PI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer
Breast Cancer. 2024 Apr 17. doi: 10.1007/s12282-024-01567-5. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is a highly heterogeneous tumor lacking estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. It has higher aggressiveness and metastasis than other subtypes, with limited effective therapeutic strategies, leading to a poor prognosis. The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is prevalently over-activated in human cancers and contributes to breast cancer (BC) gro...
Source: Breast Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Huan-Ping Zhang Rui-Yuan Jiang Jia-Yu Zhu Ke-Na Sun Yuan Huang Huan-Huan Zhou Ya-Bing Zheng Xiao-Jia Wang Source Type: research
The usefulness of artificial intelligence in breast reconstruction: a systematic review
CONCLUSIONS: In breast reconstruction, AI can help the surgeon by optimizing the perioperative patients' counseling to predict negative outcomes, allowing execution of timely interventions and reducing the postoperative burden, which leads to obtaining the most successful results and improving patient satisfaction.PMID:38619786 | DOI:10.1007/s12282-024-01582-6 (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Karla C Maita Francisco R Avila Ricardo A Torres-Guzman John P Garcia Gioacchino D De Sario Velasquez Sahar Borna Sally A Brown Clifton R Haider Olivia S Ho Antonio Jorge Forte Source Type: research
Inter- and intra-observer variability of qualitative visual breast-composition assessment in mammography among Japanese physicians: a first multi-institutional observer performance study in Japan
CONCLUSIONS: Qualitative visual assessment of mammographic breast composition using the new Japanese classification revealed excellent intra-observer reproducibility. However, persistent inter-observer variability, presenting a challenge in establishing it as the gold standard in Japan.PMID:38619787 | DOI:10.1007/s12282-024-01580-8 (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Yoichi Koyama Kazuaki Nakashima Shunichiro Orihara Hiroko Tsunoda Fuyo Kimura Natsuki Uenaka Kanako Ban Yukiko Michishita Yoshihide Kanemaki Arisa Kurihara Kanae Tawaraya Masataka Taguri Takashi Ishikawa Takayoshi Uematsu Source Type: research
The usefulness of artificial intelligence in breast reconstruction: a systematic review
CONCLUSIONS: In breast reconstruction, AI can help the surgeon by optimizing the perioperative patients' counseling to predict negative outcomes, allowing execution of timely interventions and reducing the postoperative burden, which leads to obtaining the most successful results and improving patient satisfaction.PMID:38619786 | DOI:10.1007/s12282-024-01582-6 (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Karla C Maita Francisco R Avila Ricardo A Torres-Guzman John P Garcia Gioacchino D De Sario Velasquez Sahar Borna Sally A Brown Clifton R Haider Olivia S Ho Antonio Jorge Forte Source Type: research
Inter- and intra-observer variability of qualitative visual breast-composition assessment in mammography among Japanese physicians: a first multi-institutional observer performance study in Japan
CONCLUSIONS: Qualitative visual assessment of mammographic breast composition using the new Japanese classification revealed excellent intra-observer reproducibility. However, persistent inter-observer variability, presenting a challenge in establishing it as the gold standard in Japan.PMID:38619787 | DOI:10.1007/s12282-024-01580-8 (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Yoichi Koyama Kazuaki Nakashima Shunichiro Orihara Hiroko Tsunoda Fuyo Kimura Natsuki Uenaka Kanako Ban Yukiko Michishita Yoshihide Kanemaki Arisa Kurihara Kanae Tawaraya Masataka Taguri Takashi Ishikawa Takayoshi Uematsu Source Type: research
Acute adverse events of ultra-hypofractionated whole-breast irradiation after breast-conserving surgery for early breast cancer in Japan: an interim analysis of the multi-institutional phase II UPBEAT study
CONCLUSIONS: Acute AEs following ultra-HF-WBI were within acceptable limits among Japanese women, indicating that the continuation of the study was appropriate.PMID:38607499 | DOI:10.1007/s12282-024-01577-3 (Source: Breast Cancer)
Source: Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Peter J K Tokuda Takamasa Mitsuyoshi Yuka Ono Takahiro Kishi Yoshiharu Negoro Setsuko Okumura Itaru Ikeda Takashi Sakamoto Yumi Kokubo Ryo Ashida Toshiyuki Imagumbai Mikiko Yamashita Hiroaki Tanabe Sayaka Takebe Mariko Tokiwa Eiji Suzuki Chikako Yamauchi Source Type: research
Acute adverse events of ultra-hypofractionated whole-breast irradiation after breast-conserving surgery for early breast cancer in Japan: an interim analysis of the multi-institutional phase II UPBEAT study
CONCLUSIONS: Acute AEs following ultra-HF-WBI were within acceptable limits among Japanese women, indicating that the continuation of the study was appropriate.PMID:38607499 | DOI:10.1007/s12282-024-01577-3 (Source: Breast Cancer)
Source: Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Peter J K Tokuda Takamasa Mitsuyoshi Yuka Ono Takahiro Kishi Yoshiharu Negoro Setsuko Okumura Itaru Ikeda Takashi Sakamoto Yumi Kokubo Ryo Ashida Toshiyuki Imagumbai Mikiko Yamashita Hiroaki Tanabe Sayaka Takebe Mariko Tokiwa Eiji Suzuki Chikako Yamauchi Source Type: research
Sacituzumab govitecan in metastatic triple-negative breast cancer patients treated at Institut Curie Hospitals: efficacy, safety, and impact of brain metastases
CONCLUSIONS: The observed response rate and safety of SG are consistent with the results of the ASCENT trial, with efficacy observed in patients with brain metastases, but observed PFS and OS are numerically shorter.PMID:38600429 | DOI:10.1007/s12282-024-01565-7 (Source: Breast Cancer)
Source: Breast Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Alexandre De Moura Delphine Loirat Sarah Vaillant Sinen Korbi Nicolas Kiavue Diana Bello Roufai Laurence Escalup Romain Desmaris Pauline Vaflard Paul Cottu Jean-Yves Pierga Fran çois-Clément Bidard Luc Cabel Alexandre Acramel Source Type: research
Sacituzumab govitecan in metastatic triple-negative breast cancer patients treated at Institut Curie Hospitals: efficacy, safety, and impact of brain metastases
CONCLUSIONS: The observed response rate and safety of SG are consistent with the results of the ASCENT trial, with efficacy observed in patients with brain metastases, but observed PFS and OS are numerically shorter.PMID:38600429 | DOI:10.1007/s12282-024-01565-7 (Source: Breast Cancer)
Source: Breast Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Alexandre De Moura Delphine Loirat Sarah Vaillant Sinen Korbi Nicolas Kiavue Diana Bello Roufai Laurence Escalup Romain Desmaris Pauline Vaflard Paul Cottu Jean-Yves Pierga Fran çois-Clément Bidard Luc Cabel Alexandre Acramel Source Type: research
Association between quality of life and mortality risk in patients with breast cancer: a systematic review and meta-analysis
CONCLUSIONS: Physical QOL, emotional QOL, and role QOL are associated with mortality risk in patients with breast cancer. Furthermore, post-treatment physical QOL showed a more significant association with prolonged survival than pre-treatment physical QOL.PMID:38592636 | DOI:10.1007/s12282-024-01581-7 (Source: Breast Cancer)
Source: Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Katsuyoshi Suzuki Shinichiro Morishita Jiro Nakano Taro Okayama Junichiro Inoue Takashi Tanaka Takuya Fukushima Source Type: research
Association between quality of life and mortality risk in patients with breast cancer: a systematic review and meta-analysis
CONCLUSIONS: Physical QOL, emotional QOL, and role QOL are associated with mortality risk in patients with breast cancer. Furthermore, post-treatment physical QOL showed a more significant association with prolonged survival than pre-treatment physical QOL.PMID:38592636 | DOI:10.1007/s12282-024-01581-7 (Source: Breast Cancer)
Source: Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Katsuyoshi Suzuki Shinichiro Morishita Jiro Nakano Taro Okayama Junichiro Inoue Takashi Tanaka Takuya Fukushima Source Type: research
Association between quality of life and mortality risk in patients with breast cancer: a systematic review and meta-analysis
CONCLUSIONS: Physical QOL, emotional QOL, and role QOL are associated with mortality risk in patients with breast cancer. Furthermore, post-treatment physical QOL showed a more significant association with prolonged survival than pre-treatment physical QOL.PMID:38592636 | DOI:10.1007/s12282-024-01581-7 (Source: Breast Cancer)
Source: Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Katsuyoshi Suzuki Shinichiro Morishita Jiro Nakano Taro Okayama Junichiro Inoue Takashi Tanaka Takuya Fukushima Source Type: research
Investigation of recurrence prediction ability of EndoPredict < sup > ® < /sup > using microarray data from fresh frozen tissues in ER-positive, HER2-negative breast cancer and indication expansion of EndoPredict < sup > ® < /sup > from microarray data from fresh-frozen to FFPE tissues
CONCLUSIONS: EP using microarray data from FF tissues was useful in predicting distant recurrence risk in luminal breast cancer, and EP might be utilized in microarray data from FFPE tissues.PMID:38587783 | DOI:10.1007/s12282-024-01573-7 (Source: Breast Cancer)
Source: Breast Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Akira Watanabe Ryo Tsunashima Chikage Kato Sae Kitano Saya Matsumoto Yoshiaki Sota Midori Morita Koichi Sakaguchi Yasuto Naoi Source Type: research
Nipple-areolar complex malposition in breast reconstruction after nipple-sparing mastectomy: a multi-institutional retrospective observational study in Japan
CONCLUSIONS: This study provides insights into the tendencies and characteristics of NAC malposition.PMID:38589713 | DOI:10.1007/s12282-024-01578-2 (Source: Breast Cancer)
Source: Breast Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Sayuri Kato Hiroki Mori Miho Saiga Satoko Watanabe Shinsuke Sasada Ayano Sasaki Akiko Ogiya Mao Yamamoto Kazutaka Narui Junji Takano Hirohito Seki Naomi Nagura Makoto Ishitobi Tadahiko Shien Collaborative Study Group of Scientific Research of the Japanese Source Type: research
The Japanese breast cancer society clinical practice guidelines for radiation treatment of breast cancer, 2022 edition
We present the English version of the Radiation Therapy (RT) section of the guidelines. The JBCS formed a task force to update the 2018 version of the JBCS Clinical Practice Guidelines. The Background Questions (BQs) contain the standard treatments for breast cancer in clinical practice, whereas the Clinical Questions (CQs) address daily clinical questions that remain controversial. Future Research Questions (FRQs) explore the subjects that are considered important issues, despite there being insufficient data for inclusion as CQs. The task force selected the 12 BQs, 8 CQs, and 6 FRQs for the RT section. For each CQ, syste...
Source: Breast Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Michio Yoshimura Chikako Yamauchi Naoko Sanuki Yasushi Hamamoto Kimiko Hirata Jiro Kawamori Mariko Kawamura Mami Ogita Yutaka Yamamoto Hiroji Iwata Shigehira Saji Source Type: research
