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Long term effects of normal calcium–high fat diets on body composition and bone mass, in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity and osteoporosis share a common cell progenitor. High adipocyte count in bone marrow is directly related to bone loss, as fat cells replace osteoblasts. We investigated long-term intake effect of normal calcium (Ca) diets—with different fat content—on body composition and bone mineral content (BMC), in healthy rats. At weaning (21 days), female Wistar rats (n=30) were randomly assigned one of the following 3 groups (n=10 each). G1 was sacrificed in order to get basal values (P0); G2 and G3 were fed ad libitum one of the two isocaloric diets (A; fat=7% wt./wt. or B; fat=15% wt./wt.). Mothers (M1A and M1B) were ...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: E. Hernández, C. Suarez, A. Ferreira Monteiro, P. Rodriguez, M. Gonzáles-Chaves, G. Pellegrini, R. Orzuza, S. Zeni, S. Friedman Source Type: journals

Antioxidant and antiapoptotic properties of quercetin prevent oxidative stress caused by menadione in chick intestineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a previous work we have demonstrated that menadione (MEN) inhibits intestinal Ca2+ absorption by mitochondrial dysfunction, as a consequence of oxidative stress generated via glutathione depletion (GSH) and alteration of inner mitochondrial membrane, which leads to cytochrome c release and DNA fragmentation (Marchionatti et al., Biochim Biophys Acta 2008). Afterwards, we have observed that quercetin (QT) protects the enterocyte against oxidative stress caused by MEN, maintaining the intactness of the glutathione (GSH) content and the enzyme activity of GSH peroxidase (GPX) (Marchionatti et al., Bone 2008). The aim of th...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: A.M. Marchionatti, N. Tolosa de Talamoni Source Type: journals

Sacral fractures: Report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sacral fractures are relatively rare and can constitute a debilitating condition causing low back pain. The etiology is diverse: sacral insufficiency type fractures in elder osteoporotic people, fatigue fractures in young active individuals, metastasis and consequent irradiation therapy in gynaecological malignancies. We hereby describe 2 cases: (a) a 64-year-old woman suffering osteopenia who is under treatment with calcium tablets. She reported lower back pain and difficulty walking in the absence of trauma. Plain radiographs showed a linear fracture in the alae sacrum, while bone scinthigraphic 99mTc methylene dispospho...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: C. Gómez Acotto, E. Santini Araujo, C. Galloso, E. Roldán Source Type: journals

Rat mandible bone response to atherogenic dietEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we hypothesized that atherogenic diets could alter bone remodeling in mandible. Male weanling Wistar rats (n=11), randomly divided into control (C) and experimental (E). C received rodent stock diet (pellets) and E, atherogenic diet (pellets+saturated fatty acids+cholesterol) for 7 weeks (Tf), monitoring anthropometry and diet intake. At Tf, blood (mg/dL) lipid–lipoprotein atherogenic profile: total cholesterol (T-cho), triglycerides (TG), high density lipoprotein-cholesterol (HDL-cho), HDL-non-cholesterol (n-HDL-cho). Dissected hemimandibles, fixed in buffered formalin–PBS 10%, decalcified in EDTA (pH 7...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: C.A. Gamba, V. Macri, M. Gonzalez Chaves, R. Orzuza, V. Zago, P. Rodriguez, P. Mandalunis, S. Zeni, S.M. Friedman Source Type: journals

Connexin43 modulates PTH-induced survival signaling in osteoblasts through its interaction with β-arrestinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Connexin (Cx) 43 expression in osteoblasts is necessary for the cAMP-mediated anti-apoptotic effect of parathyroid hormone (PTH) in vitro and for bone anabolism induced by the hormone in vivo. We found that PTH response in osteoblastic cells silenced for Cx43 using shRNA was restored by expressing wild type Cx43 or a Cx43 mutant unable to form gap junctions, but not by Cx43 mutants lacking the C-terminus tail (Cx43D245) or unable to be phosphorylated at Ser368 (Cx43S368A). These results indicate that channel activity is not required whereas phosphorylation of Ser368 is indispensable for survival by PTH. We have previously ...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: V. Lezcano, N. Bivi, T. Bellido, L.I. Plotkin Source Type: journals

Calcium nutritional status and its relation to oral health, exercise, and lifestyle in a group of students ranging 18 to 34 years oldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Based on the results obtained, there is a high Ca deficiency in the studied group with dietary and lifestyle habits that would affect oral health and, in the future, skeleton status. A nutrition education would benefit the nutritional status and would improve life quality of subjects. (Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: O. Antonenko, G.G. Pellegrini, G. Brito, J. Somoza, S.N. Zeni Source Type: journals

Low fat-free soft mass in legs of Duchenne's disease carriersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Duchenne/Becker muscular dystrophy (DMD/BMD) is an X-linked disease caused by mutations in the dystrophin gene at Xp21 and therefore affects males. In these males, lower bone mineral content and lean mass, and higher fat mass, have been found by several methods, including dual x-ray absorptiometry (DXA). While women are carriers, subtle biochemical and structural alterations have been reported in them (e.g., elevation of serum creatine phosphokinase and muscle weakness). Aiming to assess whether DXA might be used for screening women with suspected DMD/BMD carrier status, whole body scans (GE Lunar Prodigy) were performed i...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: F.D. Saraví, A. Mampel, M.I. Echeverría, A.L. Vargas Source Type: journals

Genotypes of the vitamin D and the estrogen receptors in three osteoporotic members of a familyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is a relationship between some polymorphic sites of the vitamin D receptor and the estrogen receptor genes, and bone mineral density (BMD). The goal of this report is to show this relationship in three members of one family. Patient PC is a 28-year-old male, BMI 19.2 kg/m2. He smokes 10 cigarettes/d. He sustained five peripheral fractures between the ages of 8 and 20 years. When he was 23, radiographs taken for a pre-occupational examination showed osteopenia. Bone densitometry (DXA) showed T-scores of −3.3 (spine) and −3.4 (femur). Causes of secondary osteoporosis were ruled out. Treatment with oral strontium r...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: M. Echecury, E. Nebel, A. Pérez, G. Picotto, N. Tolosa de Talamoni, A. Sánchez Source Type: journals

Late onset of X-linked hypophosphatemic osteomalaciaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
X-linked Hipophosphatemic rickets (Rk) and osteomalacia (Om) is a familiar dominant inheritance disease (PHEX gene mutation) that begin in childhood. Recent studies show sporadic forms and late manifestations. A clinical sporadic case of late onset will be described: A 35 year old Paraguayan woman had bone pains in both hips since her first childbirth (22 years old) and progress after the 2nd delivery. She has no family history of Rk or Om. Hips screw was fixed in both femurs. At physical examination: weight, 70 kg; height, 1.60 m; BMI, 27.3. Inferior limbs are shortened (L), in abduction (R). She had “duck-like” gait ...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: L. Plantalech, M. Buttazzoni, S. González, M.A. Redal Source Type: journals

Does a new source of monounsaturated fatty acids improve lipid profile and body mineral content in nutritional hypercholesterolemia?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In recent years, food industries has demonstrated increased interest in food rich in high-oleic-acid sunflower oil (HOSO, ω9) made from sunflower oil (SO, ω6) to substitute trans-fatty acids. Diets containing HOSO are often promoted to treat nutritional hypercholesterolemia (NHC); however, there are limited data about the effect of this new source of monounsaturated fatty acids (MUFA; HOSO, ω9) on lipid profile and body mineral content (BMC). We performed the study in an experimental model of NH. Weaning male Wistar rats (n=34) were randomly assigned to one of 5 groups (C, Control; E, Experimental). All groups underwent...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: E.V. Macri, N. Juiz, C. Ramos, M.M. Gonzales Chaves, C. Gamba, V. Zago, L. Scherier, P. Rodriguez, S. Zeni, S. Friedman Source Type: journals

Body composition and bone markers in obese (β) growing rats: Influence of the dietary calcium contentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteoporosis and obesity are interrelated. We compare the effect of feeding different dietary Ca levels on body weight (BW) and composition and its relation to bone markers levels, in genetically modified obese (βO) rats during growth. Rats were mated and fed diets varying Ca content (g/100 g): high, 0.9 (GβH); normal, 0.5 (GβN); low, 0.2 (GβL). A Wistar group was run simultaneously (GCW) (fed according to AIN93). At weaning, male pups continued feeding the same diet till 50 days of age. Food consumption and BW were recorded. At the end of the experience, body composition, BAP, BGP, and CTX were determined. Results (m...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: A. Weisstaub, E. Hernández, M.M.S. Gonzáles Chaves, G.G. Pellegrini, C. Marotte, M. Olguin, V. Labourdette, M.L. Portela, S.N. Zeni Source Type: journals

Sporadic hypocalciuric hypercalcemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: relative hypocalciuria is probably not so an unusual finding in PHPT. PTH levels in our patients were higher than those reported in FHH, which suggests PHPT. This diagnosis was confirmed in two patients. The relationship between hypocalciuria and autoimmunity in P4 remains speculative. (Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: M. Pozzo, M. Lozano, M. Rey, H. Claus Hermberg Source Type: journals

Pseudohypoparathyroidism in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pseudohypoparathyroidism (PHP) is an hereditary disease characterized by hypocalcemia and hyperphosphatemia due to resistance to parathyroid hormone. Patients with PHP-Ia often present other hormone resistances and show a physical phenotype called Albright's hereditary osteodistrophy (AHO), brachydactyly, short stature, obesity, round face, mental retardation, and subcutaneous calcifications. We analyzed 13 patients (8 girls) with PHP. The age of beginning of the disease was variable: (X±SD) 4.7±4.4 years old (0.1–12.4). The age of consultation was 7.9.±3.9 years old (2.2–14). The mean Z-score of height was −0.1...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: C. Tau, G. Viterbo, N. Geniuk Source Type: journals

Osteoclastic recruitment in bisphosphonates-treated animals and the relation with splenic and medullary macrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antiresorptive effects of bisphosphonates (BPs) have been extensively studied. However, in vivo data regarding the osteoclast (Oc) and other cells of the mononuclear phagocytic system (MPS) remains controversial. The aim of this work was to study Oc recruitment, number, morphology, and its association with the macrophage population in animals treated with two BPs: alendronate and olpadronate (Gador SA). Wistar rats were divided into three groups: ALN: received alendronate; OPD: received olpadronate; both in an i.p. dose of 0.3 mg/kg/wk during 5 weeks. The sham group received vehicle. All animals received 5-bromo-2-deoxyu...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: N.D. Escudero, N.F. Mina, P.M. Mandalunis Source Type: journals

Histological differences in bones of rats treated with sodium fluoride (NaF) and sodium monofluorophosphate (MFP)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NaF and MFP increased BV% as a consequence of the increase in Tn and Tt. In the case of NaF inflammation, fibrosis, disorganized, and immature bone were observed. This pattern was not present in MFP treated rats. At the cortical level, MFP increased the sectional area of femoral diaphysis. (Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: L.R. Brun, S.M. Roma, F. Pérez, A. Rigalli Source Type: journals

Calcemia and tetany in hypocalcemic models in the ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this work was the development of hypocalcemic models that avoid tetany. After PX, TPTX and ablation of one parathyroid gland (1/2PX), calcemia (before and 5 and 20 days after surgery), tetany, and survival were assessed. Results were expressed as mean±SEM and differences were considered significant when p (Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: M. Lupo, A. Rigalli Source Type: journals

Dual hip densitometry: Analysis of densitometric and geometrical differencesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone mineral density (BMD) of both femurs is often requested in spite of that World Health Organization does not recommend it for assessment of densitometric categories. We used data of patients who realized dual femur densitometry to analyze the variations in densitometric and geometrical properties between both hips. Materials and methods: BMD was measured with DXA (Lunar Prodigy). BMD (mg/cm2) disparities of femoral neck and total hip were analyzed by Z score. Differences in BMD, bone mineral content (BMC, g), area (A, cm2), cross-sectional moment of inertia (CSMI, mm4), hip axis length (HAL, mm), hip axis/diaphysis axi...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: H. Claus Hermberg, M. Lozano, M. Rey, M. Pozzo Source Type: journals

Melatonin reverses apoptosis through which menadione inhibits intestinal calcium absorptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously demonstrated that menadione (MEN) inhibits intestinal calcium (Ca2+) absorption through the mitochondria apoptotic pathway (BBA, 2008). Afterwards, we have observed that this inhibition could be reversed by melatonin (MEL) administration. The aim of this study was to elucidate the molecular mechanisms of this protection caused by MEL. Four-week-old chicks were divided in four groups: 1) controls, 2) treated i.p. with 2.5 μmol MEN/kg of b.w., 3) treated i.p. with 10 mg MEL/kg of b.w., and 4) treated i.p. with MEL after i.p. MEN administration. Glutathione (GSH) content and the activities of superoxide ...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: A.R. Carpentieri, A.M. Marchionatti, A.V. Perez, V.A. Centeno, N.G. Tolosa de Talamoni Source Type: journals

Regulation of endothelial cell function by phytoestrogensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluated whether the isoflavone genistein (Gen) would modulate the cellular and molecular events associated with vascular disease. We employed rat endothelial cell (EC) cultures. After 24 hours of treatment, Gen increased DNA synthesis in synchronized EC (70.52±6.77 vs 41.24±4.49 cpm103/mg prot, Gen vs Control). This action was prevented by the presence of estrogen receptor antagonist ICI 182780 or l-NAME (nitric oxide synthase inhibitor), suggesting that the stimulation of EC growth involves ER and nitric oxide production. To study Gen's effect on leukocyte adhesion to EC, isolated monocytes were ad...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: M. Sandoval, P. Cutini, M.B. Rauschemberger, V. Massheimer Source Type: journals

Effect of aluminum toxicity on biomechanical bone quality in post-hypoxic immature ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aluminum (Al) is a nonessential element to which humans are exposed. Chronic administration induces a negative effect on bone tissue, affecting collagen synthesis and matrix mineralization. Its toxic effects are cumulative. Hypobaric hypoxia (HX) induces stress erythropoiesis leading to hypertrophy of the erythropoietic marrow and may affect bone. The aim of this investigation is to evaluate the chronic effect of aluminum on the architectural properties and the biomechanical quality of femoral diaphysis under hypoxic conditions. Female Sprague-Dawley rats, aged 21 days, received IP doses of 27 mg/kg of elemental Al, as A...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: G. Dmytrenko, M.I. Conti, M.I. Olivera, C. Bozzini, G.M. Champin, M.P. Martínez Source Type: journals

Decrease in femoral neck (FN) bone mineral density (BMD) after menopause: Relative importance of changes in bone mineral content (BMC) and area (A)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone mineral density (BMD) of the femoral neck (FN) suffers a rapid loss during the first 5–7 years after menopause. We investigated the changes of BMC and A (both determine BMD) along life in women after menopause. Materials and methods: In a cross-sectional study, BMD, BMC, and A of left FN were measured with DXA (Lunar Prodigy) in 191 women which required bone routine evaluation. Pearson regression test was used to evaluate the influence of age on the three variables on the whole population (WP) and group (G) 1 (Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: H. Claus Hermberg, M. Lozano, M. Rey, M. Pozzo Source Type: journals

Recovery in serum 25OHD by dietary vitamin D2 or D3 in an experimental model of vitamin D. Insufficiency and established osteopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Under our experimental conditions, vitD2 and vitD3 supplied daily had the same power to maintain and to increase 25(OH)D levels, in both estrogen conditions. PIP 6483. (Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: M. Gonzales Chaves, C. Marotte, G. Pellegrini, S. Friedman, S. Zeni Source Type: journals

Strontium ranelate for the treatment of osteoporosis: Starting at which age? Two clinical casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Strontium ranelate has emerged in the last few years as a first-line treatment for postmenopausal and senile osteoporosis. Its dual mechanism of action, which combines osteoblastic stimulation and osteoclastic inhibition (anabolic and antirresorptive at the same time), makes it an important element in the therapeutic armamentarium for osteoporosis. There is no published information about its use in young patients with osteopenia. We herein show the experience in two patients with secondary osteoporosis: a young male (aged 27 years) with hypopituitarism who persisted osteoporotic after replacement with testosterone and a p...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: J. Chiarpenello, A. Sánchez Source Type: journals

Vitamin D insufficiency in two groups of women from Southern Argentina: Seasonal effectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although it is frequent in elderly people, young adults may also be at risk of having inadequate vitamin D status. On this basis, 25(OH)D was evaluated at the end of winter and summer in the same group of women to observe seasonal changes in vitamin D status and its effect on PTH and bone markers levels. Healthy women from two Southern cities of Argentina: Cro. Rivadavia (45-S) and Ushuaia (54-S) (20 pre- and 20 postmenopausal) were studied in March and August. In fasting blood 25(OH)D (ng/mL) (Diasorin), PTHmm (pg/mL), b-ALP (IU/L), and CTX (ng/L) (Crosslaps, Osteometer Bio Tech) were evaluated. Results: Mean±SD levels a...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: G. Pellegrini, M. Gonzales-Chaves, M. Fajardo, G. Ponce, J. Somoza, G. Toyos, S. Zeni Source Type: journals

Doses-dependent effect of propranolol on bone biomechanical performance in an animal model of growth retardationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies performed in our laboratory showed that propranolol (P) attenuates the impairment of bone biomechanical performance in an animal model of growth retardation (NGR). The aim of the present work was to study the effect of different doses of P on morphometric parameters and bone structural properties in NGR rats. Weanling male Wistar rats were randomly assigned to eight groups: Control (C), C+P3.5, C+P7, C+P10.5, NGR, NGR+P3.5, NGRP+P7, and NGRP+P10.5. C and CP rats were fed freely with the standard diet. NGR and NGRP rats received, for 4 weeks (W4), 80% of the amount of food consumed by C and CP, respectivel...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: C.h.E. Lezón, M.I. Olivera, C. Bozzini, G. Champín, R.M. Alippi, P.M. Boyer Source Type: journals

Calcium intake and its relationship to overweight and obesity. Data obtained from the National Survey of Nutrition and Health (ENNyS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several studies performed in Argentina showed high prevalence of deficient calcium (Ca) intake independently of age and socioeconomic conditions. Overweight (OW) and obesity (OB) are increasing worldwide; Argentina is not an exception. In this regard, several epidemiological studies showed an inverse relationship between adiposity and Ca intake expressed as a quotient of caloric intake. The ENNyS during 2004–2005 detected high prevalence of inadequate Ca intake in women between 18 and 49 years old. However, the interrelationship between Ca intake and OW or OB has not been evaluated yet. The present study determined the ...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: L. Kogan, E. Abeya-Gilardon, G. Mangiolavori, A. Biblieri, S.N. Zeni Source Type: journals

Osteonecrosis of the jaw (ONJ) in chronically treated patients with bisphosphonates (BPS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report our experience in patients under BPs chronic treatment who were referred to us since 2007 by Buenos Aires suburban hospitals to the Dentomaxillofacial Department, School of Dentistry, Buenos Aires University. One man and fifteen women (62.75±4 years old) with ONJ diagnosis under BPs treatment administered during at least 6 months were evaluated. A total of 12 patients were treated with one BPs (alendronate: 56.25%; pamidronate: 12.50%; zolendronate: 25%; risendronate: 6.25%); the remaining were treated with two BPs: pamidronate/zolendronate, 1; alendronate/zolendronate, 2; and alendronate/pamidronate, 1. Two pa...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: S. Picardo, G.G. Pellegrini, E. Rey, S.N. Zeni Source Type: journals

Involvement of caveolin-1 in 1α,25(OH)2-vitamin D3 regulation of c-Src, MAPK cascades, and VDR localization in skeletal muscle cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previously, we demonstrated that 1,25-dihydroxi-vitamin D3 [1,25(OH)2D3] induces non-transcriptional rapid responses through activation of MAPKs in the skeletal muscle cell line C2C12. However, there is no information on the molecular mechanism underlying the initiation of 1,25(OH)2D3 signaling through these pathways. Lipid raft components have been involved in steroid non-genomic effects. In this work we investigated the role of caveolae and caveolin-1 (cav-1) in phosphorylation of MAPKs and c-Src activation by 1,25(OH)2D3. When proliferating C2C12 cells were pre-treated with methyl-beta-cyclodextrin (MbCD), a caveolae di...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: C. Buitrago, R. Boland Source Type: journals

Protective role of sex hormones in apoptosis of skeletal muscleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The loss of muscle mass and strength with aging, also referred to as sarcopenia, is a prevalent condition among elderly and predicts adverse outcomes, including disability, institutionalization, and mortality. Sarcopenia has been associated to a deficit of sex hormones since the levels of estrogens and/or testosterone decline upon ageing. Although the mechanisms underlying sarcopenia are far for being clarified, evidence suggests that an age-related acceleration of myocyte loss via apoptosis might represent a mechanism responsible for muscle loss performance. Furthermore, increased levels of apoptosis have also been report...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: L. Pronsato, A. Ronda, L. Milanesi, A. Vasconsuelo, R. Boland Source Type: journals

Experimental models of nutritional deficiencies and hormonal status that influence bone massEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elderly people often had a low food intake and sun exposure which could contribute to the high prevalence of osteopenia and fracture risk observed in this population. To evaluate the influence of the low protein intake and/or vitamin D (vit. D) status in the pathogenesis of osteoporosis, we developed the present experimental models. Wistar rats (300±50 g) were OVX (n=20) or SHAM operated (n=20). During 15 days after surgery, all rats were fed a diet containing 15% protein and 200 IU% of vit. D. Then, rats were divided into 5 groups, fed a specified diet during an additional period of 45 days: G1: SHAM+15% casein and 2...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: C. Marotte, M.M.S. Gonzales Chaves, G.G. Pellegrini, P. Mandalunis, S.M. Friedman, S.N. Zeni Source Type: journals

Prevalence of deficit of vitamin D in patients with overweight and obesityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vitamin D (VD) is essential for bone and muscle health. Obesity is a risk factor for hypovitaminosis D because obese patients often have less exposure to UV radiation either by making physical activity less or the possible kidnapping of VD by the adipocytes. This determined lower synthesis of 25(OH) VD due to a negative feedback with 1.25(OH)2D and PTH. A recent survey shows that 10.6% of people between 20 and 49 years were overweight and obese and have VD values ≥36 ng/ml. Objective: To establish the prevalence of VD deficiency in postmenopausal (PM), osteoporotic, overweight, and obese women. Materials and methods: 39...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: M. Larrroude, M. Moggia, R. Díaz, M. Pérez Sainz, G. Macías, Z. Man Source Type: journals

25-OH-Vitamin D serum levels in patients with osteogenesis imperfecta from VenezuelaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present study was to evaluate 25-OH-vitamin D levels in 41 patients from Venezuela with OI randomly selected from the total population of affected patients in Venezuela; 31 of them had received treatment with pamidronate before, but none had received oral vitamin D supplements. 25-OH-Vitamin D levels were measured in Buenos Aires by a commercial radioimmune assay (Diasorin, Stillwater, MN, USA). Patients were classified according to Holick in deficient (< 20 ng/ml), insufficient (20–32 ng/ml), sufficient (32–100 ng/ml), or with normal levels (54–90 ng/ml). Of the 41 patients, 26 (63%) were women ...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: E.Y. Herrera González, E. Fradinger, A.L. Negri Source Type: journals

Extracellular ATP activates MAP kinase cascades and increases intestinal Caco-2 cell proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the role of ATP in the activation of the MAP kinases (MAPKs) ERK1/2, JNK1/2, and p38 and their involvement in the modulation of transcription factors and proliferation of human colon cancer Caco-2 cells. ATP induces the phosphorylation of MAPKs in a time- and dose-dependent manner. Moreover, UTP and ATPgS but not ADP or ADPβS increased phosphorylation of MAPKs, indicating the involvement of, at least, P2Y2/P2Y4 purinergic receptor subtypes. RT–PCR studies and PCR product sequencing supported the expression of P2Y2 and P2Y4 receptors in this cell line. Spectrofluorimetric measurements showed that cell stimula...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: N. Buzzi, P. Scodelaro Bilbao, R. Boland, A. Russo de Boland Source Type: journals

Relationship in the musculo-skeletal syndrome Prader–WilliEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It can be concluded that a possible cause of osteopenia is due to the lack of adequate stimulation of bone mechanostat. The lack in muscular mass due to sedentary lifestyle and overweight are important factors to consider in this syndrome. (Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: V. Montangero, R. Capiglioni, E. Roldan Source Type: journals

AnnouncementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Source Type: journals

IBMS Membership ApplicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Source Type: journals

IBMS 2009 Corporate PartnersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Bone - October 29, 2009 Category: Orthopaedics Source Type: journals

IBMS Elected Board of Directors 2009 - 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Bone)
Source: Bone - October 29, 2009 Category: Orthopaedics Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Bone - October 29, 2009 Category: Orthopaedics Source Type: journals

Corrigendum to “Effects of silencing connective tissue growth factor (CTGF) by RNA interference on expression of matrix metalloproteinase-1 and -2 in human osteoblasts” [Bone 43 (2008) S41–S41]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The author regrets that the institution was inadvertently omitted from the affiliation line. The corrected affiliation appears above. (Source: Bone)
Source: Bone - October 5, 2009 Category: Orthopaedics Authors: Yiqun Peng, Guoliang Sui, Eryuan Liao Tags: Corrigendum Source Type: journals

AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Bone - September 28, 2009 Category: Orthopaedics Source Type: journals

IBMS Membership ApplicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Bone - September 28, 2009 Category: Orthopaedics Source Type: journals

IBMS 2009 Corporate PartnersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Bone - September 28, 2009 Category: Orthopaedics Source Type: journals

IBMS Elected Board of Directors 2009–2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Bone - September 28, 2009 Category: Orthopaedics Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Bone)
Source: Bone - September 28, 2009 Category: Orthopaedics Source Type: journals

Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral densityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Polymorphisms of the sex hormone-binding globulin (SHBG) gene are associated with differences in SHBG levels, influencing the risk for breast cancer and polycystic ovarian syndrome, but no association has been reported for osteoporosis in postmenopausal women.Objective: To determine the effect of G to A substitution in the 5′UTR (rs1799941) and the Asp356Asn (rs6259) polymorphisms of the SHBG gene on bone mineral density (BMD).Methods: This is a cross-sectional study in a university-based research center from May, 2002 to December, 2007. A total of two hundred and thirteen healthy postmenopausal Cau...
Source: Bone - September 28, 2009 Category: Orthopaedics Authors: Nicola Napoli, Ana Varadharajan, Giovam Batista Rini, Romano Del Fiacco, Jayasree Yarramaneni, Steven Mumm, Dennis T. Villareal, Reina Armamento-Villareal Tags: Original Articles Source Type: journals

Sonic hedgehog alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of bone marrow stromal cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: To assess the influence of high extracellular glucose levels on the osteogenic differentiation of bone marrow stromal cells (BMSCs) and to determine if Sonic hedgehog (Shh) protein can alleviate those effects. BMSCs were incubated with NG (normal glucose), NG+Shh (200 ng/ml Shh in normal glucose), NG+Shh+Gan (200 ng/ml Shh and 5 μmol/L GANT61 in normal glucose), HG (high glucose), HG+Shh (200 ng/ml Shh in high glucose), and HG+Shh+Gan (200 ng/ml Shh and 5 μmol/L GANT61 in high glucose). The expression levels of Shh signaling pathway genes Patched 1 (PTCH1) and osteogenesis-related genes were tested, which...
Source: Bone - September 14, 2009 Category: Orthopaedics Authors: Cheng-chao Guan, Ming Yan, Xin-quan Jiang, Ping Zhang, Xiu-li Zhang, Jing Li, Dong-xia Ye, Fu-qiang Zhang Tags: Original Articles Source Type: journals

A 246-km continuous running race causes significant changes in bone metabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study showed that an ultra-distance run of nearly 250 km induced changes in RANK/RANKL/OPG interaction, which suggests a transient uncoupling of bone metabolism, increased bone resorption, and suppressed bone formation. (Source: Bone)
Source: Bone - September 9, 2009 Category: Orthopaedics Authors: Katharina Kerschan-Schindl, Markus Thalmann, Gottfried H. Sodeck, Katerina Skenderi, Antonia L. Matalas, Stephan Grampp, Christof Ebner, Peter Pietschmann Tags: Original Articles Source Type: journals

Grizzly bears (Ursus arctos horribilis) and black bears (Ursus americanus) prevent trabecular bone loss during disuse (hibernation)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Disuse typically causes an imbalance in bone formation and bone resorption, leading to losses of cortical and trabecular bone. In contrast, bears maintain balanced intracortical remodeling and prevent cortical bone loss during disuse (hibernation). Trabecular bone, however, is more detrimentally affected than cortical bone in other animal models of disuse. Here we investigated the effects of hibernation on bone remodeling, architectural properties, and mineral density of grizzly bear (Ursus arctos horribilis) and black bear (Ursus americanus) trabecular bone in several skeletal locations. There were no difference...
Source: Bone - September 7, 2009 Category: Orthopaedics Authors: Meghan E. McGee-Lawrence, Samantha J. Wojda, Lindsay N. Barlow, Thomas D. Drummer, Alesha B. Castillo, Oran Kennedy, Keith W. Condon, Janene Auger, Hal L. Black, O. Lynne Nelson, Charles T. Robbins, Seth W. Donahue Tags: Original Articles Source Type: journals

Chloride intracellular channel 1 regulates osteoblast differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We have identified chloride intracellular channel 1 (CLIC1) through proteomic approach, which was increased in response to canonical wnt signaling while being almost shut-off by adipogenic treatment in mouse mesenchymal C3H10T1/2 cells. We found that CLIC1 was expressed in mouse (MC3T3-E1), rat (ROS 17/2.8 and UMR-106) or human (MG63 and SaOS2) osteoblastic cell lines as well as primary culture of mouse calvarial cells by RT-PCR or Western blot analysis. The expression level of CLIC1 is increased upon treatment of osteogenic medium, whereas it almost disappeared in adipogenic condition, confirming the proteomic d...
Source: Bone - September 7, 2009 Category: Orthopaedics Authors: Jae-Yeon Yang, Ju Yeon Jung, Sun Wook Cho, Hyung Jin Choi, Sang Wan Kim, Seong Yeon Kim, Hee Joong Kim, Chang Han Jang, Min Goo Lee, Jin Han, Chan Soo Shin Tags: Original Articles Source Type: journals