Breast Cancer Research and Treatment
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1311 records returned
Five common single nucleotide polymorphisms in the PALB2 gene and susceptibility to breast cancer in eastern Chinese population
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Abstract Certain rare germline mutations in the PALB2 gene have been confirmed to increase susceptibility to breast cancer in diverse
populations, but it has not been very clear that whether some common polymorphic variants in PALB2 also increase breast cancer
risk. We conducted a case–control study to validate the association of common variations in the PALB2 gene and breast cancer
in eastern Chinese population. A total of six common single nucleotide polymorphisms (rs8053188, rs16940342, rs249954, rs447529,
rs249935, and rs3096145), which tagged the known common variants (minor allele frequency >0.1) ...
Source: Breast Cancer Research and Treatment - November 18, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer riskEmail this article to a colleague.
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Abstract MicroRNAs (miRNAs) regulate pathways involved in cell differentiation, proliferation, development, and apoptosis by degradation
of target mRNAs and/or repression of their translation. Although the single nucleotide polymorphisms (SNPs) in miRNAs target
sites have been studied, the effects of SNPs in miRNAs are largely unknown. In our study, we first systematically sequenced
miRNA genes reported to be involved in breast cancer to identify/verify SNPs. We analyzed four SNPs, one located in the pre-miRNA
and the other three located in miRNA flanking regions, for a putative association with breast cance...
Source: Breast Cancer Research and Treatment - November 18, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cellsEmail this article to a colleague.
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Abstract Zinc-finger enhancer binding protein (ZEB1) is a transcription factor involved in the progression of cancer primarily through
promoting epithelial to mesenchymal transition (EMT). ZEB1 represses the expression of E-cadherin by binding to E-box sequences
in the promoter, thus decreasing epithelial differentiation. We show that ZEB1 and androgen receptor (AR) cross-talk in triple
negative breast cancer cell lines. Chromatin immunoprecipitation analysis demonstrates that ZEB1 binds directly to the E-box
located in the AR promoter. ZEB1 suppression by stably transfecting shRNA in a triple negative breas...
Source: Breast Cancer Research and Treatment - November 18, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Gene promoter methylation is associated with increased mortality among women with breast cancerEmail this article to a colleague.
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Abstract To better understand breast cancer etiology and progression, we explored the association between promoter methylation status
of three breast cancer-related genes (BRCA1, APC, and p16) and survival in a large cohort of women with breast cancer. About 800 archived tumor tissues were collected from women diagnosed
with a first primary invasive or in situ breast cancer in 1996–1997. The vital status of the participants was followed through
the end of year 2005 with a mean follow-up time of 8.0 years. Promoter methylation was assessed by methylation-specific PCR
(for BRCA1) and MethyLight (for APC...
Source: Breast Cancer Research and Treatment - November 18, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriersEmail this article to a colleague.
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This study showed no evidence for altered risk of breast cancer for individuals with the GSTT1 and GSTM1 deletion variants, but did report that the GSTP1 Ile105Val (rs1695) variant was associated with increased breast cancer risk in carriers. We investigated the association
between these three GST polymorphisms and breast cancer risk using existing data from 718 women BRCA1 and BRCA2 mutation carriers from Australia, the UK, Canada, and the USA. Data were analyzed within a proportional hazards framework
using Cox regression. There was no evidence to show that any of the polymorphisms modified disease risk for BRCA1 or BR...
Source: Breast Cancer Research and Treatment - November 18, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Concordant HER2 status between metastatic breast cancer cells in CSF and primary breast cancer tissueEmail this article to a colleague.
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Abstract It is not known whether the HER2 status of malignant CSF cells coincides with that of the original breast carcinoma cells.
We investigated whether CSF cytology specimens were suitable to evaluate HER2 status by fluorescence in situ hybridization
(FISH) in patient with leptomeningeal metastasis (LM). Both formalin-fixed paraffin-embedded (FFPE) breast cancer tissue and
liquid based CSF cytology specimens were evaluated for HER2 status in 16 patients with LM. We evaluated HER2 gene amplification using FISH on destained CSF cytology slides containing a minimum of 20 malignant cells per slide, and
compa...
Source: Breast Cancer Research and Treatment - November 14, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancerEmail this article to a colleague.
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Abstract The Notch ligand, JAG1 is associated with breast cancer recurrence. Herein, we report on a genomics approach to elucidate
mechanisms downstream of JAG1 that promote breast cancer growth. In a survey of 46 breast cancer cell lines, we found that
triple negative (TN; basal and mesenchymal ER-, PR-, and Her2-negative) lines express JAG1 at significantly higher levels
than do HER2+ or luminal (ER+) Her2− cell lines. In contrast to the luminal lines tested (T47D and MCF7), TN breast cancer cell lines (HCC1143 and MDA MB231)
display high-level JAG1 expression and growth inhibition with RNA interference-...
Source: Breast Cancer Research and Treatment - November 13, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Fifteen-year trends in metastatic breast cancer survival in GreeceEmail this article to a colleague.
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In this study, information is based on a total of 1361 patients with a median follow up of 3.7 years and median survival
of 1.9 years (median survival 1.28, 1.68, 2.20, and 2.57 years for 1991–1994, 1995–1998, 1999–2002, and 2003–2006, respectively).
Survival improved significantly across diagnosis time periods, by 25, 44, and 51%, respectively, in each time period (1995–1998:
HR = 0.75, P = 0.004; 1999–2002: HR = 0.56, P < 0.001; 2003–2006: HR = 0.49, P < 0.001) as compared to the first time period (1991–1994). The effect o...
Source: Breast Cancer Research and Treatment - November 13, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cellsEmail this article to a colleague.
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Abstract Tamoxifen is the most frequently used anti-hormonal drug for treatment of women with hormone-dependent breast cancer. The
aim of this study is to investigate the mechanism of tamoxifen resistance and the impact of the new estrogen G-protein coupled
receptor (GPR30). MCF-7 cells were continuously exposed to tamoxifen for 6 months to induce resistance to the inhibitory effect
of tamoxifen. These tamoxifen-resistant cells (TAM-R) exhibited enhanced sensitivity to 17-ß-estradiol and GPR30 agonist,
G1, when compared to the parental cells. In TAM-R cells, tamoxifen was able to stimulate the cell gro...
Source: Breast Cancer Research and Treatment - November 12, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironmentEmail this article to a colleague.
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In this study, we sought
to examine the prognostic relevance of ALDH1, a putative cancer stem cell marker, by immunohistochemistry. The four cohorts
analyzed included an adjuvantly treated series of 245 invasive cancers, a neoadjuvantly treated series of 34 cases, and two
series of 58 and 40 triple negative cases, respectively. Both tumor cell and stromal expression for ALDH1 was evaluated, where
possible. Tumor cell ALDH1 expression significantly correlated only with basal-like and HER2 tumor types in the adjuvant series
and tumor grade in the neoadjuvant cohort. No significant enrichment for ALDH1 positive cells was...
Source: Breast Cancer Research and Treatment - November 12, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Women’s decisions regarding tamoxifen for breast cancer prevention: responses to a tailored decision aidEmail this article to a colleague.
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This study is the largest to date to test women’s preferences for taking
tamoxifen and one of the largest to have tested the impact of a tailored DA. After viewing the DA, women demonstrated good
understanding of tamoxifen’s risks and benefits, but most were not interested in taking tamoxifen for breast cancer chemoprevention.
Content Type Journal ArticleCategory Clinical TrialDOI 10.1007/s10549-009-0618-4Authors
Angela Fagerlin, Ann Arbor VA HSR&D, Center for Clinical Management Research Ann Arbor MI USABrian J. Zikmund-Fisher, Ann Arbor VA HSR&D, Center for Clinical Management Research Ann Arbor MI USADylan M....
Source: Breast Cancer Research and Treatment - November 11, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Some common mutations of RAD50 and NBS1 in western populations do not contribute significantly to Chinese non-BRCA1/2 hereditary breast cancerEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10549-009-0629-1Authors
A-Yong Cao, Fudan University Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Institutes of Biomedical Science 270 Dong’an Road 200032 Shanghai People’s Republic of ChinaZhen Hu, Fudan University Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Institutes of Biomedical Science 270 Dong’an Road 200032 Shanghai People’s Republic of ChinaWen-Jin Yin, Fudan University Breast Cancer Institute, Cancer Hospi...
Source: Breast Cancer Research and Treatment - November 10, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancerEmail this article to a colleague.
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Abstract GPR30 is a novel G protein-coupled estrogen receptor (ER) associated with metastases in breast cancer (BC) and poor survival
in endometrial and ovarian tumors. The association of GPR30 expression with inflammatory breast cancer (IBC), an aggressive
and commonly hormone-independent form of BC, has not been studied. GPR30, ER, progesterone receptor (PR), epidermal growth
factor receptor (EGFR), and HER-2 expression were assessed by immunohistochemistry (and FISH for HER-2) in 88 primary IBCs.
GPR30 expression was correlated with patient overall survival (OS), disease-free survival (DFS), pathologic va...
Source: Breast Cancer Research and Treatment - November 9, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Gli1 promotes cell survival and is predictive of a poor outcome in ERα-negative breast cancerEmail this article to a colleague.
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In conclusion, we demonstrate a positive association between expression of Gli1 and
ERα; however, our data indicate a greater functional effect of Gli1 in ERα-negative cancers.
Content Type Journal ArticleCategory Preclinical StudyDOI 10.1007/s10549-009-0617-5Authors
Lusheng Xu, University of Alabama at Birmingham Department of Pathology Kaul 640B, 1530 Third Avenue South Birmingham AL 35294 USAYeon-Jin Kwon, University of Alabama at Birmingham Department of Pathology Kaul 640B, 1530 Third Avenue South Birmingham AL 35294 USANatalya Frolova, University of Alabama at Birmingham Department of Pathology Kaul 640B, 153...
Source: Breast Cancer Research and Treatment - November 9, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
A unique proteolytic fragment of alpha1-antitrypsin is elevated in ductal fluid of breast cancer patientEmail this article to a colleague.
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In conclusion, elevated C-41/42 is likely the result of elevated AAT synthesis,
and the activity of specific MMPs present within the tumor. As other C-terminal fragments of AAT are reported to function
as tumor-derived suppressors to the host immune-system, elevated C-41/42 may also be predictive of a poor outcome.
Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-009-0625-5Authors
Junma Zhou, Johns Hopkins Medical Institutions Department of Pathology Baltimore MD 21287 USABruce Trock, Johns Hopkins Medical Institutions Department of Urology Baltimore MD 21287 USATheodore N. Tsangaris, Johns H...
Source: Breast Cancer Research and Treatment - November 9, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cellsEmail this article to a colleague.
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In this study, we determined that GM-CSF was one of the tumor-derived soluble factors that induced differentiation of CD11b-Gr1-
progenitor cells from within monocytic/granulocytic bone marrow cells into CD11b+Gr1+ cells. We also showed that CD11b+Gr1+
cells in FVBN202 mice consisted of CD11b+Ly6G-Ly6C+ suppressive and CD11b+Ly6G+Ly6C+ non-suppressive subsets. Previously reported
variations between tumor-free and tumor-bearing animals in the function of their CD11b+Gr1+ cells were found to be due to
the variations in the proportion of these two subsets. Therefore, increasing ratios of CD11b+Gr1+ cells derived from tumo...
Source: Breast Cancer Research and Treatment - November 7, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Targeting breast stem cells with the cancer preventive compounds curcumin and piperineEmail this article to a colleague.
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Abstract The cancer stem cell hypothesis asserts that malignancies arise in tissue stem and/or progenitor cells through the dysregulation
or acquisition of self-renewal. In order to determine whether the dietary polyphenols, curcumin, and piperine are able to
modulate the self-renewal of normal and malignant breast stem cells, we examined the effects of these compounds on mammosphere
formation, expression of the breast stem cell marker aldehyde dehydrogenase (ALDH), and Wnt signaling. Mammosphere formation
assays were performed after curcumin, piperine, and control treatment in unsorted normal breast epithel...
Source: Breast Cancer Research and Treatment - November 6, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Clinical relevance of the putative stem cell marker p63 in breast cancerEmail this article to a colleague.
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Abstract P63 is a member of the p53 family. This protein is crucial for the maintenance of a stem cell population in the human epithelium
and necessary for the normal development of all epithelial tissues including mammary glands. In normal breast tissue, the
p63 seems to be a specific myoepithelial cell marker. P63 expression has been described in highly aggressive ER negative basal-like
breast tumors. The value of p63 expression in ER positive disease is less clear. The expression levels of p63 mRNA by Affymetrix
microarray analysis in a combined cohort of 2,158 ER positive breast cancers and its prognosti...
Source: Breast Cancer Research and Treatment - November 6, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Reductions in use of hormone replacement therapy: effects on Swedish breast cancer incidence trends only seen after several yearsEmail this article to a colleague.
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We examined breast
cancer incidence trends in Sweden between 1997 and 2007, a period characterized by a drop in the use of HRT. Incidence trends
were assessed using data from three population-based Regional Clinical Registries on breast cancer covering 2/3 of the Swedish
population. Information on HRT sales was obtained from national pharmacy data. The prevalence of HRT use in age group 50–59 years
decreased from a peak of 36% in 1999 to 27% in 2002 and further to 9% in 2007. Incidence rates of breast cancer in women 50 years
and older increased between 1997 and 2003. A significant decrease in incidence be...
Source: Breast Cancer Research and Treatment - November 5, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal studyEmail this article to a colleague.
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We report
one of the first longitudinal, controlled studies of cognitive effects of chemotherapy in older post-menopausal women. Sixty-one
post-menopausal women with non-metastatic BC were administered neuropsychological tests before adjuvant therapy (Time1), six
months after treatment (Time2), and at a final 6-month follow-up (Time3). Thirty women were treated with chemotherapy; thirty-one
women who received no chemotherapy were controls. Cognitive domains measured included motor, language, attention/concentration/working
memory, visuospatial, and memory (verbal and visual). Time-by-treatment interaction was signific...
Source: Breast Cancer Research and Treatment - November 5, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural effusion breast cancer modelEmail this article to a colleague.
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Abstract Breast cancer is the second leading cause of malignant effusions in cancer patients. Pleural effusion indicates incurable
disease with limited palliative treatment options and poor outcome. Here, we demonstrate the therapeutic efficacy of measles
virus (MV) vaccine strain derivative against malignant pleural effusion in an MDA-MB-231 xenograft model of advanced breast
cancer. Both systemic intravenous (i.v.) and intrapleural (t.t.) administered virus caused massive infection and syncytia
formation in the pleural tumor deposits. Intrapleural administration of 1.5 × 106 plaque-forming units...
Source: Breast Cancer Research and Treatment - November 5, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
SLC37A1 Gene expression is up-regulated by epidermal growth factor in breast cancer cellsEmail this article to a colleague.
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Abstract Phospholipid biosynthesis exerts an important role in the proliferation of tumor cells; however, the regulation of the proteins
involved in this context still remains to be fully evaluated. SLC37A1 protein belongs to a small family of sugar-phosphate/phosphate
exchangers. The sequence homology with the bacterial glycerol-3-phosphate transporter (30%) suggests that SLC37A1 might be
able to catalyze an exchange of glycerol-3-phosphate against phosphate. Glycerol-3-phosphate, found in different cellular
compartments, is a fundamental substrate in phospholipid biosynthesis. In the present study, we demo...
Source: Breast Cancer Research and Treatment - November 5, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Identification and comprehensive characterization of large genomic rearrangements in the BRCA1 and BRCA2 genesEmail this article to a colleague.
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Abstract Large genomic rearrangements are estimated to account for approximately 5–10% of all disease-causing mutations in BRCA1 and BRCA2 genes in patients with hereditary breast and ovarian cancer syndrome (HBOC). We use MRC-Holland Multiplex Ligation-dependent
Probe Amplification (MLPA) to screen for such rearrangements in patients with HBOC and as a first step in our genetic testing
workflow. The technique was applied to a set of 310 independent patients and detected eight different copy number alterations,
corresponding to 2.6% of the studied samples. MLPA was also found to identify point mutations loc...
Source: Breast Cancer Research and Treatment - November 5, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Evaluation of breast cancer service screening programme with a Bayesian approach: mortality analysis in a Finnish regionEmail this article to a colleague.
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Abstract Evaluation of long-term effectiveness of population-based breast cancer service screening program in a small geographic area
may suffer from self-selection bias and small samples. Under a prospective cohort design with exposed and non-exposed groups
classified by whether women attended the screen upon invitation, we proposed a Bayesian acyclic graphic model for correcting
self-selection bias with or without incorporation of prior information derived from previous studies with an identical screening
program in Sweden by chronological order and applied it to an organized breast cancer service screenin...
Source: Breast Cancer Research and Treatment - November 4, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 in relation to breast cancer among Hispanic and white, non-Hispanic women in the US SouthwestEmail this article to a colleague.
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In conclusion, the association between IGF-1 and breast cancer differed by ethnicity, while no ethnic differences were observed
in IGFBP-3-associated breast cancer.
Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0609-5Authors
Dana E. Rollison, H. Lee Moffitt Cancer Center and Research Institute Division of Cancer Prevention and Control Magnolia Drive Tampa FL 33612 USAAnna R. Giuliano, H. Lee Moffitt Cancer Center and Research Institute Division of Cancer Prevention and Control Magnolia Drive Tampa FL 33612 USABetsy C. Risendal, University of Colorado School of Medicine Denver CO USACarol Swe...
Source: Breast Cancer Research and Treatment - November 3, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Breast cancer risks in individuals testing negative for a known family mutation in BRCA1 or BRCA2Email this article to a colleague.
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Abstract Genetic testing for BRCA1 and BRCA2 mutations in family members of individuals with known deleterious mutations can distinguish between patients at high risk
of disease and those who are not. Some studies have suggested that individuals testing negative for known familial mutations
(true negatives), may still have a higher risk of breast cancer (BC) than the general population. We have examined a prospectively
followed cohort of true negative women in the US. Subjects were close relatives of known BRCA1 and BRCA2 mutation carriers who had undergone genetic testing, were negative for the known familia...
Source: Breast Cancer Research and Treatment - November 3, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breastEmail this article to a colleague.
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In conclusion, preoperative MRI in patients with ILC can reduce re-excision rates without increasing the rate of
mastectomies.
Content Type Journal ArticleCategory Clinical trialDOI 10.1007/s10549-009-0616-6Authors
R. M. Mann, Radboud University Nijmegen Medical Centre Department of Radiology huispost 667, Geert Grooteplein 10 P.O. Box 9101 6500 HB Nijmegen The NetherlandsC. E. Loo, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital Department of Radiology Amsterdam The NetherlandsT. Wobbes, Radboud University Nijmegen Medical Centre Department of Surgery Nijmegen The NetherlandsP. Bult, Radboud Univers...
Source: Breast Cancer Research and Treatment - November 3, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Metabolic profile, physical activity, and mortality in breast cancer patientsEmail this article to a colleague.
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Abstract Metabolic components [body mass index (BMI), blood pressure, serum lipids] and physical activity may affect biological mechanisms
of importance for breast cancer prognosis. A population-based survival study among 1,364 breast cancer cases within the Norwegian
Counties Study during 1974–2005 was conducted. Pre-diagnostic measurements of BMI, blood pressure, serum lipids, and self-reported
physical activity were assessed. Multivariable Cox proportional hazard models were used in analyses (SAS version 9.11). Among
these breast cancer cases (age at diagnosis 27–79 years), 429 women died (8.2 me...
Source: Breast Cancer Research and Treatment - October 30, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancerEmail this article to a colleague.
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In this study, we examine whether a BRCA1-dependent transcriptional mechanism may underpin the link between BRCA1 and basal-like
phenotype. In methods section, the mRNA and protein were harvested from a number of BRCA1 mutant and wild-type breast cancer
cell lines and from matched isogenic controls. Microarray-based expression profiling was used to identify potential BRCA1-regulated
transcripts. These gene targets were then validated (by in silico analysis of tumour samples) by real-time PCR and Western
blot analysis. Chromatin immunoprecipitation (ChIP) assays were used to confirm recruitment of BRCA1 to specific prom...
Source: Breast Cancer Research and Treatment - October 30, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Assessment of false-negative cases of breast MR imaging in women with a familial or genetic predispositionEmail this article to a colleague.
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Abstract In order to assess the characteristics of malignant breast lesions those were not detected during screening by MR imaging.
In the Dutch MRI screening study (MRISC), a non-randomized prospective multicenter study, women with high familial risk or
a genetic predisposition for breast cancer were screened once a year by mammography and MRI and every 6 months with a clinical
breast examination (CBE). The false-negative MR examinations were subject of this study and were retrospectively reviewed
by two experienced radiologists. From November 1999 until March 2006, 2,157 women were eligible for study ...
Source: Breast Cancer Research and Treatment - October 29, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Loco-regional treatment in metastatic breast cancer patients: Is there a survival benefit?Email this article to a colleague.
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Abstract A number of studies have recently demonstrated a survival benefit in stage IV breast cancer patients following surgical resection
of the primary tumor. Here, we investigate the relationship between loco-regional treatment and survival in patients with
metastatic breast cancer and evaluate the impact of different loco-regional treatments. We conducted a systematic review of
the literature using PubMed to analyze studies with the following criteria: Type of loco-regional treatment (surgery alone
or combined with radiation, radiotherapy), overall survival, progression-free survival, selection factors f...
Source: Breast Cancer Research and Treatment - October 29, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriersEmail this article to a colleague.
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Abstract Integrins containing the β3 subunit are key players in tumor growth and metastasis. A functional Leu33Pro polymorphism (rs5918) in the β3 subunit of the integrin gene (ITGB3) has previously been suggested to act as a modifier of ovarian cancer risk in Polish BRCA1 mutation carriers. To investigate the association further, we genotyped 9,998 BRCA1 and 5,544 BRCA2 mutation carriers from 34 studies from the Consortium of Investigators of Modifiers of BRCA1/2 for the ITGB3 Leu33Pro polymorphism. Data were analysed within a Cox-proportional hazards framework using a retrospective likelihood approach.
Ther...
Source: Breast Cancer Research and Treatment - October 29, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Sensitivity analyses including and excluding the HWE-violating studies are required for meta-analyses of genetic association studiesEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10549-009-0605-9Authors
C. Mao, Southern Medical University Department of Epidemiology, School of Public Health and Tropical Medicine Guangzhou ChinaR. Y. Liao, Southern Medical University Department of Epidemiology, School of Public Health and Tropical Medicine Guangzhou ChinaQ. Chen, Southern Medical University Department of Epidemiology, School of Public Health and Tropical Medicine Guangzhou China
Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 29, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer riskEmail this article to a colleague.
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Abstract Breast cancer is a complex disease and in recent years a number of breast cancer susceptibility genes have been identified,
but the role of low penetrance susceptibility genes has not been completely resolved. Glutathione S-transferases (GSTs) are
phase II xenobiotic metabolizing enzymes involved in the detoxification of chemical carcinogens and environmental pollutants
and play an important role in cell defense mechanisms against oxidative stress. They have been in the spot light for the investigation
of a potential association with breast cancer risk but so far, sparse or even no data for a potent...
Source: Breast Cancer Research and Treatment - October 26, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancerEmail this article to a colleague.
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Abstract Breast cancer arises through the accumulation of multiple genetic alterations and epigenetic changes such as methylation,
which silences gene expression in a variety of cancers. In the present study, we applied genomic screening to identify genes
upregulated by the demethylating agent 5-aza-2′-deoxycytidine (DAC) in a human breast cancer cell line (MCF7). We identified
288 genes upregulated and 29 genes downregulated more than fivefold after treatment with DAC, and gene ontology analyses revealed
the genes to be involved in immune responses, apoptosis, and cell differentiation. In addition, real-t...
Source: Breast Cancer Research and Treatment - October 26, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistanceEmail this article to a colleague.
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In this study, SKBR3 cell line clones expressing EGFR were generated to examine
the role of EGFR over-expression on trastuzumab sensitivity in an, ER-negative breast carcinoma cell line. A stable clone,
SKBR3/EGFR (clone 4) expressing moderate levels of EGFR remained sensitive to trastuzumab, whereas a stable clone, SKBR3/EGFR
(clone 5) expressing high levels of EGFR, became resistant to trastuzumab. Depletion of EGFR by EGFR small-interfering RNAs
in the SKBR3/EGFR (clone 5) reversed trastuzumab resistance. However, the SKBR3/EGFR (clone 5) cell line remained sensitive
to lapatinib, an EGFR/HER2 inhibitor. Biochemica...
Source: Breast Cancer Research and Treatment - October 26, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Analysis of breast cancer related gene expression using natural splines and the Cox proportional hazard model to identify prognostic associationsEmail this article to a colleague.
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Abstract Many studies correlating gene expression data to clinical parameters assume a linear increase or decrease of the clinical
parameter under investigation with the expression of a gene. We have studied genes encoding important breast cancer-related
proteins using a model for survival-type data that is based on natural splines and the Cox proportional hazard model, thereby
removing the linearity assumption. Expression data of 16 genes were studied in relation to metastasis-free probability in
a cohort of 295 consecutive breast cancer patients treated at The Netherlands Cancer Institute. The independent ...
Source: Breast Cancer Research and Treatment - October 26, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Erratum to: Urinary polyphenols and breast cancer risk: results from the Shanghai Women’s Health StudyEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s10549-009-0599-3Authors
Jianfeng Luo, Vanderbilt University School of Medicine Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center Sixth Floor, Suite 600, 2525 West End Avenue Nashville TN 37203-1738 USAYu-Tang Gao, Shanghai Cancer Institute Department of Epidemiology Shanghai ChinaWong-Ho Chow, Department of Health and Human Services Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH Bethesda MD USAXiao-Ou Shu, Vanderbilt University School of Medicine Departme...
Source: Breast Cancer Research and Treatment - October 24, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Mutation screening of breast cancer susceptibility genes in Chinese high-risk families: the results will develop the genetic testing strategy in ChinaEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10549-009-0598-4Authors
A-Yong Cao, Fudan University Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College 270 Dong’an Road 200032 Shanghai People’s Republic of ChinaZhen Hu, Fudan University Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College 270 Dong’an Road 200032 Shanghai People’s Republic of ChinaZhi-Ming Shao, Fudan University Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical Col...
Source: Breast Cancer Research and Treatment - October 23, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1Email this article to a colleague.
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In conclusion, SNPs/haplotypes in the GSTM3 gene within the GSTMs gene cluster are likely to contribute to breast cancer risk when the GSTM1 is absent. We infer that GSTM3 catalyzing ability in normal breast tissue might protect against breast carcinogenesis.
Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0585-9Authors
Ke-Da Yu, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute 399 Ling-Ling Road Shanghai 200032 ChinaLei Fan, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute 399 Ling-L...
Source: Breast Cancer Research and Treatment - October 23, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Meta-analysis of vitamin D, calcium and the prevention of breast cancerEmail this article to a colleague.
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Abstract Vitamin D and calcium intake have been suggested to have protective effects against breast cancer; however, the data have
been inconclusive. The present meta-analysis examined the overall effects of vitamin D intake, circulating 25(OH)D and 1α,25(OH)2D levels, and calcium intake on breast cancer risk. Data from 11 studies on vitamin D intake, 7 studies on circulating 25(OH)D
levels, 3 studies of circulating 1α,25(OH)2D levels, and 15 studies on calcium intake and breast cancer risk were included in this analysis. From the meta-analysis,
there was a significant inverse relationship between vitamin D...
Source: Breast Cancer Research and Treatment - October 22, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
The association of metabolic syndrome with triple-negative breast cancerEmail this article to a colleague.
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Abstract Metabolic syndrome, a conglomerate of obesity, insulin resistance, dyslipidemia, and hypertension has been linked with an
increased risk of breast cancer. We investigated the possible association of highly aggressive triple-negative breast cancer
and the metabolic syndrome. Information on metabolic syndrome components and tumor characteristics were reviewed in a cohort
of 176 patients (including 86 triple-negatives). Retrospective comparison was performed using Pearson Chi-square test or Student’s
t test for data analysis. A statistically significant association of triple-negative breast cancer wi...
Source: Breast Cancer Research and Treatment - October 22, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
High-risk human papilloma virus infection, tumor pathophenotypes, and BRCA1/2 and TP53 status in juvenile breast cancerEmail this article to a colleague.
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Abstract Juvenile breast cancer is rare and poorly known. We studied a series of five breast cancer patients diagnosed within 25 years
of age that included two adolescents, 12- and 15-years-old, and 3 young women, 21-, 21-, and 25-years-old, respectively. All
cases were scanned for germline mutations along the entire BRCA1/2 coding sequences and TP53 exons 4–10, using protein truncation test, denaturing high performance liquid chromatography and direct sequencing. Paraffin-embedded
primary tumors (available for 4/5 cases), and a distant metastasis (from the 15-years-old) were characterized for histolog...
Source: Breast Cancer Research and Treatment - October 22, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesisEmail this article to a colleague.
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Abstract The mechanism of the association between breast cancer and obesity remains unknown. To investigate this mice over-expressing
HER2/Neu in the mammary gland (MMTV-HER2/Neu) were fed either a high-fat diet (45% of calories) (HFD) or low-fat diet (10%)
(LFD) from 4 weeks of age and followed for up to 1 year, or sacrificed when a mammary tumor reached 1.5 cm. There was a small
but significant increase in body weight on HFD (P < 0.05) and the HFD mice displayed a greater fat mass determined by MRI (P < 0.01). Mild glucose intolerance was observed from 3 months ...
Source: Breast Cancer Research and Treatment - October 22, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferationEmail this article to a colleague.
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Abstract The specific role of dietary fat in breast cancer progression is unclear, although a low-fat diet was associated with decreased
recurrence of estrogen receptor alpha negative (ER−) breast cancer. ER− basal-like MDA-MB-231 and MDA-MB-436 breast cancer cell lines contained a greater number of cytoplasmic lipid droplets compared
to luminal ER+ MCF-7 cells. Therefore, we studied lipid storage functions in these cells. Both triacylglycerol and cholesteryl ester (CE)
concentrations were higher in the ER− cells, but the ability to synthesize CE distinguished the two types of breast cancer cells. Highe...
Source: Breast Cancer Research and Treatment - October 22, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Screening for clonal hematopoiesis as a predictive marker for development of therapy-related myeloid neoplasia (t-MN) following neoadjuvant therapy for breast cancer: a Southwest Oncology Group study (S0012)Email this article to a colleague.
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Abstract A serious complication associated with breast cancer treatment is the increased risk for development of therapy-related myeloid
neoplasms (t-MN). To determine whether dose-intensive adjuvant regimens for breast cancer induce genetic damage to hematopoietic
stem cells, defined by the emergence of clonal hematopoiesis, and whether detection of clonal hematopoiesis could be used
as an early marker for the subsequent development of t-MN, the Southwest Oncology Group designed a pilot clonality investigation
to estimate the incidence of clonal hematopoiesis during and shortly after completion of the dose-...
Source: Breast Cancer Research and Treatment - October 22, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Coffee and tea intake and risk of breast cancerEmail this article to a colleague.
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Abstract Known risk factors account for about 10–15% of breast cancer incidence suggesting that lifestyle exposures are crucial in
its etiology. Previous epidemiological studies on the association between coffee and tea consumption and breast cancer risk
have been inconsistent. We investigated the association of coffee and tea consumption with the risk of breast cancer among
women in EPIC-NL cohort, a population-based prospective cohort in Netherlands with 27,323 participants. Exposure was measured
by a validated food frequency questionnaire, and the outcome was verified by direct linkage with the Netherla...
Source: Breast Cancer Research and Treatment - October 21, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells: possibility of a novel predictive factor for tamoxifen resistanceEmail this article to a colleague.
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Abstract Multiple coactivator and corepressor complexes play an important role in endocrine processes and breast cancer; in particular,
estrogen and estrogen receptor-α (ERα) promote the proliferation of breast cancer cells. Menin is a tumor suppressor encoded
by Men1 that is mutated in the human-inherited tumor syndrome multiple endocrine neoplasia type 1 (MEN1); it also serves as a critical
link in the recruitment of nuclear receptor-mediated transcription. Here, we show that menin expressed in breast cancer cell
line MCF-7 is colocalized with ERα and functions as a direct coactivator of ER-mediated tra...
Source: Breast Cancer Research and Treatment - October 21, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Alcohol consumption and breast tumor mitochondrial DNA mutationsEmail this article to a colleague.
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Abstract Mitochondrial DNA (mtDNA) mutations are frequent in breast tumors, but the etiology of these mutations is unknown. We hypothesized
that these mutations are associated with exposures that affect oxidative stress such as alcohol metabolism. Using archived
tumor blocks from incident breast cancer cases in a case control study, the Western New York Exposures and Breast Cancer (WEB)
study, analysis of mtDNA mutations was conducted on 128 breast cancer cases selected based on extremes of alcohol intake.
Temporal temperature gradient gel electrophoresis (TTGE) was used to screen the entire mtDNA genome and...
Source: Breast Cancer Research and Treatment - October 21, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancerEmail this article to a colleague.
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Abstract Mutations in the alpha catalytic subunit of phosphoinositol-3-kinase (PIK3CA) occur in ~30% of ER positive breast cancers.
We therefore sought to determine the impact of PIK3CA mutation on response to neoadjuvant endocrine therapy. Exons 9 (helical
domain) and 20 (kinase domain—KD) mutations in PIK3CA were determined samples from four neoadjuvant endocrine therapy trials.
Interactions with clinical, pathological, and biomarker response parameters were examined. A weak negative interaction between
PIK3CA mutation status and clinical response to neoadjuvant endocrine treatment was detected (N =...
Source: Breast Cancer Research and Treatment - October 21, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
