COPD: Journal of Chronic Obstructive Pulmonary Disease 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The Application of Diaphragm Ultrasound in Chronic Obstructive Pulmonary Disease: A Narrative Review
This article aims to review the structural measurement and functional evaluation methods through the use of diaphragmatic ultrasound and relevant research on its application in clinical practice for COPD patients. Thus, it serves to provide valuable insights for clinical monitoring of diaphragm function in COPD patients, facilitating early clinical intervention and aiding in the recovery of diaphragm function.PMID:38634575 | DOI:10.1080/15412555.2024.2331202 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 18, 2024 Category: Respiratory Medicine Authors: Heng Mu Qunxia Zhang Source Type: research
Alleviatory Role of < em > Panax Notoginseng < /em > Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications
This study delves into the therapeutic potential and mechanistic underpinnings of Panax notoginseng Saponins (PNS) in alleviating inflammation and pulmonary vascular remodeling in a COPD rat model. Symmap and ETCM databases provided Panax notoginseng-related target genes, and the CTD and DisGeNET databases provided COPD-related genes. Intersection genes were subjected to protein-protein interaction analysis and pathway enrichment to identify downstream pathways. A COPD rat model was established, with groups receiving varying doses of PNS and a Roxithromycin control. The pathological changes in lung tissue and vasculature w...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 16, 2024 Category: Respiratory Medicine Authors: Yanan Hu Qiuyang Fan Bo Qiao Ou Xu Bijun Lv Niping Han Xiaomei Zhang Source Type: research
Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression
COPD. 2024 Dec;21(1):2322605. doi: 10.1080/15412555.2024.2322605. Epub 2024 Apr 9.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential transition metal ions, notably iron, copper, and zinc, stands as a critical nexus in the perpetuation of inflammatory processes and oxidative damage within the lungs of COPD patients. Unraveling the intricate interplay between metal homeostasis, o...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 9, 2024 Category: Respiratory Medicine Authors: Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang Source Type: research
Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study
In this study, we employed a two-sample Mendelian randomization (MR) analysis, utilizing the genome-wide association study database, to investigate the causal association between 731 immune-cell signatures and the susceptibility to COPD from a host genetics perspective. To validate the consistency of our findings, we utilized MR analysis results of lung function data to assess directional concordance. Furthermore, we employed MR-Egger intercept tests, Cochrane's Q test, MR-PRESSO global test, and "leave-one-out" sensitivity analyses to evaluate the presence of horizontal pleiotropy, heterogeneity, and stability, respective...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 4, 2024 Category: Respiratory Medicine Authors: Xinru Xiao Ziqi Ding Yujia Shi Qian Zhang Source Type: research
Comparative Efficacy of Budesonide/Formoterol Versus Fluticasone/Salmeterol in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
CONCLUSION: Compared with FS, BF therapy appears to be a more promising treatment strategy for patients with moderate-to-severe COPD; however, this should be verified in further high-quality studies.PMID:38573085 | DOI:10.1080/15412555.2024.2328708 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 4, 2024 Category: Respiratory Medicine Authors: Nan Shang Yang Liu Yueping Jin Source Type: research
Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study
In this study, we employed a two-sample Mendelian randomization (MR) analysis, utilizing the genome-wide association study database, to investigate the causal association between 731 immune-cell signatures and the susceptibility to COPD from a host genetics perspective. To validate the consistency of our findings, we utilized MR analysis results of lung function data to assess directional concordance. Furthermore, we employed MR-Egger intercept tests, Cochrane's Q test, MR-PRESSO global test, and "leave-one-out" sensitivity analyses to evaluate the presence of horizontal pleiotropy, heterogeneity, and stability, respective...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 4, 2024 Category: Respiratory Medicine Authors: Xinru Xiao Ziqi Ding Yujia Shi Qian Zhang Source Type: research
Comparative Efficacy of Budesonide/Formoterol Versus Fluticasone/Salmeterol in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
CONCLUSION: Compared with FS, BF therapy appears to be a more promising treatment strategy for patients with moderate-to-severe COPD; however, this should be verified in further high-quality studies.PMID:38573085 | DOI:10.1080/15412555.2024.2328708 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 4, 2024 Category: Respiratory Medicine Authors: Nan Shang Yang Liu Yueping Jin Source Type: research
