Left in the dark at the end of life
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 14, 2018 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research

Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 14, 2018 Category: Pathology Tags: Issue Information Source Type: research

Our 2017 Cancer Cytopathology Young Investigator
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 16, 2018 Category: Pathology Authors: Celeste N. Powers Tags: A Note from the Editor Source Type: research

Bracing for disaster
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 16, 2018 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research

Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 16, 2018 Category: Pathology Tags: Issue Information Source Type: research

Well differentiated grade 3 pancreatic neuroendocrine tumors compared with related neoplasms: A morphologic study
CONCLUSIONSThe prevalence of cytologic features differs in WD grade 3 pancreatic neuroendocrine neoplasms compared with grade 2 neoplasms and NECs, and these differences assist in the recognition of this newly classified entity. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 16, 2018 Category: Pathology Authors: Carlie S. Sigel, Vitor Werneck Krauss Silva, Michelle D. Reid, David Chhieng, Olca Basturk, Keith M. Sigel, Tanisha D. Daniel, David S. Klimstra, Laura H. Tang Tags: Original Article Source Type: research

Reply to FNA biopsy in grading pancreatic neuroendocrine tumors: Methodological issues regarding diagnostic value
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 12, 2018 Category: Pathology Authors: Xiaofei Wang Tags: Correspondence Source Type: research

Cytologic ‐histologic correlation of programmed death‐ligand 1 immunohistochemistry in lung carcinomas
CONCLUSIONSTumor PD‐L1 IHC positivity in cytology specimens appears to correlate strongly with results obtained from matching surgical specimens. PD‐L1 IHC in ICs within cytology specimens does not reflect results in matched surgical specimens and should not be used in clinical decision making. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 5, 2018 Category: Pathology Authors: Eleanor Russell ‐Goldman, Sasha Kravets, Suzanne E. Dahlberg, Lynette M. Sholl, Marina Vivero Tags: Original Article Source Type: research

Programmed death ligand 1 testing in non –small cell lung carcinoma cytology cell block and aspirate smear preparations
CONCLUSIONSThe results show that NSCLC cytology samples evaluated for PD‐L1 have high concordance with paired core‐needle biopsy samples and can be used for assessing PD‐L1 expression. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 1, 2018 Category: Pathology Authors: Bryce Noll, Wei ‐Lien Wang, Yun Gong, Jun Zhao, Neda Kalhor, Victor Prieto, Gregg Staerkel, Sinchita Roy‐Chowdhuri Tags: Original Article Source Type: research

Different qualifiers of AUS/FLUS thyroid FNA have distinct BRAF, RAS, RET/PTC, and PAX8/PPARg alterations
CONCLUSIONSBRAF and RAS mutations are associated with different AUS/FLUS qualifiers and hence have different risks of malignancy. Consequently, a hybrid molecular and morphological subcategorization system could improve the malignancy risk stratification of thyroid FNA samples diagnosed as AUS/FLUS. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 1, 2018 Category: Pathology Authors: Claudio Bellevicine, Roberta Sgariglia, Ilaria Migliatico, Elena Vigliar, Melania D'Anna, Maria Antonia Nacchio, Nicola Serra, Umberto Malapelle, Massimo Bongiovanni, Giancarlo Troncone Tags: Original Article Source Type: research

Detection of ROS1 ‐positive non‐small cell lung cancer on cytological specimens using immunocytochemistry
CONCLUSIONSROS1 ICC is an accurate method for the detection of ROS1 rearrangements in NSCLC. Given the high costs and technical challenges of FISH and the rarity of ROS1 rearrangements, ICC is rapid and therefore well suited as a screening method. Cases with equivocal or positive findings on ICC can be confirmed by FISH or molecular tests. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 1, 2018 Category: Pathology Authors: Tatjana Vlajnic, Spasenija Savic, Audrey Barascud, Betty Baschiera, Michel Bihl, Bruno Grilli, Michelle Herzog, Julien Rebetez, Lukas Bubendorf Tags: Original Article Source Type: research

All ‐in‐one: The dream and reality of molecular cytopathology testing on routine lung cancer smears
If cytopathologists are used to dedicating 1 or more fine‐needle aspiration passes to prepare a tumor‐representative cell block, the testing laboratory may strongly rely on anaplastic lymphoma kinase (ALK), ROS proto‐oncogene 1, receptor tyrosine kinase (ROS1), and programmed death‐ligand 1 (PD‐L1) immunocytochemistry assays. Conversely, when sample procurement and diagnostic interpretation are based primarily on smeared material, cytopathologists should promote, in conjunction with the molecular team, ALK and ROS1 RNA‐based testing approaches on smears, saving the cell block only for PD‐L1 staining. See also...
Source: Cancer Cytopathology - January 24, 2018 Category: Pathology Authors: Giancarlo Troncone Tags: Editorial Source Type: research

Expression of microRNAs in the ascites of patients with peritoneal carcinomatosis and peritonitis
CONCLUSIONSThe data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA‐based molecular approach for the differential diagnosis of PCA. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 23, 2018 Category: Pathology Authors: Philipp Schindler, Juozas Kupcinskas, Simonas Juzenas, Jurgita Skieceviciene, Violeta Salteniene, Christian Schulz, Jochen Weigt, Peter Malfertheiner, Alexander Link Tags: Original Article Source Type: research

The risk of malignancy of atypical urothelial cells of undetermined significance in patients treated with chemohyperthermia or electromotive drug administration
CONCLUSIONSIn the urine samples from patients treated with EMDA/MMC or C‐HT/MMC, a diagnosis of SHGUC could be made even on degenerated urothelial cells when considering cellular degeneration as a “physiological” consequence of the treatment that involves either normal or neoplastic cells. Cancer (Cancer Cytopathol) 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 23, 2018 Category: Pathology Authors: Francesco Pierconti, Esther Diana Rossi, Patrizia Straccia, Guido Fadda, Luigi Maria Larocca, Pier Francesco Bassi, Emilio Sacco, Giovanni Schinzari Tags: Original Article Source Type: research

When words matter: A “suspicious” urinary tract cytology diagnosis improves patient follow‐up among nonurologists
CONCLUSIONSUse of the word “suspicious” for the high‐risk indeterminate category results in greater follow‐up among nonurologists ordering UTC specimens. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 23, 2018 Category: Pathology Authors: J. Judd Fite, Dorothy L. Rosenthal, Christopher J. VandenBussche Tags: Original Article Source Type: research