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Stem Cell Therapy: A Promising and Prospective Approach in the Treatment of Patients With Severe Buerger's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No effective blood-flow enhancement therapies are available for patients with severe peripheral arterial disease (SPAD), thus amputation remains the only option for relief of rest pain or gangrene. Autologous bone marrow—derived stem cell therapy (ABMSCT) is an emerging modality to induce angiogenesis from endothelial progenitors. A total of 5 patients with SPAD were treated by ABMSCT using isolated CD34+ cells with characterized phenotype administered by intramuscular injections. The follow-up before and 1, 3, 6, 9, and 12 months after ABMSCT was based on clinical (rest pain, walking distance without pain, nonhealin...
Source: Clinical and Applied Thrombosis/Hemostasis - November 12, 2009 Category: Hematology Authors: Boda, Z., Udvardy, M., Razso, K., Farkas, K., Toth, J., Jambor, L., Olah, Z., Ilonczai, P., Szarvas, M., Kappelmayer, J., Vereb, Z., Rajnavolgyi, E. Tags: Articles Source Type: journals

Biological Marker Candidates of Alzheimer's Disease in Blood, Plasma, and Serum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
At the earliest clinical stages of Alzheimer's disease (AD), when first symptoms are mild, making a reliable and accurate diagnosis is difficult. AD related brain pathology and underlying molecular mechanisms precede symptoms. Biological markers can serve as supportive early screening and diagnostic tools as well as indicators of presymptomatic biochemical change. Moreover, biomarkers cover a variety of roles and functions such as disease prediction, indicating disease acuity and progression, and may ensure biological mapping of treatment outcome. Early screening, detection, and diagnosis of AD would permit earlier dis...
Source: CNS Neuroscience and Therapeutics - October 13, 2009 Category: Neuroscience Authors: Schneider P, Hampel H, Buerger K Tags: CNS Neurosci Ther Source Type: journals

Platelet microparticle levels: A biomarker of thromboangiitis obliterans (Buerger's disease) exacerbation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19818096 [PubMed - as supplied by publisher] (Source: J Cell Mol Med)
Source: J Cell Mol Med - October 9, 2009 Category: Molecular Biology Authors: Darnige L, Helley D, Fischer AM, Emmerich J, Smadja DM, Fiessinger JN Tags: J Cell Mol Med Source Type: journals

Association between periodontitis and anti-cardiolipin antibodies in Buerger disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Elevated anti-CL antibody levels were associated with periodontal destruction in BD patients. Periodontopathic bacteria may serve as exogenous antigens that stimulate the anti-CL antibody production through molecular mimicry between the bacterial peptides and a host plasma protein. PMID: 19678860 [PubMed - as supplied by publisher] (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - August 11, 2009 Category: Dentistry Authors: Chen YW, Nagasawa T, Wara-Aswapati N, Ushida Y, Wang D, Takeuchi Y, Kobayashi H, Umeda M, Inoue Y, Iwai T, Ishikawa I, Izumi Y Tags: J Clin Periodontol Source Type: journals

Efficacy of the transfer function index using the pulse volume recording as a parameter to assess intermittent claudicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion TFIcalf was useful to distinguish moderate or severe IC from mild IC in diabetic patients even if the ABPI was sufficient in nondiabetic patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-009-3940-xAuthors Rieko Nakashima, Tokyo Medical and Dental University Graduate School Department of Vascular and Applied Surgery 1-5-45 Yushima, Bunkyo-ku Tokyo 113-8519 JapanYoshinori Inoue, Tokyo Medical and Dental University Graduate School Department of Vascular and Applied Surgery 1-5-45 Yushima, Bunkyo-ku Tokyo 113-8519 JapanNorihide Sugano, Tokyo Medical and Dental Uni...
Source: Surgery Today - July 28, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell proliferation of neural progenitors in the subventricular zone (SVZ) of Parkinson disease (PD) patients and animal models is decreased. It was previously demonstrated that the neurotransmitter dopamine modulates cell proliferation in the embryonic brain. The aim of the presentstudy was to analyze whether oral treatment with the dopamine receptor agonist pramipexole (PPX) modulates adult neurogenesis in the SVZ/ olfactory bulb system in a dopaminergic lesion model. 6-Hydroxydopamine (6-OHDA) lesioned adult rats received either PPX (1,0 mg/kg) or PBS orally twice daily and bromodeoxyuridine (BrdU, a cell proliferati...
Source: Experimental Neurology - July 16, 2009 Category: Neurology Authors: Winner B, Desplats P, Hagl C, Klucken J, Aigner R, Ploetz S, Laemke J, Karl A, Aigner L, Masliah E, Buerger E, Winkler J Tags: Exp Neurol Source Type: journals

Validation of Alzheimer's disease CSF and Plasma Biological Markers The Multi-Center Reliability Study of the Pilot European Alzheimer's Disease Neuroimaging Initiative (E-ADNI).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The use of frozen rather than fresh samples renders higher diagnostic accuracy within a multicenter context. We confirmed the feasibility of a multi-centre AD biomarker programme for future clinical trials. PMID: 19539742 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 15, 2009 Category: Geriatrics Authors: Buerger K, Frisoni G, Uspenskaya O, Ewers M, Zetterberg H, Geroldi C, Binetti G, Johannsen P, Rossini PM, Wahlund LO, Vellas B, Blennow K, Hampel H Tags: Exp Gerontol Source Type: journals

TOB1 Is Regulated by EGF-Dependent HER2 and EGFR Signaling, Is Highly Phosphorylated, and Indicates Poor Prognosis in Node-Negative Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 and epidermal growth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast cancer. In a cellular model of this phenotype using differential gene expression analysis, we identified TOB1 to be up-regulated depending on EGF stimulation and transduction through phosphorylation of HER2 tyrosine 1248. mRNA expression analysis of breast cancers from a cohort of node-negative patients showed significantly shortened distant metastasis-free survival for patients with high TOB1 expression. In subsequent tissue micro...
Source: Cancer Research - June 15, 2009 Category: Cancer & Oncology Authors: Helms, M. W., Kemming, D., Contag, C. H., Pospisil, H., Bartkowiak, K., Wang, A., Chang, S.-Y., Buerger, H., Brandt, B. H. Tags: Cell, Tumor, and Stem Cell Biology Source Type: journals

Intraoperative Fluoroscopy-Guided Removal of Orbital Foreign Bodies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors report their experience using real-time intraoperative orbital fluoroscopy as an aid in the surgical removal of orbital foreign bodies.Page: 215DOI: 10.1097/IOP.0b013e3181a3006aAuthors: Cho, Raymond I. M.D. *+; Kahana, Alon M.D., Ph.D. *; Patel, Bhupendra M.D. ++; Sivak-Callcott, Jennifer M.D. [S]; Buerger, Daniel E. M.D., F.A.C.S. |; Durairaj, Vikram D. M.D. [P]; Vidor, Ira M.D. [S]; Mawn, Louise A. M.D., F.A.C.S. # (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - May 21, 2009 Category: Opthalmology Tags: Abstract HTML PDF (399 K) Source Type: journals

Comparison of Vascularized Osteoperiosteal Femur Flaps and Nonvascularized Femur Grafts for Reconstruction of Mandibular Defects: An Experimental StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of this study suggest that NVFGs have a greater bone resorption rate than do VFFs. Furthermore, the histomorphometric results imply that reconstruction of the mandibular defects with vascularized osteoperiosteal femur flaps will provide greater strength. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - May 19, 2009 Category: ENT & OMF Authors: Mehmet Emre Benlidayı, Alexander Gaggl, Heinz Buerger, Mehmet Kürkcü, Hakkı Ünlügenç, Danyal Önal, Sait Polat, Leman Sencar Tags: Basic and Patient-Oriented Research Source Type: journals

[Peripheral occlusive arterial disease in the young patient.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lower limb arterial disease has unusual features when occurring before 50 years old. The most important one is the number of causes: atherosclerosis in 2/3 cases, Leo Buerger's disease in 1/4, but also sometimes embolic cardiopathies, antiphospholipid syndrome, myeloproliferative disorders, genetic or compressive diseases, inflammatory arterial disease. When peripheral arterial disease occurs before 50, explorations have to be performed according to anamnesis: duplex echography, EKG, blood sample. Afterwards other explorations may be performed such as other vascular imaging techniques, echocardiography or more complete...
Source: Presse Medicale - May 10, 2009 Category: Journals (General) Authors: Constans J, Solanilla A, Boulon C, Conri C Tags: Presse Med Source Type: journals

Epidural Neurostimulation of Posterior Funiculi for the Treatment of Buerger's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Neurostimulation of the posterior funiculi could be considered not only as palliative care but also as a therapeutic option. (Source: Neuromodulation)
Source: Neuromodulation - April 20, 2009 Category: Neurology Authors: Lorena Vaquer Quiles, Lucrecia Blasco González, Juan Asensio Samper, Vicente Luis Villanueva Pérez, María Dolores López Alarcón, José De Andrés Ibáñez Tags: Case Reports Source Type: journals

Landmark Publication from The American Journal of the Medical Sciences, 'Thrombo-Angiitis Obliterans: A Study of the Vascular Lesions Leading to Presenile Spontaneous Gangrene'.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 274DOI: 10.1097/MAJ.0b013e31818c8bc9Authors: Buerger, Leo MD (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 18, 2009 Category: Journals (General) Tags: HTML PDF (3.016 M) Source Type: journals

Buerger's Disease: Thromboangiitis Obliterans 100 Years After the Initial Description.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 285DOI: 10.1097/MAJ.0b013e318198d011Authors: Espinoza, Luis R. MD (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 18, 2009 Category: Journals (General) Tags: HTML PDF (358 K) Source Type: journals

Leo Buerger (1879-1943) Revisited.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 287DOI: 10.1097/MAJ.0b013e318198d030Authors: Luft, Friedrich C. MD (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 18, 2009 Category: Journals (General) Tags: HTML PDF (45 K) Source Type: journals

CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Overexpression and alternative splicing of CD44 have been implicated in tumour progression. Here we describe the identification of a high level amplification of human 11p13, encompassing the CD44 gene, in primary breast cancers and cell lines and test whether CD44 acts as the driver of this amplicon. aCGH analysis revealed 11p13 amplification in 3% (3/100) of primary breast carcinomas and in two cell lines. The minimal region of amplification was 34.38–37.62 Mb. Amplification was confirmed by dual-colour FISH in these cell lines and further validated by CISH in an independent tumour cohort. CD...
Source: Breast Cancer Research and Treatment - April 7, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Harvest Technologies Announces Interim Study Results From Critical Limb Ischemia Trial In Chennai IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Harvest Technologies Corp. (http://www.harvesttech.com) announced that the interim study report was completed for the first thirty (30) patients in the clinical trial of patients suffering with non-reconstructable critical limb ischemia due to advanced thromboangitis obliterans, commonly referred to as Buerger's Disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 2, 2009 Category: Consumer Health News Tags: Vascular Source Type: news

Leo Buerger (1879-1943) revisited.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19365176 [PubMed - indexed for MEDLINE] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 31, 2009 Category: Journals (General) Authors: Luft FC Tags: Am J Med Sci Source Type: journals

Buerger's disease: thromboangiitis obliterans 100 years after the initial description.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19365175 [PubMed - indexed for MEDLINE] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 31, 2009 Category: Journals (General) Authors: Espinoza LR Tags: Am J Med Sci Source Type: journals

Landmark publication from the American Journal of the Medical Sciences, 'Thrombo-angiitis obliterans: a study of the vascular lesions leading to presenile spontaneous gangrene'. 1908.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19365174 [PubMed - indexed for MEDLINE] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 31, 2009 Category: Journals (General) Authors: Buerger L Tags: Am J Med Sci Source Type: journals

Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results show the power of aCGH analysis in unraveling the genetic profiles of specific subgroups of cancer and for the identification of novel therapeutic targets. PMID: 19318498 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 24, 2009 Category: Cancer & Oncology Authors: Natrajan R, Lambros MB, Rodríguez-Pinilla SM, Moreno-Bueno G, Tan DS, Marchió C, Vatcheva R, Rayter S, Mahler-Araujo B, Fulford LG, Hungermann D, Mackay A, Grigoriadis A, Fenwick K, Tamber N, Hardisson D, Tutt A, Palacios J, Lord CJ, Buerger H, Tags: Clin Cancer Res Source Type: journals

Streptococcal adhesion to various luting systems and the role of mixing errors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Various luting systems revealed considerable differences in their potential to adhere S. mutans. Variations from recommended cement proportions led to significant changes in the amount of adhering streptococci. PMID: 19235565 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)
Source: Acta Odontologica Scandinavica - February 23, 2009 Category: Dentistry Authors: Buergers R, Hahnel S, Reischl U, Mueller R, Rosentritt M, Handel G, Behr M Tags: Acta Odontol Scand Source Type: journals

Characterization of the Intrinsic and TSC2-GAP-Regulated GTPase Activity of Rheb by Real-Time NMR.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tuberous sclerosis complex 2 (TSC2), whose gene is frequently mutated in tuberous sclerosis, increases the guanosine triphosphatase (GTPase) activity of the small heterotrimeric GTP-binding protein (G protein) Rheb, thus resulting in the decreased activity of the mammalian target of rapamycin (mTOR), the master regulator of cell growth. Here, we describe the development of a nuclear magnetic resonance (NMR)-based, quantitative, real-time assay to explore the molecular mechanism of the intrinsic and TSC2-catalyzed GTPase activity of Rheb. We confirmed that TSC2 accelerated GTP hydrolysis by Rheb 50-fold through an "aspa...
Source: Science Signaling - January 31, 2009 Category: Biomedical Science Authors: Marshall CB, Ho J, Buerger C, Plevin MJ, Li GY, Li Z, Ikura M, Stambolic V Tags: Sci Signal Source Type: journals

[Research Article] Characterization of the Intrinsic and TSC2-GAP-Regulated GTPase Activity of Rheb by Real-Time NMREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An NMR-based assay enables real-time analysis of the GTPase activity of Rheb and of the effect of its GTPase-activating protein TSC2. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - January 29, 2009 Category: Science Authors: Christopher B. Marshall, Jason Ho, Claudia Buerger, Michael J. Plevin, Guang-Yao Li, Zhihong Li, Mitsuhiko Ikura, Vuk Stambolic Source Type: info

Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Loss of the long arm of chromosome 16 (16q) is observed in the vast majority of low grade/grade I (GI) invasive ductal carcinomas of no special type (IDC-NSTs), whereas this event is uncommonly seen in high grade/grade III (GIII) IDC-NSTs. Together with data on the pathology and genetics of breast cancer recurrences, this has led to the proposal that GI and GIII breast cancers evolve through distinct genetic pathways and that progression from GI to GIII is an unlikely biological phenomenon. We compared the genomic profiles of GIII-IDC-NSTs with 16q whole arm loss (16qWL) according to estrogen receptor (ER) status. 16qWL wa...
Source: Genes, Chromosomes and Cancer - January 20, 2009 Category: Cancer & Oncology Authors: Rachael Natrajan, Maryou B. K. Lambros, Felipe C. Geyer, Caterina Marchio, David S. P. Tan, Radost Vatcheva, Kai-Keen Shiu, Daniela Hungermann, Socorro Maria Rodriguez-Pinilla, Jose Palacios, Alan Ashworth, Horst Buerger, Jorge S. Reis-Filho Source Type: journals

Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO). PMID: 19135391 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 7, 2009 Category: Cardiology Authors: Edo N, Miyai K, Ogata S, Nakanishi K, Hiroi S, Tominaga S, Aiko S, Kawai T Tags: Cardiovasc Pathol Source Type: journals

Buerger's disease-like vasculitis associated with Kimura's disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 46-year-old man was first diagnosed as Buerger's disease according to his clinical and radiological features because he had no evidence of parasitic, allergic and connective tissue disease. Soft subcutaneous nodules suspected of lymphadenopathy on the bilateral inguinal regions were recognized after admission. Positron emission tomography scan showed the increased uptake of (18)F-fluoro-2-deoxyglucose in the bilateral inguinal regions. We finally diagnosed him as Kimura's disease based on pathologic findings and laboratory data, and started steroid therapy. The uptake of (18)F-fluoro-2-deoxyglucose disappeared and hi...
Source: International Journal of Cardiology - January 6, 2009 Category: Cardiology Authors: Takaoka H, Takano H, Nakagawa K, Kobayashi Y, Hiroshima K, Komuro I Tags: Int J Cardiol Source Type: journals

Cell Therapy in Peripheral Arterial DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Management of advanced obstructive vascular disease affecting the extremities poses tremendous challenges for physicians and patients. Peripheral arterial disease is often a consequence of obstructive atherosclerosis affecting the ileofemoral circulation but is also rarely a result of nonatherosclerotic conditions such as thromboangiitis obliterans (Buerger's disease). Consequences range from the presence of asymptomatic obstruction to intermittent claudication, development of rest pain, ulceration, gangrene, and amputation. A relatively new and promising approach using cell therapy has recently been developed to treat int...
Source: Angiology - December 15, 2008 Category: Cardiology Authors: Al Mheid, I., Quyyumi, A. A. Tags: Article Source Type: journals

Interactions of neutrophils with silver-coated vascular polyester graftsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The results may indicate that silver-coated vascular polyester grafts activate neutrophils chronically which may favor tissue destruction and impaired antimicrobial effects. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00423-008-0439-7Authors Joerg Tautenhahn, University Hospital Department of General, Abdominal, and Vascular Surgery Leipziger Strasse 44 39120 Magdeburg GermanyFrank Meyer, University Hospital Department of General, Abdominal, and Vascular Surgery Leipziger Strasse 44 39120 Magdeburg GermanyThomas Buerger, University Hospital Department of General, Abdomi...
Source: Langenbeck's Archives of Surgery - December 2, 2008 Category: Surgery Tags: Langenbeck's Archives of Surgery Source Type: journals

Penile and scrotal involvement in Buerger's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 47-year-old man with scrotal and penile necrosis. Partial penectomy, scrotal debridement and urethra-cutaneous anastomosis were performed. (Source: Andrologia)
Source: Andrologia - November 25, 2008 Category: Urology & Nephrology Authors: T. Aktoz, M. Kaplan, O. Yalcın, I. H. Atakan, O. Inci Tags: CASE REPORT Source Type: journals

Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wnt signalling regulates proliferation, self renewal and cell fate. Aberrant Wnt signalling is thought to contribute to AML pathogenesis by enhancing self renewal. Herein, we provide evidence for increased expression of Frizzled-4, a receptor for Wnt ligands, in primary AML blasts compared to normal bone marrow on the protein level. In addition, Frizzled-4 is highly expressed in human CD34 positive cells as well as in lineage negative sorted mouse bone marrow cells. Functionally, Frizzled-4 expression modulates apoptosis and enhances Wnt3a induced beta-catenin stability in myeloid progenitor cells. Frizzled-4-dependent...
Source: International Journal of Oncology - November 23, 2008 Category: Cancer & Oncology Authors: Tickenbrock L, Hehn S, Sargin B, Choudhary C, Bäumer N, Buerger H, Schulte B, Müller O, Berdel WE, Müller-Tidow C, Serve H Tags: Int J Oncol Source Type: journals

Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The 14-gene signature is significantly associated with risk of distant metastasis. The signature has a predominance of proliferation genes which have prognostic significance above that of Ki-67 LI and may aid in prioritizing future mechanistic studies and therapeutic interventions. (Source: BMC Cancer)
Source: BMC Cancer - November 21, 2008 Category: Cancer & Oncology Authors: Andrew Tutt, Alice Wang, Charles Rowland, Cheryl Gillett, Kit Lau, Karen Chew, Hongyue Dai, Shirley Kwok, Kenneth Ryder, Henry Shu, Robert Springall, Paul Cane, Blair McCallie, Lauren Kam-Morgan, Steve Anderson, Horst Buerger, Joe Gray, James Bennington, Source Type: journals

Chemical sympatholysis: indications, technique and complications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemical sympatholysis is commonly performed for palmar or plantar hyperhidrosis, Buerger's disease, critical lower limb ischaemia where there is no revascularization option available and palliation of pain. The outcome varies from symptomatic improvement to failure, which may result in limb loss in the case of ischaemic limbs. PMID: 19069269 [PubMed - in process] (Source: British Journal of Hospital Medicine)
Source: British Journal of Hospital Medicine - November 1, 2008 Category: Internal Medicine Authors: Durai R, Hoque H Tags: Br J Hosp Med (Lond) Source Type: journals

Grade I chondrosarcoma of bone: the Münster experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, intralesional resection of a grade I chondrosarcoma has a higher overall risk of local recurrence but is not associated with a poorer survival. This procedure can be recommended for stage I A tumours of the long bones of the extremities. However, in pelvic lesions it should be avoided because of a 100% recurrence rate. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-008-0486-zAuthors Arne Streitbürger, University Hospital of Münster Münster GermanyHelmut Ahrens, University Hospital of Münster Münster GermanyMaurice Balke, University Hospital of Münster Münster GermanyHorst...
Source: Journal of Cancer Research and Clinical Oncology - October 15, 2008 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Buerger's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
— Comprehensive overview covers symptoms of this disease that affects your blood vessels. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - September 20, 2008 Category: Consumer Health News Source Type: news

CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: MMSE and CSF t-tau represent different aspects of disease severity. Whilst MMSE is closely related to impaired cerebral glucose metabolism, CSF t-tau is less closely related and appears to be less well suited for assessment of disease progression. (Source: European Journal of Neurology)
Source: European Journal of Neurology - September 18, 2008 Category: Neurology Authors: C. Haense, K. Buerger, E. Kalbe, A. Drzezga, S. J. Teipel, P. Markiewicz, K. Herholz, W. D. Heiss, H. Hampel Source Type: journals

Streptococcal adhesion to novel low-shrink silorane-based restorative.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
OBJECTIVES: The aim of the present study was to compare the susceptibility of one novel silorane-based and four widely used conventional methacrylate-based resin composites to adhere oral streptococci and to relate any differences to surface roughness, hydrophobicity and type of matrix. METHODS: Specimens of restoratives Filtek Silorane, Filtek Z250, Tetric EvoCeram, Quixfil and Spectrum TPH were prepared (10.0-mm diameter, 2.0-mm height). Surface roughness was assessed by perthometer measurements and hydrophobicity according to water contact angles was determined by computerized image analysis. Bacterial suspensions o...
Source: Dental Materials - September 1, 2008 Category: Materials Science Authors: Buergers R, Schneider-Brachert W, Hahnel S, Rosentritt M, Handel G Tags: Dent Mater Source Type: journals

Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease British Journal of Cancer advance online publication, August 12, 2008. doi:10.1038/sj.bjc.6604556 Authors: M W Helms, D Kemming, H Pospisil, U Vogt, H Buerger, E Korsching, C Liedtke, C M Schlotter, A Wang, S Y Chan & B H Brandt (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - August 12, 2008 Category: Cancer & Oncology Authors: M W HelmsD KemmingH PospisilU VogtH BuergerE KorschingC LiedtkeC M SchlotterA WangS Y ChanB H Brandt Source Type: journals

Allelic imbalances of the egfr gene as key events in breast cancer progression--the concept of committed progenitor cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The introduction of concepts proposing multiple cellular subgroups in the normal female breast leads to the hypothesis that distinct cellular phenotypes in the female breast give rise to different subtypes of breast carcinomas e.g. expressing ER, HER2 and EGFR differentially. Therefore, origin of breast carcinoma types may be based on the formation of a cancer prone field in which the committed progenitor cells pass mutations to their progenies, glandular as well as myoepithelial cells. The existence of such field within the human breast was inferred from the results on primary breast cancer obtained by PCR-based micro...
Source: Current Cancer Drug Targets - August 1, 2008 Category: Cancer & Oncology Authors: Agelopoulos K, Buerger H, Brandt B Tags: Curr Cancer Drug Targets Source Type: journals

Spontaneous Compartment Syndrome: Hughes and Buerger Smoking.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 685DOI: 10.1097/SMJ.0b013e31817c13f0Authors: Sanda, Robert B. MBBS, FRCSI (Source: Southern Medical Journal)
Source: Southern Medical Journal - July 9, 2008 Category: Journals (General) Tags: HTML PDF (78 K) Source Type: journals

Compartment Syndrome in Patients with Buerger Disease and Anticardiolipin Antibodies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of acute compartment syndrome in the anterior compartment of the lower limbs of patients with Buerger disease associated with positive anticardiolipin antibodies. We comment on the rarity of the case and on the possibility of interference of two associated thrombogenic conditions. The need for early fasciotomy is emphasized since the progression to necrosis is time dependent. Fasciotomy was the only reperfusion surgery utilized on these patients with resolution of the ischemia.Page: 748DOI: 10.1097/SMJ.0b013e31817c13d2Authors: Pereira de Godoy, Jose Maria MD; Braile, Domingo Marcolino MD; Torres, Carlos...
Source: Southern Medical Journal - July 9, 2008 Category: Journals (General) Tags: Abstract HTML PDF (88 K) Source Type: journals

Primary Hepatic Lymphoma of Mucosa-Associated Lymphoid Tissue Type: A Case Report With Cytogenetic StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary hepatic lymphoma of mucosa-associated lymphoid tissue type is extremely rare. Only 38 cases have been reported to date. A case of a 59-year-old man with Helicobacter pylori—resistant gastric ulcers and Buerger disease who was followed up since 1999 is reported. A 2-cm hepatic nodule was incidentally found during partial gastrectomy and corresponded to mucosa-associated lymphoid tissue—type lymphoma without underlying liver disease. Molecular studies showed a clonal immunoglobulin heavy-chain gene rearrangement. Investigations for the mucosa-associated lymphoid tissue lymphoma-associated translocations t...
Source: International Journal of Surgical Pathology - June 22, 2008 Category: Pathology Authors: Koubaa Mahjoub, W., Chaumette-Planckaert, M.-T., Penas, E. M. M., Dierlamm, J., Leroy, K., Delfau, M.-H., Loriau, J., Gaulard, P., Delchier, J.-C., Zafrani, E.-S., Copie-Bergman, C. Tags: Article Source Type: journals

Efficacy of denture disinfection methods in controlling Candida albicans colonization in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Only soaking in sodium hypochlorite (1%; 10 min), microwave irradiation immersed in water (800 W; 6 min), and application of effervescent cleansing tabs (Blend-a-dent tabs; 10 min) proved to be effective against C. albicans colonization on soft denture relining material. PMID: 18568477 [PubMed - indexed for MEDLINE] (Source: Acta Odontologica Scandinavica)
Source: Acta Odontologica Scandinavica - June 1, 2008 Category: Dentistry Authors: Buergers R, Rosentritt M, Schneider-Brachert W, Behr M, Handel G, Hahnel S Tags: Acta Odontol Scand Source Type: journals

[Superficial Migratory Thrombophlebitis: A Clinical and Histologic Review of 8 Cases.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The possible association of SMT with systemic diseases, including cancer, makes its diagnosis important. In our case series we did not find evidence of associated disease in the majority of cases. However, since cancer can manifest months and even years after the appearance of SMT, follow-up is necessary in these patients. PMID: 18501171 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - May 27, 2008 Category: Dermatology Authors: Laguna C, Alegre V, Pérez A Tags: Actas Dermosifiliogr Source Type: journals

Changes in angiogenesis-related factors in serum following autologous bone marrow cell implantation for severe limb ischemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated ... (Source: Expert Opinion: Expert Opinion on Biological Therapy: Table of Contents)
Source: Expert Opinion: Expert Opinion on Biological Therapy: Table of Contents - May 15, 2008 Category: Drugs & Pharmacology Tags: article Source Type: journals

Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Expression of EGFR in high grade osteosarcomas has been observed to be correlated with an improved prognosis. Yet, the underlying mechanism remained unclear since amplifications of EGFR have rarely been described. Recently, the length of a polymorphic CA repeat located at a 5[prime]-regulatory sequence in the intron 1 of the EGFR gene (SSR I) has been shown to be associated with its basal transcriptional activity. We therefore determined the allelic length of CA SSR-I in 219 cases of high grade osteosarcoma and correlated the results with EGFR expression in 34 cases, the presence of amplifications within the CA SSR-I repea...
Source: Genes, Chromosomes and Cancer - May 7, 2008 Category: Cancer & Oncology Authors: Christian Kersting, Konstantin Agelopoulos, Hartmut Schmidt, Eberhard Korsching, Christian August, Georg Gosheger, Uta Dirksen, Heribert Juergens, Wilfried Winkelmann, Burkhard Brandt, Stefan Bielack, Horst Buerger, Carsten Gebert Source Type: journals

Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study showed that the HCV peptide vaccine IC41 can induce HCV-specific Th1/Tc1 responses in a subset of difficult to treat HCV nonresponder patients despite persisting viremia. However, changes in HCV RNA occurred only in single patients. Because strongest T-cell responses were associated with HCV RNA decline, further studies with optimized vaccine regimens and combination therapies have been initiated. PMID: 18471515 [PubMed - in process] (Source: Gastroenterology)
Source: Gastroenterology - May 1, 2008 Category: Gastroenterology Authors: Klade CS, Wedemeyer H, Berg T, Hinrichsen H, Cholewinska G, Zeuzem S, Blum H, Buschle M, Jelovcan S, Buerger V, Tauber E, Frisch J, Manns MP Tags: Gastroenterology Source Type: journals

Painful digital infarction in a male smoker treated as Buerger's disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 40-year-old male smoker presented with a 3-week history of painful digital infarction involving the hands. Histology was unhelpful, showing lichen simplex chronicus. A provisional diagnosis of a vasculitic disease was made. Treatment included aspirin, azathioprine, iloprost, methylprednisolone, nifedipine and prednisolone. After failure of these treatments an alternative clinical diagnosis of Buerger's disease was made. Treatment was to advise the patient of the importance of continuing to abstain from smoking, to perform bilateral video-assisted thoracoscopic sympathectomies and to commence folate supplementation. T...
Source: The Australasian Journal of Dermatology - May 1, 2008 Category: Dermatology Authors: Foley S, Gibbs H, Muir J Tags: Australas J Dermatol Source Type: journals

[Reviews] Basal carcinoma of the breast revisited: an old entity with new interpretationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The introduction of global gene expression analysis in breast cancer research has focused attention onto a repeatedly described subgroup of invasive breast cancer, the basal-like carcinomas. This subgroup is characterised by the expression of high-molecular weight cytokeratins 5, 14 and 17; using immunohistochemical diagnosis, it represents approximately 7–20% of invasive breast cancers. Some of these tumours fulfil the criteria of grade 3 invasive ductal carcinoma, the so-called triple negative carcinomas. However, other rare subgroups of metaplastic, medullary and myoepithelial carcinomas also belong to this entity...
Source: Journal of Clinical Pathology - April 25, 2008 Category: Pathology Authors: Korsching, E, Jeffrey, S S, Meinerz, W, Decker, T, Boecker, W, Buerger, H Tags: Reviews Source Type: journals

En bloc spondylectomy in malignant tumors of the spineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract En bloc spondylectomy is a technique that enables wide or marginal resection of malignant lesions of the spine. Both all posterior techniques as well as combined approaches are reported. Aim of the present study was to analyse the results of 21 patients with malignant lesions of the spine, all treated with en bloc excision in a combined posteroanterior (n = 19) or all posterior approach (n = 2). Twenty-one consecutive patients, operated between 1997 and 2005, were included into this retrospective study. Thirteen patients had primary malignant lesions, eight patients had solitary m...
Source: European Spine Journal - January 24, 2008 Category: Orthopaedics Tags: European Spine Journal Source Type: journals