PPP2R1A silencing suppresses LUAD progression by sensitizing cells to nelfinavir-induced apoptosis and pyroptosis
Lung adenocarcinoma is a major public health problem with the low 5-year survival rate (15%) among cancers. Aberrant alterations of meiotic genes, which have gained increased attention recently, might contribu... (Source: Cancer Cell International)
Source: Cancer Cell International - April 23, 2024 Category: Cancer & Oncology Authors: Yating Liu, Lianlian Ouyang, Shiyao Jiang, Lu Liang, Yuanbing Chen, Chao Mao, Yiqun Jiang and Li Cong Tags: Research Source Type: research
C6orf15 promotes liver metastasis via WNT/ β-catenin signalling in colorectal cancer
Colon cancer ranks third among global tumours and second in cancer-related mortality, prompting an urgent need to explore new therapeutic targets. C6orf15 is a novel gene that has been reported only in Sjogren... (Source: Cancer Cell International)
Source: Cancer Cell International - April 23, 2024 Category: Cancer & Oncology Authors: Jiankang Yu, Jian Sun, Jingtong Tang, Jiayu Xu, Guanru Qian and Jianping Zhou Tags: Research Source Type: research
Toxoplasma gondii suppresses proliferation and migration of breast cancer cells by regulating their transcriptome
Breast cancer is the most common cancer in women worldwide. Toxoplasma gondii (T. gondii) has shown anticancer activity in breast cancer mouse models, and exerted beneficial effect on the survival of breast cance... (Source: Cancer Cell International)
Source: Cancer Cell International - April 23, 2024 Category: Cancer & Oncology Authors: Hengming Ye, Xiaotao Zhou, Bike Zhu, Tiantian Xiong, Weile Huang, Feng He, Hui Li, Lihua Chen, Luying Tang and Zefang Ren Tags: Research Source Type: research
Unravelling immune microenvironment features underlying tumor progression in the single-cell era
The relationship between the immune cell and tumor occurrence and progression remains unclear. Profiling alterations in the tumor immune microenvironment (TIME) at high resolution is crucial to identify factor... (Source: Cancer Cell International)
Source: Cancer Cell International - April 22, 2024 Category: Cancer & Oncology Authors: Qilian Du, Qi An, Jiajun Zhang, Chao Liu and Qinyong Hu Tags: Review Source Type: research
High LGALS3 expression induced by HCP5/hsa-miR-27b-3p correlates with poor prognosis and tumor immune infiltration in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is widely recognized for its unfavorable prognosis. Increasing evidence has revealed that LGALS3 has an essential function in initiating and developing several malignancies in hu... (Source: Cancer Cell International)
Source: Cancer Cell International - April 20, 2024 Category: Cancer & Oncology Authors: Yinghui Ren, Yongmei Qian, Qicheng Zhang, Xiaoping Li, Mingjiang Li, Wei Li, Pan Yang, Hengchang Ren, Hongxia Li, Yiqi Weng, Dengwen Li, Ke Xu and Wenli Yu Tags: Research Source Type: research
Sparassis latifolia and exercise training as complementary medicine mitigated the 5-fluorouracil potent side effects in mice with colorectal cancer: bioinformatics approaches, novel monitoring pathological metrics, screening signatures, and innovative management tactic
Prompt identification and assessment of the disease are essential for reducing the death rate associated with colorectal cancer (COL). Identifying specific causal or sensitive components, such as coding RNA (c... (Source: Cancer Cell International)
Source: Cancer Cell International - April 18, 2024 Category: Cancer & Oncology Authors: Navid Abedpoor, Farzaneh Taghian, Khosro Jalali Dehkordi and Kamran Safavi Tags: Research Source Type: research
Spatial and single-cell explorations uncover prognostic significance and immunological functions of mitochondrial calcium uniporter in breast cancer
The mitochondrial calcium uniporter (MCU) is a transmembrane protein facilitating the entry of calcium ions into mitochondria from the cell cytosol. Maintaining calcium balance is crucial for enhancing cellula... (Source: Cancer Cell International)
Source: Cancer Cell International - April 17, 2024 Category: Cancer & Oncology Authors: Chia-Jung Li, Yen-Dun Tony Tzeng, Jui-Hu Hsiao, Ling-Ming Tseng, Tzu-Sheng Hsu and Pei-Yi Chu Tags: Research Source Type: research
Exosomes biogenesis was increased in metformin-treated human ovary cancer cells; possibly to mediate resistance
Exosomes derived from tumor cells contribute to the pathogenesis of cancers. Metformin, the most usually used drug for type 2 diabetes, has been frequently investigated for anticancer effects. Here, we examine... (Source: Cancer Cell International)
Source: Cancer Cell International - April 16, 2024 Category: Cancer & Oncology Authors: Reza Abbasi, Vahid Nejati and Jafar Rezaie Tags: Research Source Type: research
Comprehensive analysis of m6A modification in immune infiltration, metabolism and drug resistance in hepatocellular carcinoma
N6-methyladenosine (m6A) is important in regulating mRNA stability, splicing, and translation, and it also contributes to tumor development. However, there is still limited understanding of the comprehensive e... (Source: Cancer Cell International)
Source: Cancer Cell International - April 16, 2024 Category: Cancer & Oncology Authors: Yunxing Shi, Kai Li, Yichuan Yuan, Chenwei Wang, Zhiwen Yang, Dinglan Zuo, Yi Niu, Jiliang Qiu, Binkui Li, Yunfei Yuan and Wei He Tags: Research Source Type: research
A novel immunogenic cell death-related classification indicates the immune landscape and predicts clinical outcome and treatment response in acute myeloid leukemia
This study aims to explore the molecular characteristics of ICD in acute myeloid leukemia (... (Source: Cancer Cell International)
Source: Cancer Cell International - April 16, 2024 Category: Cancer & Oncology Authors: Fangmin Zhong, Shuyang He, Ni Guo, Luyi Shi, Linlin Zhang, Hua Jin and Guangyao Kong Tags: Research Source Type: research
Significance of PSCA as a novel prognostic marker and therapeutic target for cancer
One of the contributing factors in the diagnosis and treatment of most cancers is the identification of their surface antigens. Cancer tissues or cells have their specific antigens. Some antigens that are pres... (Source: Cancer Cell International)
Source: Cancer Cell International - April 16, 2024 Category: Cancer & Oncology Authors: Tina Nayerpour Dizaj, Abolfazl Doustmihan, Behnaz Sadeghzadeh Oskouei, Morteza Akbari, Mehdi Jaymand, MirAhmad Mazloomi and Rana Jahanban-Esfahlan Tags: Review Source Type: research
Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer
Hydrogen sulfide (H2S) is a significant endogenous mediator that has been implicated in the progression of various forms of cancer including breast cancer (BC). Cystathionine- β-synthase (CBS), cystathionine-γ-lya... (Source: Cancer Cell International)
Source: Cancer Cell International - April 16, 2024 Category: Cancer & Oncology Authors: Alyaa Dawoud, Rana A. Youness, Heba Nafea, Tamer Manie, Carole Bourquin, Csaba Szabo, Reham M. Abdel-Kader and Mohamed Z. Gad Tags: Research Source Type: research
Micropeptides: potential treatment strategies for cancer
Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although noncoding RNAs (ncRNAs) have been previously assumed to constitute a class of RNA transcripts w... (Source: Cancer Cell International)
Source: Cancer Cell International - April 15, 2024 Category: Cancer & Oncology Authors: He Zhou, Yan Wu, Ji Cai, Dan Zhang, Dongfeng Lan, Xiaofang Dai, Songpo Liu, Tao Song, Xianyao Wang, Qinghong Kong, Zhixu He, Jun Tan and Jidong Zhang Tags: Review Source Type: research
Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors
The application of chimeric antigen receptor (CAR) T cells in the management of hematological malignancies has emerged as a noteworthy therapeutic breakthrough. Nevertheless, the utilization and effectiveness... (Source: Cancer Cell International)
Source: Cancer Cell International - April 15, 2024 Category: Cancer & Oncology Authors: Tong Chen, Mingzhao Wang, Yanchao Chen and Yutao Liu Tags: Review Source Type: research
The troglitazone derivative EP13 disrupts energy metabolism through respiratory chain complex I inhibition in breast cancer cells and potentiates the antiproliferative effect of glycolysis inhibitntriors
The metabolism of cancer cells generally differs from that of normal cells. Indeed, most cancer cells have a high rate of glycolysis, even at normal oxygen concentrations. These metabolic properties can potent... (Source: Cancer Cell International)
Source: Cancer Cell International - April 10, 2024 Category: Cancer & Oncology Authors: Claire Muller, Victorine Lacroix-Malgras, J érôme Kluza, William Laine, Yonca Güler, Frédéric Bost, Michel Boisbrun, Sabine Mazerbourg and Stéphane Flament Tags: Research Source Type: research
