Identifying predictors of COVID-related delays in cancer-specific medical care
CONCLUSION: These findings may inform cancer care delivery during periods of instability when treatment may be disrupted by informing clinicians about concerns that patients have during the treatment process. Future research should assess whether delays in cancer care impact long-term cancer outcomes and whether delays exacerbate existing disparities in cancer outcomes.PMID:38629238 | DOI:10.1002/cam4.7183 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Breanna B Greteman Natalie J Del Vecchio Crystal J Garcia-Auguste Amanda R Kahl Brian M Gryzlak Elizabeth A Chrischilles Mary E Charlton Sarah H Nash Source Type: research
Surufatinib combined with transarterial embolization versus surufatinib monotherapy in patients with liver metastatic neuroendocrine tumors: Study protocol for a prospective, randomized, controlled trial
This study was conducted to compare the clinical outcome of surufatinib combined with TAE versus surufatinib monotherapy in liver metastatic NETs.METHODS: This is a prospective, multicenter, open-label, and randomized controlled trial. Patients diagnosed with liver metastatic NETs will be enrolled. Participants are randomly assigned in a 1:1 ratio to either the experimental group or the control group. Patients will be treated with surufatinib plus TAE in the experimental group, while patients in the control group will receive surufatinib monotherapy. The primary endpoint is progression-free survival (PFS) assessed by a bli...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ruizhen Li Xiaofen Li Xin You Minggang Su Yuzhi Liu Nengwen Ke Dan Cao Source Type: research
Off-label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center
CONCLUSIONS: At our institution, ICI was most commonly prescribed in the relapsed/refractory setting to patients with metastatic disease. The treatment was generally well-tolerated in the pediatric population. The overall response rate was low, and the majority of patients eventually experienced disease progression. A few patients, however, had durable treatment responses. Further studies are needed to identify which pediatric patients are most likely to benefit from ICI.PMID:38629258 | DOI:10.1002/cam4.7154 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ajami Gikandi Susan N Chi Kee Kiat Yeo Allison F O'Neill David S Shulman Steven G DuBois Natalie B Collins Source Type: research
Effect of Clavipectoral Fascia Suturing on Postmastectomy Seroma Formation
Conclusions:</b> Clavipectoral fascia suture technique is a simple and effective method for reducing seroma formation after mastectomy in breast cancer patients and is advisable in patients at a high risk for seroma formation.</br>.PMID:38629279 | DOI:10.5604/01.3001.0053.5996 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Mahmoud Mohammed Hesham Hamza Mohamed I Omar Mohammed Hussein Moaaz Tohamy Basma Farouk Khalid Rezk Source Type: research
Eukaryotic Initiation Factor 3C Can Affect the Proliferation and Invasion of Ovarian Cancer by Regulating the p53 Signalling Pathway
CONCLUSION: There is a correlation between overexpression of EIF3C in tumour tissues of ovarian cancer patients and this is associated with a poorer prognosis. By influencing the p53 signaling pathway, EIF3C facilitates the growth and infiltration of cells in ovarian cancer.PMID:38629365 | DOI:10.2174/0115748928292248240401051408 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Jingkaiwen Zhang Hanlin Yang Fang Wen Qing Li Hao Luo Dan Zi Source Type: research
Unleashing the power of chlorogenic acid: exploring its potential in nutrition delivery and the food industry
This article commences with a comprehensive overview, summarizing the dietary sources and primary biological activities of CGA. These encompass antioxidant, anti-inflammatory, antibacterial, anti-cancer, and neuroprotective activities. Next, a comprehensive overview of the current research on nutrient delivery systems incorporating CGA is provided. This exploration encompasses nanoparticle, liposome, hydrogel, and emulsion delivery systems. Additionally, the article explores the latest applications of CGA in the food industry. Serving as a cutting-edge theoretical foundation, this paper contributes to the design and develo...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Shumeng Hu Runan Zhao Xuesong Chi Tao Chen Yangjing Li Yu Xu Beiwei Zhu Jiangning Hu Source Type: research
Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine Learning Methods
This study, using machine learning, investigated immune regulation and its potential role in chromate-induced genetic damage, providing insights into complex relationships and emphasizing the need for further research.PMID:38629869 | DOI:10.1021/acs.est.4c00433 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Zekang Su Yali Zhang Shiyi Hong Qiaojian Zhang Zhiqiang Ji Guiping Hu Xiaojun Zhu Fang Yuan Shanfa Yu Tianchen Wang Li Wang Guang Jia Source Type: research
Effect of a Single-Session Mindfulness-Based Swinging Technique (MBST) Intervention on Emotional Distress in Cancer Patients Undergoing PET-CT Scan: A Randomized Controlled Trial
Conclusion: The findings suggest the potential role of MBST intervention in mitigating emotional distress in patients undergoing complex diagnostic imaging procedures. Integrating this with conventional care in nuclear medicine settings can provide patient-centered care that addresses their unmet requirements. There is a need for further validation with a larger sample size. Clinical Trial Registration Number: CTRI/2023/04/051243 (Registered prospectively on 03/04/2023).PMID:38629890 | DOI:10.1089/jicm.2023.0488 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Anjali Mangesh Joshi Sonal Sakhale Suchitra Ajay Mehta Santoshi Wadhwani Source Type: research
Protocol for a Randomized Controlled Trial to Evaluate a Permissive Blood Pressure Target Versus Usual Care in Critically Ill Children with Hypotension (PRESSURE)
CONCLUSIONS: Trial findings will be disseminated in U.K. national and international conferences and in peer-reviewed journals.PMID:38629915 | DOI:10.1097/PCC.0000000000003516 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Robert Darnell Alanna Brown Emma Laing Julia Edwards David A Harrison Joseph C Manning Mark J Peters Padmanabhan Ramnarayan Samiran Ray Zia Sadique Barnaby R Scholefield Dermot Shortt Lamprini Lampro Carly Au Kathy M Rowan Paul Mouncey David P Inwald Prot Source Type: research
Maintenance pembrolizumab therapy in patients with metastatic HER2-negative breast cancer with prior response to chemotherapy
CONCLUSIONS: Pembrolizumab monotherapy achieved durable treatment responses. Patients with a high baseline T-cell clonality had prolonged disease control with pembrolizumab.PMID:38629963 | DOI:10.1158/1078-0432.CCR-23-2947 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Toshiaki Iwase Evan N Cohen Hui Gao Angela Alexander Megumi Kai Vivian Chiv Xiaoping Wang Savitri Krishnamurthy Diane Liu Yu Shen Kumiko Kida Alexandre Reuben Rachel Layman David Ramirez Debu Tripathy Stacy L Moulder Clinton Yam Vicente Valero Bora Lim Ja Source Type: research
Comparing PCSK9 Monoclonal Antibody Treatment Strategies Following Myocardial Infarction Using Negative Control Outcomes: A Target Trial Emulation Study
CONCLUSION: A comparative effectiveness study of these treatments using the current approach would likely bias results due to the low number of PCSK9 mAb initiators.PMID:38629975 | DOI:10.1097/EDE.0000000000001730 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Rosa Sloot Alexander Breskin Lisandro D Colantonio Andrew G Allmon Ying Yu Swati Sakhuja Ligong Chen Paul Muntner M Alan Brookhart Nafeesa Dhalwani Source Type: research
Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer
J Med Chem. 2024 Apr 17. doi: 10.1021/acs.jmedchem.3c02433. Online ahead of print.ABSTRACTMultitarget medications represent an appealing therapy against the disease with multifactorial abnormalities─cancer. Therefore, simultaneously targeting son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR), two aberrantly expressed proteins crucial for the oncogenesis and progression of prostate cancer, may achieve active antitumor effects. Here, we discovered dual SOS1/EGFR-targeting compounds via pharmacophore-based docking screening. The most prominent compound SE-9 exhibited nanomolar inhibition activity against...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Lufeng Zheng Yuxin Zhang Shuang Mei Tianyuan Xie Yunting Zou Yuting Wang Han Jing Shengtao Xu Pierre Dramou Zhen Xu Jindong Li Yang Zhou Miao-Miao Niu Source Type: research
Postoperative leukocyte counts as a surrogate for surgical stress response in matched robot- and video-assisted thoracoscopic surgery cohorts of patients: A preliminary report
The objective is to preliminary evaluated postoperative leukocyte counts as a surrogate for the surgical stress response in NSCLC patients who underwent RATS or VATS for further prospective analyses with proper assessment of surgical stress response and tissue trauma. We retrospectively analyzed patients with stageI-IIIA NSCLC who underwent RATS or VATS at a hospital between 8 May 2020 and 31 December 2021. Analysis of leukocytes (including neutrophils and lymphocytes) and albumin on postoperative days (PODs) 1 and 3 in patients with NSCLC treated with RATS or VATS after propensity score matching (PSM). In total, 1824 pati...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Sidi Liu Huichao Huang Chunfang Zhang Letao Chen Xuelian Feng Yaling Wu Qing Xia Xun Huang Source Type: research
Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females). In addition, trace element levels were analyzed in bone marrow samples from the patient gr...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ayse Nilgun Kul Bahar Ozturk Kurt Source Type: research
When DNA-damage responses meet innate and adaptive immunity
This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.PMID:38630271 | DOI:10.1007/s00018-024-05214-2 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Jie Tong Jiangwei Song Wuchao Zhang Jingbo Zhai Qingli Guan Huiqing Wang Gentao Liu Chunfu Zheng Source Type: research
