CD99 expression is strongly associated with clinical outcome in children with B ‐cell precursor acute lymphoblastic leukaemia
SummaryOur study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B ‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high‐risk BCP‐ALL, e.g.BCR ‐ABL1 andCRLF2Re/Hi, and that highCD99mRNA levels are strongly associated with a high frequency of relapse, high proportion of positive for minimal residual disease at day 29 and poor overall survival in paediatric cohorts, which indicate that CD99 is a potential biomarker for BCP ‐ALL. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Dongfeng Chen,
Alessandro Camponeschi,
Qingqing Wu,
Natalija Gerasimcik,
Huiqi Li,
Xue Shen,
Yujie Tan,
Helene Sj ögren,
Jessica Nordlund,
Gudmar Lönnerholm,
Jonas Abrahamsson,
Linda Fogelstrand,
Inga‐Lill Mårtensson Tags: Short Report Source Type: research
Plasma cells in classical Hodgkin lymphoma: a new player in the microenvironment?
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Lydia Visser Tags: Editorial Comment Source Type: research
Therapeutic recommendations for early stage Hodgkin lymphomas
SummaryCombined modality treatment has been the standard option for the treatment of early stage Hodgkin lymphoma for several decades. Because of the high success rate and the risk of late toxicities, recent clinical trials have focused on reducing the treatment burden. Field and dose of radiotherapy, and number of cycles of chemotherapy have been successfully reduced, particularly for favourable early stage patients. However, the impact of these treatment reductions on the rate of secondary malignancies remains still unclear. Positron emission tomography ‐computed tomography (PET‐CT) scanning has emerged as a very imp...
Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Julien Depaus,
Anne Delcourt,
Marc Andr é Tags: Review Source Type: research
Modern principles in the management of nodular lymphocyte ‐predominant Hodgkin lymphoma
SummaryNodular lymphocyte ‐predominant Hodgkin lymphoma (NLPHL) is a unique rare subtype of Hodgkin lymphoma (HL) which differs clinically, pathologically and biologically from classic HL, warranting a nuanced approach to treatment. CD20 expression by malignant lymphocyte‐predominant cells, a tendency for late relapses, and the risk of transformation to aggressive large B‐cell lymphoma are characteristic features with important implications for treatment and follow‐up. Recognition of histopathological variant patterns is also critical, with important implications for prognosis and treatment. The optimal managem ent...
Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Michael A. Spinner,
Gaurav Varma,
Ranjana H. Advani Tags: Review Source Type: research
Venetoclax for chronic lymphocytic leukaemia patients who progress after more than one B ‐cell receptor pathway inhibitor
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 27, 2018 Category: Hematology Authors: William G. Wierda,
John C. Byrd,
Matthew S. Davids,
Richard R. Furman,
Bruce D. Cheson,
Paul M. Barr,
Herbert Eradat,
Leonard Heffner,
Lang Zhou,
Maria Verdugo,
Jalaja Potluri,
Michael Choi Tags: Correspondence Source Type: research
A guideline for the diagnosis and management of polycythaemia vera. A British Society for Haematology Guideline
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 27, 2018 Category: Hematology Authors: Mary Frances McMullin,
Claire N. Harrison,
Sahra Ali,
Catherine Cargo,
Frederick Chen,
Joanne Ewing,
Mamta Garg,
Anna Godfrey,
Steven Knapper S,
Donal P. McLornan,
Jyoti Nangalia,
Mallika Sekhar,
Frances Wadelin,
Adam J. Mead,
on behalf of t Tags: Guidelines Source Type: research
Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case ‐control study
SummaryIt is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self ‐reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [<6 ·1 (reference), 6·1–7·0 (2nd), ≥7·0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0·98 (0·69–1·37) 2nd vs. reference, 0·97 (0·58–1·...
Source: British Journal of Haematology - November 27, 2018 Category: Hematology Authors: Ruifang Li ‐Gao,
Vânia M. Morelli,
Willem M. Lijfering,
Suzanne C. Cannegieter,
Frits R. Rosendaal,
Astrid Hylckama Vlieg Tags: Short Report Source Type: research
Issue Information
British Journal of Haematology, Volume 183, Issue 4, Page 525-533, November 2018. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 27, 2018 Category: Hematology Tags: Issue Information Source Type: research
Phase II trial to investigate efficacy and safety of bendamustine, dexamethasone and thalidomide in relapsed or refractory multiple myeloma patients after treatment with lenalidomide and bortezomib
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Michael Mian,
Norbert Pescosta,
Stefania Badiali,
Paola Cristina Cappelletto,
Luigi Marcheselli,
Stefano Luminari,
Francesca Patriarca,
Renato Zambello,
Anna Pascarella,
Giuseppe Tagariello,
Alessandra Marabese,
Patrizia Mondello,
Atto Billio, Tags: Correspondence Source Type: research
Class 1 HDAC and HDAC6 inhibition inversely regulates CD38 induction in myeloma cells via interferon ‐α and ATRA
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Ariunzaya Bat ‐Erdene,
Shingen Nakamura,
Asuka Oda,
Masami Iwasa,
Jumpei Teramachi,
Mohannad Ashtar,
Takeshi Harada,
Hirokazu Miki,
Hirofumi Tenshin,
Masahiro Hiasa,
Shiro Fujii,
Kimiko Sogabe,
Masahiro Oura,
Kengo Udaka,
Kumiko Kagawa,
S Tags: Correspondence Source Type: research
Receiving treatment at a specialist centre confers an overall survival benefit for patients with mantle cell lymphoma
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Rory McCulloch,
Alexandra Smith,
Nicola Crosbie,
Russell Patmore,
Simon Rule Tags: Correspondence Source Type: research
Erythropoietin and ferritin response in native highlanders aged 4 –19 years from the Leh‐Ladakh region of India
SummaryThe pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19 years) from Leh‐Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively . The mean EPO le...
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Uday Yanamandra,
Harikishan Senee,
Sushma Yanamadra,
Subrat K. Das,
Srinivas A. Bhattachar,
Reena Das,
Suman Kumar,
Pankaj Malhotra,
Subhash Varma,
Neelam Varma,
Velu Nair Tags: Research Paper Source Type: research
Refining statistics clarifies leukaemic stem cell genomics
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Shelley M. Herbrich,
Keith A. Baggerly,
Marina Konopleva Tags: Correspondence Source Type: research
Carcinocythaemia in an advanced stage of invasive ductal carcinoma of the breast
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Aina Oliver ‐Caldes,
Blanca Gonzalez‐Farre,
Anna Merino,
Maria Rozman Tags: Images in Haematology Source Type: research
Guidelines for the diagnosis and management of primary central nervous system diffuse large B ‐cell lymphoma
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 23, 2018 Category: Hematology Authors: Christopher P. Fox,
Elizabeth H. Phillips,
Jeffery Smith,
Kim Linton,
Eve Gallop ‐Evans,
Claire Hemmaway,
Dorothee P. Auer,
Charlotte Fuller,
Andrew J. Davies,
Pamela McKay,
Kate Cwynarski, on behalf of
the British Society for Haematology Tags: Guideline Source Type: research
