Correction
British Journal of Pharmacology, EarlyView. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 26, 2018 Category: Drugs & Pharmacology Tags: CORRECTION Source Type: research

Issue Information
British Journal of Pharmacology, Volume 175, Issue 24, Page 4399-4400, December 2018. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 26, 2018 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

When pharmacology meets the microbiome: new targets for therapeutics?
This article is part of a themed section on When Pharmacology Meets the Microbiome: New Targets for Therapeutics? To view the other articles in this section visithttp://onlinelibrary.wiley.com/doi/10.1111/bph.v175.24/issuetoc (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 26, 2018 Category: Drugs & Pharmacology Authors: Niall P Hyland, John F Cryan Tags: EDITORIAL Source Type: research

Correction
British Journal of Pharmacology, EarlyView. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 26, 2018 Category: Drugs & Pharmacology Tags: CORRECTION Source Type: research

Issue Information
British Journal of Pharmacology, Volume 175, Issue 24, Page 4399-4400, December 2018. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 26, 2018 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

When pharmacology meets the microbiome: new targets for therapeutics?
This article is part of a themed section on When Pharmacology Meets the Microbiome: New Targets for Therapeutics? To view the other articles in this section visithttp://onlinelibrary.wiley.com/doi/10.1111/bph.v175.24/issuetoc (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 26, 2018 Category: Drugs & Pharmacology Authors: Niall P Hyland, John F Cryan Tags: EDITORIAL Source Type: research

Amyloid precursor protein ‐mediated mitochondrial regulation and Alzheimer's disease
Despite clear evidence of a neuroprotective physiological role of amyloid precursor protein (APP) and its non ‐amyloidogenic processing products, APP has been investigated mainly in animal and cellular models of amyloid pathology in the context of Alzheimer's disease. The rare familial mutations in APP and presenilin‐1/2, which sometimes drive increased amyloid beta (Aβ) production, may have unduly inf luenced Alzheimer's disease research. APP and its cleavage products play important roles in cellular and mitochondrial metabolism, but many studies focus solely on Aβ. Mitochondrial bioenergetic metabolism is essential...
Source: British Journal of Pharmacology - November 24, 2018 Category: Drugs & Pharmacology Authors: M Isabel G Lopez Sanchez, Peter Wijngaarden, Ian A Trounce Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Hypoglycemic Effects of Glimepiride in Sulfonylurea Receptor Deficient Rat
Conclusion and ImplicationsGlimepiride possesses extrapancreatic blood glucose ‐lowering effectin vivo, which might be attributed to its direct effect on insulin ‐sensitive tissues. Therefore, the combination of glimepiride with multiple insulin injection should not be excluded per se. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 24, 2018 Category: Drugs & Pharmacology Authors: Xiaojun Zhou, Rui Zhang, Zhiwei Zou, Xue Shen, Tianyue Xie, Chunmei Xu, Jianjun Dong, Lin Liao Tags: RESEARCH PAPER Source Type: research

β‐adrenoceptors as drug targets in melanoma: novel preclinical evidence for a role of β3‐adrenoceptors
Stress plays a role in tumorigenesis through catecholamines acting at β‐adrenoceptors including β1‐, β2‐ and β3‐adrenoceptors and the use of β‐adrenoceptor antagonists seems to counteract tumor growth and progression. Preclinical evidence and meta‐analysis data demonstrate that melanoma shows a positive response to β‐adrenoceptor blockers and in pa rticular to propranolol acting mainly at β1‐ and β2‐adrenoceptors. Although evidence suggesting that β3‐adrenoceptors may play a role as a therapeutic target in infantile hemangiomas has been recently reviewed, a comprehensive analysis of the availab...
Source: British Journal of Pharmacology - November 24, 2018 Category: Drugs & Pharmacology Authors: Massimo Dal Monte, Maura Calvani, Maurizio Cammalleri, Claudio Favre, Luca Filippi, Paola Bagnoli Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Amyloid precursor protein ‐mediated mitochondrial regulation and Alzheimer's disease
Despite clear evidence of a neuroprotective physiological role of amyloid precursor protein (APP) and its non ‐amyloidogenic processing products, APP has been investigated mainly in animal and cellular models of amyloid pathology in the context of Alzheimer's disease. The rare familial mutations in APP and presenilin‐1/2, which sometimes drive increased amyloid beta (Aβ) production, may have unduly inf luenced Alzheimer's disease research. APP and its cleavage products play important roles in cellular and mitochondrial metabolism, but many studies focus solely on Aβ. Mitochondrial bioenergetic metabolism is essential...
Source: British Journal of Pharmacology - November 24, 2018 Category: Drugs & Pharmacology Authors: M Isabel G Lopez Sanchez, Peter Wijngaarden, Ian A Trounce Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Hypoglycemic Effects of Glimepiride in Sulfonylurea Receptor Deficient Rat
Conclusion and ImplicationsGlimepiride possesses extrapancreatic blood glucose ‐lowering effectin vivo, which might be attributed to its direct effect on insulin ‐sensitive tissues. Therefore, the combination of glimepiride with multiple insulin injection should not be excluded per se. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 24, 2018 Category: Drugs & Pharmacology Authors: Xiaojun Zhou, Rui Zhang, Zhiwei Zou, Xue Shen, Tianyue Xie, Chunmei Xu, Jianjun Dong, Lin Liao Tags: RESEARCH PAPER Source Type: research

β‐adrenoceptors as drug targets in melanoma: novel preclinical evidence for a role of β3‐adrenoceptors
Stress plays a role in tumorigenesis through catecholamines acting at β‐adrenoceptors including β1‐, β2‐ and β3‐adrenoceptors and the use of β‐adrenoceptor antagonists seems to counteract tumor growth and progression. Preclinical evidence and meta‐analysis data demonstrate that melanoma shows a positive response to β‐adrenoceptor blockers and in pa rticular to propranolol acting mainly at β1‐ and β2‐adrenoceptors. Although evidence suggesting that β3‐adrenoceptors may play a role as a therapeutic target in infantile hemangiomas has been recently reviewed, a comprehensive analysis of the availab...
Source: British Journal of Pharmacology - November 24, 2018 Category: Drugs & Pharmacology Authors: Massimo Dal Monte, Maura Calvani, Maurizio Cammalleri, Claudio Favre, Luca Filippi, Paola Bagnoli Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Correction
British Journal of Pharmacology, EarlyView. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 22, 2018 Category: Drugs & Pharmacology Tags: CORRECTION Source Type: research

The role of the Histamine H4 receptor in atopic dermatitis and psoriasis
Atopic dermatitis (AD) and psoriasis are common skin diseases with a high negative impact on patients ´ quality of life. Both diseases are mediated by a pro‐inflammatory infiltrate consisting of various cell types like T cells, antigen presenting cells and granulocytes and display disturbed keratinocyte differentiation. Given the fact that histamine levels are also highly elevated in inflamed ski n, it is likely that histamine plays a relevant role in disease pathology. However, antagonists blocking histamine H1 receptor (HRH1) and HRH2 are largely ineffective in reducing chronic symptoms in AD and psoriasis. Over the l...
Source: British Journal of Pharmacology - November 21, 2018 Category: Drugs & Pharmacology Authors: Katrin Schaper ‐Gerhardt, Kristine Rossbach, Eirini Nikolouli, Thomas Werfel, Ralf Gutzmer, Susanne Mommert Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research