Cancer Biology and TherapyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5

226 records returned

Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A common metabolic change in cancer is the acquisition of glycolytic phenotypes. Increased expression of glycolytic enzymes is considered as one contributing factor. The role of mitochondrial defects in acquisition of glycolytic phenotypes has been postulated but remains controversial. Here we show that functional defects in mitochondrial respiration could be induced by oncogenic H-Ras(Q61L) transformation, even though the mitochondrial contents or mass was not reduced in the transformed cells. First, mitochondrial respiration, as measured by mitochondrial oxygen consumption, was suppressed in NIH-3T3 cells transformed...
Source: Cancer Biology and Therapy - November 20, 2009 Category: Cancer & Oncology Authors: Yang D, Wang MT, Tang Y, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D Tags: Cancer Biol Ther Source Type: journals

Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The recommended dose of curcumin is 6,000 mg/d for 7 consecutive days every 3 weeks in combination with a standard dose of docetaxel. From the encouraging efficacy results, a comparative phase II trial of this regimen plus docetaxel versus docetaxel alone is ongoing in advanced and metastatic breast cancer patients. PMID: 19901561 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - November 11, 2009 Category: Cancer & Oncology Authors: Bayet-Robert M, Kwiatkowski F, Leheurteur M, Gachon F, Planchat E, Abrial C, Mouret-Reynier MA, Durando X, Barthomeuf C, Chollet P Tags: Cancer Biol Ther Source Type: journals

Heat shock protein 110 improves the anti-tumor effects of the cytotoxic T lymphocyte epitope E7(49-57) in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several strategies have been used to enhance the vaccine-induced immunity of peptide vaccines and effective therapeutic benefits, including the utilization of heat shock proteins (HSP), especially the HSP70 family. HSP110 exhibits a higher binding affinity with protein and is capable of enhancing the immunogenicity of protein antigens; however, whether HSP110 can also increase the efficiency of peptide vaccine remains unclear. Here, we investigated mHSP110 as a chaperone immunoadjuvant to enhance the immune response to HPV16 oncoprotein E7-derived CTL epitope E7(49-57) in a mouse model. We developed the HSP110-E7(49-57...
Source: Cancer Biology and Therapy - November 11, 2009 Category: Cancer & Oncology Authors: Ren F, Xu Y, Mao L, Ou R, Ding Z, Zhang X, Tang J, Li B, Jia Z, Tian Z, Ni B, Wu Y Tags: Cancer Biol Ther Source Type: journals

Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gankyrin, a small and highly conserved protein which is identical to the p28 gene product, was found to be related with the malignant phenotypes in liver and esophageal carcinoma. However, the roles of gankyrin in colorectal carcinoma (CRC) are still unknown. In the present study, the gankyrin mRNA and protein expression in human CRC cell lines and clinical tissue samples were evaluated and correlated with clinicopathological features. Possible mechanisms by which gankyrin regulates the malignant phenotype of CRC cells were also investigated. The results demonstrated that gankyrin was obviously overexpressed in CRC tis...
Source: Cancer Biology and Therapy - November 11, 2009 Category: Cancer & Oncology Authors: Tang S, Yang G, Meng Y, Du R, Li X, Fan R, Zhao L, Bi Q, Jin J, Gao L, Zhang L, Li H, Fan M, Wang Y, Wu K, Liu J, Fan D Tags: Cancer Biol Ther Source Type: journals

Further analysis of the survival benefit of clodronate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bisphosphonates have a firm role in the treatment of metastatic prostate cancer as it has been shown to retard skeletal events secondary to prostate cancer. Recent studies also show possible anti-tumor and anti-angiogenic effects from the use of bisphosphonates, specifically with the aminobisphosphonates. Clodronate is an older first-generation bisphosphonate that has recently been shown to improve overall survival in metastatic prostate cancer as reported by Dearnaley and colleagues in the September issue of The Lancet Oncology. The finding of improved overall survival has significant implications since no therapy to ...
Source: Cancer Biology and Therapy - October 27, 2009 Category: Cancer & Oncology Authors: Aragon-Ching JB Tags: Cancer Biol Ther Source Type: journals

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Matrix metalloproteinases (MMPs), and especially membrane type-1 matrix metalloproteinase (MT1-MMP, MMP-14), play a role in cancer progression and can have a prognostic value. Various synthetic broad-spectrum MMP inhibitors have been developed but have had little success in cancer patient treatment owing to side effects. Until recently, selective targeting of specific MMPs has not been possible due to lack of specific inhibitors. Here we have developed a selective MT1-MMP peptide-inhibitor GACFSIAHECGA, which did not affect the activities of many other MMPs including MMP-1, -2, -3, -7, -8, -9, -10, -11, -12, -13, -15, ...
Source: Cancer Biology and Therapy - October 27, 2009 Category: Cancer & Oncology Authors: Suojanen J, Salo T, Koivunen E, Sorsa T, Pirilä E Tags: Cancer Biol Ther Source Type: journals

DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A better way to treat complex diseases such as cancer is to aim for several targets at once. Beta-carboline derivatives have been shown to have anticancer activity, but these compounds may target several enzymes required for cell division. Polo-like kinases (PLKs) are well conserved serine/threonine kinases and PLK1 plays multiple roles in cell proliferation. Thus, PLK1 is one of the attractive mitotic targets for anticancer drugs. We found that DH166, a beta-carboline derivative, inhibits the growth of cdc5-2 temperature-sensitive mutant more profoundly than wild-type yeast cells. Because Cdc5 is the human PLK1 homolo...
Source: Cancer Biology and Therapy - October 27, 2009 Category: Cancer & Oncology Authors: Zhang J, Li Y, Guo L, Cao R, Zhao P, Jiang W, Ma Q, Yi H, Li Z, Jiang J, Wu J, Wang Y, Si S Tags: Cancer Biol Ther Source Type: journals

Quantitative assessment of DNA hypermethylation in the inflammatory and non-inflammatory breast cancer phenotypes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, a comparative quantitative methylation profiling of inflammatory breast cancer (IBC) and non-IBC was set up for the identification of tumor-specific methylation patterns. Methylation ratios of six genes (DAPK, TWIST, HIN-1, RASSF1A, RARbeta2 and APC) were measured in benign breast tissues (n = 9) and in tumor samples from non-IBC (n = 81) and IBC (n = 19) patients using quantitative methylation-specific PCR. Median methylation ratios observed in breast cancer (n = 100) were significantly higher than those observed in benign breast tissues for 5 of 6 genes (TWIST, HIN-1, RASSF1A, RARbeta2 and APC). Only one o...
Source: Cancer Biology and Therapy - October 16, 2009 Category: Cancer & Oncology Authors: Van der Auwera I, Bovie C, Svensson C, Limame R, Trinh XB, van Dam P, Van Laere SJ, Van Marck E, Vermeulen PB, Dirix LY Tags: Cancer Biol Ther Source Type: journals

Combined anti-angiogenic therapy against VEGF and integrin alpha(V)beta(3) in an orthotopic model of ovarian cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Bevacizumab and etaracizumab are more effective in combination than individually in some ovarian cancer models, but not all. Both can sensitize taxane-resistant ovarian cancer cells to paclitaxel, though bevacizumab was superior to etaracizumab in this regard. Further study of this dual anti-angiogenic therapy is warranted. PMID: 19829059 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - October 16, 2009 Category: Cancer & Oncology Authors: Kim TJ, Landen CN, Lin YG, Mangala LS, Lu C, Nick AM, Stone RL, Merritt WM, Armaiz-Pena G, Jennings NB, Coleman RL, Tice DA, Sood AK Tags: Cancer Biol Ther Source Type: journals

Establishment and characterization of patient tumor-derived head and neck squamous cell carcinoma xenografts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The overall purpose of this study was to establish human head and neck squamous cell carcinoma (HNSCC) xenografts in mice by transplantation of surgical tumor tissue and to characterize the growth, histologic and vascular properties of these xenografts. Primary surgical specimens of HNSCC were xenografted into eight-to-twelve week old severe combined immunodeficiency (SCID) mice. Histologic features of primary HNSCC specimens, initial and established xenografts were compared for tumors established from three different head and neck subsites, namely, oral cavity, larynx and base of tongue (one tumor per site). Growth ra...
Source: Cancer Biology and Therapy - October 16, 2009 Category: Cancer & Oncology Authors: Seshadri M, Merzianu M, Tang H, Rigual NR, Sullivan M, Loree TR, Popat SR, Repasky EA, Hylander BL Tags: Cancer Biol Ther Source Type: journals

3D imaging of the response to CDC25 inhibition in multicellular spheroids.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we performed a 3D analysis of the response to the CDC25 phosphatase inhibitor IRC-083864 in HCT116 spheroids. Continuous exposure to IRC-083864 strongly inhibits the growth of spheroids and is shown to correlate with a decrease in Ki-67 positive cells. The cytotoxicity induced by IRC-083864 was examined by two-photon laser microscopy imaging and 3D reconstruction. Visualization in 3D allowed us to demonstrate that IRC-083864 treatment results in the inhibition of mitosis and induces cell death specifically localized in the outer proliferative cell layers of the spheroid structure. These results emphasize the...
Source: Cancer Biology and Therapy - October 14, 2009 Category: Cancer & Oncology Authors: Frongia C, Lorenzo C, Gianni F, Prevost GP, Ducommun B, Lobjois V Tags: Cancer Biol Ther Source Type: journals

Molecular imaging of gefitinib activity in an epidermal growth factor receptor (EGFR)-bearing xenograft model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Finding noninvasive methods to discern which patients' tumors bear a specific target molecule, and are presumably more likely to respond, remains a critical challenge. An anti-phospho-tyrosine antibody was labeled with indium ((111)In) using ethylenedicysteine (EC) as a chelator ((111)In-EC-P-Tyr). We hypothesized that tumor phosphokinase activity would be discernible by imaging with (111)In-EC-P-Tyr. A xenograft of A431 cells, a human epithelial carcinoma cell line overexpressing epidermal growth factor receptor (EGFR), was employed. Biodistribution studies confirmed increased tumor/muscle ratios of (111)In-EC-P-Tyr i...
Source: Cancer Biology and Therapy - October 14, 2009 Category: Cancer & Oncology Authors: Gong J, Yang DJ, Kohanim S, Angelo LS, Kurzrock R Tags: Cancer Biol Ther Source Type: journals

Tissue permittivity: A monitor for progressive tissue fibrosis as observed in bystander tissues following experimental high dose rate irradiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fibrosis is a pathological condition resulting from radiation injury which often limits the prescription of higher (or boost) doses of radiation, risking inadequate tumor control in patients. Recent studies have documented reduction in fibrotic lesions after administration of pentoxyfilline and tocopherol combinations to breast cancer patients receiving adjuvant radiation therapy. Despite the promise of these findings, no techniques or markers are available which can be used to identify the onset or progression of fibrosis in such patients at stages early enough to allow maximum benefit from these types of pharmacologi...
Source: Cancer Biology and Therapy - October 14, 2009 Category: Cancer & Oncology Authors: Skourou C, Hoopes PJ, Paulsen KD Tags: Cancer Biol Ther Source Type: journals

Ancient drugs, modern targets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19783897 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Bunz F Tags: Cancer Biol Ther Source Type: journals

High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MEK/ERK activities are increased in many primary lung cancers, and MEK inhibitors have been tested clinically for treatment of non-small cell lung cancers. The molecular mechanisms of resistance to MEK inhibitors have not been clearly demonstrated, however, and no molecular biomarker that can predict lung cancer response to MEK inhibitors is available. By determining the dose-responses of 35 human lung cancer cell lines to MEK-specific inhibitor AZD6244, we identified subsets of lung cancer cell lines that are either sensitive or resistant to this agent. Subsequent molecular characterization showed that treatment with ...
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Meng J, Peng H, Dai B, Guo W, Wang L, Ji L, Minna JD, Chresta CM, Smith PD, Fang B, Roth JA Tags: Cancer Biol Ther Source Type: journals

Design and development of masked therapeutic antibodies to limit off-target effects: Application to anti-EGFR antibodies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Therapeutic antibodies frequently cause side effects by binding antigen in non-target tissues. Here we demonstrate a novel molecular design of antibodies that addresses this problem by reversibly "masking" antibody complementarity determining regions until they reach diseased tissues containing disease-associated proteases. Specifically, two distinct single-chain Fv (scFv) fragments derived from antibodies against the epidermal growth factor receptor (cetuximab and 425) were fused with a protease susceptible linker to their epitopes engineered to encourage intermolecular association. Surface plasmon resonance and flow ...
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC Tags: Cancer Biol Ther Source Type: journals

The biology of hormone refractory breast and prostate cancer: An NCI workshop report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The molecular regulation of growth and progression of hormone refractory breast and prostate cancers remains challenging. The Division of Cancer Biology, NCI organized a small "think tank" style workshop and invited scientists in relevant areas to assess the state of science on the biology of hormone refractory tumors and to identify potential research opportunities to enhance a better understanding of the molecular regulation of these tumors. The meeting, held on May 27-29, 2008 in Bethesda, MD, was co-chaired by Drs. Michael Geoffrey Rosenfeld and Michael Press. While expression of estrogen or progesterone receptors ...
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Mohla S, Stearns V, Sathyamoorthy N, Rosenfeld MG, Nelson P Tags: Cancer Biol Ther Source Type: journals

Inhibition of KSHV infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we extended these studies to explore the possibility that manipulation of the Notch signaling by GSI would prevent the growth of the PEL tumors in vivo. We observed that the onset of tumorigenesis of KSHV infected PELs was significantly delayed in GSI treated SCID mice harboring the PEL cell lines. We also found that GSI treatment resulted in necrosis as well as apoptosis in tumors generated by the xenotransplanted KSHV positive PEL cell lines. In contrast, GSI had no effect on mice harboring BJAB cells, a KSHV negative Burkitt's lymphoma cell line where ICN levels were negligible. Our study provides further...
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Lan K, Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES Tags: Cancer Biol Ther Source Type: journals

Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Experimental design: Telomere repeat binding factor 2 (TRF2) plays a key role in the protective activity of telomere and is overexpression in several kinds of solid cancer cells. However, the role of overexpressed TRF2 in colorectal carcinoma remains unclear. The aim of this study was to determine the expression of TRF2, address the mechanism of TRF2 overexpression in human colorectal carcinoma. In present study, we examined the expression of TRF2 in colorectal cancer tissues from 39 patients, peritumoral normal tissues from 21 patients, and colon carcinoma SW480 cell line by quantitative PCR, immunohistochemistry and ...
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Dong W, Shen R, Wang Q, Gao Y, Qi X, Jiang H, Yao J, Lin X, Wu Y, Wang L Tags: Cancer Biol Ther Source Type: journals

Emerging role of notch signaling in epidermal differentiation and skin cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Signaling mediated by the Notch receptor governs tissue development during embryonal organogenesis, while in adult tissues it contributes to maintenance of cellular differentiation, proliferation and apoptosis. In addition, control by the Notch pathway of stem cell self-renewal and multi-potency points to an expanding role of Notch signaling in the progression of solid tumors. Notch and its ligands are abundantly expressed in the epidermis, where Notch signaling functions as a molecular switch that intervenes in cell transition between different skin layers during the epidermal differentiation process. More recent find...
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Panelos J, Massi D Tags: Cancer Biol Ther Source Type: journals

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Triptolide, a diterpene triepoxide derived from Trypterygium wilfordii, is documented to have antitumor activity in a broad range of solid tumors and leukemia. The mechanisms that are involved in triptolide-mediated apoptosis or growth inhibition in cancer cells are not fully understood. We identified a disintegrin and metalloproteinase 10 (ADAM10) as a novel molecular target of triptolide using affinity chromatography and mass spectrometry. The identification was confirmed by western blot analysis using an anti-ADAM10 antibody. The expression of ADAM10 is enhanced in several tumors including leukemia and is involved i...
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Soundararajan R, Sayat R, Robertson GS, Marignani PA Tags: Cancer Biol Ther Source Type: journals

Local and systemic antitumor effect of intratumoral and peritumoral IL-12 electrogene therapy on murine sarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluated the antitumor effect of IL-12 electrogene therapy (EGT) on murine SA-1 fibrosarcoma. The therapeutic plasmid was injected either intratumorally into subcutaneous SA-1 nodules or intradermally into the peritumoral region. We achieved a remarkable local and systemic antitumor effect with both approaches after single plasmid DNA application, with significant intratumoral and systemic production of IL-12 and IFNgamma. Intratumoral IL-12 EGT resulted in over 90% complete response rate of the treated tumors with 60% of cured mice being resistant to challenge with SA-1 tumor cells. Peritumoral EGT resu...
Source: Cancer Biology and Therapy - September 18, 2009 Category: Cancer & Oncology Authors: Pavlin D, Cemazar M, Kamensek U, Tozon N, Pogacnik A, Sersa G Tags: Cancer Biol Ther Source Type: journals

Amplification of chromosomal segment 4q12 in non-small cell lung cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In cancer, proto-oncogenes are often altered by genomic amplification. Here we report recurrent focal amplifications of chromosomal segment 4q12 overlapping the proto-oncogenes PDGFRA and KIT in non-small cell lung cancer (NSCLC). Single nucleotide polymorphism (SNP) array and fluorescent in situ hybridization (FISH) analysis indicate that 4q12 is amplified in 3-7% of lung adenocarcinomas and 8-10% of lung squamous cell carcinomas. In addition, we demonstrate that the NSCLC cell line NCI-H1703 exhibits focal amplification of PDGFRA and is dependent on PDGFRalpha activity for cell growth. Treatment of NCI-H1703 cells wi...
Source: Cancer Biology and Therapy - September 18, 2009 Category: Cancer & Oncology Authors: Ramos AH, Dutt A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Stiedl AC, Tanaka KE, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna JD, Chirieac LR, Lindeman NI, Giordano T, Beer DG, Wagner P, Wistuba II, Rubin MA, Meyerson M Tags: Cancer Biol Ther Source Type: journals

Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Identification of biomarkers potentially provides prognostic information that can help guide clinical decision-making. Given the relationship between estrogen exposure and endometrial cancer, especially low grade endometrioid carcinoma, we hypothesized that high expression of genes induced by estrogen would identify low risk endometrioid endometrial cancers. cDNA microarray and qRT-PCR verification were used to identify six genes that are highly induced by estrogen in the endometrium. These estrogen-induced biomarkers were quantified in 72 endometrial carcinomas by qRT-PCR. Unsupervised cluster analysis was performed, ...
Source: Cancer Biology and Therapy - September 18, 2009 Category: Cancer & Oncology Authors: Westin SN, Broaddus RR, Deng L, McCampbell A, Lu KH, Lacour RA, Milam MR, Urbauer DL, Mueller P, Pickar JH, Loose DS Tags: Cancer Biol Ther Source Type: journals

Identification of HLA-A11-restricted CTL epitopes derived from HPV type 18 using DNA immunization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, two HLA-A11-restricted epitopes derived from human papillomavirus (HPV)18 E6 oncoprotein were identified. HLA-A11-transgenic mice immunized with these epitopes could specifically induce interferon-gamma (IFNgamma) production, cytotoxicity and peptide/HLA-A11 tetramer binding in CD8(+) T cells. To study intracellular processing of CTL epitopes, we constructed a DNA plasmid containing an endoplasmic reticulum (ER) targeting sequence as well as the HPV18 E6 and E7 genes (pEK/HPV18E6E7). CTL responses against peptide-pulsed T2/A11 cells could be detected after immunizing HLA-A11-transgenic mice with pEK/HPV18E6E...
Source: Cancer Biology and Therapy - September 11, 2009 Category: Cancer & Oncology Authors: Chen HW, Leng CH, Liu HY, Cheng WF, Chang YW, Wu PY, Lien SP, Huang TY, Chiang SK, Lin MH, Tao MH, Chong P, Liu SJ Tags: Cancer Biol Ther Source Type: journals

Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multicenter french study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In advanced hepatocarcinoma, we report SRS uptake in 35.7% of livers and 41.2% of metastatic sites. SRS value in screening patients for somatostatin analogue treatment remains to be assessed. PMID: 19738430 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 11, 2009 Category: Cancer & Oncology Authors: Nguyen-Khac E, Ollivier I, Aparicio T, Moullart V, Hugentobler A, Lebtahi R, Lobry C, Susini C, Duhamel C, Hommel S, Cadranel JF, Joly JP, Barbare JC, Tramier B, Dupas JL Tags: Cancer Biol Ther Source Type: journals

Obesity promotes melanoma tumor growth: Role of leptin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epidemiological studies suggest that obesity increases the risk of developing several cancers, including melanoma. Obesity increases the expression of angiogenic factors, such as leptin, that may contribute to tumor growth. However, a direct cause and effect relationship between obesity and tumor growth has not been clearly established and the role of leptin in accelerating tumor growth is unclear. Our objective in the present study was to examine the rate of melanoma tumor growth in lean and obese mice with leptin deficiency or high levels of plasma leptin. We injected 1 x 10(6) B16F10 melanoma cells subcutaneously in...
Source: Cancer Biology and Therapy - August 29, 2009 Category: Cancer & Oncology Authors: Brandon EL, Gu JW, Cantwell L, He Z, Wallace G, Hall JE Tags: Cancer Biol Ther Source Type: journals

Toll prevents a move.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19713742 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 29, 2009 Category: Cancer & Oncology Authors: Chan VS, Tsao SW, Lin CL Tags: Cancer Biol Ther Source Type: journals

Natural products pave their way in cancer therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19713746 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 29, 2009 Category: Cancer & Oncology Authors: Efferth T Tags: Cancer Biol Ther Source Type: journals

A new step ahead for the consideration of ERCC1 as a candidate biomarker to select NSCLC patients for the treatment of cetuximab in combination with cisplatin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19713753 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 29, 2009 Category: Cancer & Oncology Authors: Olaussen KA Tags: Cancer Biol Ther Source Type: journals

Nuphar lutea thioalkaloids inhibit the nuclear factor kappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We screened thirty-four methanolic plant extracts for inhibition of the constitutive nuclear factor kappaB (NFkappaB) activity by a NFkappaB-luciferase reporter gene assay. Strong inhibition of NFkappaB activity was found in extracts of leaf and rhizome from Nuphar lutea L. SM. (Nuphar). The inhibitory action was narrowed down to a mixture of thionupharidines and/or thionuphlutidines that were identified in chromatography fractions by one- and two-dimensional NMR analysis. Dimeric sesquiterpene thioalkaloids were identified as the major components of the mixture. The Nuphar alkaloids mixture (NUP) showed a dose depende...
Source: Cancer Biology and Therapy - August 29, 2009 Category: Cancer & Oncology Authors: Ozer J, Eisner N, Ostrozhenkova E, Ostrozhenkova E, Bacher A, Eisenreich W, Benharroch D, Golan-Goldhirsh A, Gopas J Tags: Cancer Biol Ther Source Type: journals

shRNA technology: Investigating Ras-dependent cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19713764 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 29, 2009 Category: Cancer & Oncology Authors: Stein EV, Price DK, Figg WD Tags: Cancer Biol Ther Source Type: journals

Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Melanoma in its advanced stages is resistant not only to chemotherapy but also to radiation treatment. In line with efforts to identify genes that are key regulators of the disease and as such, may prove valuable targets for adjuvant and neo-adjuvant therapy of melanomas, we previously reported the presence of Serial Analysis of Gene Expression (SAGE) tags, corresponding to the Ataxia Telangiectasia Mutated (ATM) gene, in SAGE libraries generated from tissues representing primary and metastatic melanomas. In the present study, we document that ATM is expressed at high levels in advanced-stage melanomas. Given its cruci...
Source: Cancer Biology and Therapy - August 18, 2009 Category: Cancer & Oncology Authors: Moschos SJ, Dodd NR, Jukic DM, Fayewicz SL, Wang X, Becker D Tags: Cancer Biol Ther Source Type: journals

Possible angiogenic roles for claudin-4 in ovarian cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Claudin proteins are frequently overexpressed in various tumors such as breast, prostate and ovarian cancer. While their functions in cancer have not been completely elucidated, roles in survival, adhesion and invasion have been suggested. In order to clarify the roles of claudins in ovarian cancer, we have performed gene expression profiling of ovarian surface epithelial cells overexpressing claudin-4 and compared the expression patterns to the parental, non-expressing cells. Claudin-4 expression leads to the differential expression of several genes, including many that have previously been implicated in angiogenesis....
Source: Cancer Biology and Therapy - August 9, 2009 Category: Cancer & Oncology Authors: Li J, Chigurupati S, Agarwal R, Mughal MR, Mattson MP, Becker KG, Wood WH, Zhang Y, Morin PJ Tags: Cancer Biol Ther Source Type: journals

TLR3 activation inhibits nasopharyngeal carcinoma metastasis via downregulation of chemokine receptor CXCR4.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the effect of TLR3 activation on the metastasis of nasopharyngeal carcinoma (NPC). We found that NPC cells expressed TLR3 gene transcript and protein. TLR3 activation downregulated the expression of chemokine receptor CXCR4 in a dose-dependent manner, and inhibited cell migration in response to CXCR4 ligand stromal cell-derived factor-1alpha (SDF-1alpha) in chemotaxis assays. Furthermore, TLR3 activation significantly reduced the capacity of NPC cells to form metastasis in draining lymph nodes when injected in athymic mice. The anti-metastasis activity of endogenous human TLR3 expression in cance...
Source: Cancer Biology and Therapy - August 5, 2009 Category: Cancer & Oncology Authors: Zhang Y, Sun R, Liu B, Deng M, Zhang W, Li Y, Zhou G, Xie P, Li G, Hu J Tags: Cancer Biol Ther Source Type: journals

BB, a novel epidermal growth factor receptor inhibitor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19625764 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - July 25, 2009 Category: Cancer & Oncology Authors: Wheeler DL, Dunn EF Tags: Cancer Biol Ther Source Type: journals

Downregulation of a mitochondria associated protein SLP-2 inhibits tumor cell motility, proliferation and enhances cell sensitivity to chemotherapeutic reagents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from tissue microarray in this study and our previous reports revealed that stomatin-like protein 2 (SLP-2) is notably associated with tumorigenesis and metastasis. Many members of stomatin family are involved in tumor as mitochondrial component, and recent study has revealed that SLP-2 may also function in mitochondria. To further investigate the function of SLP-2, we used siRNA target SLP-2. Data showed that knock-down of SLP-2 potently inhibited cell motility, proliferation and slightly altered cell cycle without any significant change of apoptosis. Moreover, by combined application with different chemothera...
Source: Cancer Biology and Therapy - July 16, 2009 Category: Cancer & Oncology Authors: Wang Y, Cao W, Yu Z, Liu Z Tags: Cancer Biol Ther Source Type: journals

Enhancing radiosensitivity: Targeting the DNA repair pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Radiotherapy is very effective in local control of cancerous tumors, but its curative potential is often limited by intrinsic radioresistance of the tumor cells. Since DNA repair pathways remove radiation-induced DNA lesions and protect cells from lethality, these pathways represent potential therapeutic targets to radiosensitize tumors. In order to achieve a therapeutic gain, however, there must be a differential between tumor and normal cells that can be exploited to preferentially target the DNA repair of the tumor, while sparing surrounding normal tissues, and this has represented a significant challenge to progres...
Source: Cancer Biology and Therapy - March 20, 2009 Category: Cancer & Oncology Authors: Jorgensen TJ Tags: Cancer Biol Ther Source Type: journals

The emerging role of RBL2/p130 in multi-step retinoblastoma tumorigenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19276650 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 14, 2009 Category: Cancer & Oncology Authors: Cheah PY Tags: Cancer Biol Ther Source Type: journals

p53-dependent apoptosis in response to spindle damage linked to loss of Bub1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19270499 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 11, 2009 Category: Cancer & Oncology Authors: Beeharry N, Yen TJ Tags: Cancer Biol Ther Source Type: journals

Multidrug resistance phenotypes and MRS2 mitochondrial magnesium channel: Two players from one stemness?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19270501 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 11, 2009 Category: Cancer & Oncology Authors: Wolf FI, Trapani V Tags: Cancer Biol Ther Source Type: journals

Combined endostatin and TRAIL gene transfer suppresses human hepatocellular carcinoma growth and angiogenesis in nude mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endostatin can inhibit tumor growth by blocking angiogenesis, whereas tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may function as a soluble cytokine to selectively kill cancer cells without toxicity to most normal cells. To establish the combined anti-tumor therapeutic effect of endostatin and soluble TRAIL (sTRAIL), we performed intra-tumoral human endostatin and sTRAIL gene transfer using plasmid pVAX1 as a vector in a nude mouse model of human liver cancer. For subcutaneously inoculated human BEL7402 cancer, co-expression of both transgenes conferred marked anti-tumor activity with a significant ...
Source: Cancer Biology and Therapy - February 21, 2009 Category: Cancer & Oncology Authors: Zhang Y, Qu ZH, Cui M, Guo C, Zhang XM, Ma CH, Sun WS Tags: Cancer Biol Ther Source Type: journals

Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previously, we discovered a novel class of salicylhydrazide compounds with remarkable activity in hormone-dependent and -independent human cancer cells. We then designed and synthesized numerous analogues. Among these analogues, a quinoxalinhydrazide compound, SC144, exhibited desirable physicochemical and drug-like properties and therefore, was selected for further preclinical investigation. In the present study, we evaluated the in vitro activity of SC144 in a range of drug-sensitive and -resistant cancer cell lines as well as its in vivo efficacy in MDA-MB-435 and HT29 mice xenograft models. The broad-spectrum cytot...
Source: Cancer Biology and Therapy - February 19, 2009 Category: Cancer & Oncology Authors: Plasencia C, Grande F, Oshima T, Cao X, Yamada R, Sanchez T, Aiello F, Garofalo A, Neamati N Tags: Cancer Biol Ther Source Type: journals

Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epigenetic modification is one of the mechanisms leading to gene silencing in neoplastic cells. By methylation-specific PCR, we analyzed the promoter methylation of three cancer-related genes: Ras Association domain Family 1A (RASSF1A), Death Associated Protein kinase (DAP-kinase) and Retinoic Acid Receptor beta2 (RARbeta2) in two NPC xenografts (C15 and C17), 68 primary NPC tumors, and 9 normal nasopharyngeal epithelia. We showed that C15 and C17 displayed a complete promoter methylation of RASSF1A, RARbeta2 and DAP-kinase genes. In primary NPC tumors, the incidence of promoter methylation was very high for all three ...
Source: Cancer Biology and Therapy - February 19, 2009 Category: Cancer & Oncology Authors: Fendri A, Masmoudi A, Khabir A, Sellami-Boudawara T, Daoud J, Frikha M, Ghorbel A, Gargouri A, Mokdad-Gargouri R Tags: Cancer Biol Ther Source Type: journals

Gefitinib in lung cancer therapy: Clinical results, predictive markers of response and future perspectives.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over the past few years, epidermal growth factor receptor has emerged as one of the most important targets in tumorgenesis and several drugs targeting signal transduction pathways have been developed. The first among these agents to be approved for the treatment of NSCLC was gefitinib, a potent, selective and reversible inhibitor of HER1/EGFR tyrosine kinase activity. The review summarizes its clinical development and the new therapeutic options, with particular focus on predictive markers of susceptibility to this drug. PMID: 19182534 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - February 4, 2009 Category: Cancer & Oncology Authors: Adamo V, Franchina T, Adamo B, Denaro N, Gambadauro P, Chiofalo G, Scimone A, Caristi N, Russo A, Giordano A Tags: Cancer Biol Ther Source Type: journals

Radiation-induced apoptosis is modulated by the post-irradiation tumor microenvironment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The sensitivity of cells to radiation-induced apoptosis is considered to be low in solid tumors. This is thought to arise largely from inherent resistance caused by apoptotic pathway mutations. However, other factors may contribute to apoptotic resistance. Poor vasculature and abnormal tumor metabolism lead to a tumor microenvironment characterized by conditions of hypoxia, low glucose and extracellular acidosis. Hypoxia during irradiation is well known to cause resistance and is a barrier to successful treatment. We hypothesized that post-irradiation microenvironmental conditions can modulate radiation-induced apoptos...
Source: Cancer Biology and Therapy - January 25, 2009 Category: Cancer & Oncology Authors: Hendrikse AS, Renan MJ, Hunter AJ Tags: Cancer Biol Ther Source Type: journals

Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimetic.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in human adults of the Western world and no definitive cure is yet available. The disease is characterized by accumulation of clonal malignant B lymphocytes resistant to apoptosis. Strategies to hit the anti-apoptotic drift of the Bcl-2 family in B-CLL cells are being explored. A novel peptidomimetic based on the BH3 domain of the pro-apoptotic protein Bim and recently shown to exert significant apoptotic activity on acute myeloid leukemia cells, both in vitro and in vivo, was assayed on ex-vivo derived leukemic cells from untreated B-CLL patients ...
Source: Cancer Biology and Therapy - January 25, 2009 Category: Cancer & Oncology Authors: Ghiotto F, Fais F, Tenca C, Tomati V, Morabito F, Casciaro S, Mumot A, Zoppoli G, Ciccone E, Parodi S, Bruno S Tags: Cancer Biol Ther Source Type: journals

Micro-RNAs and their potential target genes in leukemia pathogenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the common science supporting miRNAs and their potantial target genes in leukemia pathogenesis. PMID: 19106636 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - December 26, 2008 Category: Cancer & Oncology Authors: Dong C, Ji M, Ji C Tags: Cancer Biol Ther Source Type: journals

Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Proteasome inhibitors and protease inhibitors are currently being discussed to be useful to sensitize drug-resistant cancer cells to chemotherapeutic agents or to act independently as single agents on drug resistant cancer cells. We tested the effect of the clinically applied HIV protease inhibitor nelfinavir on ovarian cancer cells. Nelfinavir efficiently induced cell death in carboplatin- sensitive (SKOV3, OV-GH-5) and carboplatin-resistant (OVCAR3, OV-GH-1) ovarian cancer cell lines as well as in cancer biopsies and ascites samples from patients with recurrent ovarian cancer. Nelfinavir significantly changed the mor...
Source: Cancer Biology and Therapy - December 26, 2008 Category: Cancer & Oncology Authors: Brüning A, Burger P, Vogel M, Rahmeh M, Gingelmaiers A, Friese K, Lenhard M, Burges A Tags: Cancer Biol Ther Source Type: journals

Therapeutic potential of various beta-glucan sources in conjunction with anti-tumor monoclonal antibody in cancer therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Combined beta-glucan with anti-tumor mAb therapy has demonstrated therapeutic efficacy in murine tumor models. The current study was designed to compare the therapeutic efficacy of various sources of beta-glucans. Our studies demonstrated that yeast beta-glucan, in combination with anti-tumor mAb, resulted in significantly smaller tumor burdens and achieved enhanced long-term survival compared to mAb alone or beta-glucan extracts from mushrooms. Further studies indicated that yeast beta-glucan particle was superior to mushroom extracts in inducing cytokine secretion, particularly IL-12 production in dendritic cells (DC...
Source: Cancer Biology and Therapy - December 26, 2008 Category: Cancer & Oncology Authors: Driscoll M, Hansen R, Ding C, Cramer DE, Yan J Tags: Cancer Biol Ther Source Type: journals