentary on the Debate around Malhi et al.′s paper “Is “early intervention” in bipolar disorder what it claims to be?”
This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 26, 2018 Category: Psychiatry Authors: Lars Vedel Kessing Tags: Commentary Source Type: research

Aspirin for recurrence prevention in bipolar disorder – promising, yet clinically understudied?
This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 25, 2018 Category: Psychiatry Authors: B.C.M. Haarman, M.K. de Boer, C.M. van der Gaag, H. Burger, W.A. Nolen, R.A. Schoevers Tags: Debate Source Type: research

Compliance with the guidelines for laboratory monitoring of patients treated with lithium: a retrospective follow ‐up study among ambulatory patients in the Netherlands
ConclusionA considerable proportion of patients had not been monitored in accordance with the guidelines. Further research is needed to understand the reasons for noncompliance and to implement strategies with the ultimate goal of optimizing safety and effectiveness for patients treated with lithium.This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 25, 2018 Category: Psychiatry Authors: Mari ëtte Nederlof, Toine C.G. Egberts, Liesbeth van Londen, Maurits C.F.J. de Rotte, Patrick C. Souverein, Ron C M Herings, Eibert R Heerdink Tags: Original Article Source Type: research

Reduced Lateral Orbitofrontal Cortex (OFC) Volume and Suicide Behavior in Youth with Bipolar Disorder
ConclusionsThe OFC is involved in decision ‐making, impulsivity, and reward circuitry which have shown to be impaired in BD. Reduced OFC volume and its association with lethality of suicide suggest that suicide behavior in BD may be related to the emerging neuroanatomical substrates of the disorder, particularly abnormalities of the OFC.This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 24, 2018 Category: Psychiatry Authors: Rebekah S. Huber, Punitha Subramaniam, Douglas G. Kondo, Xianfeng Shi, Perry F. Renshaw, Deborah A. Yurgelun ‐Todd Tags: Original Article Source Type: research

Deficits in frontoparietal activation and anterior insula functional connectivity during regulation of cognitive ‐affective interference in bipolar disorder
ConclusionsOur findings show disruptions in cognitive regulation and inhibitory control in BD patients in the presence of irrelevant affective distractors. Results of this study suggest one pathway to dysregulation in BD is through inefficient integration of affective and cognitive information, and highlight the importance of developing interventions that target emotion ‐cognition integration in BD. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 22, 2018 Category: Psychiatry Authors: Kristen K. Ellard, Aishwarya K. Gosai, Julia M. Felicione, Amy T. Peters, Conor V. Shea, Louisa G. Sylvia, Andrew A. Nierenberg, Alik S. Widge, Darin D. Dougherty, Thilo Deckersbach Tags: ORIGINAL ARTICLE Source Type: research

A report of affective switching associated with ketamine: The case of ketamine ‐induced mania is not closed
This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 19, 2018 Category: Psychiatry Authors: Nicholas D. Allen, Brian R. Rodysill, J. Michael Bostwick Tags: Clinical Curiosity Source Type: research

Testing a Clinical Staging Model for Bipolar Disorder using Longitudinal Life Chart Data
ConclusionsStaging is a useful model to determine illness progression in longitudinal life chart data. Variables influencing transition rates were successfully identified.This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 17, 2018 Category: Psychiatry Authors: Afra van der Markt, Ursula M.H. Klumpers, Stasja Draisma, Annemiek Dols, Willem A. Nolen, Robert M. Post, Lori L. Altshuler, Mark A. Frye, Heinz Grunze, Paul E. Keck, Susan L. McElroy, Trisha Suppes, Aartjan T.F. Beekman, Ralph W. Kupka Tags: Original Article Source Type: research

Obesity, mixed, and bipolar features in major depression: Should we identify the usual suspects or also look for covert mediators?
Bipolar Disorders, EarlyView. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2018 Category: Psychiatry Authors: Bruno Etain, Frank Bellivier Tags: COMMENTARY Source Type: research

Acquired mania associated with a left temporal meningioma
Bipolar Disorders, EarlyView. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2018 Category: Psychiatry Authors: Susan Q. Shen, Namita Sinha, Richard J. Perrin, Nupur Ghoshal, Ammar H. Hawasli, Fay Y. Womer Tags: CLINICAL CURIOSITY Source Type: research

Neural signatures of the risk for Bipolar Disorder: a meta ‐analysis of structural and functional neuroimaging studies
ConclusionsOur findings demonstrate that increased brain volume and activation are present in RELs and may represent intermediate phenotypes for the disorder. Furthermore, some neural changes including increased rIFG volume may be associated with the resilience to BD.This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2018 Category: Psychiatry Authors: Giulia Cattarinussi, Annabella Di Giorgio, Robert Christian Wolf, Matteo Balestrieri, Fabio Sambataro Tags: Original Article Source Type: research

Use of Gray Sunglasses to Alleviate Hypomanic State in Two Patients with Bipolar II Disorder
This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 14, 2018 Category: Psychiatry Authors: Masanao Shirahama, Takeshi Terao, Koji Hatano, Kentaro Kohno, Hirofumi Hirakawa, Nobuyoshi Ishii Tags: Clinical Conundrum Source Type: research

Affective temperaments are associated with the white matter microstructure in healthy participants
ConclusionThe present findings suggest that cyclothymic, hyperthymic, and anxious temperaments are associated with brain white matter integrity in healthy participants.This article is protected by copyright. All rights reserved. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 14, 2018 Category: Psychiatry Authors: Koji Hatano, Takeshi Terao, Takuya Hayashi, Hirofumi Hirakawa, Mayu Makino, Yoshinori Mizokami, Minoru Fujiki, Tsuyoshi Shimomura Tags: Original Article Source Type: research