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This page shows you the latest news and research items in this category.

[Articles] Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer's disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial
Intravenous immunoglobulin may have an acceptable safety profile. Our results did not accord with those from previous studies. Longer trials with greater power are needed to assess the cognitive and functional effects of intravenous immunoglobulin in patients with Alzheimer's disease. (Source: Lancet Neurology)
Source: Lancet Neurology - February 15, 2013 Category: Neurology Authors: Richard Dodel, Axel Rominger, Peter Bartenstein, Frederik Barkhof, Kaj Blennow, Stefan Förster, Yaroslav Winter, Jan-Philipp Bach, Julius Popp, Judith Alferink, Jens Wiltfang, Katharina Buerger, Markus Otto, Piero Antuono, Michael Jacoby, Ralph Richter, Tags: Articles Source Type: research

Highly efficient 3D motion-compensated abdomen MRI from undersampled golden-RPE acquisitions.
CONCLUSION: Our method reduces scan time by 56 % compared to the gating technique while similar image quality is preserved. PMID: 23404682 [PubMed - as supplied by publisher] (Source: Magma)
Source: Magma - February 13, 2013 Category: Radiology Authors: Buerger C, Prieto C, Schaeffter T Tags: MAGMA Source Type: research

mTOR and its downstream signalling components are activated in psoriatic skin.
CONCLUSIONS: Altogether these results suggest a role for mTOR signalling in the epidermal changes leading to the psoriatic phenotype. mTOR inhibition might be a mode of action suitable to be explored for innovative anti-psoriatic drugs. PMID: 23398394 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 12, 2013 Category: Dermatology Authors: Buerger C, Malisiewicz B, Eiser A, Hardt K, Boehncke WH Tags: Br J Dermatol Source Type: research

mTOR and its downstream signalling components are activated in psoriatic skin
ConclusionsAltogether these results suggest a role for mTOR signalling in the epidermal changes leading to the psoriatic phenotype. mTOR inhibition might be a mode of action suitable to be explored for innovative anti‐psoriatic drugs. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 12, 2013 Category: Dermatology Authors: C. Buerger, B. Malisiewicz, A. Eiser, K. Hardt, W.H. Boehncke Tags: Concise Communication Source Type: research

Assessment of plasma prothrombotic factors in patients with Buerger's disease
The pathogenesis of Buerger’ disease (thrombangiitis obliterans; TAO) remains unknown, although a strong association with tobacco use has been established. Blood coagulation and fibrinolytic factors as well as selected clinical chemistry parameters have been evaluated in 37 patients with Buerger's disease. Median levels of prothrombotic factors were higher in patients with TAO than in healthy control: annexin V (P (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - January 31, 2013 Category: Hematology Tags: Original Articles Source Type: research

Atypical chronic sterile paronychia leading to tissue and joint space destruction in a patient with thromboangiitis obliterans
We report the case of a patient with severe thromboangiitis obliterans (Buerger's disease) and untreated paronychia which eroded into the digital joint space causing acrolysis of digits and significant soft tissue and joint destruction. (Source: Australasian Journal of Dermatology)
Source: Australasian Journal of Dermatology - November 6, 2012 Category: Dermatology Authors: Burcu Yelkovan, Keng‐Ee Thai Tags: Brief Report Source Type: research

Atypical chronic sterile paronychia leading to tissue and joint space destruction in a patient with thromboangiitis obliterans.
We report the case of a patient with severe thromboangiitis obliterans (Buerger's disease) and untreated paronychia which eroded into the digital joint space causing acrolysis of digits and significant soft tissue and joint destruction. PMID: 23127186 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - November 6, 2012 Category: Dermatology Authors: Yelkovan B, Thai KE Tags: Australas J Dermatol Source Type: research

High-mobility-group box protein 1 A box reduces development of sodium laurate-induced thromboangiitis obliterans in rats
Conclusions: HMGB1 is involved in the inflammatory state in a model of TAO induced by sodium laurate in rats, probably via its receptor RAGE. As the antagonist of HMGB1, rA box can attenuate the development of TAO, which may be a potential therapeutic target for the treatment of TAO. Clinical Relevance: Thromboangiitis obliterans (TAO), or Buerger disease, is a segmental nonatherosclerotic inflammatory disorder. Patients with Buerger disease have a lower quality of life because of intermittent claudication, rest pain, ulcers, and superficial thrombophlebitis. The specific etiology and pathologic mechanisms remain not el...
Source: Journal of Vascular Surgery - October 15, 2012 Category: Surgery Authors: Xiangqian Kong, Hai Yuan, Xuejun Wu, Jingyong Zhang, Hua Zhou, Maohua Wang, Yang Liu, Xing Jin Tags: Basic research studies Source Type: research

Buerger's disease
(Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 2, 2012 Category: Internal Medicine Authors: Broz, P., Jaeger, K. A. Tags: Images in vascular medicine Source Type: research

Endovascular Treatment Is a Hope for Patient With Buerger's Disease and Foot Ulcer: Case Report
Scarce information exists regarding the usefulness of the endovascular approach in patients with thromboangiitis obliterans and critical ischemia. A 41-old-man diagnosed with Buerger’s disease had rest pain and a severe ulceration on the big toe. He had been scheduled for a big toe amputation. Typical findings of Buerger’s disease were found in the angiogram including below-the-knee involvement and corkscrew collateral arteries. Stenoses of the posterior tibial artery were angioplastied and the plantar artery was recanalized and angioplastied. Healing was achieved and the patient remains asymptomatic 21 months ...
Source: The International Journal of Lower Extremity Wounds - September 24, 2012 Category: Surgery Authors: Aragon-Sanchez, J., Rabellino, M., Pulido-Duque, J., Zander, T., Gonzalez, G., Maynar, M. Tags: Case Report Source Type: research

A Stable Prostacyclin Analogue (Iloprost) in the Treatment of Buerger's Disease: A Prospective Analysis of 150 Patients.
Conclusion: The results of this independent study indicate that intravenous iloprost relieves ischemic symptoms efficiently in the acute phase Buerger's disease patients. Considering unsatisfactory results following surgical revascularisation and sympathectomy in Buerger's disease, prostacyclin analogues might be the first line treatment as long as complete abstinence from smoking is achieved. PMID: 22971807 [PubMed - as supplied by publisher] (Source: Annals of Thoracic and Cardiovascular Surgery)
Source: Annals of Thoracic and Cardiovascular Surgery - August 31, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Bozkurt AK, Cengiz K, Caner A, Mine DY, Oner S, Deniz DB, Ufuk D Tags: Ann Thorac Cardiovasc Surg Source Type: research

Pluristem Receives Approval From Indian Ministry of Health for Use of PLX Cells in Phase II Trial for Treatment of Buerger's Disease
HAIFA, Israel, Aug. 16, 2012 (GLOBE NEWSWIRE) -- Pluristem Therapeutics, Inc. (Nasdaq:PSTI) (TASE:PLTR), a leading developer of placenta-based cell therapies, announced today that it has received permission from the Indian Ministry of Health to proceed with a Phase II clinical trial for the treatment of thromboangiitis obliterans (Buerger's disease). This Phase II trial will be potentially followed by a larger multi-national Phase III study in the U.S., Europe and India. (Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - August 16, 2012 Category: Pharmaceuticals Source Type: news

Is there ‘progression through grade’ in ductal invasive breast cancer?
In conclusion, our results show that a morphological recognizable striking ‘progression through grade’ at least in its extreme form from G1 towards G3 is a very rare event in the natural course of invasive BC, including luminal BC. Content Type Journal ArticleCategory Preclinical StudyPages 1-11DOI 10.1007/s10549-012-2195-1Authors Barbara Schymik, Clinics of Gynecology, St. Vincenz Hospital, Paderborn, GermanyHorst Buerger, Cooperative Breast Center Paderborn, Paderborn, GermanyAnnika Krämer, Institute of Pathology, Husener Str. 46a, 33098 Paderborn, GermanyUlli Voss, Institute of Pathology, Husener Str. 46a,...
Source: Breast Cancer Research and Treatment - August 11, 2012 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: research

Long-term clinical outcome after intramuscular transplantation of granulocyte colony stimulating factor-mobilized CD34 positive cells in patients with critical limb ischemia
Conclusions: Favorable clinical outcomes as well as physiological evidences strongly indicate the long-term benefit of GCSF-mobilized CD34+ cell transplantation for retrieval from CLI, especially in patients with Buerger's disease.Highlights: ► The first clinical report of long-term outcome of CD34+ cell therapy in CLI. ► High CLI-free ratio was sustained for 4 years post CD34+ cell therapy. ► Significant improvement of TBPI and TcPO2 was sustained for 3–4 years. ► Favorable outcomes indicate long-term benefit of the cell therapy for CLI patients. (Source: Atherosclerosis)
Source: Atherosclerosis - August 8, 2012 Category: Cardiology Authors: Makoto Kinoshita, Yasuyuki Fujita, Minako Katayama, Rie Baba, Maki Shibakawa, Kimiko Yoshikawa, Nobuyuki Katakami, Yutaka Furukawa, Tomio Tsukie, Tohru Nagano, Yasuo Kurimoto, Kazuo Yamasaki, Nobuhiro Handa, Yukikatsu Okada, Kaori Kuronaka, Yukiko Nagata, Tags: Intervention Source Type: research

Regarding “New routine alternative for proximal anterior tibial artery bypass in patients with Buerger disease”
Lee et al have described a new routing alternative to perform bypasses to the proximal femoral anterior tibial artery in selected patients. In addition to their recommendation for its use in Buerger's disease, this technique might also be advantageous for patients with infective processes in the popliteal fossa. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - July 27, 2012 Category: Surgery Authors: Herbert Dardik, Vicente Orozco Tags: Letters to the Editor Source Type: research

Reply
We thank Dr Dardik for his interest in our recent article describing a new route for proximal anterior tibial artery (ATA) bypass in Buerger disease (BD) patients. Dardik suggested that a medial approach to the ATA may provide a shorter route than our method, and we do agree with his suggestion. However, we would argue that this difference is not great since in both methods the graft traverses directly between the muscles without having to go around them. Therefore, although our method may not provide the shortest route to the ATA, it is still significantly shorter than other traditional lateral approach methods. On the ot...
Source: Journal of Vascular Surgery - July 27, 2012 Category: Surgery Authors: Taeseung Lee, Hyung Sub Park, Sang Joon Kim Tags: Letters to the Editor Source Type: research

Role of Thrombophilia in Premature Peripheral Arterial Obstructive Disease – Experience of a Vascular Centre in China
Objective: To evaluate aetiology profile and role of thrombophilia in patients with premature peripheral arterial obstructive disease (PAOD) in China. Methods: Between January 2000 and January 2010, among 368 patients presenting with PAOD, but not Buerger's disease, at an age of less than 45 years, 150 patients have been screened for thrombophilia and the data analysed retrospectively. Aetiologies of thrombophilia which involved in premature PAOD were assessed and surgical outcomes were stratified for presence of thrombophilia. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - July 27, 2012 Category: Surgery Authors: L. Ni, C.-W. Liu, J.-B. Ricco, F. Dick, B. Liu, W. Ye Tags: Selected abstracts from the August issue of the European Journal of Vascular and Endovascular Surgery Source Type: research

Rapid Bravais-lattice determination algorithm for lattice parameters containing large observation errors
A new Bravais-lattice determination algorithm is introduced herein. For error-stable Bravais-lattice determination, Andrews & Bernstein [Acta Cryst. (1988), A44, 1009–1018] proposed the use of operations to search for nearly Buerger-reduced cells. Although these operations play an essential role in their method, they increase the computation time, in particular when lattice parameters obtained in (powder) auto-indexing are supposed to contain large errors. The new algorithm requires only several permutation matrices in addition to the operations that are necessary when the lattice parameters have exact values. As a resul...
Source: Acta Crystallographica Section A - July 25, 2012 Category: Chemistry Authors: Oishi-Tomiyasu, R. Tags: Bravais lattice reduction theory auto-indexing research papers Source Type: research

Imaging appearances of Buerger's disease complications in the upper and lower limbs
Thromboangiitis obliterans (Buerger's disease) is a rare, non-atherosclerotic, segmental, inflammatory vasculitis that most commonly involves small and medium-sized arteries, veins and nerves of the extremities and affects tobacco smokers between the ages of 25 and 45 years. The manifestations of Buerger's disease can be extremely variable and, therefore, awareness of the condition is important for both general and musculoskeletal radiologists. This paper presents the radiological appearance of the sequelae of Buerger's disease involving the upper and lower limbs. (Source: Clinical Radiology)
Source: Clinical Radiology - July 11, 2012 Category: Radiology Authors: S.J. Dimmick, A.C. Goh, E. Cauzza, L.S. Steinbach, I. Baumgartner, E. Stauffer, E. Voegelin, S.E. Anderson Tags: Pictorial Reviews Source Type: research

Fibrotic focus and hypoxia in male breast cancer
& Paul J van Diest (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 8, 2012 Category: Pathology Authors: Robert KornegoorAnoek H J Verschuur-MaesHorst BuergerMarieke C H HogenesPeter C de BruinJoost J OudejansBernd HinrichsPaul J van Diest Tags: fibrotic focus hypoxia male breast cancer prognosis Source Type: research

Role of Thrombophilia in Premature Peripheral Arterial Obstructive Disease – Experience of a Vascular Centre in China
Conclusion: Thrombophilia is frequently diagnosed among premature PAOD in China and adversely affects outcome after revascularisation. Clinicians should be aware of its high prevalence and aim at screening and sustained thrombophilia treatment. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - June 4, 2012 Category: Surgery Authors: L. Ni, C.-W. Liu, J.-B. Ricco, F. Dick, B. Liu, W. Ye Tags: Peripheral Arterial Disease Source Type: research

Role of Thrombophilia in Premature Peripheral Arterial Obstructive Disease - Experience of a Vascular Centre in China.
CONCLUSION: Thrombophilia is frequently diagnosed among premature PAOD in China and adversely affects outcome after revascularisation. Clinicians should be aware of its high prevalence and aim at screening and sustained thrombophilia treatment. PMID: 22658773 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - June 1, 2012 Category: Surgery Authors: Ni L, Liu CW, Ricco JB, Dick F, Liu B, Ye W Tags: Eur J Vasc Endovasc Surg Source Type: research

Immunophenotyping of male breast cancer
Conclusions: Several tissue biomarkers are associated with aggressive phenotype in male breast cancer. PR and p53 are the most promising individual prognostic markers. Based on immunophenotype, four distinctive and prognostic relevant male breast cancer groups were identified, indicating that protein expression profiling may be clinically useful in male breast cancer.© 2012 Blackwell Publishing Ltd (Source: Histopathology)
Source: Histopathology - May 29, 2012 Category: Pathology Authors: R. Kornegoor, A.H.J. Verschuur‐Maes, H. Buerger, M.C. Hogenes, P.C. de Bruin, J.J. Oudejans, B. Hinrichs, P.J. van Diest Source Type: research

[Evaluation of Hemodynamic Changes in Buerger's Disease Patients].
Conclusion: The clinical manifestations of peripheral vascular disease characteristic of TAO were reflected hemodynamically with monophasic low-resistance patterns associated with altered ABI values. Tobacco has an important role in the vascular blood flow, determinating high rates of amputation and low ABI values. PMID: 23069235 [PubMed - in process] (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - May 1, 2012 Category: Journals (General) Authors: Vicente I, Alves A, Pereira A, Roncon de Albuquerque R Tags: Acta Med Port Source Type: research

Revisiting cerebral thromboangiitis obliterans
We describe a 56-year-old patient with progressive cognitive decline in the context of heavy tobacco use and migraine, and imaging evidence of an occlusive terminal cerebral vasculopathy. The results of brain biopsy recapitulated the pathological features described by Lindenberg and Spatz in their classic 1939 treatise on cerebral thromboangiitis obliterans, or cerebral Buerger's disease. Although the condition is associated with heavy smoking, the identification of a hypercoagulable state in our patient suggests a multifactorial pathogenesis. The diagnosis of cerebral thromboangiitis obliterans in life is facilitated by m...
Source: Journal of the Neurological Sciences - April 13, 2012 Category: Neurology Authors: Carrie B. Hurelbrink, Yael Barnett, Michael E. Buckland, Mark Wilkinson, Jon Leicester, Craig Anderson, Jeffrey Brennan, Michael Barnett Tags: Short Communications Source Type: research

Pluristem Forms Peripheral Artery Disease Steering Committee
HAIFA, Israel, April 3, 2012 (GLOBE NEWSWIRE) -- Pluristem Therapeutics, Inc. (Nasdaq:PSTI) (TASE:PLTR) today announced that it has formed a steering committee to assist in advancing PLacental eXpanded (PLX) cell therapies for the treatment of Peripheral Artery Disease (PAD). The committee is comprised of vascular and immunological specialists from around the world who will offer expertise to Pluristem in furthering cell treatments for Critical Limb Ischemia (CLI), Intermittent Claudication (IC) and Buerger's Disease. (Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - April 3, 2012 Category: Pharmaceuticals Source Type: news

Natural history definition and a suggested clinical approach to Buerger's disease: a case-control study with survival analysis.
Abstract The aim of this study was first to describe the natural history of Buerger's disease (BD) and then to discuss a clinical approach to this disease based on multivariate analysis. One hundred eight patients who corresponded with Shionoya's criteria were selected from 2000 to 2007 for this study. Major amputation was considered the ultimate adverse event. Survival analyses were performed by Kaplan-Meier curves. Independent variables including gender, duration of smoking, number of cigarettes smoked per day, minor amputation events and type of treatments, were determined by multivariate Cox regression analysis...
Source: Vascular - February 28, 2012 Category: Surgery Authors: Fazeli B, Ravari H, Assadi R Tags: Vascular Source Type: research

Microbial scout hypothesis and microbial discovery.
In this study, we examine the temporal pattern of colony appearance during cultivation experiments, and whether this pattern could inform on optimizing the process of microbial discovery. In a series of long-term cultivation experiments, we observed an expected gradual increase over time of the total number of microbial isolates, culminating in a 700-fold colony count increase at 18-months. Conventional thought suggests that long-term incubations result in a culture collection enriched with species that are slow growing or rare, may be unavailable from short-term experiments, and likely novel. However, after we examined th...
Source: Applied and Environmental Microbiology - February 24, 2012 Category: Microbiology Authors: Buerger S, Spoering A, Gavrish E, Leslin C, Ling L, Epstein SS Tags: Appl Environ Microbiol Source Type: research

Microbial scout hypothesis, stochastic exit from dormancy, and the nature of slow growers.
Abstract We recently proposed a scout model of the microbial life cycle, the central element of which is a hypothesis that dormant microbial cells wake up into active ("scout") cells stochastically, independent of environmental cues. Here we check the principal prediction of this hypothesis: under growth permissive conditions, dormant cells initiate growth at random time intervals, and exhibit no species-specific lag phase. We show that a range of microorganisms, including environmental species, Escherichia coli, and Mycobacterium smegmatis, indeed wake up in a seemingly stochastic manner, and independently of envi...
Source: Applied and Environmental Microbiology - February 24, 2012 Category: Microbiology Authors: Buerger S, Spoering A, Gavrish E, Leslin C, Ling L, Epstein SS Tags: Appl Environ Microbiol Source Type: research

Improving Neural Control Of Prosthetics For Amputees
Sandia National Laboratories researchers, using off-the-shelf equipment in a chemistry lab, have been working on ways to improve amputees' control over prosthetics with direct help from their own nervous systems. Organic materials chemist Shawn Dirk, robotics engineer Steve Buerger and others are creating biocompatible interface scaffolds. The goal is improved prosthetics with flexible nerve-to-nerve or nerve-to-muscle interfaces through which transected nerves can grow, putting small groups of nerve fibers in close contact to electrode sites connected to separate, implanted electronics... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 23, 2012 Category: Consumer Health News Tags: Medical Devices / Diagnostics Source Type: news

Treatment of thromboangiitis obliterans (Buerguer's disease) with bosentan
This study assessed the effectiveness and safety of bosentan when administered to thromboangiitis obliterans (Buerger's disease) patients.MethodA clinical pilot study was designed in which patients with ulcer and/or pain at rest were treated with bosentan p.o. at a dose of 62.5 mg twice daily during the first month, which was thereafter up-titrated to 125 mg twice daily. The study endpoints were clinical improvement rate, major or minor amputation rate, haemodynamic changes, changes in endothelial function and angiographic changes. Results: Seven out of 12 patients were male (58%). Median age was 39 years (range 29-49). Th...
Source: BMC Cardiovascular Disorders - February 14, 2012 Category: Cardiology Authors: Joaquin De HaroFrancisco AcinSilvia BledaCesar VarelaLeticia Esparza Source Type: research

Combined Revascularization and Free-Tissue Transfer for Limb Salvage in a Buerger Disease Patient
Buerger disease is a limb-threatening condition occurring in young smokers, and its treatment has been a challenging problem, although a large number of medical and surgical options have been suggested. Combined surgery for revascularization and free-tissue transfer for Buerger disease is an aggressive and attractive option. This complex surgery enables successful treatment of tissue loss caused by ischemia. We performed revascularization and free-tissue transfer to the critically ischemic limb in a patient with Buerger disease. In this case, the procedure is attempted to salvage a limb from amputation. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - January 27, 2012 Category: Surgery Authors: Kanae Ikeda, Takatoshi Yotsuyanagi, Koshiro Arai, Tetsuya Suda, Tamotsu Saito, Kyori Ezoe Tags: Case Report Abstracts Source Type: research

Prospective high‐resolution respiratory‐resolved whole‐heart MRI for image‐guided cardiovascular interventions
This article demonstrates how dynamic roadmaps using an affine motion model can be obtained from one respiratory‐resolved three‐dimensional whole‐heart acquisition using the previously introduced Radial Phase Encoding‐Phase Ordering with Automatic Window Selection method. Respiratory motion in different regions of the heart was analyzed in 10 volunteers, and it was shown that the use of dynamic roadmaps can reduce misalignment errors from more than 10 down to less than 1.5 mm. Furthermore, the results suggest that reliable motion information can be obtained from highly undersampled images due to the advantageous un...
Source: Magnetic Resonance in Medicine - December 19, 2011 Category: Radiology Authors: Christoph Kolbitsch, Claudia Prieto, Christian Buerger, James Harrison, Reza Razavi, Jouke Smink, Tobias Schaeffter Tags: Note Source Type: research

Molecular subtyping of male breast cancer by immunohistochemistry
& Paul J van Diest (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - November 4, 2011 Category: Pathology Authors: Robert KornegoorAnoek H J Verschuur-MaesHorst BuergerMarieke C H HogenesPeter C de BruinJoost J OudejansPetra van der GroepBernd HinrichsPaul J van Diest Tags: breast cancer immunohistochemistry male molecular typing Source Type: research

Fast generation of 4D PET-MR data from real dynamic MR acquisitions.
Abstract We have implemented and evaluated a framework for simulating simultaneous dynamic PET-MR data using the anatomic and dynamic information from real MR acquisitions. PET radiotracer distribution is simulated by assigning typical FDG uptake values to segmented MR images with manually inserted additional virtual lesions. PET projection data and images are simulated using analytic forward projections (including attenuation and Poisson statistics) implemented within the image reconstruction package STIR. PET image reconstructions are also performed with STIR. The simulation is validated with numerical simulation...
Source: Physics in Medicine and Biology - October 8, 2011 Category: Physics Authors: Tsoumpas C, Buerger C, King AP, Mollet P, Keereman V, Vandenberghe S, Schulz V, Schleyer P, Schaeffter T, Marsden PK Tags: Phys Med Biol Source Type: research

New routing alternative for proximal anterior tibial artery bypass in patients with Buerger disease
Femoral-anterior tibial artery bypasses with autogenous grafts are difficult to perform when sufficiently long saphenous veins are not available. We performed 12 bypasses on patients with Buerger disease during a 20-year period using a new intermuscular tunneling technique. The graft is passed from the thigh between the muscle compartments without penetrating the muscle fibers, providing an anatomically superior and shorter path. The primary patency rates were 75% at 5 years and 65% at 10 years. We believe that our tunneling technique is safe and durable and might be a viable alternative for proximal femoral-anterior tibia...
Source: Journal of Vascular Surgery - September 26, 2011 Category: Surgery Authors: Taeseung Lee, Hwan Do Ra, Yang Jin Park, Hyung Sub Park, Sang Joon Kim Tags: Vascular and endovascular techniques Source Type: research

[Knee disarticulation and through-knee amputation.]
Abstract OBJECTIVE: A knee disarticulation or a through-knee stump is superior compared to a transfemoral stump. The thigh muscles are all preserved, and the muscle balance remains undisturbed. The range of motion of the hip joint is not limited. The bulbous shape of the stump allows full weight bearing at the stump end and can easily be fitted with a prosthesis. An amputee with a bilateral knee disarticulation is able to walk "barefoot". INDICATIONS: A more distal amputation level, e.g., an ultra-short transtibial amputation, is not possible. Important alternative to transfemoral amputations. Possible for any etio...
Source: Operative Orthopadie und Traumatologie - September 23, 2011 Category: Orthopaedics Authors: Baumgartner R Tags: Oper Orthop Traumatol Source Type: research

Systematic analysis of in vitro chemosensitivity and mib-1 expression in molecular breast cancer subtypes
Conclusion: Breast cancer molecular subclasses show differences regarding in vitro chemotherapy sensitivity. These may in part explain differences observed between breast cancer molecular subtypes in vivo. (Source: European Journal of Cancer)
Source: European Journal of Cancer - September 19, 2011 Category: Cancer & Oncology Authors: Cornelia Liedtke, Jens Packeisen, Kenneth R. Hess, Ulf Vogt, Ludwig Kiesel, Christian Kersting, Eberhardt Korsching, Burkhard Brandt, Horst Buerger Tags: Basic and preclinical research Source Type: research

[Forefoot and midfoot amputations.]
Abstract OBJECTIVE: Partial foot amputations are feasible regardless of the causal condition, including peripheral vascular disease with a few exceptions. Compared to higher amputation levels, a good foot stump permits full end bearing and enables the patient, even with a hindfoot stump, to walk without the need for a prosthesis. The more peripheral the amputation level selected, the greater the need for gentle tissue handling and meticulous postoperative care, but also the greater the risk of a breakdown requiring stump revision surgery. In the forefoot, partial amputation of the metatarsals preserves the length o...
Source: Operative Orthopadie und Traumatologie - September 17, 2011 Category: Orthopaedics Authors: Baumgartner R Tags: Oper Orthop Traumatol Source Type: research

Flow-mediated vasodilation is augmented in a corkscrew collateral artery compared with that in a native artery in patients with thromboangiitis obliterans (Buerger disease)
Conclusions: Endothelial function of a corkscrew collateral artery in patients with Buerger disease is maintained, while endothelial function is impaired in a native artery in Buerger disease. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - September 12, 2011 Category: Surgery Authors: Yuichi Fujii, Noritaka Fujimura, Shinsuke Mikami, Tatsuya Maruhashi, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Yukihito Higashi Tags: Clinical research studies Source Type: research

Thoracic respiratory motion estimation from MRI using a statistical model and a 2-D image navigator
Graphical abstract: Highlights: ► Respiratory motion model that can predict intra- and inter-cycle motion variability. ► PCA-based model applied using a real-time 2-D MRI ‘navigator’. ► Model application gives feedback on suitability of model to current breathing style. ► Motion model used to select optimal positioning for 2-D MRI ‘navigator’. ► Technique demonstrated for purpose of MRI-based motion correction of PET imaging.Abstract: Respiratory motion models have potential application for estimating and correcting the effects of motion in a wide range of applications, for example in PET-MR imaging. Give...
Source: Medical Image Analysis - September 7, 2011 Category: Radiology Authors: A.P. King, C. Buerger, C. Tsoumpas, P.K. Marsden, T. Schaeffter Source Type: research

Pluristem's PLX Cells Receive Orphan Drug Status for Treatment of Buerger's Disease
HAIFA, Israel, Aug. 25, 2011 (GLOBE NEWSWIRE) -- Pluristem Therapeutics, Inc. (Nasdaq:PSTI) (TASE:PLTR) today announced that on August 22, 2011, the U.S. Food and Drug Administration (FDA) designated Pluristem's PLX cells orphan status for the treatment of thromboangiitis obliterans (Buerger's disease). The Company also announced that a concurrent application in Europe at the EMA's Committee for Orphan Medicinal Products is pending. (Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - August 25, 2011 Category: Pharmaceuticals Source Type: news

Management of thromboangiitis obliterans using distraction osteogenesis: A retrospective study
Conclusion: The principle of the distraction osteogenesis including neoangiogenesis can be used for treatment of TAO and has an acceptable complication rate. (Source: Table of Contents : Indian Journal of Orthopaedics : 2007 - 41(1))
Source: Table of Contents : Indian Journal of Orthopaedics : 2007 - 41(1) - August 17, 2011 Category: Orthopaedics Authors: Sunil KulkarniGS KulkarniAshok K ShyamMilind KulkarniRuta KulkarniVidisha Kulkarni Source Type: research

Effectiveness of bosentan in the treatment of ischemic lesions in a case of thromboangiitis obliterans (Buerger disease): A case report.
We report the case of a 35-year-old woman with active TAO, refractory to smoking cessation and conventional therapy, who exhibited a favorable clinical response to treatment with bosentan, an oral dual endothelin receptor antagonist, administered on a compassionate-use basis. Six months after starting bosentan therapy, the pain and trophic lesions in the patient's toes had completely disappeared. Bosentan was well tolerated, without any observed adverse reaction. The findings of this case report suggest that bosentan may be considered a therapeutic option for patients with active disease, despite quitting smoking, or for t...
Source: Dermatol Online J - August 10, 2011 Category: Dermatology Authors: Palomo-Arellano A, Cervigón-González I, Torres-Iglesias LM Tags: Dermatol Online J Source Type: research

Longitudinal changes of fractional anisotropy in Alzheimer’s disease patients treated with galantamine: a 12-month randomized, placebo-controlled, double-blinded study
Abstract Diffusion tensor imaging (DTI) demonstrates decline of fractional anisotropy (FA) as a marker of fiber tract integrity in Alzheimer’s disease (AD). We aimed to assess the longitudinal course of white matter microstructural changes in AD and healthy elderly control (HC) subjects and to evaluate the effects of treatment with the cholinesterase inhibitor galantamine on white matter microstructure in AD patients. We enrolled 28 AD patients and 11 healthy elderly control subjects (HC). AD patients were randomly assigned to 6-month double-blind galantamine treatment or placebo, with a 6-month open-label...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 5, 2011 Category: Neuroscience Tags: European Archives of Psychiatry and Clinical Neuroscience Source Type: research

Does a species of Rickettsia play a role in the pathophysiology of Buerger's disease?
We report a patient with Buerger's disease for whom a left below-knee amputation was done. Twenty-five biopsies for DNA extraction were obtained from the arteries, veins and microvasculature of the amputated limb. Three samples were positive for Rickettsia. The finding may explain the proliferation of endothelial cells in the pathology of Buerger's disease, segmental nature of the disease, involving small- and medium-sized vessels, and the prevalence of Buerger's disease among the low socioeconomic class of the society. Understanding the infectious etiology of Buerger's disease would be invaluable, since early antibiotic t...
Source: Vascular - July 28, 2011 Category: Surgery Authors: Fazeli B, Ravari H, Farzadnia M Tags: Vascular Source Type: research

In vitro effects of perifosine, bortezomib and lenalidomide against hematopoietic progenitor cells from healthy donors
Summary The novel AKT inhibitor perifosine possesses myelopoiesis-stimulating effects in rodents. We studied the in vitro effects of the novel agents perifosine, bortezomib and lenalidomide in addition to adriamycin against normal human hematopoietic progenitor cells (HPC) using different clonogenic and non-clonogenic assays. All agents inhibited colony-forming unit (CFU) formation, perifosine inhibiting mainly CFU-granulocyte/macrophage formation and the other agents burst-forming unit-erythroid formation. Perifosine combined with lenalidomide or adriamycin tended to act antagonistically in suppressing CFU ...
Source: Investigational New Drugs - July 13, 2011 Category: Drugs & Pharmacology Tags: Investigational New Drugs Source Type: research

Reconstruction of the Soft Tissue Defects of Foot and Ankle with Neural-Island Flaps: Mono-Institutional Case Series
J reconstr MicrosurgDOI: 10.1055/s-0031-1281514ABSTRACTThe aim of this report is to show the results obtained from using the neural-island flap to cover the soft tissue defects of the foot and ankle. This is the first report of the neural-island flap series since the introduction of this flap to the literature in 2003. Between 2002 and 2009 “neural-island flap” was used to treat 20 patients of various lesions on the foot and ankle. All of the patients had serious soft tissue defects that compromised tendons, bones, or joints. In 16 patients, the tissue defects were completely and successfully covered with an un...
Source: Journal of Reconstructive Microsurgery - June 28, 2011 Category: Surgery Authors: Sonmez, ErhanSafak, Tunc Source Type: research

Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease
In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects. (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - June 20, 2011 Category: Neuroscience Authors: Michael Ewers, Susanne Schmitz, Oskar Hansson, Cathal Walsh, Annette Fitzpatrick, David Bennett, Lennart Minthon, John Q. Trojanowski, Leslie M. Shaw, Yetunde O. Faluyi, Bruno Vellas, Bruno Dubois, Kaj Blennow, Katharina Buerger, Stefan J. Teipel, Michael Tags: Regular Papers Source Type: research