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A glycomics approach to the discovery of potential cancer biomarkers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glycosylation is highly sensitive to the biochemical environment and plays a key role in development and disease manifestation. Moreover, glycan biosynthesis depends on several highly competitive processes; thus, variations in the concentration of specific glycosyltransferases produce different products. For this reason, monitoring changes in glycosylation may be a more specific and sensitive approach to biomarker discovery and possibly disease diagnosis. Glycans in serum are of particular interest as approximately half of all proteins are glycosylated. We have developed the methods for profiling the glycans in human s...
Source: Cancer Control - November 4, 2009 Category: Cancer & Oncology Authors: An HJ, Lebrilla CB Tags: Methods Mol Biol Source Type: journals

Target gene discovery for novel therapeutic agents in cancer treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Target identification of novel therapeutic drugs is pivotal for the establishment of (1) new anticancer regimens, (2) to control side effects of the drugs, and (3) to identify appropriate combinations with established drugs.Here, we describe several in vitro assays applicable to characterize different characteristics of tumor cells. Furthermore, we present a protocol for establishing a reporter gene system for in vivo imaging, allowing for the study of drug effects in small animal models. PMID: 19882275 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - November 4, 2009 Category: Cancer & Oncology Authors: Ammerpohl O, Tiwari S, Kalthoff H Tags: Methods Mol Biol Source Type: journals

Weekly docetaxel in patients with platinum-refractory metastatic or recurrent squamous cell carcinoma of the head and neck.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Weekly docetaxel regimen had good clinical activity with an acceptable toxicity in patients with platinum-refractory SCCHN. PMID: 19381630 [PubMed - indexed for MEDLINE] (Source: Cancer Control)
Source: Cancer Control - October 14, 2009 Category: Cancer & Oncology Authors: Cho BC, Keum KC, Shin SJ, Choi HJ, Lee YJ, Kim SH, Choi EC, Kim JH Tags: Cancer Chemother Pharmacol Source Type: journals

Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and ERbeta proteins in the human testis. Testis tissue samples were obtained from 12 men undergoing orchiectomy as adjuvant treatment for prostate cancer, and were stained by immunohistochemistry for c-fos, phosphorylated c-fos and ER...
Source: Cancer Control - October 3, 2009 Category: Cancer & Oncology Authors: Araújo FC, Oliveira CA, Reis AB, Del Puerto HL, Martins AS, Reis FM Tags: Histol Histopathol Source Type: journals

Different spectra of therapeutic vaccine development against HPV infections.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human papillomaviruses (HPVs) are simple, non-enveloped, double-stranded DNA viruses and responsible for an enormous global burden of genital disease. HPV is annually associated with 500,000 new cases of cervical cancer and 250,000 cervical cancer deaths worldwide. The association between HPV infection and cervical cancer indicates that HPV serves as an ideal target for development of preventive and therapeutic vaccines. A novel approach for primary prevention of cervical cancer has become available by the discovery of efficient prophylactic HPV vaccines based on virus-like particles. Therapeutic vaccination has been l...
Source: Cancer Control - August 18, 2009 Category: Cancer & Oncology Authors: Bolhassani A, Mohit E, Rafati S Tags: Hum Vaccin Source Type: journals

Intratumoral injection of alpha-gal glycolipids induces a protective anti-tumor T cell response which overcomes Treg activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
alpha-Gal glycolipids capable of converting tumors into endogenous vaccines, have alpha-gal epitopes (Gal alpha 1-3 Gal beta 1-4GlcNAc-R) and are extracted from rabbit RBC membranes. alpha-Gal epitopes bind anti-Gal, the most abundant natural antibody in humans constituting 1% of immunoglobulins. alpha-Gal glycolipids insert into tumor cell membranes, bind anti-Gal and activate complement. The complement cleavage peptides C5a and C3a recruit inflammatory cells and APC into the treated lesion. Anti-Gal further opsonizes the tumor cells and targets them for effective uptake by recruited APC, via Fc gamma receptors. These...
Source: Cancer Control - August 14, 2009 Category: Cancer & Oncology Authors: Abdel-Motal UM, Wigglesworth K, Galili U Tags: Cancer Immunol Immunother Source Type: journals

Dramatic efficacy improvement of a DC-based vaccine against AML by CD25 T cell depletion allowing the induction of a long-lasting T cell response.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, C57BL6 mice were vaccinated with DC pulsed with peptides eluted (EP) from the syngeneic C1498 myelomonocytic leukemic cell line in a prophylactic setting. In this model, a natural antileukemic immunity mediated by NK cells was observed in the control unloaded DC-vaccinated group. On the other hand, we showed that the cytotoxic antileukemic immune response induced by vaccination with eluted peptides pulsed-DC (DC/EP), in vitro and in vivo, was mainly mediated by CD4(+) T cells. Treatment with anti-CD25 antibody to deplete CD4(+) CD25(+) regulatory T cells before DC-vaccination dramatically improved the antil...
Source: Cancer Control - August 14, 2009 Category: Cancer & Oncology Authors: Delluc S, Hachem P, Rusakiewicz S, Gaston A, Marchiol-Fournigault C, Tourneur L, Babchia N, Fradelizi D, Regnault A, Sang KH, Chiocchia G, Buzyn A Tags: Cancer Immunol Immunother Source Type: journals

Anti-cancer activity and mechanistic features of a NK cell activating molecule.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we found that Gö6983, a PKC inhibitor, induced a remarkable increase of NCR expression on primary NK cells, but other PKC inhibitors and NK cell stimulators such as IL-2 and PMA, did not. Gö6983 increased the expression of NCR in a time- and concentration-dependent manner. Furthermore, Gö6983 strongly upregulated the surface expression of death ligands FasL and TRAIL, but not cytotoxic molecules perforin and granzyme B. Unlike two other NK stimulating molecules, IL-2, and PMA, Gö6983 did not induce NK cell proliferation. Up-regulation of NCRs and death ligands on NK cells by Gö6983 r...
Source: Cancer Control - August 14, 2009 Category: Cancer & Oncology Authors: Kim HR, Lee KH, Park SJ, Kim SY, Yang YK, Tae J, Kim J Tags: Cancer Immunol Immunother Source Type: journals

Treatment of non-Hodgkin's lymphoma xenografts with the HB22.7 anti-CD22 monoclonal antibody and phosphatase inhibitors improves efficacy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The relatively specific association of SHP-1 with CD22 suggests that CD22-specific signal augmentation by phosphatase inhibitors can improve the clinical outcome of anti-CD22 based immunotherapy. PMID: 19294384 [PubMed - indexed for MEDLINE] (Source: Cancer Control)
Source: Cancer Control - August 14, 2009 Category: Cancer & Oncology Authors: O'Donnell RT, Pearson D, McKnight HC, Ma YP, Tuscano JM Tags: Cancer Immunol Immunother Source Type: journals

Factors Interacting with HIF-1 mRNA: Novel Therapeutic Targets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor-1) induces angiogenesis, a process that is aberrantly elevated in cancer. The HIF-1 subunit is constitutively expressed, but the levels of the HIF-1 subunit are robustly regulated, increasing under hypoxic conditions and decreasing in normoxia. These changes result from rapid alterations in the rates of HIF-1 production and degradation. While the regulation of HIF-1 degradation is understood in significant detail, much less is known about the regulation of HIF-1 biosynthesis. Here, we review recent evidence that HIF-1 production is effectively contr...
Source: Cancer Control - August 14, 2009 Category: Cancer & Oncology Authors: Galbán S, Gorospe M Tags: Curr Pharm Des Source Type: journals

Dietary zinc supplementation and methotrexate-induced small intestinal mucositis in metallothionein-knockout and wild-type mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Dietary Zn supplementation did not ameliorate MTX-induced small bowel damage, possibly signifying a deficiency in induction of MT by Zn. However, the presence of MT was able to reduce histological damage and neutrophil infiltration caused by MTX in the gut. PMID: 19633421 [PubMed - as supplied by publisher] (Source: Cancer Control)
Source: Cancer Control - July 29, 2009 Category: Cancer & Oncology Authors: Tran CD, Sundar S, Howarth GS Tags: Cancer Biol Ther Source Type: journals

Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted to explore the possible therapeutic approach of Cox-2 promoter-directed suicide gene therapy with herpes simplex virus thymidine kinase (HSV-tk) in combination with adenoviral technology for advanced colorectal cancer. Firstly, the activity of Cox-2 promoter was assessed by dual luciferase and enhanced green fluorescent protein reporter gene assays in colorectal cancer cell lines and normal human intestinal epithelial cell line. Then, the expression of coxsackievirus and adenovirus receptor (CAR) was detected in colorectal cancer cell lines. The Cox-2 promoter-directed HSV-tk/ganciclovir (GCV) syst...
Source: Cancer Control - July 5, 2009 Category: Cancer & Oncology Authors: Wang ZX, Bian HB, Yang JS, De W, Ji XH Tags: Cancer Biol Ther Source Type: journals

Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Celecoxib has demonstrated an outstanding inhibitory effect on bladder cancer chemoprevention, which might be due to its expected anti-inflammatory actions, as well as by anti-proliferatory and antioxidant actions. This data supports a pivotal role of cancer chemoprevention strategies based on COX-2 inhibition. PMID: 19571668 [PubMed - as supplied by publisher] (Source: Cancer Control)
Source: Cancer Control - July 5, 2009 Category: Cancer & Oncology Authors: Parada B, Sereno J, Reis F, Teixeira-Lemos E, Garrido P, Pinto AF, Cunha MF, Pinto R, Mota A, Figueiredo A, Teixeira F Tags: Cancer Biol Ther Source Type: journals

Parameters of protection against ultraviolet radiation-induced skin cell damage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epidemiological and experimental evidence has supported the notion that solar ultraviolet (UV) radiation is the leading cause of skin cell damage and skin cancer. Non-melanoma skin cancer, one of the malignancies with the most rapidly increasing incidence, is suggested to be directly related to the total exposure to solar UV light. Over the past few years, the mechanisms of cellular responses to UV radiation have received unprecedented attention. Understanding how skin cells respond to UV radiation will undoubtedly help decipher what goes wrong in a variety of clinical skin disorders including skin cancer and will faci...
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Cao C, Wan Y Tags: J Cell Physiol Source Type: journals

Dietary energy density in relation to subsequent changes of weight and waist circumference in European men and women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our results suggest that lower ED diets do not prevent weight gain but have a weak yet potentially beneficial effect on the prevention of abdominal obesity as measured by waist circumference. PMID: 19396357 [PubMed - indexed for MEDLINE] (Source: Cancer Control)
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Du H, van der A DL, Ginder V, Jebb SA, Forouhi NG, Wareham NJ, Halkjaer J, Tjønneland A, Overvad K, Jakobsen MU, Buijsse B, Steffen A, Palli D, Masala G, Saris WH, Sørensen TI, Feskens EJ Tags: PLoS One Source Type: journals

Epidemiology of the complications of gastroesophageal reflux disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The complications of gastroesophageal reflux disease (GERD) include ulcers, strictures, Barrett's esophagus and carcinoma. Although the prevalence of GERD is very high, the development of complications remains quite rare and usually occurs in association with factors generally observed in more severe disease such as hiatal hernia, bile reflux or severely disturbed motility. Recent studies have emphasized the role of obesity and genetic factors as aggravating factors in the development of GERD complications. Barrett's esophagus is the most prevalent complication of GERD and seems to be associated with an increased morta...
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Belhocine K, Galmiche JP Tags: Dig Dis Source Type: journals

Chemoprevention of adenocarcinoma associated with Barrett's esophagus: potential options.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article focuses on known and postulated targets for prevention of distal esophageal cancer. PMID: 19439956 [PubMed - indexed for MEDLINE] (Source: Cancer Control)
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Neumann H, Mönkemüller K, Vieth M, Malfertheiner P Tags: Dig Dis Source Type: journals

Screening and surveillance of Barrett's esophagus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Screening and surveillance of Barrett's esophagus is a matter of discussion in the current world literature due to uncertainties concerning its cost-effectiveness. Important and valid arguments for and against it are available. Despite the fact that this issue is still to be resolved, screening using standard gastroscopy once in a lifetime and surveillance using repeated endoscopies with multiple blind biopsies are widely practiced by individual gastroenterologists. Further studies that mainly focus on finding better predictors of progression to cancer are needed to be able to prepare clear and useful guidelines. The u...
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Regula J Tags: Dig Dis Source Type: journals

Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to determine the feasibility of an acupuncture clinical trial to prevent radiation therapy (RT)-induced fatigue. We conducted a cross-sectional survey study and a single-arm acupuncture clinical trial among patients undergoing RT. Patients with a Karnofsky score of less than 60, severe anemia, or substantial psychological diagnoses were excluded. Patients received up to 12 treatments of acupuncture over the entire course of their RT. The Lee Fatigue Scale (LFS) was administered at baseline, in the middle of RT, and at the end of RT, along with the Patient Global Impression of Change (PGIC)...
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Mao JJ, Styles T, Cheville A, Wolf J, Fernandes S, Farrar JT Tags: J Soc Integr Oncol Source Type: journals

New double-stapling technique for esophagojejunostomy and esophagogastrostomy in gastric cancer surgery, using a peroral intraluminal approach with a digital stapling system.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a new double-stapling technique for esophagojejunostomy and esophagogastrostomy, using a peroral intraluminal approach with a digital stapling system, a flexible shaft remote-control stapler - the Surg-ASSIST and Power Circular Stapler 21 mm (PCS). The overtube of the flexible shaft of the PCS is prepared with a nylon tie and secured to a nasogastric (NG) tube. The flexible shaft is manually advanced down the esophagus with guidance by pulling the NG tube from the abdominal cavity side. The trocar of the flexible shaft is removed from the stump of the abdominal esophagus and connected to the anvil and they are ...
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Ohdaira H, Noro T, Terada H, Kameyama J, Ohara T, Yoshino K, Kitajima M, Suzuki Y Tags: Gastric Cancer Source Type: journals

Duodenal stump cancer after Billroth-II distal gastrectomy for gastric cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Duodenal cancer is an uncommon neoplasm and it mostly arises from the periampullary area. However, metachronous or even recurrent cancer at the duodenal stump following Billroth II type distal gastrec tomy for gastric cancer is extremely rare and, to our knowledge, has not yet been reported. A 68-year-old man underwent Billroth II distal gastrectomy with D2 lymph node dissection for an advanced gastric cancer. At that time the tumor stage was T2bN3M0, with 44 of 78 retrieved lymph nodes showing metastasis. He was well without recurrence for 3 years; however, he visited our hospital because of the abrupt onset of dizzin...
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Lee J, Lee K, Kim W Tags: Gastric Cancer Source Type: journals

Use of DNA combing to study DNA replication in xenopus and human cell-free systems.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe (a) the preparation and use of egg extracts and demembranated sperm chromatin templates; (b) a simple method for preparing silanized glass coverslips suitable for DNA combing and fluorescence detection; (c) two alternative replicative DNA labelling schemes and their respective advantages; and (d) a protocol for combining replicative labelling with detection of specific DNA sequences by fluorescent in situ hybridization (FISH). Although most observations made in Xenopus egg extracts are applicable to other eukaryotes, there are differences in cell-cycle regulation between mammalian somatic cells and embryonic am...
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Marheineke K, Goldar A, Krude T, Hyrien O Tags: Methods Mol Biol Source Type: journals

Molecular mechanisms of endothelial hyperpermeability: implications in inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endothelial hyperpermeability is a significant problem in vascular inflammation associated with trauma, ischaemia-reperfusion injury, sepsis, adult respiratory distress syndrome, diabetes, thrombosis and cancer. An important mechanism underlying this process is increased paracellular leakage of plasma fluid and protein. Inflammatory stimuli such as histamine, thrombin, vascular endothelial growth factor and activated neutrophils can cause dissociation of cell-cell junctions between endothelial cells as well as cytoskeleton contraction, leading to a widened intercellular space that facilitates transendothelial flux. Suc...
Source: Cancer Control - July 1, 2009 Category: Cancer & Oncology Authors: Kumar P, Shen Q, Pivetti CD, Lee ES, Wu MH, Yuan SY Tags: Expert Rev Mol Med Source Type: journals

Active transcription of rRNA operons condenses the nucleoid in Escherichia coli: examining the effect of transcription on nucleoid structure in the absence of transertion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In Escherichia coli the genome must be compacted approximately 1,000-fold to be contained in a cellular structure termed the nucleoid. It is proposed that the structure of the nucleoid is determined by a balance of multiple compaction forces and one major expansion force. The latter is mediated by transertion, a coupling of transcription, translation, and translocation of nascent membrane proteins and/or exported proteins. In supporting this notion, it has been shown consistently that inhibition of transertion by the translation inhibitor chloramphenicol results in nucleoid condensation due to the compaction forces tha...
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Cabrera JE, Cagliero C, Quan S, Squires CL, Jin DJ Tags: J Bacteriol Source Type: journals

[Results and participation factors to the European Randomized study of Screening for Prostate Cancer (ERSPC) with Prostate Specific Antigen: French departments of Tarn and Hérault.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Participation rate at first round was modest. Profile of men who participated compared to men who did not were different. The control group was probably contaminated by PSA testing outside study protocol. Consequences at ERSPC level of this low participation rate on final analysis remain to be determined. PMID: 19559380 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Jegu J, Tretarre B, Grosclaude P, Rebillard X, Bataille V, Malavaud B, Iborra F, Salama G, Rischmann P, Villers A Tags: Prog Urol Source Type: journals

Molecular epidemiology of primary brain tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although primary brain tumors (PBTs) are generally considered to be a multifactorial disorder, understanding the genetic basis and etiology of the disease is essential for PBT risk assessment. Understanding of the genetic susceptibility for PBT has come from studies of rare genetic syndromes, linkage analysis, family aggregation, early-onset pediatric cases, and mutagen sensitivity. There are currently no effective markers to assess biological dose of exposures and genetic heterogeneity. The priorities recently recommended by the Brain Tumor Epidemiology Consortium emphasized the need for expanding research in genetics...
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Gu J, Liu Y, Kyritsis AP, Bondy ML Tags: Neurotherapeutics Source Type: journals

Triple negative breast cancer: a study from the point of view of basal CK5/6 and HER-1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Expression of CK5/6 and HER-1 is frequent in ER-negative breast cancers, in triple negative and in non-triple negative tumours. In a minority of cases, HER-1 overexpression may be caused by HER-1 gene amplification. Further studies are needed to investigate whether such cases might benefit from anti-HER-1 therapy. PMID: 19561231 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Pintens S, Neven P, Drijkoningen M, Van Belle V, Moerman P, Christiaens MR, Smeets A, Wildiers H, Vanden Bempt I Tags: J Clin Pathol Source Type: journals

Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, Fumagillin was found to suppress colorectal cancer growth and metastasis by suppressing angiogenesis. PMID: 19563408 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Hou L, Mori D, Takase Y, Meihua P, Kai K, Tokunaga O Tags: Pathol Int Source Type: journals

Cancer risk among children with very low birth weights.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggested no association between most cancers and very low birth weight, with the exception of the known association of hepatoblastoma and possibly moderately increased risks of other gliomas and retinoblastoma, which may warrant confirmation. PMID: 19564288 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Spector LG, Puumala SE, Carozza SE, Chow EJ, Fox EE, Horel S, Johnson KJ, McLaughlin CC, Reynolds P, Behren JV, Mueller BA Tags: Pediatrics Source Type: journals

Primary lung cancer and TNF-alpha gene polymorphisms: A case-control study in a Croatian population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study indicates that the TNF-alpha-308 and TNF-alpha-238 polymorphisms do not influence susceptibility to or severity of lung cancer in a Croatian population.<br /> PMID: 19564826 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Flego V, Radojcic Badovinac A, Bulat-Kardum L, Matanic D, Crnic-Martinovic M, Kapovic M, Ristic S Tags: Med Sci Monit Source Type: journals

FAS and FAS Ligand Polymorphisms in the Promoter Regions and Risk of Gastric Cancer in Southern China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FAS and FAS ligand (FASLG) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis. Functional promoter polymorphisms of the FAS and FASLG genes can alter transcriptional activities and thus alter risk of cancer. We hypothesized that the FAS -1377G>A, FAS -670A>G, and FASLG -844T>C polymorphisms in the promoter regions are associated with risk of gastric cancer. In a population-based case-control study of 332 gastric cancer cases and 324 controls, we genotyped these three polymorphisms and evaluated their associatio...
Source: Cancer Control - June 29, 2009 Category: Cancer & Oncology Authors: Wang M, Wu D, Tan M, Gong W, Xue H, Shen H, Zhang Z Tags: Biochem Genet Source Type: journals

The Role and Extent of Pelvic Lymphadenectomy in the Management of Patients with Invasive Urothelial Carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
OPINION STATEMENT: Lymph node metastases are the most important prognostic variable in determining outcome following radical cystectomy. An anatomic bilateral node dissection includes at a minimum the external and internal iliac and obturator lymph nodes. An extended node dissection may include the distal aortic and vena caval nodes, bilateral common iliac, and pre-sacral nodes, which receive direct lymphatic drainage from the posterior bladder and trigone. This approach sets up the cystectomy, maximizes sensitivity for detection of nodal metastasis, assures optimum local pelvic cancer control, and accurately identifie...
Source: Cancer Control - June 29, 2009 Category: Cancer & Oncology Authors: Lerner SP Tags: Curr Treat Options Oncol Source Type: journals

Accelerated mammary maturation and differentiation, and delayed MMTVneu-induced tumorigenesis of K303R mutant ERalpha transgenic mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We identified a somatic mutation in estrogen receptor-alpha (ERalpha) in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors and altered posttranslational modifications of ERalpha. We have developed a transgenic mouse expressing the K303R mutant ERalpha under control of the mouse mammary tumor virus (MMTV) promoter. At 4 months of age, K303R ERalpha transgenic animals demonstrate precocious alveolar budding compared with wild-type ERalpha transgenic mice or nontransgenic littermates. Despite these morphologic di...
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: Herynk MH, Lewis MT, Hopp TA, Medina D, Corona-Rodriguez A, Cui Y, Beyer AR, Fuqua SA Tags: Oncogene Source Type: journals

Infections in non-myeloablative hematopoietic stem cell transplantation patients with lymphoid malignancies: spectrum of infections, predictors of outcome and proposed guidelines for fungal infection prevention.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The overall risk of infections is lower in patients undergoing non-myeloablative allogeneic stem cell transplantation (NST) than in conventional stem cell transplant recipients. We sought to evaluate conditions associated with increased risk of infections after NST. In 81 patients, 187 infection episodes were noted; chronic lymphocytic leukemia (138 episodes/100 person-years) and recipients of matched unrelated donor graft (128 episodes/100 person-years) had higher risk of infection. Only half of the cytomegalovirus (CMV) infections occurred 31-100 days after transplantation. Most patients with CMV infection were non-n...
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: Safdar A, Rodriguez GH, Mihu CN, Mora-Ramos L, Mulanovich V, Chemaly RF, Champlin RE, Khouri I Tags: Bone Marrow Transplant Source Type: journals

Serum soluble CD44v6 levels in patients with oral and maxillofacial malignancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The possible roles of CD44v6 in the diagnosis of oral and maxillofacial malignancy deserve further elucidation and evaluation. Serum sCD44v6 may be a valuable marker in monitoring treatment response in patients with OSCC. PMID: 19563418 [PubMed - as supplied by publisher] (Source: Cancer Control)
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: Chang SM, Xing RD, Zhang FM, Duan YQ Tags: Oral Dis Source Type: journals

A phase III clinical trial of exercise modalities on treatment side-effects in men receiving therapy for prostate cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: The principal outcome of this project will be the determination of the strength of effect of exercise on the well established musculoskeletal, cardiovascular and insulin metabolism side effects of androgen deprivation in prostate cancer patients. As this project is much longer term than previous investigations in the area of exercise and cancer, we will gain knowledge as to the continuing effects of exercise in this patient population specifically targeting bone density, cardiovascular function, lean and fat mass, physical function and falls risk as primary study endpoints. In terms of advancement of prostate c...
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: Newton RU, Taaffe DR, Spry N, Gardiner RA, Levin G, Wall B, Joseph D, Chambers SK, Galvao DA Tags: BMC Cancer Source Type: journals

NMD inhibition fails to identify tumour suppressor genes in microsatellite stable gastric cancer cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although UPF1 was substantially repressed, thus resulting in the inhibition of the NMD system, we did not find genes inactivated by nonsense mutations. Our results show that the GINI strategy leads to a high number of false positives. PMID: 19563644 [PubMed - as supplied by publisher] (Source: Cancer Control)
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: Buffart TE, Tijssen M, El-Bchiri J, Duval A, van de Wiel MA, Ylstra B, Meijer GA, Carvalho B Tags: BMC Med Genomics Source Type: journals

CXCR4 expression on circulating pan-cytokeratin positive cells is associated with survival in patients with advanced non-small cell lung cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study suggests that CXCR4 may be a prognostic marker in NSCLC, and provides hypothesis-generating results, which may be important in determining metastatic potential. In future studies, we will prospectively evaluate the prognostic significance of pan-cytokeratin/CXCR4+ cells, and determine the mechanisms involved in the regulation of CXCR4 expression on tumor cells in a larger patient population. PMID: 19563666 [PubMed - as supplied by publisher] (Source: Cancer Control)
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: Reckamp KL, Figlin RA, Burdick MD, Dubinett SM, Elashoff RM, Strieter RM Tags: BMC Cancer Source Type: journals

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150Glued and late endosome positioning.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Late endosomes (LEs) have characteristic intracellular distributions determined by their interactions with various motor proteins. Motor proteins associated to the dynactin subunit p150(Glued) bind to LEs via the Rab7 effector Rab7-interacting lysosomal protein (RILP) in association with the oxysterol-binding protein ORP1L. We found that cholesterol levels in LEs are sensed by ORP1L and are lower in peripheral vesicles. Under low cholesterol conditions, ORP1L conformation induces the formation of endoplasmic reticulum (ER)-LE membrane contact sites. At these sites, the ER protein VAP (VAMP [vesicle-associated membrane ...
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: Rocha N, Kuijl C, van der Kant R, Janssen L, Houben D, Janssen H, Zwart W, Neefjes J Tags: J Cell Biol Source Type: journals

Homodimerization Controls the FGF9 Subfamily's Receptor Binding and Heparan Sulfate Dependent Diffusion in the Extracellular Matrix.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Uncontrolled fibroblast growth factor (FGF) signaling can lead to human diseases necessitating multiple layers of self-regulatory control mechanisms to keep its activity in check. Herein we demonstrate that FGF9 and FGF20 ligands undergo a reversible homodimerization, occluding their key receptor binding sites. To test the role of dimerization in ligand autoinhibition we introduced structure-based mutations into the dimer interfaces of FGF9 and FGF20. The mutations weakened the ability of the ligands to dimerize, effectively increasing the concentrations of monomeric ligands capable of binding and activating their cogn...
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: Kalinina J, Byron SA, Makarenkova HP, Olsen SK, Eliseenkova AV, Larochelle WJ, Dhanabal M, Blais S, Ornitz DM, Day LA, Neubert TA, Pollock PM, Mohammadi M Tags: Mol Cell Biol Source Type: journals

Building a Protocol Expressway: The Case of Mayo Clinic Cancer Center.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: DMAIC framework combined with Lean methodologies is an effective tool to structure the definition, planning, analysis, and implementation of significant process changes. PMID: 19564529 [PubMed - as supplied by publisher] (Source: Cancer Control)
Source: Cancer Control - June 28, 2009 Category: Cancer & Oncology Authors: McJoynt TA, Hirzallah MA, Satele DV, Pitzen JH, Alberts SR, Rajkumar SV Tags: J Clin Oncol Source Type: journals

Impact of Graphic and Text Warnings on Cigarette Packs: Findings from Four Countries over Five Years.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Australia's new health warnings increased reactions that are prospectively predictive of cessation activity. Warning size increases warning effectiveness and graphic warnings may be superior to text-based warnings. While there is partial wear-out in the initial impact associated with all warnings, stronger warnings tend to sustain their effects for longer. These findings support arguments for governments to exceed minimum FCTC requirements on warnings. PMID: 19561362 [PubMed - as supplied by publisher] (Source: Cancer Control)
Source: Cancer Control - June 27, 2009 Category: Cancer & Oncology Authors: Borland R, Wilson N, Fong GT, Hammond D, Cummings KM, Yong HH, Hosking W, Hastings GB, Thrasher J, McNeill A Tags: Tob Control Source Type: journals

Cancer Control; +2969 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
2969 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Cancer Control These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Cancer Control)
Source: Cancer Control - June 27, 2009 Category: Cancer & Oncology Tags: Report Source Type: journals

Safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for cervical cancer prevention: A pooled analysis of 11 clinical trials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, analysis of this large database shows the HPV-16/18 AS04-adjuvanted cervical cancer vaccine to have a favorable safety profile in women of all ages. PMID: 19221517 [PubMed - as supplied by publisher] (Source: Cancer Control)
Source: Cancer Control - February 20, 2009 Category: Cancer & Oncology Authors: Descamps D, Hardt K, Spiessens B, Izurieta P, Verstraeten T, Breuer T, Dubin G Tags: Hum Vaccin Source Type: journals

Effects of potentised substances on growth rate of the water plant Lemna gibba L.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Lemna gibba may be considered as a suitable test organism for further studies on the efficacy of homeopathic potencies. Evidence accumulates, that adjacent potency levels may strongly differ in their biological activity. Potential consequences for therapeutical application might be worth investigating. PMID: 19185263 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - February 4, 2009 Category: Cancer & Oncology Authors: Scherr C, Simon M, Spranger J, Baumgartner S Tags: Complement Ther Med Source Type: journals

National audit of provision of MRI services 2006/07.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2003 the Royal College of Radiologists Clinical Radiology Audit Sub-Committee began an audit process evaluating the standards of provision of magnetic resonance imaging (MRI) services. This was prompted by the publication of the 2002 Audit Commission Report, which had identified that lack of MRI provision was responsible for more than half of the total waiting times for diagnostic imaging investigations. The audit found that the time from request to report did not meet the standard for cancer staging examinations, but nationally, was within the target set for routine orthopaedic examinations. However, national mean ...
Source: Cancer Control - February 4, 2009 Category: Cancer & Oncology Authors: Barter S, Drinkwater K, Remedios D Tags: Clin Radiol Source Type: journals

Assessment of selection bias in clinic-based populations of childhood cancer survivors: a report from the childhood cancer survivor study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Applying chronic condition prevalence estimates from a clinical population to the general population of childhood cancer survivors must be undertaken with caution. Survivorship research must maintain a high level of scientific rigor to ensure that results reported in the literature are interpreted within the appropriate context. PMID: 18989878 [PubMed - indexed for MEDLINE] (Source: Cancer Control)
Source: Cancer Control - February 1, 2009 Category: Cancer & Oncology Authors: Ness KK, Leisenring W, Goodman P, Kawashima T, Mertens AC, Oeffinger KC, Armstrong GT, Robison LL Tags: Pediatr Blood Cancer Source Type: journals

Targeting 11q23 positive acute leukemia cells with high molecular weight-melanoma associated antigen-specific monoclonal antibodies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HMW-MAA-specific mAb down-regulated P-Pyk2 expression and enhanced the anti-proliferative effect of cytarabine in vitro, but had no detectable effect on survival or growth of leukemia cells in vivo. Whether the HMW-MAA-specific mAb can be used as carriers of toxins or chemotherapeutic agents against 11q23-acute leukemia remains to be determined. PMID: 18677475 [PubMed - indexed for MEDLINE] (Source: Cancer Control)
Source: Cancer Control - January 30, 2009 Category: Cancer & Oncology Authors: Drake AS, Brady MT, Wang XH, Sait SJ, Earp JC, Ghoshal Gupta S, Ferrone S, Wang ES, Wetzler M Tags: Cancer Immunol Immunother Source Type: journals

LCA5, a Rare Genetic Cause of Leber Congenital Amaurosis in Koreans.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This result shows that mutation in LCA5 is likely to be a rare genetic cause in Koreans and suggests that further investigation to identify other causative genes is necessary in Koreans. PMID: 19172513 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - January 29, 2009 Category: Cancer & Oncology Authors: Seong MW, Kim SY, Yu YS, Hwang JM, Kim JY, Park SS Tags: Ophthalmic Genet Source Type: journals

A nursing quality program driven by evidence-based practice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the activities of the Best Practice Council and the projects of teams assigned to study best practice in (1) preventing bloodstream infection (related to central lines), (2) preventing patient falls, (3) assessing and preventing pressure ulcers, and (4) ensuring good hand-off communication. PMID: 19167551 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - January 28, 2009 Category: Cancer & Oncology Authors: Anderson JJ, Mokracek M, Lindy CN Tags: Nurs Clin North Am Source Type: journals