M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research

Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2328382. doi: 10.1080/15384047.2024.2328382. Epub 2024 Mar 26.ABSTRACTNon-small cell lung cancer (NSCLC) is among the most difficult malignancies to treat. Type III collagen (COL3A1) can affect the progression and chemoresistance development of NSCLC. We herein explored the mechanism that drives COL3A1 dysregulation in NSCLC. Potential RNA-binding proteins (RBPs) and transcription factors (TFs) that could bind to COL3A1 were searched by bioinformatics. mRNA expression was detected by quantitative PCR. Protein expression was evaluated using immunoblotting and immunohistochemistry. The eff...
Source: Cancer Biology and Therapy - March 26, 2024 Category: Cancer & Oncology Authors: Jiankun Ren Songwei Zhao Junyu Lai Source Type: research

The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
Cancer Biol Ther. 2024 Dec 31;25(1):2332000. doi: 10.1080/15384047.2024.2332000. Epub 2024 Mar 23.ABSTRACTThyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and despite the approved combination of BRAF and MEK1/2 inhibition for BRAF-mutant ATC, resistance often occurs. Here, we assess growth and signaling responses to combined BRAF and MEK1/2 inhibition in a panel of BRAF-mutant thyroid cancer cell lines. We first showed that combined BRAF a...
Source: Cancer Biology and Therapy - March 24, 2024 Category: Cancer & Oncology Authors: Hannah M Hicks Veronica L Nassar Jane Lund Madison M Rose Rebecca E Schweppe Source Type: research

The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
Cancer Biol Ther. 2024 Dec 31;25(1):2332000. doi: 10.1080/15384047.2024.2332000. Epub 2024 Mar 23.ABSTRACTThyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and despite the approved combination of BRAF and MEK1/2 inhibition for BRAF-mutant ATC, resistance often occurs. Here, we assess growth and signaling responses to combined BRAF and MEK1/2 inhibition in a panel of BRAF-mutant thyroid cancer cell lines. We first showed that combined BRAF a...
Source: Cancer Biology and Therapy - March 24, 2024 Category: Cancer & Oncology Authors: Hannah M Hicks Veronica L Nassar Jane Lund Madison M Rose Rebecca E Schweppe Source Type: research

The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
Cancer Biol Ther. 2024 Dec 31;25(1):2332000. doi: 10.1080/15384047.2024.2332000. Epub 2024 Mar 23.ABSTRACTThyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and despite the approved combination of BRAF and MEK1/2 inhibition for BRAF-mutant ATC, resistance often occurs. Here, we assess growth and signaling responses to combined BRAF and MEK1/2 inhibition in a panel of BRAF-mutant thyroid cancer cell lines. We first showed that combined BRAF a...
Source: Cancer Biology and Therapy - March 24, 2024 Category: Cancer & Oncology Authors: Hannah M Hicks Veronica L Nassar Jane Lund Madison M Rose Rebecca E Schweppe Source Type: research

CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research

CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research

CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research

CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research

CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research

Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes
Cancer Biol Ther. 2024 Dec 31;25(1):2329368. doi: 10.1080/15384047.2024.2329368. Epub 2024 Mar 14.ABSTRACTRedox adaptation causes poor prognosis by adapting cancer cells to excessive oxidative stress. Previously, we introduced an oxidative stress-resistant metastatic prostate cancer (mPC) model (LNCaP-HPR) that redox adaptation reduced the effect of Cabazitaxel (Cab), the last taxane-derivative for metastatic castration-resistant PC (mCRPC). Whereas, we investigated for the first time whether there is an association between the altered apoptotic effect and pro-oxidant efficacy of Cab on the redox adaptation in PC cells wit...
Source: Cancer Biology and Therapy - March 15, 2024 Category: Cancer & Oncology Authors: Isil Ezgi Eryilmaz Unal Egeli Gulsah Cecener Source Type: research

Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes
Cancer Biol Ther. 2024 Dec 31;25(1):2329368. doi: 10.1080/15384047.2024.2329368. Epub 2024 Mar 14.ABSTRACTRedox adaptation causes poor prognosis by adapting cancer cells to excessive oxidative stress. Previously, we introduced an oxidative stress-resistant metastatic prostate cancer (mPC) model (LNCaP-HPR) that redox adaptation reduced the effect of Cabazitaxel (Cab), the last taxane-derivative for metastatic castration-resistant PC (mCRPC). Whereas, we investigated for the first time whether there is an association between the altered apoptotic effect and pro-oxidant efficacy of Cab on the redox adaptation in PC cells wit...
Source: Cancer Biology and Therapy - March 15, 2024 Category: Cancer & Oncology Authors: Isil Ezgi Eryilmaz Unal Egeli Gulsah Cecener Source Type: research

Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes
Cancer Biol Ther. 2024 Dec 31;25(1):2329368. doi: 10.1080/15384047.2024.2329368. Epub 2024 Mar 14.ABSTRACTRedox adaptation causes poor prognosis by adapting cancer cells to excessive oxidative stress. Previously, we introduced an oxidative stress-resistant metastatic prostate cancer (mPC) model (LNCaP-HPR) that redox adaptation reduced the effect of Cabazitaxel (Cab), the last taxane-derivative for metastatic castration-resistant PC (mCRPC). Whereas, we investigated for the first time whether there is an association between the altered apoptotic effect and pro-oxidant efficacy of Cab on the redox adaptation in PC cells wit...
Source: Cancer Biology and Therapy - March 15, 2024 Category: Cancer & Oncology Authors: Isil Ezgi Eryilmaz Unal Egeli Gulsah Cecener Source Type: research

Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy
Cancer Biol Ther. 2024 Dec 31;25(1):2323765. doi: 10.1080/15384047.2024.2323765. Epub 2024 Mar 11.ABSTRACTAdipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains inadequately explicated. Primary patient-derived xenograft models (PDXs) and stromal cell co-culture system are employed in this study. We show that the dynamic evolution of BM adipocytes from initial diagnosis of B-ALL to th...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Xi Jia Naying Liao Yunqian Yao Xutao Guo Kai Chen Pengcheng Shi Source Type: research

The relationship between long non-coding gene < em > CASC21 < /em > polymorphisms and cervical cancer
CONCLUSION: Our finding firstly determined that two CASC21 SNPs (rs16902094, rs16902104) were associated with an increased risk of cervical cancer, which adds to our knowledge regarding the effect of CASC21 on cervical carcinogenesis.PMID:38465665 | PMC:PMC10936591 | DOI:10.1080/15384047.2024.2322207 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Lili Han Jing Liu Mireayi Shataer Chengyong Wu Mayinuer Niyazi Source Type: research