USP19 regulates DNA methylation damage repair and confers temozolomide resistance through MGMT stabilization
CONCLUSION: The regulation of MGMT ubiquitination by USP19 plays a critical role in DNA methylation damage repair and GBM patients' temozolomide chemotherapy response.PMID:38644551 | PMC:PMC11033335 | DOI:10.1111/cns.14711 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Jiaqi Liu Kaikai Wang Qian Zhu Yixin Zhang Yuping Chen Zhenkun Lou Jian Yuan Source Type: research
Brain activation and connection across resting and motor-task states in patients with generalized tonic-clonic seizures
CONCLUSION: Convergent findings suggested the over-response of activation and connection of the brain to motor execution in GTCS, providing new clues to uncover motor susceptibility underlying the disease.PMID:38644561 | PMC:PMC11033329 | DOI:10.1111/cns.14672 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Sisi Jiang Yuehan Wang Haonan Pei Hechun Li Junxia Chen Yutong Yao Qifu Li Dezhong Yao Cheng Luo Source Type: research
Radiotherapy plus temozolomide with or without anlotinib in H3K27M-mutant diffuse midline glioma: A retrospective cohort study
CONCLUSIONS: This study first reported that anlotinib combined with Stupp regimen is a safe and feasible regimen for newly diagnosed patients with H3K27M-DMG. Further, anlotinib showed significant efficacy for H3K27M-DMG located in the infratentorial region.PMID:38644565 | PMC:PMC11033330 | DOI:10.1111/cns.14730 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Chao Liu Shuwen Kuang Tianxiang Huang Jun Wu Longbo Zhang Xuan Gong Source Type: research
C/EBP β: A transcription factor associated with the irreversible progression of Alzheimer's disease
CONCLUSION: The overexpression of C/EBPβ accelerates the irreversible progression of AD pathophysiology. Additionally, C/EBPβ plays a crucial role in mediating multiple pathways linked to AD pathology, some of which engender vicious cycles, leading to the establishment of feedback mechanisms. To sum up, targeting C/EBPβ could hold promise as a therapeutic strategy not only for AD but also for other degenerative diseases.PMID:38644578 | PMC:PMC11033503 | DOI:10.1111/cns.14721 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Qing Yao Chubing Long Pengcheng Yi Guangyong Zhang Wei Wan Xiuqin Rao Jun Ying Weidong Liang Fuzhou Hua Source Type: research
Brain areas interconnected to ventral pathway circuits are independently able to induce enhancement in object recognition memory and cause reversal in object recognition memory deficit
CONCLUSIONS: These results suggest that brain areas interconnected to ventral pathway circuits facilitate ORM enhancement by an increase in synaptic connectivity between the local brain area circuits and the passing by ventral pathway circuits and an upregulation in activity of ventral pathway circuits. In addition, the finding of the reversal of ORM deficit through activation of an interconnected brain area might serve as a platform for developing not only therapy against memory deficits but also strategies for other brain diseases in which neuronal circuits are compromised.PMID:38644593 | PMC:PMC11033489 | DOI:10.1111/cn...
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Mariam Masmudi-Mart ín Irene Navarro-Lobato Manuel F L ópez-Aranda Mar ía E Quiros-Ortega Marta Carretero-Rey Mar ía F Garcia-Garrido Juan F L ópez Téllez Inmaculada Jim énez-Recuerda Cristina A Mu ñoz de Leon López Zafar U Khan Source Type: research
USP19 regulates DNA methylation damage repair and confers temozolomide resistance through MGMT stabilization
CONCLUSION: The regulation of MGMT ubiquitination by USP19 plays a critical role in DNA methylation damage repair and GBM patients' temozolomide chemotherapy response.PMID:38644551 | PMC:PMC11033335 | DOI:10.1111/cns.14711 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Jiaqi Liu Kaikai Wang Qian Zhu Yixin Zhang Yuping Chen Zhenkun Lou Jian Yuan Source Type: research
Brain activation and connection across resting and motor-task states in patients with generalized tonic-clonic seizures
CONCLUSION: Convergent findings suggested the over-response of activation and connection of the brain to motor execution in GTCS, providing new clues to uncover motor susceptibility underlying the disease.PMID:38644561 | PMC:PMC11033329 | DOI:10.1111/cns.14672 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Sisi Jiang Yuehan Wang Haonan Pei Hechun Li Junxia Chen Yutong Yao Qifu Li Dezhong Yao Cheng Luo Source Type: research
Radiotherapy plus temozolomide with or without anlotinib in H3K27M-mutant diffuse midline glioma: A retrospective cohort study
CONCLUSIONS: This study first reported that anlotinib combined with Stupp regimen is a safe and feasible regimen for newly diagnosed patients with H3K27M-DMG. Further, anlotinib showed significant efficacy for H3K27M-DMG located in the infratentorial region.PMID:38644565 | PMC:PMC11033330 | DOI:10.1111/cns.14730 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Chao Liu Shuwen Kuang Tianxiang Huang Jun Wu Longbo Zhang Xuan Gong Source Type: research
C/EBP β: A transcription factor associated with the irreversible progression of Alzheimer's disease
CONCLUSION: The overexpression of C/EBPβ accelerates the irreversible progression of AD pathophysiology. Additionally, C/EBPβ plays a crucial role in mediating multiple pathways linked to AD pathology, some of which engender vicious cycles, leading to the establishment of feedback mechanisms. To sum up, targeting C/EBPβ could hold promise as a therapeutic strategy not only for AD but also for other degenerative diseases.PMID:38644578 | PMC:PMC11033503 | DOI:10.1111/cns.14721 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Qing Yao Chubing Long Pengcheng Yi Guangyong Zhang Wei Wan Xiuqin Rao Jun Ying Weidong Liang Fuzhou Hua Source Type: research
Brain areas interconnected to ventral pathway circuits are independently able to induce enhancement in object recognition memory and cause reversal in object recognition memory deficit
CONCLUSIONS: These results suggest that brain areas interconnected to ventral pathway circuits facilitate ORM enhancement by an increase in synaptic connectivity between the local brain area circuits and the passing by ventral pathway circuits and an upregulation in activity of ventral pathway circuits. In addition, the finding of the reversal of ORM deficit through activation of an interconnected brain area might serve as a platform for developing not only therapy against memory deficits but also strategies for other brain diseases in which neuronal circuits are compromised.PMID:38644593 | PMC:PMC11033489 | DOI:10.1111/cn...
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Mariam Masmudi-Mart ín Irene Navarro-Lobato Manuel F L ópez-Aranda Mar ía E Quiros-Ortega Marta Carretero-Rey Mar ía F Garcia-Garrido Juan F L ópez Téllez Inmaculada Jim énez-Recuerda Cristina A Mu ñoz de Leon López Zafar U Khan Source Type: research
Multi-omics technologies and molecular biomarkers in brain tumor-related epilepsy
CONCLUSIONS: Based on the synthesized information, this review provided new research perspectives and insights into the early diagnosis, etiological factors, and personalized treatment of BTRE.PMID:38641945 | PMC:PMC11031674 | DOI:10.1111/cns.14717 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 20, 2024 Category: Neuroscience Authors: Yaoqiang Du Rusong Li Danqing Fu Biqin Zhang Ailin Cui Yutian Shao Zeyu Lai Rongrong Chen Bingyu Chen Zhen Wang Wei Zhang Lisheng Chu Source Type: research
DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage
CONCLUSION: The results demonstrated that ferroptosis occurs via the Nedd4/DMT1 pathway during ICH, suggesting it potential as a valuable target to inhibit ferroptosis for the treatment of ICH.PMID:38634270 | PMC:PMC11024684 | DOI:10.1111/cns.14685 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 18, 2024 Category: Neuroscience Authors: Bingchen Lv Ping Fu Miao Wang Likun Cui Lei Bao Xingzhi Wang Lu Yu Chao Zhou Mengxin Zhu Fei Wang Ye Pang Suhua Qi Zuohui Zhang Guiyun Cui Source Type: research
DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage
CONCLUSION: The results demonstrated that ferroptosis occurs via the Nedd4/DMT1 pathway during ICH, suggesting it potential as a valuable target to inhibit ferroptosis for the treatment of ICH.PMID:38634270 | PMC:PMC11024684 | DOI:10.1111/cns.14685 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 18, 2024 Category: Neuroscience Authors: Bingchen Lv Ping Fu Miao Wang Likun Cui Lei Bao Xingzhi Wang Lu Yu Chao Zhou Mengxin Zhu Fei Wang Ye Pang Suhua Qi Zuohui Zhang Guiyun Cui Source Type: research
Novel α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) potentiator LT-102: A promising therapeutic agent for treating cognitive impairment associated with schizophrenia
CONCLUSION: We conclude that LT-102 ameliorates cognitive impairments in a phencyclidine-induced model of schizophrenia by enhancing synaptic function, which could make it a potential therapeutic candidate for CIAS.PMID:38615362 | PMC:PMC11016348 | DOI:10.1111/cns.14713 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Xueyu Qi Xueli Yu Long Wei Han Jiang Jiangwen Dong Hongxing Li Yingying Wei Liansheng Zhao Wei Deng Wanjun Guo Xun Hu Tao Li Source Type: research
The promotion-like effect of the M1-STN hyperdirect pathway induced by ccPAS enhanced balance performances: From the perspective of brain connectivity
CONCLUSION: The ccPAS enhanced balance performance by promotion-like plasticity mechanisms through the hyperdirect pathway.PMID:38615363 | PMC:PMC11016345 | DOI:10.1111/cns.14710 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Yu-Lin Li Jia-Jia Wu Xu-Yun Hua Mou-Xiong Zheng Jian-Guang Xu Source Type: research
