Issue Information
Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 211-215, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 29, 2016 Category: Perinatology & Neonatology Source Type: research

Developmental toxicity studies of lumefantrine and artemether in rats and rabbits
Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 243-257, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 29, 2016 Category: Perinatology & Neonatology Authors: Robert L. Clark, Maureen Youreneff, Anthony M. DeLise Source Type: research

Issue Information
Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 211-215, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 29, 2016 Category: Perinatology & Neonatology Source Type: research

Developmental toxicity studies of lumefantrine and artemether in rats and rabbits
Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 243-257, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 29, 2016 Category: Perinatology & Neonatology Source Type: research

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Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 211-215, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 29, 2016 Category: Perinatology & Neonatology Source Type: research

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Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 243-257, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 29, 2016 Category: Perinatology & Neonatology Source Type: research

Developmental toxicity studies of lumefantrine and artemether in rats and rabbits
This report describes the results of embryo‐fetal development studies of artemether alone, lumefantrine alone, and the combination in rats and rabbits as well as toxicokinetic studies of lumefantrine in pregnant rabbits. The developmental no‐effect levels for lumefantrine were 300 mg/kg/day in rats (based on a 25% decrease in litter size at 1000 mg/kg/day) and 1000 mg/kg/day in rabbits. The calculated safety margins based on human equivalent dose and plasma Cmax and AUC values were in the range of 2.5‐ to 17‐fold. The developmental no‐effect levels for artemether were 3 mg/kg/day in rats and 25 mg/kg/day in rabbi...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 28, 2016 Category: Perinatology & Neonatology Authors: Robert L. Clark, Maureen Youreneff, Anthony M. DeLise Tags: RESEARCH ARTICLE Source Type: research

Lost in translation: The search for an in vitro screen for spermatogenic toxicity
Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 225-242, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 26, 2016 Category: Perinatology & Neonatology Authors: Robert E. Chapin, Timothy Winton, William Nowland, Nichole Danis, Steven Kumpf, Kjell Johnson, Aleasha Coburn, Jan ‐Bernd Stukenborg Source Type: research

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Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 225-242, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 26, 2016 Category: Perinatology & Neonatology Source Type: research

Issue Information
(Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - November 30, 2016 Category: Perinatology & Neonatology Tags: ISSUE INFORMATION Source Type: research

Exposure to high ‐concentration oxygen in the neonatal period induces abnormal retinal vascular patterning in mice
Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 216-224, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - October 28, 2016 Category: Perinatology & Neonatology Authors: Akane Morita, Hiroko Ushikubo, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara Source Type: research

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Birth Defects Research Part B: Developmental and Reproductive Toxicology,Volume 107, Issue 6, Page 216-224, December 2016. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - October 28, 2016 Category: Perinatology & Neonatology Source Type: research

Lost in translation: The search for an in vitro screen for spermatogenic toxicity
The last two decades have seen an increasing search for in vitro models that can replace the use of animals for safety testing. We adapted the methods from a recent nonquantitative report of spermatogenesis occurring in ex vivo mouse testis explants and tried to develop them into a screening assay. The model consisted of small pieces of neonatal mouse testis (testis “chunks”), explanted and placed on pillars of agarose or chamber inserts, and cultured at the air–liquid interface. A peripheral torus‐shaped zone in these explants would often contain tubules showing spermatogenesis, while the middle of each chunk was ...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - July 31, 2016 Category: Perinatology & Neonatology Authors: Robert E. Chapin, Timothy Winton, William Nowland, Nichole Danis, Steven Kumpf, Kjell Johnson, Aleasha Coburn, Jan ‐Bernd Stukenborg Tags: Research Article Source Type: research