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[Advanced ovarian cancer: criteria of resectability.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Residual disease is the first predictive factor for survival in women with ovarian cancer. Neoadjuvant chemotherapy still has not proved superiority in terms of overall survival compared with complete initial resection. Hence, initial surgery remains the cornerstone of management for patients with advanced ovarian cancer. Various parameters have been proposed to evaluate the ability of complete resection. Clinical evaluation of peritoneal carcinomatosis and ascite is not relevant enough while general status (ASA score) is correlated with the risk of postoperative complications. Preoperative dosage of CA-125 higher than...
Source: Bulletin du Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Chéreau E, Ballester M, Rouzier R, Coutant C, Daraï E Tags: Bull Cancer Source Type: journals

[New drugs and targeted therapeutic agents in ovarian cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian cancers are the leading cause of death from gynaecological malignancies in Western countries. Despite optimal treatment combining surgery and chemotherapy, relapse is observed in the majority of patients. This review aims to present the results of trials having evaluated new drugs in ovarian cancers. Advances in the understanding of cancer biology and more specifically of cell signalling pathways have led to the identification of several potential molecular targets and to the development of new agents directed against these targets. The assessment of targeted therapies is relatively recent in this field. So far...
Source: Bulletin du Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Rouge TD, Petrella MC, Michels J, Even C, Balleyguier C, Duclos J, Mazeron R, Morice P, Pautier P, Lhommé C Tags: Bull Cancer Source Type: journals

[Pharmacological bases of intraperitoneal chemotherapy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intraperitoneal chemotherapy is a very attractive therapeutic alternative in the treatment of advanced ovarian carcinoma, due to its intraperitoneal spreading. Pharmacokinetic rational was described 30 years ago: a drug administered within the peritoneal cavity diffuse through the peritoneum towards the plasmatic compartment, depending on both its molecular weight and its lipid solubility. A slow output of the drug from the peritoneal cavity and a high plasma clearance are associated with a great pharmacokinetic advantage, illustrated by the area under the concentration time curve ratio. Then it is possible to increase...
Source: Bulletin du Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Gladieff L, Chatelut E, Dalenc F, Ferron G Tags: Bull Cancer Source Type: journals

[Quality control criteria in the surgical management of advanced ovarian cancers.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two concurrent policies can be proposed to improve the quality of care for ovarian cancer surgery: organization of care, audit. The two policies are not to be opposed: the efficacy of any policy must be audited, targets are more rapidly reached and more easily audited when an underlying organization is available. However, the arbitrary definition of criteria is a challenge. The interpretation of results depends on the context of each individual center. There is a definite risk of unwanted effects: competition to reach the cut-off if quantitative caseload criteria are demanded, reduction of the quality of cytoreduction ...
Source: Bulletin du Cancer - November 17, 2009 Category: Cancer & Oncology Authors: Querleu D, Narducci F Tags: Bull Cancer Source Type: journals

[Towards a new standard in cytoreductive surgery for advanced ovarian cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The dismal outcome of ovarian, fallopian tube, and primary peritoneal carcinomas calls for an increase in surgical aggressiveness. After a long era during which incomplete cytoreduction was considered acceptable, it has been established that the outcome is directly related to the amount of diseased tissue left in place. Probably as a result of technical imitations of surgeons and anesthesiologists, the majority of teams have fixed a cut-off value of 2 cm to define what was called "optimal" cytoreduction. Although it is now established that reaching the 2 cm cut-off value is the minimal required target, the target has m...
Source: Bulletin du Cancer - November 17, 2009 Category: Cancer & Oncology Authors: Querleu D, Gladieff L, Ferron G, Rougé P Tags: Bull Cancer Source Type: journals

[Using medical imaging for a comprehensive breast cancer screening program.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We described here the national breast cancer-screening program that is used, in France, today. First we depict official rules and regulations along with the organization needed to screen a whole population. Then, a technical assessment is made on the efficacy and limits on mammography analyses leading to tumor classification. Finally, an evaluation of the program is discussed. PMID: 19887333 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - November 4, 2009 Category: Cancer & Oncology Authors: Dilhuydy MH Tags: Bull Cancer Source Type: journals

[Positron emission tomography and evaluation of response to targeted therapies.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The development of new-targeted therapies has highlighted the need to adapt the criteria used so far for radiological assessment of tumor response, but also the search for new criteria for a more appropriate evaluation. Nuclear medicine, and especially positron emission tomography (PET) offers a variety of functional imaging for early assessment of tumor response to targeted therapies. In this paper, we first describe data in the literature on PET technique with fluorodeoxyglucose (FDG) in this indication and the associated new molecules. The second part discusses the new positron-emitting tracers that are potentially ...
Source: Bulletin du Cancer - October 30, 2009 Category: Cancer & Oncology Authors: Gauthier H Tags: Bull Cancer Source Type: journals

[Liver chemoembolization: an update.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Percutaneous intraarterial techniques for treatment of liver tumors are continuously under development. New therapeutic methods are available (such as microsphere-encapsulated chemotherapy or yttrium 90 microspheres) and presently under evaluation. These methods enlarge the field of indications, i.e. in metastasis from colorectal cancer. Hepatocellular carcinoma and metastasis from neuroendocrine tumours are the main pathologies favourably responding to "conventional" chemoembolization. Thank to controlled studies and meta-analysis performed along the last ten years, curative-palliative-as well as adjuvant-indications ...
Source: Bulletin du Cancer - October 29, 2009 Category: Cancer & Oncology Authors: Roche A Tags: Bull Cancer Source Type: journals

[Radiofrequency ablation in the treatment of liver and lung tumors.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Radiofrequency (RF) ablation is a technique of thermotherapy which emerged over the last fifteen years in the field of oncology. RF directed toward a specific tumor mass is known to be very effective (over 90%) for treating tumors less than 2.5 cm. RF is used for patients with early-stage lung or liver cancers who are not surgical candidates, With improvements in systemic therapy, increasing interest in the use of local therapy for metastases has arisen. Eradication of residual metastases via local therapies has a sense in patients with stabilized disease. Nonsurgical alternative like RF has become popular because it i...
Source: Bulletin du Cancer - October 27, 2009 Category: Cancer & Oncology Authors: Palussière J, Descat E, Fonck M, Bonichon F, Chomy F, Bécouarn Y, Avril A, Kind M, Ravaud A Tags: Bull Cancer Source Type: journals

[CT and MRI imaging in tumoral angiogenesis.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiogenesis is the process of activating dormant endothelial cells to form new vessels, after stimulation and it is essential in tumor growth. In many types of cancer, angiogenesis results from the activation of oncogenes that stimulate the production of Vascular Endothelial Growth Factor (VEGF). However, these newly formed vessels have a great number of abnormalities: increased density of fragile and hyperpermeable microvessels, arterial-venous shunts, caliber abnormalities and flow instabilities susceptible to flow direction inversion according to interstitial pressure. Anti-angiogenic treatments inhibit VEGF activi...
Source: Bulletin du Cancer - October 27, 2009 Category: Cancer & Oncology Authors: Bazelaire CD, Calmon R, Chapellier M, Pluvinage A, Frija J, Kerviler ED Tags: Bull Cancer Source Type: journals

[Interventional radiology procedures in the treatment of bone metastasis.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over the last ten years, there has been much development in the treatment of bone metastases using percutaneous image-guided interventional radiology procedures. They are helpful in the managment of patients resulting in stabilization of bone lysis in order to achieve additional biomechanical stability and in significant symptomatic relief. Vertebroplasty consisting in an injection of an acrylic cement into a structurally weakened or destructed bone plays a major role in the management of specific bone weakening. Advances have been made also with the application of thermoablation procedures to bone tumors (radiofrequen...
Source: Bulletin du Cancer - October 27, 2009 Category: Cancer & Oncology Authors: Palussière J, Dixmerias F, Buy X, Descat E, Bonichon F, Debled M, Pointillart V, Gangi A Tags: Bull Cancer Source Type: journals

[Imaging in oncology and international rules for evaluation: the nuclear medicine.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The growing success of isotopic explorations in oncology is related to the number of growing radiotracers and progress in the methods for detection and imaging. Today, the nuclear medicine is able to answer important questions raised by biology and therapeutic progress results from this. The new radiopharmaceutical compounds are able to explore in vivo the metabolism, the proliferation, the hypoxia and the expression of some receptors or antigens in tumor cells. This progress in radiopharmaceuticals design can be combined with the new tools for detection, such as the cameras coupled to a tomodensitometer (TEMP-TDM and ...
Source: Bulletin du Cancer - October 26, 2009 Category: Cancer & Oncology Authors: Bourre JC, Vuillez JP Tags: Bull Cancer Source Type: journals

[Radiological digital imaging: a new tool for the patient medical file.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper will focus on the positive vs negative in-puts of new radiological imaging in the patient medical file. PMID: 19846387 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 21, 2009 Category: Cancer & Oncology Authors: Kind M Tags: Bull Cancer Source Type: journals

[Decision process in oncology: the importance of multidisciplinary meeting.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to determine the place of MDM in the decision process. From November 2004 to July 2005, we observed 29 meetings at the Tours Hospital and 324 case presentations, 80 in orthopaedics, 151 in gastroenterology and 93 in chest medicine. Forty physicians attending the meetings answered a questionnaire exploring their opinions on MDM and the collegial decision. We found that MDM is mostly the place for technical discussions and that patients' wishes are rarely addressed. The different medical specialities are well represented but we observed that only physicians attend MDM. Decisions for straightforward cases are ...
Source: Bulletin du Cancer - October 13, 2009 Category: Cancer & Oncology Authors: Orgerie MB, Duchange N, Pélicier N, Chapet S, Dorval E, Rosset P, Lemarié E, Hervé C, Moutel G Tags: Bull Cancer Source Type: journals

[New influenza A (H1N1) pandemia and cancer patients: what do we do?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The new swine-origin influenza A (H1N1) strain (S-OIV) pandemia may expose immunodepressed cancer patients under chemotherapy to an increased risk of mortality. Here, we put into perspective available antiviral treatments and influenza vaccination efficacy in cancer patients and consider that recommandations for seasonal influenza vaccination for these patients are applicable for the upcoming S-OIV vaccines. We recommend a triple vaccination in cancer patients (seasonal influenza, S-OIV, streptococus pneumoniae), if possible at least two weeks before beginning chemotherapy. In case of an influenza-like illness under ch...
Source: Bulletin du Cancer - October 12, 2009 Category: Cancer & Oncology Authors: Barrière J, Otto J, Cua E, Coindard G, Peyrade F Tags: Bull Cancer Source Type: journals

Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Krüppel-like C(2)H(2) zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 an...
Source: Bulletin du Cancer - October 11, 2009 Category: Cancer & Oncology Authors: Dehennaut V, Leprince D Tags: Bull Cancer Source Type: journals

[High risk of cardiac dysfunction after treatment of secondary acute myeloid leukemia following chemotherapy and radiotherapy for breast cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Secondary acute myeloid leukaemia (AML) occurring after breast cancer is a rare long-term complication of the chemo- and/or radiation therapy required to treat breast cancer. The usually recognized curative option of these secondary AML includes courses of anthracycline-based chemotherapy followed by haematopoietic stem cell transplantation (HSCT). Cardiac dysfunction during AML treatment of these patients previously treated with anthracyclines for breast cancer has not been reported to date. We evaluated the evolution of cardiac function in seven patients treated with anthracyclines and/or autologous or allogeneic bon...
Source: Bulletin du Cancer - October 8, 2009 Category: Cancer & Oncology Authors: Willems L, Suarez F, Messas E, Baubion N, Decaudin D, Fourquet A, Ghez D, Delarue R, Hermine O, Buzyn A, Varet B, Rubio MT Tags: Bull Cancer Source Type: journals

[Specificity of paediatric oncology pharmacology.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anticancer chemotherapy plays a key role in the treatment of cancer in children. Following its increased efficacy, three children out of four can now be cured. Nevertheless, given the fact that 25% of the children with cancer are not cured and chemotherapy-induced long-term side effects are numerous there is a need to keep developing new agents and new strategies to fight cancer. Moreover studies investigating off-patents drugs should be stimulated in paediatric oncology in order to improve our knowledge of "old" drugs. Here we will review the specificities of children as compared to adults in the context of clinical d...
Source: Bulletin du Cancer - October 7, 2009 Category: Cancer & Oncology Authors: André N, Leblond P, Verschuur A Tags: Bull Cancer Source Type: journals

[Is there an interest in para-aortic lymphadenectomy in operable endometrial cancer?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The indication and extent of lymph node dissection in the surgical management of endometrial cancer remains controversial especially concerning the para-aortic lymph nodes. The therapeutic benefit of the lymph node dissection is criticized mainly for low-risk patients for extra-uterine spread. Surgically staging patients is the best method to predict node involvement and it allows an optimal decision for adjuvant therapy to be taken. The different prognostic factors for para-aortic lymph nodes metastasis are histological grade and size of the tumour, myometrial wall invasion and lymphovascular dissemination, as well as...
Source: Bulletin du Cancer - October 6, 2009 Category: Cancer & Oncology Authors: Bouquier J, Bricou A, Delpech Y, Tulpin L, Akerman G, Barranger E Tags: Bull Cancer Source Type: journals

[Basaloid squamous cell carcinomas of the head and neck.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Basaloid squamous cell carcinomas (SCC) are a rare variant of SCC of the head and neck. Their histological characteristics have been described by Wain in 1986 and are reported in the 2005 WHO classification. A poorer prognosis of BSCC has been reported. Two recent case-control studies have shown a higher rate of distant metastases (15-40%, mean over 30%). Conversely, BSCC have similar or better locoregional control rates, a relatively good radiosensitivity and locoregional control. The role of chemotherapy in the neoadjuvant, concomitant or adjuvant setting needs to be redefined due to high metastatic failure rates; ch...
Source: Bulletin du Cancer - September 30, 2009 Category: Cancer & Oncology Authors: Thariat J, Badoual C, Faure C, Mones ED, Butori C, Santini J, Poissonnet G, Maingon P, Faivre S, Klijanienko J, Saint-Guily JL, Righini C Tags: Bull Cancer Source Type: journals

[Impact of radiotherapy on fertility in female patients.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although insufficiently documented, the impact of radiation therapy on fertility should not be neglected in female patients. Toxicity on reproductive function is dual and is characterized by both mechanistic deleterious effects on the genital tract and partial or complete loss of ovarian function. Moreover, gonadic toxicity may be increased by the concurrent use of chemotherapy or surgical procedure. In some circumstances, ovarian transposition may be justified for young patients. But no compromise may be accepted in terms of carcinologic results. At least, the effect of low-doses of irradiation has not been demonstrat...
Source: Bulletin du Cancer - September 28, 2009 Category: Cancer & Oncology Authors: Chargari C, Castadot P, Gillion N, Bauduceau O, Védrine L, Haie-Meder C, Spano JP, Magné N Tags: Bull Cancer Source Type: journals

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Bull Cancer. 2009 Sep 23; Authors: Hœrni B PMID: 19773216 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 22, 2009 Category: Cancer & Oncology Authors: Hœrni B Tags: Bull Cancer Source Type: journals

[Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC): evaluation, prevention and policies to avoid occupational exposure for operating room personnel.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To develop a treatment strategy for peritoneal carcinomatosis using a combination of extended peritoneal resections, local destructive procedures and hyperthermic intraperitoneal chemotherapy creates great concern between healthcare workers involved in these procedures. New professional risks exist: risk of exposure to cytotoxic drugs, environmental risks (inhalation of smoke, aerosolization of chemotherapy agents). Information, education and training of healthcare workers is mandatory in order to ensure proper evaluation, prevention, and management of professional exposure risks in coordination with the occupational h...
Source: Bulletin du Cancer - September 17, 2009 Category: Cancer & Oncology Authors: Simon L, Halilou MC, Gladieff L, Gadiou M, Herin F, Hennebelle I, Chatelut E, Ferron G Tags: Bull Cancer Source Type: journals

[Access to preventative care, screening and treatment of women in vulnerable socio-economic groups presenting with cervical cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionCervical screening is not taken up adequately throughout the general population. Access to health care is poorly tailored to the needs of the socially deprived. Social deprivation did not demonstrate an association with levels of pelvic recurrence, metastasis or death. The low doctor to patient ratio in certain geographical areas reduces access to medical care. PMID: 19762324 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 17, 2009 Category: Cancer & Oncology Authors: Dalmon C, Guillot E, Rodrigues A, Alves K, Madelenat P, Mahieu-Caputo D, Uzan M, Reyal F Tags: Bull Cancer Source Type: journals

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Bull Cancer. 2009 Sep 18; Authors: Zhai XD, Mo YN, Xue XQ, Zhao GS, Gao LB, Ai HW, Ye Y Numerous candidate genes have been proposed as susceptibility factors for the development of esophageal squamous cell carcinoma (ESCC). XRCC1 (X-ray cross-complementing group 1) codon 280 and ERCC2 (excision repair cross complementing group 2) codon 751 polymorphisms were studied in ESCC in a Chinese population. The aim of this study is to investigate the potential association between single-nucleotide polymorphisms (SNP) of XRCC1 codon 280 His and ERCC2 codon 751 Gln polymorphisms and ESCC. Peripheral blood samples of 200 cases...
Source: Bulletin du Cancer - September 17, 2009 Category: Cancer & Oncology Authors: Zhai XD, Mo YN, Xue XQ, Zhao GS, Gao LB, Ai HW, Ye Y Tags: Bull Cancer Source Type: journals

[PET/CT in breast cancer: an update.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors discuss the various roles of 18F-FDG PET/CT in the management of breast cancer. Roles of new tracers such as F-18 fluoro-L-thymidine (a marker of cell proliferation), 18-fluoro-17-B-estradiol (marker of estrogen receptor) and sodium fluoride (marker of bone matrix) are also mentioned. There is little justification for the use of FDG-PET/CT in patient with clinically T1 (</= 2 cm) N0 tumours. Notably, it cannot be used as a substitute to SLNB "sentinel lymph node biopsy" for axillary staging due to limited sensitivity for the detection of small metastases. The case is different in higher risk patients, an...
Source: Bulletin du Cancer - September 16, 2009 Category: Cancer & Oncology Authors: Groheux D, Moretti JL, Giacchetti S, Hindié E, Teyton P, Cuvier C, Bousquet G, Misset JL, Boin C, Espié M Tags: Bull Cancer Source Type: journals

[Extracranial stereotactic radiotherapy avancer by robotic radiosurgery: preliminary experience of the center Alexis-Vautrin.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stereotactic radiotherapy delivers allows for a highly precise irradiation, and was originally developed in the 70s by neurosurgeons. Gradually, it has been developed in extracranial indications. Moreover new innovative treatment devices such as the robotic radiosurgery with CyberKnife(R) have emerged. Indications are currently being validated by the HAS in intracranial locations that are treated by conventional radiosurgery for several decades. Three robotic radiosurgery facilities were opened in France in 2006 thanks to a grant from the INCa. Those are posed in Lille, Nice, Nancy. Since 2007, 140 patients were treate...
Source: Bulletin du Cancer - September 13, 2009 Category: Cancer & Oncology Authors: Taste H, Beckendorf V, Bernier V, Graff P, Marchesi V, Noël A, Peiffert D Tags: Bull Cancer Source Type: journals

[Cancer genetics: estimation of the needs of the population in France for the next ten years.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organised since 1990 in France, cancer genetics has been strengthened since 2003 by the programme "Plan Cancer" which resulted in an improvement of the organisation of activities. The aim of this review is to present an update of the estimation of the needs of the population in this field for the next ten years, provided by a group of experts mandated by the French National Cancer Institute. Identification and management of major hereditary predispositions to cancer have a major impact on decrease in mortality and incidence. Sensitivity of criteria for the detection of BRCA1/2 mutations could be substantially improved ...
Source: Bulletin du Cancer - September 13, 2009 Category: Cancer & Oncology Authors: Bonaïti-Pellié C, Andrieu N, Arveux P, Bonadona V, Buecher B, Delpech M, Jolly D, Julian-Reynier C, Luporsi E, Noguès C, Nowak F, Olschwang S, Orsi F, Pujol P, Saurin JC, Sinilnikova O, Stoppa-Lyonnet D, Thépot F Tags: Bull Cancer Source Type: journals

[Estimation of individual breast cancer risk: relevance and limits of risk estimation models.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several risk estimation models for breast or ovarian cancers have been developed these last decades. All these models take into account the family history, with different levels of sophistication. Gail model was developed in 1989 taking into account the family history (0, 1 or >/= 2 affected relatives) and several environmental factors. In 1990, Claus model was the first to integrate explicit assumptions about genetic effects, assuming a single gene dominantly inherited occurring with a low frequency in the population. BRCAPRO model, posterior to the identification of BRCA1 and BRCA2, assumes a restricted transmissi...
Source: Bulletin du Cancer - September 10, 2009 Category: Cancer & Oncology Authors: Pauw AD, Stoppa-Lyonnet D, Andrieu N, Asselain B Tags: Bull Cancer Source Type: journals

[Locally advanced head and neck cancers: recommendations of an expert panel and perspectives for the use of TPF regimen (docetaxel, cisplatin and fluoro-uracil) as induction therapy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionProgresses in induction chemotherapy have allowed improving the prognosis of patients with locally advanced SCCHN. The TPF regimen represents a major improvement in this indication, and ongoing strategic clinical trials should refine its indications. PMID: 19744919 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 10, 2009 Category: Cancer & Oncology Authors: Bardet E, Bourhis J, Cals L, Fayette J, Guigay J, Hans S, Saint-Guily JL, Lagarde F, Lallemant B, Milano G, Rolland F, Lefebvre JL Tags: Bull Cancer Source Type: journals

[Involvement of human papillomavirus in upper aero-digestive tracts cancers.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human papillomavirus (HPV) is one of the most common causes of sexually transmitted infection in the world. France and Belgium present one of the highest incidence of head and neck squamous cell carcinomas (HNSCC) worldwide. Besides, considering only the male population, HNSCCs represent the fourth most frequent cancer after prostate, lung and colon cancers. Although the causal link between high-risk HPVs and cervical carcinoma is well established, the implication of this viral infection in HNSCC remains debatable. Here, we discuss current knowledge concerning the HPV implication in HNSCCs. Based on our literature revi...
Source: Bulletin du Cancer - September 9, 2009 Category: Cancer & Oncology Authors: Neufcoeur PE, Arafa M, Delvenne P, Saussez S Tags: Bull Cancer Source Type: journals

[Current indications and ongoing clinical trials with CyberKnife (R) stereotactic radiotherapy in France in 2009.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Image-guided frameless fractionated stereotactic radiotherapy can be performed with millimetric accuracy using the CyberKnife(R) (Accuray Inc. Sunnyvale, USA) equipped with an integrated tracking system for intra- and extracranial lesions. Highly conformal hypofractionated irradiation has been used to treat lesions with curative or palliative intent. It is advantageous for radioresistant tumors, re-irradiating lesions, boosting small volumes and treating tumors that move with respiration. It also limits travel costs and improves the quality of life. Over 60,000 patients have been treated worldwide using CyberKnife(R) i...
Source: Bulletin du Cancer - September 7, 2009 Category: Cancer & Oncology Authors: Thariat J, Li G, Angellier G, Marchal S, Palamini G, Rucka G, Bénézery K, Castelli J, Trimaud R, Mammar H, Marcie S, Gérard JP, Bondiau PY Tags: Bull Cancer Source Type: journals

[Guidelines for prophylaxis and treatment of chemotherapy-induced nausea and vomiting.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For the past two decades, significant developments have been made in supportive care for the management of chemotherapy-induced nausea and vomiting (CINV). A better understanding of the pathophysiology of vomiting and the introduction of two new classes of antiemetic agents with a high therapeutic index (serotonin type 3 receptor antagonists [anti-5HT3 or setrons] in the 1990s and neurokinin type 1 receptor antagonists [anti-NK1] in 2000), possibly combined with corticosteroids, have helped to improve the management of this distressing side effect, constantly feared by patients. It is essential to distinguish between t...
Source: Bulletin du Cancer - September 6, 2009 Category: Cancer & Oncology Authors: Durand JP, Madelaine I, Scotté F Tags: Bull Cancer Source Type: journals

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Bull Cancer. 2009 Aug 21; Authors: Adem C PMID: 19696003 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Adem C Tags: Bull Cancer Source Type: journals

[Satisfaction survey of Serbian oncologists after experience in French hospitals.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionTo optimise these training's, basic knowledge of French and well-targeted expectations are essential. To improve professional practise of oncologists, the answers go to a best internal communication and the establishment of a politic of education for doctors and the rest of the personal in oncology services. PMID: 19696004 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Bujan S, Marković-Denić L Tags: Bull Cancer Source Type: journals

[Prevalence of elevated serum CA 15-3 at time of metastatic relapse of breast cancer and correlation with hormone receptor status.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CA15-3, a peptide derived from MUC-1, an hormonally-regulated protein, is the most widely used serum marker of breast cancer. CA15-3 level increases at the metastatic phase in 50-80% breast cancer patients. Although rise of CA15-3 precede symptoms of metastasis by a mean time of 2-9 months, current international guidelines do not recommend its routine use for screening for metastases because of moderate sensitivity and absence of clinical impact. We conducted a retrospective study among all patients with metastatic breast cancer seen by three senior breast oncologists during a 4-month period. We evaluated correlation o...
Source: Bulletin du Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Bensouda Y, André F, Boulet T, Al-Ghuzlan A, Conforti R, Troalen F, Bourgier C, Errihani H, Spielmann M, Delaloge S Tags: Bull Cancer Source Type: journals

[Impact of the chemotherapy protocols for metastatic breast cancer on the treatment cost and the survival time of 371 patients treated in three hospitals of the Rhone-Alpes region.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The chemotherapy of the metastatic breast cancer is characterized by the diversity of the treatment protocols and the utilisation of new expensive molecules posing the double problem of outcomes for the patients and financial effects for the hospitals. This survey describes the different chemotherapy treatments prescribed in the metastatic breast cancer and the direct costs supported by the hospitals according to the patient survival time. A cohort of 371 patients treated for a metastatic breast cancer was followed in three hospitals of the Rhone-Alpes region between 2001 and 2006. The detail of their different antineo...
Source: Bulletin du Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Paviot BT, Bachelot T, Clavreul G, Jacquin JP, Mille D, Rodrigues JM Tags: Bull Cancer Source Type: journals

[Chronic lymphocytic leukemia in Subsaharian Africa: clinical outcome experience of Côte d'Ivoire.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported in this retrospective study the clinical outcome of 56 chronic lymphoïd leukemia of black African in Ivory Coast and the predicting prognosis factors. The mean age was 62 years old with average of 38 to 84 years. According to Binet staging, 29 patients with stage A, and respectively 11 and 16 patient for stage B and C. All patient received chemotherapy protocol regimens (CVP, chlorambucil, CHOP). The global response was 51.78%. The death occurred in 29 patients. The mean survival was 8.22 years. The disease free survival was 58.8% at 5 years. In univariate analysis, factors with high-risk of death are pati...
Source: Bulletin du Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Koffi K, Nanho D, Tolo A, N'dathz E, Kouakou B, Meite N, Ayemou R, Sanogo I Tags: Bull Cancer Source Type: journals

[Improvement of quality of practices for the preparation of cytotoxic drugs: results of a "before-after" study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study shows that appropriate handling helps decrease the number of samples contaminated, making it possible to recommend these controls for evaluating and improving the quality of practices. Since 2007, the network's laboratory has extended its activities to all French hospitals interested in this quality assurance programme. PMID: 19696008 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Gilles L, Favier B, Catillon F, Dussart C, Peyron F, Simoens X, Latour JF, Farsi F, Biron P Tags: Bull Cancer Source Type: journals

[Recommendations for diagnostic and therapeutic management of soft tissue sarcoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Soft tissue sarcomas are rare tumors. They may occur in any part of the body. Early step of management are essential because they directly affect functional consequences and survival of patients. It is very important to rapidly evoke the diagnostic of soft tissue sarcoma. Multidisciplinary discussion is indispensable at different step of the management: before the diagnostic to organize radiological check up and preoperative biopsy, before resection of localized tumor to decide the surgical procedure, with anatomopathological results to discuss an adjuvant treatment, at metastatic setting to decide a systemic treatment...
Source: Bulletin du Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Dufresne A, Blay J, Cassier P, Vanel D, Bui B, Cesne AL Tags: Bull Cancer Source Type: journals

[A difficult end of life.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The law specifies how a doctor may write a medical certifcate and how a patient or his beneficiaries can obtain his medical records. It's important for a doctor to know this rules. A 56 years old patient was referred to our hospital for pulmonary adenocarcinoma cT2N2M1, the clinical stage was IV. The patient underwent radiotherapy and chemotherapy. During the treatment, the relations with the family were difficult. The patient refuse to accept the doctors tell his son any information and get married with his companion in secret. After patient's death, the son and the wife asked for many medical certificates. The doctor...
Source: Bulletin du Cancer - August 3, 2009 Category: Cancer & Oncology Authors: Traclet J, Arpin D, Gérinière L, Deygas S, Rhomer B, Audras S, Bertoletti L, Cortot A, Coudurier M, Couraud S, Girard N Tags: Bull Cancer Source Type: journals

[Confidentiality in medical practice: tell no one?...]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medical confidentiality is sometimes difficult to impose on patient's families, especially in the field of oncology. Here, we describe the case of a 54-years-old woman with a T1N0M0 lung adenocarcinoma. After the diagnosis was made, she advised the medical team not to inform her family about her disease. Although the patient was aware of the high-risk of relapse, she was lost of follow-up after first-line treatment. Five years later, she presented with multi-metastatic recurrence and had to be admitted in an intensive-care unit for severe respiratory failure due to tumor progression. She kept refusing to inform her fam...
Source: Bulletin du Cancer - August 3, 2009 Category: Cancer & Oncology Authors: Couraud S, Arpin D, Perol M, Guérin JC, Gérinière L, Deygas S, Rhomer B, Audras S, Bertoletti L, Cortot A, Coudurier M, Girard N Tags: Bull Cancer Source Type: journals

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Bull Cancer. 2009 Jul 20; Authors: Magné N, Daisne JF, Moretti L, Berben D, Meert N, Alen R, Bral S, Cleef AV, Haustermans K, Houtte PV, Scalliet P The aim of the present study was to perform a rectal cancer practice survey in order to re-assess in 2005 the Belgian state of the art. A questionnaire based on the past 1999 peer review, supplemented with general questions, was circulated to 16 radiotherapy centres in Belgium. A case was also proposed for treatment planification. In 2005, a formal multidisciplinary team was in place in all visited centres. Endorectal ultrasound, colonoscopy, CEA and an initial pat...
Source: Bulletin du Cancer - July 19, 2009 Category: Cancer & Oncology Authors: Magné N, Daisne JF, Moretti L, Berben D, Meert N, Alen R, Bral S, Cleef AV, Haustermans K, Houtte PV, Scalliet P Tags: Bull Cancer Source Type: journals

Targeting IGF-1R in the treatment of sarcomas: past, present and future.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of multimodality therapy has resulted in markedly improved cure rates for patients with sarcomas in the past 25 years. However, for virtually all patients with metastatic or recurrent disease, survival remains dismal. The important role that members of the insulin-like growth factor (IGF) family play in tumorigenesis has been known for decades. But it has only been in the last five years, that humanized and fully human antibodies targeting insulin-like growth factor receptor 1 (IGF-1R) have been developed. The use of these agents in clinical trials has been accompanied by several dramatic responses in patients ...
Source: Bulletin du Cancer - July 19, 2009 Category: Cancer & Oncology Authors: Kim SY, Wan X, Helman LJ Tags: Bull Cancer Source Type: journals

[Contribution to the qualification of hospital ethics bodies in the cancer centers.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present op-ed article reports on a thesis study which examines the emergence of ethics committees in health care institutions. These committees have developed rapidly over the past few years in order to address ethical issues related to the management and care of patients. However, the question is raised of whether the ethics committees established in hospitals are an appropriate and effective response to the demands of the law (bill L. 6111-1), which states that institutions should implement ethical policies but does not provide any guidance on what should be done in practice. PMID: 19592327 [PubMed - as suppl...
Source: Bulletin du Cancer - July 9, 2009 Category: Cancer & Oncology Authors: Mazeres JE Tags: Bull Cancer Source Type: journals

[The ethical implications of prospective payment and patient care.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With the introduction of the new prospective payment system considerable concern is being expressed that with the dominant emphasis on coasts, the principals of access and quality might be compromised. A new concept now emerged in care: productivity. How can we conjugate with the preset price for services to its beneficiaries based on average coasts of hospital care for patients' quality of care, patients and nursing team expectations and ethic? Which room will have ethic in that new way of redefining care? Will it be a risk that some patients may become "outliers"? Will the service take over the care? PMID: 195923...
Source: Bulletin du Cancer - July 9, 2009 Category: Cancer & Oncology Authors: Thiriet-Pfeil F Tags: Bull Cancer Source Type: journals

[What good? From benevolence to autonomy principles.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In medical practice, habits and ethics, on one hand, means, on the other hand, have evolved and induce the addition of autonomy to benevolence principle. In usual cases, traditional paternalism should be abandoned for allowing the patient to express his/her good and his/her choice for medical decision. This changes deeply doctor-patient relationship. Therefore, the physicians have to improve their practice in order to decrease inconveniences and increase advantages of this new relation, to finally better respect patients and their will. PMID: 19592329 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - July 9, 2009 Category: Cancer & Oncology Authors: Hœrni B, Avril A Tags: Bull Cancer Source Type: journals

[Withholding and withdrawal decisions in oncology: legal frame and practice.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Whereas medicine is progressing in illness treatment that used to be incurable, physicians are still faced with treatment failure. Hippocrates used to say: "primum non nocere" [1]. When the patient cannot expect benefit from potentially aggressive care, current or possible treatments have to be challenged to leave just the ones giving immediate benefice. To determine a legal frame and to protect people in the end of life, law no 2005-370 concerning to the rights of ill people and end of life was declaimed during April 2005. After presenting a clinical course illustrating a situation of difficult end of life, we propose...
Source: Bulletin du Cancer - July 9, 2009 Category: Cancer & Oncology Authors: Laude C, Deygas S Tags: Bull Cancer Source Type: journals

[A difficult diagnosis...]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The patient information and obtaining their consent before any therapeutic constitute a basis for medicine exercise. However, there are situations where the physician may be in default. In that case, concepts of benefit/risk balance, of clear and appropriate information, and of legal liability for medico-surgical staff takes all their magnitude. That was the case in our observation, with a 69 years old patient with history of smoking, presenting a suspicious lung opacity which will require, following an agreement by multidisciplinary meeting, an exploration by thoracotomy despite an acceptable but altered respiratory f...
Source: Bulletin du Cancer - July 9, 2009 Category: Cancer & Oncology Authors: Porot V, Gérinière L, Souquet PJ, Deygas S, Rhomer B, Audras S, Bertoletti L, Cortot A, Coudurier M, Girard N, Couraud S Tags: Bull Cancer Source Type: journals

[JACIE: from guidelines to clinical practice and continuous quality improvement, the Léon-Bérard cancer center experience.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
[JACIE: from guidelines to clinical practice and continuous quality improvement, the Léon-Bérard cancer center experience.] Bull Cancer. 2009 Jul 10; Authors: Donot PE JACIE, a European certification program for stem cell transplantation, has now been recognized by the French Health Authorities. It can be considered as an evaluation of professional practice, an activity that can be promoted by health centres. The present article has two aims: firstly, it describes the structure of the certification standard based on the relative structure of each of its components; secondly, it reports on the experien...
Source: Bulletin du Cancer - July 9, 2009 Category: Cancer & Oncology Authors: Donot PE Tags: Bull Cancer Source Type: journals