Cancer CytopathologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Continuing excellence and embracing the futureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - January 8, 2009 Category: Pathology Authors: Celeste N. Powers Source Type: journals

Welcome to the new editorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - January 6, 2009 Category: Pathology Authors: William J. Frable Source Type: journals

Thanks to Authors and Peer ReviewersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - December 19, 2008 Category: Pathology Source Type: journals

Comparative evaluation of flow-cytometric immunophenotyping and immunocytochemistry in the categorization of malignant small round cell tumors in fine-needle aspiration cytologic specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the authors evaluated the applicability of flow-cytometric immunophenotyping (FCI) and compared it with immunocytochemistry (ICC) for the accurate categorization of MSRCTs.In total, 37 consecutive MSRCTs that had been diagnosed with FNA cytology were analyzed by ICC and FCI using a panel of antibodies against desmin, vimentin, CD99/major histocompatibility class I-related antigen 2, neuron-specific enolase, and pancytokeratin. The final diagnoses included Ewing sarcoma (n = 17), rhabdomyosarcoma (n = 6; 4 embryonal and 2 alveolar subtypes), neuroblastoma (n = 10), desmoplastic small round cell tumor (n = 2),...
Source: Cancer Cytopathology - December 17, 2008 Category: Pathology Authors: Upasana Gautam, Radhika Srinivasan, Arvind Rajwanshi, Deepak Bansal, Ram Kumar Marwaha Source Type: journals

Comparison of ProEx C with p16INK4a and Ki-67 immunohistochemical staining of cell blocks prepared from residual liquid-based cervicovaginal materialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although liquid-based cervicovaginal cytology has high sensitivity for detecting dysplastic/malignant lesions, many pitfalls exist. Cell blocks can be prepared from residual liquid-based cervicovaginal material and used for immunohistochemistry. The aim of this study was to evaluate a new marker, ProEx C, on cell blocks and its ability to distinguish dysplastic/malignant lesions from morphologically abnormal but benign cells. The results of this study were compared with previously reported results for p16 and Ki-67 on the same material.ProEx C is a cocktail of monoclonal antibodies against proteins associated with aberrant...
Source: Cancer Cytopathology - November 19, 2008 Category: Pathology Authors: Ruba A. Halloush, Ilkser Akpolat, Qihui "Jim" Zhai, Mary R. Schwartz, Dina R. Mody Source Type: journals

Placental isoform glutathione S-transferase and P-glycoprotein expression in advanced nonsmall cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of the current study were to examine GST-pi and P-gp expression in cytologic specimens from patients with unresectable NSCLC and to determine the association of that expression with response to chemotherapy and survival.Patients with unresectable, cytologically diagnosed NSCLC were eligible for the study. Diagnosis was made by fiberoptic bronchoscopy, and staging was done according to international standards. All patients received sequential chemoradiotherapy and were re-evaluated for treatment response. GST-pi and P-gp expression levels were evaluated by immunocytochemistry and immunohistochemistry of bronc...
Source: Cancer Cytopathology - November 12, 2008 Category: Pathology Authors: George S. Vlachogeorgos, Effrosini D. Manali, Ekaterini Blana, Stella Legaki, Napoleon Karagiannidis, Vlassios S. Polychronopoulos, Charis Roussos Source Type: journals

Thin core needle biopsy crush preparations in conjunction with fine-needle aspiration for the evaluation of thyroid nodulesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, the authors describe a complementary approach to thyroid biopsy that has worked well.All thyroid FNA and CB/CP that were performed in the IR Department during the year 2005 were reviewed. Follow-up histology and records of all procedural complications were retrieved.Seven hundred thirteen thyroid biopsies qualified, 225 biopsies (31%) had FNA with CB/CP (85% had only CP for evaluation), and 488 biopsies (69%) had only FNA. The final unsatisfactory rate in IR for FNA was 8.7%; this was reduced to 3.4% with the use of CB/CP. The addition of CB also helped to obtain a more definitive diagnosis in suboptimal FN...
Source: Cancer Cytopathology - November 7, 2008 Category: Pathology Authors: Songlin Zhang, Marina Ivanovic, Albert A. Nemcek Jr., Denise V. S. DeFrias, Erin Lucas, Ritu Nayar Source Type: journals

Pathology correlates of a Papanicolaou diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to compare findings after a cytologic report of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) with findings after a report of low-grade squamous intraepithelial lesion (LSIL).A review of patient records revealed that 312 women had cytologic findings of LSIL-H, and 324 consecutive women in a comparison group had cytologic findings of LSIL during 2005. Findings over 6 months after diagnosis were retrieved and analyzed using chi-square tests, Fisher exact tests, and independent group t tests.Histology was available for 194 of 312 w...
Source: Cancer Cytopathology - November 5, 2008 Category: Pathology Authors: Omar Al-Nourhji, Michael J. Beckmann, Stephen J. Markwell, L. Stewart Massad Source Type: journals

Cytologic features of extragonadal germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the current study was to evaluate and describe the cytologic features of extragonadal germ cell tumors (GCTs), both primary and metastasis from gonadal sites, in fine-needle aspiration cytology.Aspirates from 88 extragonadal GCTs were retrieved with their clinical features and cytologic smears. The smears were assessed for cellularity, cell patterns, and cytologic features, which were summarized. Histopathology was available in 47 cases, and cytohistologic correlation was done in all such cases.Of 88 cases, 57 with adequate cytologic material were analyzed. Each type of GCT, except for embryonal carcinoma,...
Source: Cancer Cytopathology - November 4, 2008 Category: Pathology Authors: Ruchika Gupta, Sandeep R. Mathur, Vinod K. Arora, Shree G. Sharma Source Type: journals

Atypical squamous cells, cannot exclude a high-grade intraepithelial lesion and its clinical significance in postmenopausal, pregnant, postpartum, and contraceptive-use patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies have confirmed the low predictive value of a diagnosis of atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion (ASC-H) in a Papanicolaou (Pap) smear for subsequent high-grade dysplasia in the postmenopausal age group. It appears plausible that the decrease in estrogen inherent in the postmenopausal state likely produces reactive cytologic atypia, which is misinterpreted as ASC-H. The change in hormone levels observed in pregnant patients, postpartum patients, and contraceptive users, as a corollary, potentially could create a similar diagnostic dilemma. In the current study,...
Source: Cancer Cytopathology - November 3, 2008 Category: Pathology Authors: Amber L. Patton, Lisa Duncan, Leneord Bloom, Geneen Phaneuf, Nadeem Zafar Source Type: journals

Detection of human papillomavirus infection in penile samples through liquid-based cytology and polymerase chain reactionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the current study was to compare the results of liquid-based cytology and HPV DNA testing through polymerase chain reaction in 99 penile samples collected from men presenting with condyloma acuminate or male partners of HPV-infected women who had attended a public health service in the city of Belo Horizonte, Minas Gerais, Brazil. Classic and nonclassic cytomorphologic signs were adopted to evaluate the presence of HPV infections in penile smears.HPV DNA was detected in 93 (93.9%) of the 99 samples analyzed. Koilocytosis was detected in 1 smear and nonclassic signs were detected in 23 smears, 22 of which w...
Source: Cancer Cytopathology - October 30, 2008 Category: Pathology Authors: Maria Gabrielle de Lima Rocha, Fábio Lopes Faria, Maria do Carmo M. Souza, Annamaria Ravara Vago, Ana Paula Fernandes, Paula Ávila Fernandes Source Type: journals

The case for pathologist ultrasound-guided fine-needle aspiration biopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - October 28, 2008 Category: Pathology Authors: John S. Abele Source Type: journals

Visual estimates of nucleus-to-nucleus ratiosEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Apart from several subjective criteria, ASCUS and LSIL are defined by nuclear enlargement of 2.5× to 3× and [ge]3× the area of a normal intermediate squamous cell nucleus, respectively. The aim of this study was to assess the ability of observers with various degrees of experience to estimate nuclear area ratios.Forty-five participants (5 anatomic pathologists, 5 cytopathologists, 2 cytopathology fellows, 16 pathology residents, 8 cytotechnologists, 6 medical students, and 3 cytopreparatory staff members) judged the area ratios of pairs of squamous cell nuclei imaged at ×100 objective magnification. For Test 1 (T1), pa...
Source: Cancer Cytopathology - September 18, 2008 Category: Pathology Authors: Jared L. Schmidt, Jonathan C. Henriksen, Dan M. McKeon, Kay Savik, H. Evin Gulbahce, Stefan E. Pambuccian Source Type: journals

Utility of cytology microarray constructed from effusion cell blocks for immunomarker validationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tissue microarray allows rapid and efficient evaluation of gene expression at the protein level and of immunochemical markers. To our knowledge, there has been no report of constructing cytology microarray using effusion cell blocks and testing its utility in immunochemical marker validation.A total of 23 malignant effusions (primary tumor of breast [5], GI tract [5], lung [5] and ovary [8]) were used to construct a cytology microarray so that 3 cores of 0.6 mm in diameter were taken from the original cell blocks. Antibodies including AE1/AE3, EMA, and Ki-67 were applied to all cases, and CK7, CK20, TTF-1, WT-1, ER, and PR...
Source: Cancer Cytopathology - September 17, 2008 Category: Pathology Authors: Robert T. Pu, Thomas J. Giordano, Claire W. Michael Source Type: journals

Sixten Franzen, MD, PHD, Honorary Professor, 1919-2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - September 17, 2008 Category: Pathology Authors: Jerry Waisman, Lambert Skoog, Edneia Tani Source Type: journals

Cytologic evaluation of lymphadenopathy associated with mycosis fungoides and Sezary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The most common presenting site of extracutaneous disease in mycosis fungoides and Sezary syndrome is the peripheral lymph node. Although fine-needle aspiration biopsy has been shown to be a valuable diagnostic technique in evaluating lymphadenopathy, its utility in patients with cutaneous T-cell lymphoma has not been extensively studied. With fine-needle aspiration biopsy, material can be collected for ancillary diagnostic studies and for morphologic evaluation.The authors report a series of 11 fine-needle aspiration biopsy specimens from 10 mycosis fungoides and Sezary syndrome patients. Flow cytometric immunophenotyping...
Source: Cancer Cytopathology - September 17, 2008 Category: Pathology Authors: Reetesh K. Pai, Franklin M. Mullins, Youn H. Kim, Christina S. Kong Source Type: journals

Cerebrospinal fluid cytology in patients with ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the CSF findings in patients with ependymal neoplasms are summarized and the cytomorphologic features of ependymoma, including its variants, are illustrated.A search of the pathology databases of 2 medical centers was performed to identify all patients with a histologic diagnosis of ependymoma in whom CSF samples were examined. Slides from CSF samples originally reported as atypical, suspicious, or positive were reviewed and the cytomorphologic features assessed. Follow-up included a review of the medical records and histologic correlation.In all, 177 patients with a diagnosis of ependymoma were identified. ...
Source: Cancer Cytopathology - August 13, 2008 Category: Pathology Authors: Xiaohua Qian, Liliana C. Goumnerova, Umberto De Girolami, Edmund S. Cibas Source Type: journals

Chromosomal abnormalities detected by multicolor fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated the use of a multicolor fluorescence in situ hybridization (FISH) probe panel specifically designed for chronic lymphocytic leukemia (CLL)/SLL and assessed the association between FISH findings and cytologic diagnosis, proliferation index, and risk of death.FNA specimens from 50 patients (32 men and 18 women; mean age, 57 years [range, 36-77 years]) with histologically confirmed CLL and/or SLL were evaluated in this study for chromosomal abnormalities of 11q22 (ATM), 12, 13q14.3, 13q34.3 (LAMP1), and 17p13.1 (p53) by using a multiprobe FISH kit. One of the 50 cases was excluded because of an insufficie...
Source: Cancer Cytopathology - August 6, 2008 Category: Pathology Authors: Nancy P. Caraway, Elizabeth Thomas, Abha Khanna, Linda Payne, Hua-Zhong Zhang, E Lin, Michael J. Keating, Ruth L. Katz Source Type: journals

Plasmablastic lymphoma: Cytologic findings in 5 cases with unusual presentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Plasmablastic lymphoma (PBL) is a rare form of non-Hodgkin lymphoma that was once believed to occur primarily in the oral cavity of human immunodeficiency virus-positive individuals. Numerous extraoral sites have also been reported to date. To the authors' knowledge, however, only 3 reports in the literature describe its cytologic features. In the current study, the cytologic findings in 5 additional patients are reported, 3 of whom had concomitant second malignancies. The goal of the current study was to define the cytomorphologic features that may help to distinguish PBL from other mimics.Five cases were identified from ...
Source: Cancer Cytopathology - August 5, 2008 Category: Pathology Authors: Michelle Reid-Nicholson, Sravankumar Kavuri, Celalettin Ustun, Jennifer Crawford, Asha Nayak-Kapoor, Preetha Ramalingam Source Type: journals

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - July 22, 2008 Category: Pathology Source Type: journals

Screening for endometrial cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - July 11, 2008 Category: Pathology Authors: William J. Frable Source Type: journals

Assuring the quality of quality assuranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rapid rescreening (RR) of negative Papanicolaou smears (PS) is used in many countries as a quality-assurance measure. Seeding of abnormal slides has been suggested as a way to increase the sensitivity of this procedure. Since 2004, the authors have carried out RR with seeding before issuing reports. In this article, they describe their experience.Abnormal seeds were sourced from the previous day's high-grade cases, both squamous and glandular. Slides were evaluated for the 'degree of difficulty' (which was defined as the number of fields required to find (fields-to-find [FTF]) the abnormality), relabeled, and redotted to m...
Source: Cancer Cytopathology - July 10, 2008 Category: Pathology Authors: Joanne Clarke, Julia K. Thurloe, Ron C. Bowditch, Jennifer M. Roberts Source Type: journals

Contribution of DNA ploidy image cytometry to the management of ASC cervical lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Bethesda system classifies smears that suggest an underlying cervical intraepithelial neoplasia (CIN) as ASC (atypical squamous cell) smears. ASC smears are subdivided into ASCUS (of undetermined significance) and ASCH (cannot exclude a high-grade lesion). Today the management of ASCUS is a triage with HR-HPV testing and colposcopy is recommended for ASCH. The aim was to conduct a study on ASC smears to determine DNA ploidy measurement for the detection of CIN2+.The link between a suspect DNA ploidy assessed by image cytometry and/or a positive HR-HPV testing was analyzed on 69 ASCUS and 82 ASCH smears, and the presenc...
Source: Cancer Cytopathology - July 10, 2008 Category: Pathology Authors: Marianne Lorenzato, Stephanie Caudroy, Jean-Marie Nou, Veronique Dalstein, Karine Joseph, Salima Bellefqih, Anne Durlach, Corinne Thil, Francine Dez, Dominique Bouttens, Christine Clavel, Philippe Birembaut Source Type: journals

Endoscopic ultrasound-guided fine-needle aspiration cytology of pancreatic neuroendocrine tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this report was to describe the cytopathologic and immunocytochemical features of NETs obtained by endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA).Forty-eight patients who were diagnosed with pancreatic NETs based on EUS-guided FNA were studied retrospectively (from 2002 to 2007). Clinical data, EUS findings, cytopathologic features, and immunocytochemical stains were reviewed for this study. The final histopathologic diagnosis from each patient also was available for comparison.Forty-eight patients (28 men and 20 women) who ranged in age from 16 years to 86 years were selected and had the ...
Source: Cancer Cytopathology - July 10, 2008 Category: Pathology Authors: Paschalis Chatzipantelis, Charitini Salla, Panagiotis Konstantinou, Ioannis Karoumpalis, Stratigoula Sakellariou, Irini Doumani Source Type: journals

Diagnostic significance of 'atypia' in instrumented versus voided urine specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the current study was to study the prevalence and significance of atypical urine cytology with regard to the effect of instrumentation and prior biopsy.All urine cytology cases seen during a 4-year period (2001-2004) with a diagnosis of atypical urothelial cells (AU) were obtained from the cytopathology computer database. In all cases with available surgical follow-up, the following data were extracted: total number and type of urine specimen, the primary histologic diagnosis, and follow-up histologic diagnosis.In all, 1653 voided and 3502 instrumented urine specimens were examined. A diagnosis of AU was r...
Source: Cancer Cytopathology - June 11, 2008 Category: Pathology Authors: Umesh Kapur, Girish Venkataraman, Eva M. Wojcik Source Type: journals

Assessment of reflex human papillomavirus DNA testing in patients with atypical endocervical cells on cervical cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report is of a 5-year experience with reflex HPV testing in women with AEC and assessment of the potential role of reflex HPV testing in guiding subsequent colposcopy-directed cervical biopsy/curettage in a large tertiary care hospital setting.All AEC cases cytologically diagnosed from July 2001 to June 2006 were retrieved from the Cleveland Clinic database. The histopathologic diagnoses and the results of HPV testing using the Hybrid Capture 2 (HC-II) method were reviewed. The most severe histopathologic diagnosis was recorded.Of a total 332,470 Papanicolaou (Pap) tests performed, 317 cases of AEC had histopathologic...
Source: Cancer Cytopathology - June 11, 2008 Category: Pathology Authors: Longwen Chen, Bin Yang Source Type: journals

Direct uterine sampling with the Tao brush sampler using a liquid-based preparation method for the detection of endometrial cancer and atypical hyperplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endometrial cytology sampling devices for direct uterine sampling have been shown in previous studies to be a reliable and relatively painless method for detecting endometrial lesions. The purpose of the current study was to determine the performance characteristics of endometrial cytology for the detection of malignancy and atypical hyperplasia using liquid-based cytology specimens collected with the Tao brush sampler.Brushings of the endometrial cavity were obtained from 139 hysterectomy specimens before routine histopathologic evaluation. Cytology specimens were fixed in PreservCyt and processed using ThinPrep technolog...
Source: Cancer Cytopathology - June 11, 2008 Category: Pathology Authors: Benjamin R. Kipp, Fabiola Medeiros, Michael B. Campion, Tammy J. Distad, Lisa M. Peterson, Gary L. Keeney, Kevin C. Halling, Amy C. Clayton Source Type: journals

Adjunctive high-risk human papillomavirus DNA testing is a useful option for disease risk assessment in patients with negative papanicolaou tests without an endocervical/transformation zone sampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current guidelines recommend that women with negative Papanicolaou (Pap) test results and no endocervical/transformation zone (EC/TZ) sample return for screening within 12 months. For some women, this represents earlier follow-up than advocated in several routine screening guidelines. Controversy remains with regard to the correlation between sampling of the EC/TZ, Pap test quality, and disease risk assessment.A retrospective study was conducted reviewing the results from 143,438 liquid-based cervical Pap tests performed at a large academic women's hospital between July 2005 and December 2006. Vaginal Pap tests were exclud...
Source: Cancer Cytopathology - May 17, 2008 Category: Pathology Authors: Chengquan Zhao, R. Marshall Austin Source Type: journals

Magnetic enrichment of bronchial epithelial cells from sputum for lung cancer diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sputum is an easily accessible diagnostic material for lung cancer early detection by cytologic and molecular genetic analysis of exfoliated airway epithelial cells. However, the use of sputum is limited by its cellular heterogeneity, which includes >95% macrophages and neutrophils and only about 1% bronchial epithelial cells. We propose to obtain concentrated and purified bronchial epithelial cells to improve early detection of lung cancer in sputum samples.Sputum was collected from patients with stage I nonsmall-cell lung cancer, cancer-free smokers, and healthy nonsmokers. Magnetic-assisted cell sorting (MACS) with anti...
Source: Cancer Cytopathology - May 16, 2008 Category: Pathology Authors: Qi Qiu, Nevins W. Todd, Ruiyun Li, Hong Peng, Zhenqiu Liu, Harris G. Yfantis, Ruth L. Katz, Sanford A. Stass, Feng Jiang Source Type: journals

Large, clear cytoplasmic vacuolation: An under-recognized cytologic clue to distinguish solid pseudopapillary neoplasms of the pancreas from pancreatic endocrine neoplasms on fine-needle aspirationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Solid pseudopapillary neoplasm (SPN) and pancreatic endocrine neoplasm (PEN) are uncommon neoplasms that demonstrate characteristic cytologic features. It is also known that both these tumors may share similar morphologic changes. These features not uncommonly pose significant diagnostic challenge for unsuspecting cytopathologists. In the current study, the authors report that recognition of clear cytoplasmic vacuoles in endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) samples from SPN serves as a useful clue that can distinguish this tumor from PEN.The cytologic features from 5 SPN and 20 PEN cases were evalu...
Source: Cancer Cytopathology - May 16, 2008 Category: Pathology Authors: Nirag Jhala, Gene P. Siegal, Darshana Jhala Source Type: journals

PEL and HHV8-unrelated effusion lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract.
Source: Cancer Cytopathology - May 13, 2008 Category: Pathology Authors: Antonino Carbone, Annunziata Gloghini Source Type: journals

Impact of the more restrictive definition of atypical squamous cells introduced by the 2001 Bethesda System on the sensitivity and specificity of the Papanicolaou testEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Bethesda 2001 (B2001) classification system raised the threshold for reporting atypical squamous cells. The category of Atypical Squamous Cells of Undetermined Significance (ASCUS)-favor reactive has been eliminated with a recommendation for cytologists to judiciously downgrade those Papanicolaou (Pap) tests that would formerly have been in this category to Negative for Intraepithelial Lesion or Malignancy (NILM). The effect of this change on sensitivity and specificity of the Pap test is not yet known.A total of 535 consecutive SurePath Pap tests interpreted as ASCUS during a period from March 1 through December 31, 2...
Source: Cancer Cytopathology - May 2, 2008 Category: Pathology Authors: Michael J. Thrall, Stefan E. Pambuccian, Edward B. Stelow, Dan M. McKeon, Lizette Miller, Kay Savik, H. Evin Gulbahce Source Type: journals

Comparison of the performance of rapid prescreening, 10% random review, and clinical risk criteria as methods of internal quality control in cervical cytopathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rapid prescreening (RPS) is an internal quality-control (IQC) method that is used both to reduce errors in the laboratory and to measure the sensitivity of routine screening (RS). Little direct comparison data are available comparing RPS with other more widely used IQC methods.The authors compared the performance of RPS, 10% random review of negative smears (R-10%), and directed rescreening of negative smears based on clinical risk criteria (RCRC) over 1 year in a community clinic setting.In total, 6135 smears were evaluated. The sensitivity of RS alone was 71.3%. RPS detected significantly more (132 cases) false-negative ...
Source: Cancer Cytopathology - May 2, 2008 Category: Pathology Authors: Suelene B. N. Tavares, Nadja L. Alves de Sousa, Edna J. C. Manrique, Zair B. Pinheiro de Albuquerque, Luiz C. Zeferino, Rita G. Amaral Source Type: journals

Publisher's noteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract.
Source: Cancer Cytopathology - April 29, 2008 Category: Pathology Source Type: journals

Quantitative detection of molecular markers ProEx C (minichromosome maintenance protein 2 and topoisomerase IIa) and MIB-1 in liquid-based cervical squamous cell cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the authors conducted a comparative quantitative evaluation of the proliferation markers ProEx C (an aberrant S-phase induction marker, human papillomavirus E6-E7 correlated) and MIB-1 in squamous intraepithelial lesions (SIL) to identify a biomolecular profile informative for the diagnosis of high-grade SIL/cervical intraepithelial neoplasia 3 or greater that was complementary to the morphologic Papanicolaou (Pap) test ("biomolecular Pap test").After the cytologic diagnosis, reflex immunocytochemistry was carried out on 76 unstained SurePath cell samples (20 routine samples that were negative for intraepith...
Source: Cancer Cytopathology - April 28, 2008 Category: Pathology Authors: Maria Donatella Beccati, Carolina Buriani, Massimo Pedriali, Sonia Rossi, Italo Nenci Source Type: journals

Thyroid fine-needle aspiration: Smears versus liquid-based preparationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - April 28, 2008 Category: Pathology Authors: Britt-Marie Ljung Source Type: journals

Choosing battles or excuses in gynecologic cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - April 28, 2008 Category: Pathology Authors: Andrew A. Renshaw Source Type: journals

Fine-needle aspiration cytology of large cell neuroendocrine carcinoma of the lungEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the current study was to describe the cytologic features of LCNEC in an attempt to distinguish it from other pulmonary carcinomas.A cytohistologic study of 11 surgical lobectomy specimens classified as LCNEC was performed. In all these cases, preoperative fine-needle aspiration cytology (FNAC) material was available for review.The cytologic features of the cases were rather similar, resulting in a repetitive pattern. The majority of smears were hypercellular with numerous single, medium-to-large cells. Naked nuclei were abundant but a variable subset of cells demonstrated evident cytoplasm. Groups were 3-d...
Source: Cancer Cytopathology - April 24, 2008 Category: Pathology Authors: Jose A. Jimenez-Heffernan, Pilar Lopez-Ferrer, Blanca Vicandi, Adrian Mariño, Eva Tejerina, Manuel Nistal, Jose M. Viguer Source Type: journals

Diagnostic utility of phosphatase and tensin homolog, [beta]-catenin, and p53 for endometrial carcinoma by thin-layer endometrial preparationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For the current report, the authors examined the characteristic features of morphology and molecular biology of phosphatase and tensin homolog (PTEN), [beta]-catenin, and p53 immunocytochemistry in endometrial carcinoma by using thin-layer cytologic preparations.During a 6-month period, 120 endometrial samples were collected directly by using the Uterobrush, and thin-layer specimens were prepared. Immunocytochemical expression levels of PTEN, [beta]-catenin, and p53 were investigated by using 40 specimens of endometrial carcinoma (EC), and 30 specimens each of proliferative endometrium, secretory endometrium, and atrophic ...
Source: Cancer Cytopathology - April 23, 2008 Category: Pathology Authors: Yoshiaki Norimatsu, Motoyuki Miyamoto, Tadao K. Kobayashi, Takuya Moriya, Keiko Shimizu, Kenji Yanoh, Choutatsu Tsukayama, Yasuyuki Miyake, Eiji Ohno Source Type: journals

Measuring the significance of workload on performance of cytotechnologists in gynecologic cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Workload is extensively regulated and often used as a measure of quality in gynecologic cytology. Whether workload correlates with the sensitivity of screening in gynecologic cytology is not known.The sensitivity of gynecologic cytology screening was measured over an 8-month period using the result of full screening coupled with the results of rapid prescreening. Sensitivity results were then correlated with daily workload volumes and the experience level of individual cytotechnologists.Rapid prescreening had an average sensitivity of 41.9% for atypical squamous cells of undetermined significance (ASCUS) and above. Full sc...
Source: Cancer Cytopathology - April 16, 2008 Category: Pathology Authors: Majorie Deschenes, Andrew A. Renshaw, Manon Auger Source Type: journals

Thyroid fine-needle aspiration samples inadequate for reverse transcriptase-polymerase chain reaction analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Analysis of different tumor markers by reverse transcriptase-polymerase chain reaction (RT-PCR) in fine-needle aspiration samples of thyroid nodules has been studied with the objective of improving the accuracy of the preoperative diagnosis of thyroid lesions. The aim of the current study was to investigate thyroid fine-needle aspiration samples inadequate for RT-PCR analysis and to determine whether there is a correlation between their proportion and the method of sampling used or the greatest dimension of the nodules.A total of 350 fine-needle aspiration samples from patients with thyroid nodules were analyzed. After the...
Source: Cancer Cytopathology - April 11, 2008 Category: Pathology Authors: Ivan Samija, Neven Matesa, Josip Lukac, Zvonko Kusic Source Type: journals

Fine-needle aspiration biopsy of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - March 8, 2008 Category: Pathology Authors: Miguel A. Sanchez, Rosalyn E. Stahl Source Type: journals

N-glycoprotein profiling of lung adenocarcinoma pleural effusions by shotgun proteomicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, reduction of sample complexity by N-GP capturing allows detection of proteins in the [mu]g to ng/mL range. Pleural effusion is a useful source for biomarker research in lung cancer. Cancer (Cancer Cytopathol) 2008. © 2008 American Cancer Society.
Source: Cancer Cytopathology - March 7, 2008 Category: Pathology Authors: Alex Soltermann, Reto Ossola, Sandra Kilgus-Hawelski, Arnold von Eckardstein, Tobias Suter, Ruedi Aebersold, Holger Moch Source Type: journals

9p21 Deletion in the diagnosis of malignant mesothelioma in serous effusions additional to immunocytochemistry, DNA-ICM, and AgNOR analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The diagnosis of malignant mesothelioma (MM) in serous effusions is difficult but may be achieved by the application of adjuvant methods.The authors cytologically diagnosed 33 effusions as suspicious or positive for MM cells by using DNA-image cytometry (DNA-ICM), immunocytochemistry and AgNOR analysis. The authors further detected 9p21 deletions by chromosomal fluorescence in situ hybridization (FISH). In addition, 31 cases of metastatic carcinomas and 39 of tumor cell-negative effusions were investigated. All diagnoses were confirmed by histologic and/or clinical follow-up.DNA aneuploidy was found in 71% of MMs, 100% of ...
Source: Cancer Cytopathology - February 28, 2008 Category: Pathology Authors: Fabiana Botelho de Miranda Onofre, Alexandre Sherlley Casimiro Onofre, Natalia Pomjanski, Birgit Buckstegge, Hans Juergen Grote, Alfred Böcking Source Type: journals

Is there still a role for fine-needle aspiration cytology in breast cancer screening?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fine-needle aspiration cytology (FNAC) has been extensively used for many years in the diagnosis of breast lesions, but its use has gradually been reduced in many screening programs because of its controversial inadequate rate and suboptimal accuracy. In the current study, the authors present the quality performance results of FNAC in the Verona screening program, in which an integrated radiopathologic, real-time assessment of suspicious lesions is operative.All cytohistologic assessments during screening at the Verona center were performed in real time by specialized pathologists and radiologists. FNAC activity performanc...
Source: Cancer Cytopathology - February 27, 2008 Category: Pathology Authors: Erminia Manfrin, Renata Mariotto, Andrea Remo, Daniela Reghellin, Daniela Dalfior, Francesca Falsirollo, Franco Bonetti Source Type: journals

Lower HER-2/chromosome enumeration probe 17 ratio in cytologic HER-2 fluorescence in situ hybridization for breast cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to elucidate the usefulness of cytologic specimens for HER-2 FISH testing.Histologic and cytologic specimens from 32 patients with invasive ductal carcinoma of the breast were subjected to comparative analysis of HER-2 status by FISH. FISH was performed by using a PathVysion HER-2 DNA Probe Kit according the manufacturer's instructions. The signal ratios of chromosome enumeration probe 17 (CEP17) and HER-2 were estimated and compared. In 15 cytologic specimens, the distance between signals (HER-2 and CEP17) and the nearest nuclear membrane were measured by using 3-dimensional image analysis ...
Source: Cancer Cytopathology - February 27, 2008 Category: Pathology Authors: Hitoshi Itoh, Yoko Miyajima, Shinobu Umemura, Robert Y. Osamura Source Type: journals

Immunochemical analysis of HPV L1 capsid protein and p16 protein in liquid-based cytology samples from uterine cervical lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HPV L1 capsid protein is expressed together with the production of infectious viral particles, but its expression and relation to p16 expression, which has been a surrogate marker for human papilloma virus (HPV) infection in cervix, are little studied in cytology samples. The authors aimed to elucidate the relation between L1 capsid protein and p16 protein expressions in liquid-based samples from uterine cervical lesions.Immunochemical analyses using antibodies against L1 capsid protein and p16 protein were carried out on cytological materials obtained from uterine cervical lesions of low-grade squamous intraepithelial les...
Source: Cancer Cytopathology - February 26, 2008 Category: Pathology Authors: Tomomi Yoshida, Takaaki Sano, Tatsuya Kanuma, Nobuo Owada, Shinji Sakurai, Toshio Fukuda, Takashi Nakajima Source Type: journals

Detection of human papillomavirus-related squamous cell carcinoma cytologically and by in situ hybridization in fine-needle aspiration biopsies of cervical metastasis: A tool for identifying the site of an occult head and neck primaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the authors explored the value of identifying HPV-related tumors in neck metastases to determine the origin of occult primary head and neck squamous cell carcinoma (HNSCC).Thirty FNA biopsies of neck metastases from patients with HNSCC were recovered from the authors' files from 2004 to 2005. The primary sites included 13 oropharynx, 13 oral cavity, and 4 larynx/hypopharynx. All patients had corresponding tissue samples from the neck mass and the primary carcinoma. The FNA specimens and corresponding tissue samples were classified as either nonkeratinizing SCC (NKSCC) or keratinizing SCC (KSCC). In situ hybr...
Source: Cancer Cytopathology - February 25, 2008 Category: Pathology Authors: Megan Q. Zhang, Samir K. El-Mofty, Rosa M. Dávila Source Type: journals

Cytologic diagnosis of lobular carcinoma of the breast: Experience with 555 patients in the Rene Huguenin Cancer CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the authors evaluated their team's performance in cytologic diagnosis of lobular carcinoma over 11 years and analyzed the reasons for diagnostic failure.Cytologic findings were analyzed in 555 consecutive fine-needle cytopuncture specimens from women with palpable, invasive lobular carcinoma of the breast. The authors also examined the influence of the cytologist's experience, the clinical tumor size, the histologic subtype, and the histologic grade on diagnostic performance. All negative samples were re-examined, along with all samples that had been obtained during the last year of the study, to refine the ...
Source: Cancer Cytopathology - February 25, 2008 Category: Pathology Authors: Emmanuelle Menet, Véronique Becette, Marianne Briffod Source Type: journals

The National Cancer Institute Thyroid Fine-Needle Aspiration State-of-the-Science Conference: Inspiration for a uniform terminology linked to management guidelinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract.
Source: Cancer Cytopathology - February 25, 2008 Category: Pathology Authors: Edmund S. Cibas, Miguel A. Sanchez Source Type: journals