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365 records returned

A Common Signaling Cascade May Underlie “Addiction” to the Src, BCR-ABL, and EGF Receptor OncogenesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sreenath V. Sharma, Patrycja Gajowniczek, Inna Way, Diana Lee, Jane Jiang, Yuki Yuza, Marie Classon, Daniel A. Haber, Jeffrey Settleman. (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

A Lymphotoxin-Driven Pathway to Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Johannes Haybaeck, Nicolas Zeller, Monika Julia Wolf, Achim Weber, Ulrich Wagner, Michael Odo Kurrer, Juliane Bremer, Giandomenica Iezzi, Rolf Graf, Pierre-Alain Clavien, Robert Thimme, Hubert Blum, Sergei A. Nedospasov, Kurt Zatloukal, Muhammad Ramzan, Sandra Ciesek, Thomas Pietschmann, Patrice N. Marche, Michael Karin, Manfred Kopf, Jeffrey L. Browning, Adriano Aguzzi, Mathias Heikenwalder. (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

p53-Dependent Translational Control of Senescence and Transformation via 4E-BPsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Emmanuel Petroulakis, Armen Parsyan, Ryan J.O. Dowling, Olivier LeBacquer, Yvan Martineau, Michael Bidinosti, Ola Larsson, Tommy Alain, Liwei Rong, Yaël Mamane, Marilene Paquet, Luc Furic, Ivan Topisirovic, David Shahbazian, Mark Livingstone, Mauro Costa-Mattioli, Jose G. Teodoro, Nahum Sonenberg. eIF4E, the mRNA 5′ cap-binding translation initiation factor, is overexpressed in numerous cancers and is implicated in mechanisms underlying oncogenesis and senescence. 4E-BPs (eIF4E-binding prot.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 OncogeneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dawang Zhou, Claudius Conrad, Fan Xia, Ji-Sun Park, Bernhard Payer, Yi Yin, Gregory Y. Lauwers, Wolfgang Thasler, Jeannie T. Lee, Joseph Avruch, Nabeel Bardeesy. Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila. We show that the Mst1 and Mst2 protein kinases, the mammalian Hippo orthologs, are cleaved and const.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl HydroxylaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Qing Zhang, Jinming Gu, Lianjie Li, Jiayun Liu, Biao Luo, Hiu-Wing Cheung, Jesse S. Boehm, Min Ni, Christoph Geisen, David E. Root, Kornelia Polyak, Myles Brown, Andrea L. Richardson, William C. Hahn, William G. Kaelin, Archana Bommi-Reddy. 2-Oxoglutarate-dependent dioxygenases, including the EglN prolyl hydroxylases that regulate HIF, can be inhibited with drug-like molecules. EglN2 is estrogen inducible in breast carcinoma cells an.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based ResistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thomas O'Hare, William C. Shakespeare, Xiaotian Zhu, Christopher A. Eide, Victor M. Rivera, Frank Wang, Lauren T. Adrian, Tianjun Zhou, Wei-Sheng Huang, Qihong Xu, Chester A. Metcalf, Jeffrey W. Tyner, Marc M. Loriaux, Amie S. Corbin, Scott Wardwell, Yaoyu Ning, Jeffrey A. Keats, Yihan Wang, Raji Sundaramoorthi, Mathew Thomas, Dong Zhou, Joseph Snodgrass, Lois Commodore, Tomi K. Sawyer, David C. Dalgarno, Michael W.N. Deininger, Brian J. Druker, Tim Clackson. Inhibition of BCR-ABL by imatinib induces durable responses in many patients with chronic myeloid leukemia (CML), but resistance attributable to kinase domain mutatio...
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-Initiating Cells in C/EBPα Mutant AMLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oxana Bereshchenko, Elena Mancini, Susan Moore, Daniel Bilbao, Robert Månsson, Sidinh Luc, Amit Grover, Sten Eirik W. Jacobsen, David Bryder, Claus Nerlov. We here use knockin mutagenesis in the mouse to model the spectrum of acquired CEBPA mutations in human acute myeloid leukemia. We find that C-terminal C/EBPα mutations increase the prolife.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-RasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sharon Y. Gidekel Friedlander, Gerald C. Chu, Eric L. Snyder, Nomeda Girnius, Gregory Dibelius, Denise Crowley, Eliza Vasile, Ronald A. DePinho, Tyler Jacks. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

Signaling to p53: Ribosomal Proteins Find Their WayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yanping Zhang, Hua Lu. Inherently disparate cell growth and division, which are intimately coupled through a delicate network of intracellular and extracellular signaling, require ribosomal biogenesis. A number of event.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

PARsing the Phrase “All in for Axin”— Wnt Pathway Targets in CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eric R. Fearon. Genetic alternations resulting in constitutive stabilization of β-catenin and altered transcription of β-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers .... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

JAK2 Gets Histone H3 RollingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Martin Sattler, James D. Griffin. Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 r.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

Mst Out and HCC InEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bin Zhao, Qunying Lei, Kun-Liang Guan. Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

Edging toward New Therapeutics with Cyclin D1 Egl'ng on CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chi V. Dang. In this issue of Cancer Cell, Zhang et al. reports that the iron-dependent 2-oxoglutarate dioxygenase or prolyl hydroxylase EglN2 induces Cyclin D1 levels, egging on breast tumorigenesis. T.... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

It's a Free for All—Insulin-Positive Cells Join the Group of Potential Progenitors for Pancreatic Ductal AdenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
John P. Morris, Matthias Hebrok. Despite significant efforts, the cellular compartment that gives rise to pancreatic ductal adenocarcinoma (PDAC), one of the most lethal human cancers, remains obscure. In this issue of Cancer .... (Source: Cancer Cell)
Source: Cancer Cell - November 3, 2009 Category: Cancer & Oncology Source Type: journals

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle AssemblyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hsiao-Chun Huang, Jue Shi, James D. Orth, Timothy J. Mitchison. Current antimitotics work by perturbing spindle assembly, which activates the spindle assembly checkpoint, causes mitotic arrest, and triggers apoptosis. Cancer cells can resist such killing by pr.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the ProstateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lizhong Wang, Runhua Liu, Weiquan Li, Chong Chen, Hiroto Katoh, Guo-Yun Chen, Beth McNally, Lin Lin, Penghui Zhou, Tao Zuo, Kathleen A. Cooney, Yang Liu, Pan Zheng. Despite clear epidemiological and genetic evidence for X-linked prostate cancer risk, all prostate cancer genes identified are autosomal. Here, we report somatic inactivating mutations and deletio.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anka Bric, Cornelius Miething, Carl Uli Bialucha, Claudio Scuoppo, Lars Zender, Alexander Krasnitz, Zhenyu Xuan, Johannes Zuber, Michael Wigler, James Hicks, Richard W. McCombie, Michael T. Hemann, Gregory J. Hannon, Scott Powers, Scott W. Lowe. Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable of accelerating lym.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Functional Interaction of Plasmacytoid Dendritic Cells with Multiple Myeloma Cells: A Therapeutic TargetEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dharminder Chauhan, Ajita V. Singh, Mohan Brahmandam, Ruben Carrasco, Madhavi Bandi, Teru Hideshima, Giada Bianchi, Klaus Podar, Yu-Tzu Tai, Constantine Mitsiades, Noopur Raje, David L. Jaye, Shaji K. Kumar, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson. Multiple myeloma (MM) remains incurable despite novel therapies, suggesting the need for further identification of factors mediating tumorigenesis and drug resistance. Using both in vitro and in v.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

A Lymphotoxin-Driven Pathway to Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Johannes Haybaeck, Nicolas Zeller, Monika Julia Wolf, Achim Weber, Ulrich Wagner, Michael Odo Kurrer, Juliane Bremer, Giandomenica Iezzi, Rolf Graf, Pierre-Alain Clavien, Robert Thimme, Hubert Blum, Sergei A. Nedospasov, Kurt Zatloukal, Muhammad Ramzan, Sandra Ciesek, Thomas Pietschmann, Patrice N. Marche, Michael Karin, Manfred Kopf, Jeffrey L. Browning, Adriano Aguzzi, Mathias Heikenwalder. Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) α and β and their recept.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Proteomic and Genetic Approaches Identify Syk as an AML TargetEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cynthia K. Hahn, Jacob E. Berchuck, Kenneth N. Ross, Rose M. Kakoza, Karl Clauser, Anna C. Schinzel, Linda Ross, Ilene Galinsky, Tina N. Davis, Serena J. Silver, David E. Root, Richard M. Stone, Daniel J. DeAngelo, Martin Carroll, William C. Hahn, Steven A. Carr, Todd R. Golub, Andrew L. Kung, Kimberly Stegmaier. Cell-based screening can facilitate the rapid identification of compounds inducing complex cellular phenotypes. Advancing a compound toward the clinic, however, generally requires the identificati.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

A Therapeutic Opportunity in Melanoma: ErbB4 Makes a Mark on SkinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Jeff Settleman. Malignant melanomas are aggressive tumors that are largely refractory to conventional drug therapies. A recent study reported in Nature Genetics identified mutationally activated ErbB4 (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Tail Wags Dog: Primary Cilia and TumorigenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Monique T. Barakat, Matthew P. Scott. Aberrant activation of the Hedgehog (Hh) signaling pathway contributes to many forms of cancer. Primary cilia are Hh signal transduction centers. Two papers in a recent issue of Nature Medicine.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

No Way Out for Tumor CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conly L. Rieder, René H. Medema. In this issue of Cancer Cell, Huang et al. report that preventing exit from mitosis provides a very efficient strategy for killing cells. Although this is not an unexpected finding, it neve.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Lymphotoxins: New Targets for Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Augusto Villanueva, Radoslav Savic, Josep M. Llovet. In this issue of Cancer Cell, Haybaeck et al. unravel the role of lymphotoxin pathway in the development of hepatocellular carcinoma (HCC). Aberrant activation of this cascade in mice liver.... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Can Treating the SYK Cell Cure Leukemia?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
James R. Downing. Targeted therapy has remained elusive for most acute myeloid leukemia patients. In this issue of Cancer Cell, Stegmaier and colleagues identify SYK as a key mediator of the differentiation .... (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Taming Supplemental MaterialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Emilie Marcus. (Source: Cancer Cell)
Source: Cancer Cell - October 6, 2009 Category: Cancer & Oncology Source Type: journals

Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of MedulloblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tracy-Ann Read, Marie P. Fogarty, Shirley L. Markant, Roger E. McLendon, Zhengzheng Wei, David W. Ellison, Phillip G. Febbo, Robert J. Wechsler-Reya. (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating AktEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Huadong Pei, Liang Li, Brooke L. Fridley, Gregory D. Jenkins, Krishna R. Kalari, Wilma Lingle, Gloria Petersen, Zhenkun Lou, Liewei Wang. Akt is a central regulator of cell growth. Its activity can be negatively regulated by the phosphatase PHLPP that specifically dephosphorylates the hydrophobic motif of Akt (Ser473 in Akt1). Howev.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

The Tensin-3 Protein, Including its SH2 Domain, Is Phosphorylated by Src and Contributes to Tumorigenesis and MetastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Xiaolan Qian, Guorong Li, William C. Vass, Alex Papageorge, Renard C. Walker, Laura Asnaghi, Peter J. Steinbach, Giovanna Tosato, Kent Hunter, Douglas R. Lowy. In cell lines from advanced lung cancer, breast cancer, and melanoma, endogenous tensin-3 contributes to cell migration, anchorage-independent growth, and tumorigenesis. Although SH2 domains have .... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug Resistance in Chronic Myeloid LeukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lars Klemm, Cihangir Duy, Ilaria Iacobucci, Stefan Kuchen, Gregor von Levetzow, Niklas Feldhahn, Nadine Henke, Zhiyu Li, Thomas K. Hoffmann, Yong-mi Kim, Wolf-Karsten Hofmann, Hassan Jumaa, John Groffen, Nora Heisterkamp, Giovanni Martinelli, Michael R. Lieber, Rafael Casellas, Markus Müschen. Chronic myeloid leukemia (CML) is induced by BCR-ABL1 and can be effectively treated for many years with Imatinib until leukemia cells acquire drug resistance through BCR-ABL1 mutati.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

Growth Factor-Antagonized Rexinoid Apoptosis Involves Permissive PPARγ/RXR Heterodimers to Activate the Intrinsic Death Pathway by NOEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pattabhiraman Shankaranarayanan, Aurélie Rossin, Harshal Khanwalkar, Susana Alvarez, Rosana Alvarez, Annica Jacobson, Angela Nebbioso, Angel R. de Lera, Lucia Altucci, Hinrich Gronemeyer. Growth factor (GF) deprivation and/or blocking of cognate signaling can induce apoptosis and is the basis of several cancer treatment paradigms. We observed that RXR agonists (rexinoids) induce ap.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wendy S. Garrett, Shivesh Punit, Carey A. Gallini, Monia Michaud, Dorothy Zhang, Kirsten S. Sigrist, Graham M. Lord, Jonathan N. Glickman, Laurie H. Glimcher. We previously described a mouse model of ulcerative colitis linked to T-bet deficiency in the innate immune system. Here, we report that the majority of T-bet−/−RAG2−.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

14-3-3ζ Cooperates with ErbB2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal TransitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Jing Lu, Hua Guo, Warapen Treekitkarnmongkol, Ping Li, Jian Zhang, Bin Shi, Chen Ling, Xiaoyan Zhou, Tongzhen Chen, Paul J. Chiao, Xinhua Feng, Victoria L. Seewaldt, William J. Muller, Aysegul Sahin, Mien-Chie Hung, Dihua Yu. ErbB2, a metastasis-promoting oncoprotein, is overexpressed in ∼25% of invasive/metastatic breast cancers, but in 50%–60% of noninvasive ductal carcinomas in situ (DCIS). It has been puzzling how .... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TANEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Zvi G. Fridlender, Jing Sun, Samuel Kim, Veena Kapoor, Guanjun Cheng, Leona Ling, G. Scott Worthen, Steven M. Albelda. TGF-β blockade significantly slows tumor growth through many mechanisms, including activation of CD8+ T cells and macrophages. Here, we show that TGF-β blockade also increases neutrophi.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

SDH5 Mutations and Familial Paraganglioma: Somewhere Warburg is SmilingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
William G. Kaelin. Paragangliomas have been linked to mutations affecting the succinate dehydrogenase complex. In a recent issue of Science, Rutter and coworkers showed that SDH5 is required for the flavinati.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

A Molecular Link between AKT Regulation and Chemotherapeutic ResponseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Christian C. Dibble, Brendan D. Manning. The protein kinase AKT is frequently activated in human cancers and has been implicated in resistance to chemotherapy. In this issue of Cancer Cell, Pei et al. show that FKBP51 negatively r.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

Src Substrate SurpriseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
G. Steven Martin. In this issue of Cancer Cell, Lowy and colleagues show that the SH2 domain of tensin-3 is regulated by phosphorylation by Src and that this phosphorylation promotes the oncogenic function o.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

Imatinib Resistance and Progression of CML to Blast Crisis: Somatic Hypermutation AIDing the WayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Matthew P. Strout, David G. Schatz. Very little is known about how acquired oncogenic mutations arise. In this issue of Cancer Cell, Klemm and colleagues present evidence supporting a role for the antibody diversification enz.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

The Yin-Yang of Tumor-Associated NeutrophilsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alberto Mantovani. Cancer-related inflammation is a key component of the tumor microenvironment. A report in this issue of Cancer Cell now indicates that tumor-associated neutrophils in lung cancer can polari.... (Source: Cancer Cell)
Source: Cancer Cell - September 9, 2009 Category: Cancer & Oncology Source Type: journals

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and MetastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Shuying Liu, Makiko Umezu-Goto, Mandi Murph, Yiling Lu, Wenbin Liu, Fan Zhang, Shuangxing Yu, L. Clifton Stephens, Xiaojiang Cui, George Murrow, Kevin Coombes, William Muller, Mien-Chie Hung, Charles M. Perou, Adrian V. Lee, Xianjun Fang, Gordon B. Mills. (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Tumor Suppression by Phospholipase C-β3 via SHP-1-Mediated Dephosphorylation of Stat5Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wenbin Xiao, Hong Hong, Yuko Kawakami, Yuko Kato, Dianqing Wu, Hiroki Yasudo, Akiko Kimura, Hiromi Kubagawa, Luigi F. Bertoli, Randall S. Davis, Luan A. Chau, Joaquin Madrenas, Cyrus C. Hsia, Anargyros Xenocostas, Thomas J. Kipps, Lothar Hennighausen, Atsushi Iwama, Hiromitsu Nakauchi, Toshiaki Kawakami. Given its catalytic activity to generate diacylglycerol and inositol 1,4,5-trisphosphate, phospholipase C (PLC) is implicated in promoting cell growth. However, we found that PLC-β3-deficient mice.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Raf-1 Addiction in Ras-Induced Skin CarcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Karin Ehrenreiter, Florian Kern, Vanishree Velamoor, Katrin Meissl, Gergana Galabova-Kovacs, Maria Sibilia, Manuela Baccarini. Ras activation is common to many human cancers and promotes cell proliferation and survival by initiating multiple signaling cascades. Accordingly, Ras-transformed cells are generally considered t.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Persistence of Leukemia-Initiating Cells in a Conditional Knockin Model of an Imatinib-Responsive Myeloproliferative DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Katherine I. Oravecz-Wilson, Steven T. Philips, Ömer H. Yilmaz, Heather M. Ames, Lina Li, Brendan D. Crawford, Alice M. Gauvin, Peter C. Lucas, Kajal Sitwala, James R. Downing, Sean J. Morrison, Theodora S. Ross. Despite remarkable responses to the tyrosine kinase inhibitor imatinib, CML patients are rarely cured by this therapy perhaps due to imatinib refractoriness of leukemia-initiating cells (LICs). Ev.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Gli2 and p53 Cooperate to Regulate IGFBP-3- Mediated Chondrocyte Apoptosis in the Progression from Benign to Malignant Cartilage TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Louisa Ho, Aneta Stojanovski, Heather Whetstone, Qing Xia Wei, Elaine Mau, Jay S. Wunder, Benjamin Alman. Clinical evidence suggests that benign cartilage lesions can progress to malignant chondrosarcoma, but the molecular events in this progression are unknown. Mice that develop benign cartilage lesi.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K SignalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report that knocking down the expression of inositol polyphosphate 4-phosphatase type II (INPP4B) in human epithelial cells, like knockdown of PTEN, resulted in enhanced Akt activation and anch.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Damià Tormo, Agnieszka Chęcińska, Direna Alonso-Curbelo, Eva Pérez-Guijarro, Estela Cañón, Erica Riveiro-Falkenbach, Tonantzin G. Calvo, Lionel Larribere, Diego Megías, Francisca Mulero, Miguel A. Piris, Rupesh Dash, Paola M. Barral, José L. Rodríguez-Peralto, Pablo Ortiz-Romero, Thomas Tüting, Paul B. Fisher, María S. Soengas. Inappropriate drug delivery, secondary toxicities, and persistent chemo- and immunoresistance have traditionally compromised treatment response in melanoma. Using cellular systems and genetically .... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of MacrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
David G. DeNardo, Jairo B. Barreto, Pauline Andreu, Lesley Vasquez, David Tawfik, Nikita Kolhatkar, Lisa M. Coussens. During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor ver.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Targeting the Molecular Defect in BRCA-Deficient Tumors for Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ashok R. Venkitaraman. Targeted therapies exploiting specific molecular defects in cancer cells promise to overcome roadblocks in the development of effective anticancer drugs. A recent report in the New England Jour.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

The SPS Affair: A Complex Tale of Illicit ProliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Benjamin S. Braun, Kevin Shannon. In this issue of Cancer Cell, Xiao et al. report that PLC-β3 mutant mice develop myeloprolfierative neoplasms and show that tumor suppressor activity does not require PLC-β3 catalytic activ.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Raf-1 and Squamous Cell Carcinoma: Rok-ing the BoatEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elda Grabocka, Dafna Bar-Sagi. Squamous cell carcinoma (SCC) is the second most common form of nonmelanoma skin cancer. In this issue of Cancer Cell, Ehrenreiter et al. unveil a critical role for the Raf-1/Rok-α interact.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals