Bulletin of Faculty of Pharmacy, Cairo University This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Editorial Board
Publication date: December 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 2Author(s): (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Differential diagnosis of mucopolysaccharidosis and oligosaccharidosis of a sample of Egyptian children
In conclusion; MPS should be excluded before suspecting oligosaccharidosis. 2-DEP and TLC alone cannot rule out the diagnosis of either MPS or oligosaccharidosis and confirmation must be done by specific lysosomal enzymatic assay. Analysis of GAGs by 2-DEP in amniotic fluid can be promising method for prenatal diagnosis of MPS. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Cynara scolymus (artichoke) and its efficacy in management of obesity
Publication date: Available online 30 October 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Mohaddese MahboubiAbstractObesity, the most prevalent metabolic disorder is associated with elevated body fat mass and body mass index. Cynara scolymus L. is famous for its hepatoprotective properties, also it seems to have good potency as anti-obese agent. In this review article, the potency of C. scolymus as anti-obese agent has been evaluated. The evidences based information were extracted from accessible international electronic databases (PubMed, Springer, Science Direct, Wiley and Google), and books (...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 31, 2018 Category: Drugs & Pharmacology Source Type: research

Reproductive indices in malaria infested mice treated with antimalarials, Phyllanthus amarus combined with vitamins
Publication date: Available online 25 October 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Matthew Obaineh Ojezele, Ighodaro Igbe, Agbonlahor OkhuaroboAbstractMalaria disease is caused by the plasmodium organism transmitted into humans by the female anopheles mosquito. The effect of chloroquine, artesunate or Phyllantus amarus alone or combined with vitamins A, B, C or K on male fertility indices has received no attention. Hence this study was designed to investigate the effect of chloroquine, artesunate or seed extract of Phyllanthus amarus with or without vitamins A, B, C or E on testosterone l...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 26, 2018 Category: Drugs & Pharmacology Source Type: research

Stability indicating methods for selective determination of Oxetacaine in the presence of its degradation products
Publication date: Available online 22 October 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Eman S. Elzanfaly, Enas A. Amer, Sara A. Galal, Hala E. ZaazaaAbstractTwo methods, HPLC and TLC were presented for the determination of Oxetacaine (OXT) in the existence of its different degradation products. HPLC method was based on the separation of OXT from its degradation products using reversed phase C18 column at room temperature and isocratic elution with mobile phase mixture of acetonitrile: 5 mM sodium dihydrogen orthophosphate dihydrate, pH was adjusted to 2.4 with orthophosphoric acid (50:50 ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 24, 2018 Category: Drugs & Pharmacology Source Type: research

Atherogenicity of diabetic rats administered single and combinatorial herbal extracts
ConclusionThe present study showed that double herbal formulations (DHFs): A. gangetica + G. latifolium and A. gangetica + A. montanus offered comparatively high protection to DM-r against atherogenic outcomes, which paralleled the capacities of these DHFs to reverse dyslipidemia.Graphical abstract (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Acute and chronic toxicity profiles of the methanol leaf extract of Acacia ataxacantha D.C (Leguminosae) in Wistar rats
This study was conducted to ascertain the toxicity profile of methanol extract of Acacia ataxacantha in laboratory animals. The acute and chronic toxicity study was conducted according to the method of Lorke (1983) and OECD guidelines (2008) respectively. The oral lethal median dose (LD50) of the extract was estimated to ≥5000 mg/kg. The extract significantly increases (p ≤ 0.05) the liver (alanine transaminase, aspartate transaminase, alkaline phosphatase) and kidney (creatinine, urea and sodium ion) parameters at the dose of 400 mg/kg body weight. Histological examination revealed moderate glomerular necrosis...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

QbD-based design and characterization of mucoadhesive microspheres of quetiapine fumarate with improved oral bioavailability and brain biodistribution potential
Publication date: Available online 27 September 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Someshwar Komati, Suryakanta Swain, Muddana Eswara Bhanoji Rao, Bikash Ranjan Jena, Sambamoorthy Unnam, Vishali DasiAbstractThe present work aims to discuss on Quality by Design based development and characterization of the sustained release mucoadhesive microspheres of quetiapine fumarate. The microspheres were prepared by non-aqueous solvent evaporation process. Factor screening study was carried out using fractional factorial design for identifying the influential factors. Systematic optimization of mi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of antioxidant properties of different extracts of Chaetomium cupreum SS02
Publication date: Available online 24 August 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Nazir Ahmad Wani, Sharmila TirumaleAbstractTo evaluate the antioxidant properties of different extracts (chloroform, ethyl acetate, n-butanol and methanol extracts) of fungus C. cupreum SS02. The antioxidant properties were evaluated by using five antioxidant methods, metal chelating assay, 2,2-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid (ABTS), hydroxyl radical (HO) scavenging assay, superoxide anion (O2) radical scavenging assay, and nitric oxide (NO) scavenging assay. Methanol extract of C. cupreum ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - August 25, 2018 Category: Drugs & Pharmacology Source Type: research

Validated potentiometric method for the determination of sulfacetamide sodium; application to its pharmaceutical formulations and spiked rabbit aqueous humor
Publication date: Available online 22 August 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Nariman A. El-Ragehy, Maha A. Hegazy, G. AbdElHamid, Samia A. TawfikAbstractSpecific, accurate and precise electrochemical method was developed and validated for the determination of sulfacetamide sodium in presence of its co-formulated drug (prednisolone acetate) and its pharmacopoeial impurities. The method was based on fabrication of membrane sensor. The characteristics of electrochemical response were estimated, and the proposed sensor displayed excellent characteristics for the determination of sulfacet...
Source: Bulletin of Faculty of Pharmacy, Cairo University - August 23, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation and evaluation of gastro retentive tablets of clarithromycin prepared by using novel polymer blend
Publication date: Available online 26 July 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Sharwaree Hardikar, Ashok BhosaleAbstractClarithromycin is a semi synthetic macrolide antibiotic that is proved to be extremely effective mono therapy in treating H. pylori infection. One of the various reasons reported for partial eradication of H. pylori infection is that the short dwelling time of antimicrobial agents in the stomach. Hence the principal object of the present work was to design and develop floating and swellable gastro retentive tablet of clarithromycin to obtain its prolonged release in the...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 26, 2018 Category: Drugs & Pharmacology Source Type: research

Resveratrol pretreatment reduces circulating inflammatory interleukins in CCl4-induced hepatotoxicity rats
In conclusion, RSV has a prophylactic effect against hepatotoxicity induced by CCl4 through decreasing the inflammatory interleukins level. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Impact of pharmacist-led collaborative patient education on medication adherence and quality of life of schizophrenia patients in a tertiary care setting
The objective of study was to assess the impact of pharmacist-led collaborative patient education on medication adherence and QOL in schizophrenia patients in a psychiatry out-patient setting of a tertiary-care setting. Patients were randomized into two groups. Interventional patients received medication review, followed by patient education session using Patient-Information Leaflets (PILs) developed for the study. Control patients received usual-care. Patients data were collected at the beginning of the study and after each follow-up of one-month interval, till 3rd follow-up. Medication adherence and QOL were assessed usi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis, characterization and pharmacological evaluation of different 1,3,4-oxadiazole and acetamide derivatives of ethyl nipecotate
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Khadija Nafeesa, Aziz-ur-Rehman, Muhammad A. Abbasi, Sabahat Z. Siddiqui, Shahid Rasool, Syed A.A. ShahAbstractA new series of N-substituted derivatives of 2-[(5-{1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl}-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide (6a-w) has been designed and synthesized with multifunctional moieties. The synthesized compounds were evaluated for their antibacterial and anti-enzymatic potential supported by % hemolytic activity. The synthesized compound 5-(1-(4-chlorophenylsulfonyl)-3-piperi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Assessment of oxLDL, anti-oxLDL antibodies and lipoprotein-associated phospholipase A2 as cardiovascular risk markers in obese adolescents with and without T1DM
ConclusionThe current data provide evidence that oxLDL, its retroactive enzyme and antibody are present in circulation early in childhood when primed by obesity and hyperglycemia in T1DM and suggests that they could be useful markers for cardiovascular diseases (CVD). (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research