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Triptans, Serotonin Agonists, and Serotonin Syndrome (Serotonin Toxicity): A ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Headache 2009;[bull][bull]:[bull][bull]-[bull][bull]) The US Food and Drug Administration (FDA) have suggested that fatal serotonin syndrome (SS) is possible with selective serotonin reuptake inhibitors (SSRIs) and triptans: this warning affects millions of patients as these drugs are frequently given simultaneously. SS is a complex topic about which there is much misinformation. The misconception that 5-HT1A receptors can cause serious SS is still widely perpetuated, despite quality evidence that it is activation of the 5-HT2A receptor that is required for serious SS. This review considers SS involving serotonin agonists...
Source: Headache: The Journal of Head and Face Pain - November 18, 2009 Category: Neurology Authors: P. Ken Gillman Source Type: journals

BUSPIRONE HYDROCHLORIDE (Buspirone) Tablet BUSPIRONE HYDROCHLORIDE (Buspirone) Tablet [Physicians Total Care, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 12, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 12, 2009 Category: Drugs & Pharmacology Source Type: organizations

BUSPIRONE HYDROCHLORIDE (Buspirone) Tablet [Physicians Total Care, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Temporal lobe epilepsy is the most common form of epilepsy in humans. Oxidative stress is a mechanism of cell death induced by seizures. Buspirone presents anxyolitic and antidepressant effects due to their ability to stimulate 5-HT(1A) receptor. We studied the buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (SE) induced by pilocarpine. In pilocarpine group there was a significant increase in lipid peroxidation and nitrite levels. However, no alteration was observed in superoxide dismutase and catalase activities. Buspirone pretreatment produces significantly reduction the...
Source: Brain Research Bulletin - September 30, 2009 Category: Neurology Authors: Freitas RL, Santos IM, Souza GF, Saldanha GB, Freitas RM Tags: Brain Res Bull Source Type: journals

BUSPIRONE HYDROCHLORIDEtablet [Major Pharmaceuticals]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

A placebo-controlled trial of buspirone for the treatment of marijuana dependenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The present study investigated the potential efficacy of buspirone for treating marijuana dependence. Participants received either buspirone (maximum 60mg/day) (n=23) or matching placebo (n=27) for 12 weeks, each in conjunction with motivational interviewing. In the modified intention-to-treat analysis, the percentage of negative UDS results in the buspirone-treatment group was 18 percentage points higher than the placebo-treatment group (95% CI: −2% to 37%, p=0.071). On self-report, participants receiving buspirone reported not using marijuana 45.2% of days and participants receiving placebo reported not using...
Source: Drug and Alcohol Dependence - September 14, 2009 Category: Addiction Authors: Aimee L. McRae-Clark, Rickey E. Carter, Therese K. Killeen, Matthew J. Carpenter, Amy E. Wahlquist, Stacey A. Simpson, Kathleen T. Brady Tags: Full length reports Source Type: journals

Low-Dose Buspirone, Melatonin and Low-Dose Bupropion Added to Mood Stabilizers for Severe Treatment-Resistant Bipolar DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Psychother Psychosom 2009;78:391-393 (DOI:10.1159/000235985) (Source: Karger Publishers)
Source: Karger Publishers - September 7, 2009 Category: Cancer & Oncology Source Type: journals

Relations between open-field, elevated plus-maze, and emergence tests in C57BL/6J and BALB/c mice injected with GABA- and 5HT-anxiolytic agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two 5HT1A receptor agonists and chlordiazepoxide were examined in open-field, elevated plus maze, and emergence tests. At doses with no effect in the open-field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT1A receptor agonists showed an anxiolytic response on a single measure. The anxiolytic action of chlordiazepoxide was limited to the less active BALB/c strain. Unlike the 5HT1A receptor agonists, chlordiazepoxide was also anxiolytic in the emergence test, once again only in BALB/c and not C57BL/6J mice. Significant correlations were found be...
Source: Fundamental and Clinical Pharmacology - September 3, 2009 Category: Drugs & Pharmacology Authors: Robert Lalonde, Catherine Strazielle Source Type: journals

Fluoxetine-induced sleep bruxism in an adolescent treated with buspirone: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reports on a case history of an adolescent with fluoxetine-induced bruxism that was successfully treated with buspirone. As SSRI use is on the rise for treating childhood psychiatric disorders, this case report highlights the importance of recognizing SSRI-induced bruxism and the possible related adverse dental side effects. Furthermore, this report supports the efficacy of a treatment strategy in adolescents, which has previously been reported only for adult patients. (Source: Special Care in Dentistry)
Source: Special Care in Dentistry - August 24, 2009 Category: Dentistry Authors: Osman Sabuncuoglu, Ozalp Ekıncı, Meral Berkem Source Type: journals

BUSPIRONE HYDROCHLORIDEtablet [TEVA Pharmaceuticals USA Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Aug 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - August 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The relatively high background matrix in in vivo samples typically poses difficulties in drug metabolite identification, and causes repeated analytical runs on unit resolution liquid chromatography/mass spectrometry (LC/MS) systems before the completion of biotransformation characterization. Ballpark parameter settings for the LTQ-Orbitrap are reported herein that enable complete in vivo metabolite identification within two HPLC/MS injections on the hybrid LTQ-Orbitrap data collection system. By setting the FT survey full scan at 60K resolution to trigger five dependent LTQ MS(2) scans, and proper parameters of Repeat ...
Source: Rapid Communications in Mass Spectrometry : RCM - August 12, 2009 Category: Chemistry Authors: Li AC, Ding J, Jiang X, Denissen J Tags: Rapid Commun Mass Spectrom Source Type: journals

Defeating Normal Thermoregulatory Defenses. Induction of Therapeutic Hypothermia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Therapeutic hypothermia may be useful in various circumstances including stroke. However, core body temperature is normally tightly regulated. Even mild hypothermia in conscious subjects thus provokes vigorous thermoregulatory defenses which are potentially harmful in fragile patients. Furthermore, thermoregulatory responses are effective, which reduces the rate at which hypothermia can be induced. Drugs are thus often given to blunt normal thermoregulatory defenses. General anesthetics profoundly impair thermoregulatory control, but prolonged general anesthesia is rarely practical or appropriate. A variety of other dr...
Source: Stroke - August 12, 2009 Category: Neurology Authors: Sessler DI Tags: Stroke Source Type: journals

5HT1A-mediated stimulation of cortisol release in major depression: use of non-invasive cortisol measurements to predict clinical responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined whether the sensitivity of the 5HT1A receptor, as measured by the difference in salivary cortisol levels immediately before and 90 min following the administration of a single dose of the 5HT1A-selective agonist buspirone, predicted treatment outcome following an 8-week, fixed-dose, open trial of the SSRI escitalopram in 17 outpatients with MDD. Change in cortisol levels before and 90 min after the administration of buspirone were not found to predict treatment outcome, whether defined as clinical response (50% or greater reduction in symptom severity), or remission of symptoms. In conclusion, in...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 30, 2009 Category: Neuroscience Tags: European Archives of Psychiatry and Clinical Neuroscience Source Type: journals

Unlikely Treatment Identified By BrainCells Neurogenesis Platform Improved Clinical Outcomes In Patients Suffering From DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BrainCells Inc., a company leading the scientific research of neurogenesis using its proprietary platform technology to identify novel pathways for the treatment of central nervous system (CNS) diseases, announced results from the first clinical proof-of-concept study of BCI-952, a combination of low dose buspirone and melatonin, for the treatment of major depressive disorder (MDD). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 28, 2009 Category: Consumer Health News Tags: Depression Source Type: news

Treatment of cognitive dysfunction in chronic schizophrenia by augmentation of atypical antipsychotics with buspirone, a partial 5-HT1A receptor agonistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess effects of a semi-acute administration of buspirone in comparison to a placebo on cognitive function and negative symptoms in patients with schizophrenia and schizoaffective disorder.In a 6-week, double-blind, placebo-controlled, independent groups study 18 subjects (14 males, four females) received in random order either placebo or buspirone (15-30 mg/day). A neuropsychological assessment using the Hopkins verbal learning test (HVLT) simple reaction time (SRT), choice reaction time (CRT), n-back spatial working memory task and the stroop colour and word test was performed at baseline and final visit. Symptom rat...
Source: Human Psychopharmacology: Clinical and Experimental - July 27, 2009 Category: Psychiatry Authors: Danijela Pi[scaron]kuli[cacute], James S. Olver, Paul Maruff, Trevor R. Norman Source Type: journals

Unlikely Treatment Identified By BrainCells Neurogenesis Platform Improved Clinical Outcomes In Patients Suffering From DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BrainCells Inc., a company leading the scientific research of neurogenesis using its proprietary platform technology to identify novel pathways for the treatment of central nervous system (CNS) diseases, announced recently results from the first clinical proof-of-concept study of BCI-952, a combination of low dose buspirone and melatonin, for the treatment of major depressive disorder (MDD). (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - July 27, 2009 Category: Pharmaceuticals Source Type: news

Magnitude of potentially inappropriate prescribing in Germany among older patients with generalized anxiety disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: GPs in Germany often prescribe medications that have been designated as potentially inappropriate to their elderly patients with GAD--especially those with comorbid depressive disorders. Further research is needed to ascertain whether there are specific subgoups of elderly patients with GAD for whom the benefits of these medications outweigh their risks. (Source: BMC Geriatrics)
Source: BMC Geriatrics - July 26, 2009 Category: Geriatrics Authors: Ariel BergerMarko MychaskiwEllen DukesJohn EdelsbergGerry Oster Source Type: journals

Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These studies implicate the role of 5-HT7, 5-HT2C, and 5-HT1A receptors in the improvement of cognitive dysfunction of relevance to schizophrenia. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1618-0Authors Samantha L. McLean, University of Bradford Bradford School of Pharmacy Bradford West Yorkshire BD7 1DP UKMarie L. Woolley, GlaxoSmithKline New Frontiers Science Park, Third Avenue Harlow Essex CM19 5AW UKDave Thomas, GlaxoSmithKline New Frontiers Science Park, Third Avenue Harlow Essex CM19 5AW UKJoanna C. Neill, University of Bradford Bradford School o...
Source: Psychopharmacology - July 25, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Development of high performance liquid chromatography method for buspirone in rabbit serum: Application to pharmacokinetic study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A simple and sensitive high performance liquid chromatographic (HPLC) method for quantification of buspirone (BUSP) in rabbit serum was developed and validated. BUSP and internal standard (IS), diltiazem hydrochloride were extracted into dichloromethane and separated using an isocratic mobile phase, on a Kromasil C(8) column. The eluent was monitored by UV detector at 235 nm and at a flow rate of 1.0 mL min(-1). The linearity range of proposed method was 1-3000 ng mL(-1). The intra-day and inter-day coefficient of variation and percent error values of the assay method were less than 15% and mean recovery was more than ...
Source: Analytica Chimica Acta - July 15, 2009 Category: Chemistry Authors: Gannu R, Yamsani SK, Palem CR, Yamsani VV, Kotagiri H, Yamsani MR Tags: Anal Chim Acta Source Type: journals

Reduction of the number of new cells reaching olfactory bulbs impairs olfactory perception in the adult opossum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, lower numbers of new neurons in the opossums OB correlated with their worse behavioral performance in a test based on olfactory perception. PMID: 19593331 [PubMed - in process] (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - July 14, 2009 Category: Neurology Authors: Grabiec M, Turlejski K, Djavadian R Tags: Acta Neurobiol Exp (Wars) Source Type: journals

Buspar (Buspirone) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Buspar (Buspirone) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 6, 2009 Category: Drugs & Pharmacology Source Type: consumer

Successful management of psychogenic alopecia with buspirone in a crossbreed catEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 1-year-old male crossbreed cat was presented for evaluation of alopecia in dorsal lumbar and sacral regions. The owner had moved to his current residence 2 months prior to the admission date. It seemed that the cat was uncomfortable in this new place. The client noticed excessive vocalisation, restlessness, unusual over-licking and self-grooming. One month after moving to the current residence, the owner brought an African grey parrot to the house. These events seem to have increased the cat’s anxiety, and the owner noticed excessive grooming and other signs of anxiety, such as vocalisation...
Source: Comparative Clinical Pathology - June 17, 2009 Category: Pathology Tags: Comparative Clinical Pathology Source Type: journals

Proposal of buspirone collision-induced dissociation rearrangement by exact mass measurements.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19415774 [PubMed - in process] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - May 31, 2009 Category: Chemistry Authors: Li AC, Shou WZ, Jiang X Tags: Rapid Commun Mass Spectrom Source Type: journals

Effect of buspirone on thermal sensory and pain thresholds in human volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Buspirone in the maximal recommended dose was without significant effect on thermal pain. However, as it is only a partial agonist at the 5-HT1A receptor and also acts on other receptor types, the negative results of the present study do not rule out a possible analgesic effect of more specific 5-HT1A receptor agonists. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 29, 2009 Category: Drugs & Pharmacology Authors: Goran PavlakovicJulija TiggesThomas Crozier Source Type: journals

Atypical AntidepressantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Information about some of the newer 'atypical' antidepressants - Buspar buspirone Desyrel trazodone Effexor venlafaxine Remeron mirtazapine Serzone nefazodone Wellbutrin bupropion. (Source: About.com Mental Health)
Source: About.com Mental Health - May 4, 2009 Category: Psychiatry Tags: health Source Type: consumer

Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A panel of novel D2 and D3 dopamine receptor selective antagonists, partial agonists and full agonists have been evaluated for the ability to attenuate L-dopa-associated abnormal involuntary movements (AIMs) in 6-hydroxydopamine (6-OHDA) unilaterally lesioned male Sprague Dawley rats, which is an animal model of L-dopa-induced dyskinesia (LID). LID is often observed in patients with Parkinson's Disease following chronic treatment with L-dopa. The intrinsic activity of these dopaminergic compounds was determined using a forskolin-dependent adenylyl cyclase inhibition assay with transfected HEK 293 cells expressing eithe...
Source: Neuropharmacology - April 30, 2009 Category: Drugs & Pharmacology Authors: Kumar R, Riddle LR, Griffin SA, Chu W, Vangveravong S, Neisewander J, Mach RH, Luedtke RR Tags: Neuropharmacology Source Type: journals

Evaluation of the D3 dopamine receptor selective antagonist PG01037 on L-dopa-dependent abnormal involuntary movements in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The D3 dopamine receptor selective antagonist PG01037 has been evaluated for the ability to attenuate L-dopa-associated abnormal involuntary movements (AIMs) in unilaterally lesioned male Sprague-Dawley rats, which is a model of L-dopa-dependent dyskinesia in patients with Parkinson's Disease. The intrinsic activity of PG01037 was determined using a) a forskolin-dependent adenylyl cyclase inhibition assay with transfected HEK 293 cells expressing either the human D2Long or D3 dopamine receptor subtype and b) an assay for agonist-associated mitogenesis. For the initial experiments, the 5-HT1A receptor selective partial ...
Source: Neuropharmacology - April 30, 2009 Category: Drugs & Pharmacology Authors: Kumar R, Riddle L, Griffin SA, Grundt P, Newman AH, Luedtke RR Tags: Neuropharmacology Source Type: journals

The partial 5-HT1A receptor agonist buspirone enhances neurogenesis in the opossum (Monodelphis domestica)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We demonstrate for the first time that neurogenesis in the adult Monodelphis opossum has a typical mammalian pattern and occurs only in the dentate gyrus (DG) and subventricular zone (SVZ) of the lateral ventricles. In these two brain regions neurogenesis is present throughout the lifespan, although its rate is reduced by half in the old age. Treatment with buspirone, a partial 5-HT1A receptor agonist which is used in human clinic as an anxiolytic agent, boosts proliferation in the SVZ and DG in both adult and aged opossums. The neuronal phenotype dominates among newly generated cells in both non-treated and busp...
Source: European Neuropsychopharmacology - April 29, 2009 Category: Psychiatry & Psychology Authors: Marta Grabiec, Kris Turlejski, Rouzanna L. Djavadian Tags: Research papers Source Type: journals

Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Ketanserin but not propranolol had a fully sedative profile and may confound pupillometric assessment of EDS. Beta adrenergic receptors do not appear to participate in arousal and pupillary functions, while 5HT1a receptors reduce pupil size without affecting arousal. Pupil size may not be used unequivocally as an index of the level of alertness in the case of drug-induced changes, when drugs interfere with the central pupil control mechanism in ways that are unrelated to their effects on arousal. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1508-5Authors...
Source: Psychopharmacology - March 14, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Medications for AnxietyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medications for anxiety benzodiazepines clonazepam Klonopin alprazolam Xanax diazepam Valium lorazepam Ativan buspirone buspar propranolol Inderal Inderide (Source: About.com Mental Health)
Source: About.com Mental Health - March 14, 2009 Category: Psychiatry Tags: health Source Type: consumer

Assorted MedicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Assorted medications somtimes used to treat anxiety - Buspar (buspirone), Neurontin (gabapentin), beta blockers Inderal (propranolol) (Source: About.com Mental Health)
Source: About.com Mental Health - March 14, 2009 Category: Psychiatry Tags: health Source Type: consumer

The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions BMY-14802 exerts its AIM-suppressing effects via a 5-HT1A agonist mechanism, similar to buspirone. Other 5-HT1A agonists have failed clinical trials, possibly due to submicromolar affinity at other receptors, including D2, which may exacerbate PD symptoms. BMY-14802 is a promising candidate for clinical trials due to its extremely low affinity for the D2 receptor and lack of extrapyramidal effects during prior clinical trials for schizophrenia. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1505-8Authors Melanie A. Paquette, Oregon Health and Science Uni...
Source: Psychopharmacology - March 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

BuSpar Side EffectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Catalogue of side effects for the medication Buspirone - brand name BuSpar - an antianxiety drug sometimes prescribed for the treatment of bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 7, 2009 Category: Psychiatry Tags: health Source Type: consumer

Buspar Side Effects - Side Effects of Buspar BuspironeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Members share their personal experiences with Buspar (buspirone) side effects. First hand accounts of what side effects you can expect with Buspar (buspirone). (Source: About.com Depression)
Source: About.com Depression - March 7, 2009 Category: Psychiatry Tags: health Source Type: consumer

Combined Neuroprotective Modalities Coupled with Thrombolysis in Acute Ischemic Stroke: A Pilot Study of Caffeinol and Mild HypothermiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Combining caffeinol with hypothermia in patients with acute stroke given IV t-PA is feasible. A prospective placebo-controlled randomized study is needed to further assess safety and to test the efficacy of caffeinol, hypothermia, or both. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 1, 2009 Category: Neurology Authors: Sheryl Martin-Schild, Hen Hallevi, Hashem Shaltoni, Andrew D. Barreto, Nicole R. Gonzales, Jarek Aronowski, Sean I. Savitz, James C. Grotta Tags: Original Articles Source Type: journals

The partial 5-HT1A receptor agonist buspirone enhances neurogenesis in the opossum (Monodelphis domestica).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We demonstrate for the first time that neurogenesis in the adult Monodelphis opossum has a typical mammalian pattern and occurs only in the dentate gyrus (DG) and subventricular zone (SVZ) of the lateral ventricles. In these two brain regions neurogenesis is present throughout the lifespan, although its rate is reduced by half in the old age. Treatment with buspirone, a partial 5-HT1A receptor agonist which is used in human clinic as an anxiolytic agent, boosts proliferation in the SVZ and DG in both adult and aged opossums. The neuronal phenotype dominates among newly generated cells in both non-treated and buspirone-...
Source: European Neuropsychopharmacology - February 25, 2009 Category: Psychiatry & Psychology Authors: Grabiec M, Turlejski K, Djavadian RL Tags: Eur Neuropsychopharmacol Source Type: journals

The Effect of Oral Buspirone, Pyridostigmine, and Bethanechol on Esophageal Function Evaluated With Combined Multichannel Esophageal Impedance-manometry in Healthy Volunteers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 253DOI: 10.1097/MCG.0b013e318167b89dAuthors: Blonski, Wojciech MD, PhD * +; Vela, Marcelo F. MD *; Freeman, Janice RN *; Sharma, Neeraj MD *; Castell, Donald O. MD * (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 22, 2009 Category: Gastroenterology Tags: Abstract HTML PDF (197 K) Source Type: journals

Pharmacological Exploration of the Sedative Mechanism of Hesperidin Identified as the Active Principle of Citrus sinensis FlowersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1185306AbstractThe infusion of flowers of several species of genera is used as a sedative to treat insomnia in Mexican traditional medicine. The aims of this study were to investigate the sedative effect of different extracts of flowers of (L.) Osbeck (Rutaceae) and describe the pharmacological action mechanism of the sedative active compounds of this plant. The methanol and dichloromethane extracts, obtained from the flowers of (L.) Osbeck (Rutaceae), showed a dose-dependent sedative effect in the exploratory cylinder model in mice, with ED () values of 47.04 ± 12.03 mg/kg ...
Source: Planta Medica - February 14, 2009 Category: Drugs & Pharmacology Tags: Original Paper Source Type: journals

Receptor reserve-dependent properties of antipsychotics at human dopamine D(2) receptors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aripiprazole is the first dopamine D(2)/D(3) receptor partial agonist approved for use in the treatment of psychiatric disorders including schizophrenia, bipolar disorder, and unipolar depression in the US. Aripiprazole has demonstrated a relatively favorable side effect profile compared to other commonly prescribed antipsychotics, including a low propensity for treatment-limiting extrapyramidal symptoms, hyperprolactinemia, and body weight gain. In an effort to elucidate aripiprazole's pharmacological activity in relation to clinically relevant fluctuation of dopamine D(2) receptor reserves, we compared the properties...
Source: European Journal of Pharmacology - February 12, 2009 Category: Drugs & Pharmacology Authors: Tadori Y, Forbes RA, McQuade RD, Kikuchi T Tags: Eur J Pharmacol Source Type: journals

Ice-Cold Saline for the Induction of Mild Hypothermia in Patients With Acute Ischemic Stroke. A Pilot Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This pilot study suggests that rapid ICS infusions in combination with pethidine and buspirone lower the body temperature significantly without major side effects. PMID: 19182084 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - January 29, 2009 Category: Neurology Authors: Kollmar R, Schellinger PD, Steigleder T, Köhrmann M, Schwab S Tags: Stroke Source Type: journals

Worsening of bruxism with atomoxetine: A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of Atomoxetine-related exacerbation of nocturnal bruxism in a 12-yr old boy with ADHD, subsiding on discontinuing the drug, but re-worsening with retrial, finally subsiding upon adding Buspirone. This is the first report of its kind showing such an association, not included in any pre- or post-marketing data. Clinical implications and possible mechanisms are discussed. PMID: 19165653 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - January 22, 2009 Category: Psychiatry Authors: Mendhekar D, Lohia D Tags: World J Biol Psychiatry Source Type: journals

5-HT1A Receptors in the Frontal Cortical Brain Areas in Cloninger Type 1 and 2 Alcoholics Measured by Whole-Hemisphere AutoradiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The detected decrease of 5-HT1A receptor density on the pACC suggests further that the serotoninergic system is defected in the so-called affect region, especially in the type 1 alcoholics. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - December 17, 2008 Category: Addiction Authors: Storvik, M., Hakkinen, M., Tupala, E., Tiihonen, J. Tags: Genetics and Cell Biology Source Type: journals

Sensitization, Duration, and Pharmacological Blockade of Anxiety-Like Behavior Following Repeated Ethanol Withdrawal in Adolescent and Adult RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Adolescent rats exhibit sensitized anxiety-like behavior following repeated withdrawals at ED concentrations similar to those used in adults. However, this effect is longer lasting in adolescent rats. Drugs modulating CRF, 5-HT, or GABA systems during initial withdrawals prevent the development of anxiety-like behavior otherwise manifest during a final withdrawal in adolescent rats. (Source: Alcoholism: Clinical and Experimental Research)
Source: Alcoholism: Clinical and Experimental Research - December 16, 2008 Category: Addiction Authors: Tiffany A. Wills, Darin J. Knapp, David H. Overstreet, George R. Breese Source Type: journals

Dysthymia TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are a number of effective treatment approaches to help treat dysthymic disorder (also known as dysthymia). Often times a person with dysthymia will seek out treatment because of increased stress or personal difficulties which may be situationally-related. Only after a careful diagnostic interview is conducted (or after a few therapy sessions) may the chronic nature of the problem become apparent. The best treatment approach for people with dysthymia appears to be a combination approach — psychotherapy combined with antidepressant medication. One large multisite study in the New England Journal of Medicine by K...
Source: Psych Central - November 10, 2008 Category: Psychiatry Authors: Administrator Tags: General Disorders Depression Psychotherapy Medications Treatment Chronic Pain Source Type: consumer

Antinociceptive activity of Tilia americana var. mexicana inflorescences and quercetin in the formalin test and in an arthritic pain model in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tilia species are well known around the world for their properties in traditional medicine. Antinociceptive activity of hexane, methanol and aqueous extracts from Tilia americana var. mexicana inflorescences was evaluated in the pain-induced functional impairment model in rats (PIFIR). A preliminar 300 mg/kg dosage of aqueous extracts i.p., but not the same dose of methanol or hexane extract, produced an antinociceptive response in rats similar to that of tramadol (17.8 mg/kg i.p.). A dose-response curve from aqueous extract allowed the determination of ED(50) = 364.97 mg/kg in comparison to ED(50) = 10.35 mg/kg for tr...
Source: Neuropharmacology - November 5, 2008 Category: Drugs & Pharmacology Authors: Martínez AL, González-Trujano ME, Aguirre-Hernández E, Moreno J, Soto-Hernández M, López-Muñoz FJ Tags: Neuropharmacology Source Type: journals

Resistive polymer versus forced-air warming: comparable heat transfer and core rewarming rates in volunteers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Heating efficacy and core rewarming rates were similar with full-body forced-air and full-body resistive polymer heating in healthy volunteers. PMID: 18931221 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 24, 2008 Category: Anesthesiology Authors: Kimberger O, Held C, Stadelmann K, Mayer N, Hunkeler C, Sessler DI, Kurz A Tags: Anesth Analg Source Type: journals

Prokinetics and fundic relaxants in upper functional GI disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastrointestinal prokinetics are a heterogeneous class of drugs that stimulate smooth muscle contractions to enhance gastric emptying and intestinal transit. Recently studied prokinetics include antidopaminergic agents (itopride), serotonergic agents (tegaserod and others), and motilin receptor agonists and ghrelin receptor agonists (mitemcinal, TZP101). It has been difficult to establish symptomatic benefit with prokinetic drugs in gastroparesis and functional dyspepsia, because of pathophysiological heterogeneity of the patient populations, a lack of well-accepted endpoints, and inconsistent relationships between cha...
Source: Current Opinion in Pharmacology - October 18, 2008 Category: Drugs & Pharmacology Authors: Tack J Tags: Curr Opin Pharmacol Source Type: journals

Prevalence of ergot derivatives in natural ryegrass pastures: Detection and pathogenicity in the horse.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study, we determined the incidence and effects of season and weather on clinical manifestations of endophyte-infected ryegrass toxicity, performed chemical detection and pharmacological bioassays on ryegrass extracts, and conducted trials on: (i) effects of domperidone or metochlopramide on ovarian inactivity induced by endophyte-infected ryegrass; (ii) efficacy of buspirone or dihydrochloro phenyl piperazine (m-CPP) for preventing suppressed milk production induced by endophyte-infected ryegrass; and (iii) efficacy of domperidone to induce ovulation during winter anestrus. Mares with toxicosis had prolo...
Source: Theriogenology - September 25, 2008 Category: Genetics & Stem Cells Authors: Lezica FP, Filip R, Gorzalczany S, Ferraro G, de Erausquin GA, Rivas C, Ladaga GJ Tags: Theriogenology Source Type: journals

Discriminative stimulus properties of the “atypical” antidepressant, mirtazapine, in rats: a pharmacological characterizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Mirtazapine elicits a DS in rats for which selective antagonists at 5-HT2C receptors display dose-dependent substitution, whereas drugs acting at other sites recognized by mirtazapine are ineffective. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-008-1259-8Authors Anne Dekeyne, Department of Neuropharmacology, Institut de Recherches Servier Centre de Recherches de Croissy 125 Chemin de Ronde 78290 Croissy-sur-Seine, Paris FranceMark J. Millan, Department of Neuropharmacology, Institut de Recherches Servier Centre de Recherches de Croissy 125 Chemin de Ronde 782...
Source: Psychopharmacology - August 16, 2008 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Effect of buspirone on the behavioral regulation of rats in low versus high anxiety conditions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results showed that in an open-field setting buspirone appears to have a dual effect. The reduced activity and increase in time spent in the center areas are indicative of both an anxiogenic and an anxiolytic effect, respectively. This was found in both open-field settings, suggesting that the effects of buspirone are independent of the anxiety level. PMID: 18677968 [PubMed - in process] (Source: Arzneimittel-Forschung)
Source: Arzneimittel-Forschung - August 6, 2008 Category: Drugs & Pharmacology Authors: Lim LW, Temel Y, Visser-Vandewalle V, Steinbusch H, Schruers K, Hameleers R, Esquivel G, Griez E, Blokland A Tags: Arzneimittelforschung Source Type: journals