TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia [Research Articles]
This article is highlighted in the In This Issue feature, p. 1201 (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Lobbardi, R., Pinder, J., Martinez-Pastor, B., Theodorou, M., Blackburn, J. S., Abraham, B. J., Namiki, Y., Mansour, M., Abdelfattah, N. S., Molodtsov, A., Alexe, G., Toiber, D., de Waard, M., Jain, E., Boukhali, M., Lion, M., Bhere, D., Shah, K., Gutierr Tags: Research Articles Source Type: research
Notch Shapes the Innate Immunophenotype in Breast Cancer [Research Articles]
This article is highlighted in the In This Issue feature, p. 1201 (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Shen, Q., Cohen, B., Zheng, W., Rahbar, R., Martin, B., Murakami, K., Lamorte, S., Thompson, P., Berman, H., Zuniga-Pflücker, J. C., Ohashi, P. S., Reedijk, M. Tags: Research Articles Source Type: research
Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models [Research Articles]
This article is highlighted in the In This Issue feature, p. 1201 (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Mata, M., Gerken, C., Nguyen, P., Krenciute, G., Spencer, D. M., Gottschalk, S. Tags: Research Articles Source Type: research
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma [Research Articles]
This article is highlighted in the In This Issue feature, p. 1201 (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Yao, X., Tan, J., Lim, K. J., Koh, J., Ooi, W. F., Li, Z., Huang, D., Xing, M., Chan, Y. S., Qu, J. Z., Tay, S. T., Wijaya, G., Lam, Y. N., Hong, J. H., Lee-Lim, A. P., Guan, P., Ng, M. S. W., He, C. Z., Lin, J. S., Nandi, T., Qamra, A., Xu, C., Myint, S. Tags: Research Articles Source Type: research
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles [Research Articles]
This study identifies chemical features of dimeric compounds that increase their lysosomal specificity, and a new molecular target for these compounds, reclassifying these compounds as targeted therapies. Targeting PPT1 blocks mTOR signaling in a manner distinct from catalytic inhibitors, while concurrently inhibiting autophagy, thereby providing a new strategy for cancer therapy. Cancer Discov; 7(11); 1266–83. ©2017 AACR.
See related commentary by Towers and Thorburn, p. 1218.
This article is highlighted in the In This Issue feature, p. 1201 (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Rebecca, V. W., Nicastri, M. C., McLaughlin, N., Fennelly, C., McAfee, Q., Ronghe, A., Nofal, M., Lim, C.-Y., Witze, E., Chude, C. I., Zhang, G., Alicea, G. M., Piao, S., Murugan, S., Ojha, R., Levi, S. M., Wei, Z., Barber-Rotenberg, J. S., Murphy, M. E., Tags: Research Articles Source Type: research
Recurrent Tumor Cell-Intrinsic and -Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation [Research Articles]
This article is highlighted in the In This Issue feature, p. 1201 (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Song, C., Piva, M., Sun, L., Hong, A., Moriceau, G., Kong, X., Zhang, H., Lomeli, S., Qian, J., Yu, C. C., Damoiseaux, R., Kelley, M. C., Dahlman, K. B., Scumpia, P. O., Sosman, J. A., Johnson, D. B., Ribas, A., Hugo, W., Lo, R. S. Tags: Research Articles Source Type: research
Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells [Research Brief]
This article is highlighted in the In This Issue feature, p. 1201 (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Shum, T., Omer, B., Tashiro, H., Kruse, R. L., Wagner, D. L., Parikh, K., Yi, Z., Sauer, T., Liu, D., Parihar, R., Castillo, P., Liu, H., Brenner, M. K., Metelitsa, L. S., Gottschalk, S., Rooney, C. M. Tags: Research Brief Source Type: research
Tissue Force Programs Cell Fate and Tumor Aggression [Review]
Biomechanical and biochemical cues within a tissue collaborate across length scales to direct cell fate during development and are critical for the maintenance of tissue homeostasis. Loss of tensional homeostasis in a tissue not only accompanies malignancy but may also contribute to oncogenic transformation. High mechanical stress in solid tumors can impede drug delivery and may additionally drive tumor progression and promote metastasis. Mechanistically, biomechanical forces can drive tumor aggression by inducing a mesenchymal-like switch in transformed cells so that they attain tumor-initiating or stem-like cell properti...
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Northey, J. J., Przybyla, L., Weaver, V. M. Tags: Review Source Type: research
Insights into Epigenetic Remodeling in VHL-Deficient Clear Cell Renal Cell Carcinoma [In the Spotlight]
Summary: Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the von Hippel–Lindau tumor suppressor gene (VHL), and the functional tumorigenic consequences of this loss have been used to develop therapies for advanced ccRCC, such as targeting activation of the HIF pathway. Yao and colleagues elucidate how VHL loss contributes to chromatin alteration at both gene promoters and enhancers/superenhancers, in both an HIF-dependent as well as independent manner, and how this may provide additional targets for therapeutic intervention in advanced ccRCC. Cancer Discov; 7(11); 1221–3. ©2017 AACR.
Se...
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Ricketts, C. J., Linehan, W. M. Tags: In the Spotlight Source Type: research
Targeting the Lysosome for Cancer Therapy [In the Spotlight]
Summary: Lysosomes are the recycling centers of the cell where organelles and proteins are degraded during autophagy and macropinocytosis; they also serve as signaling hubs that control the activity of mTORC1. In this issue, Rebecca and colleagues report the development of a new type of lysosomal inhibitor for cancer therapy that can inhibit multiple lysosomal activities that are needed for tumor cell survival and growth. Cancer Discov; 7(11); 1218–20. ©2017 AACR.
See related article by Rebecca et al., p. 1266. (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Towers, C. G., Thorburn, A. Tags: In the Spotlight Source Type: research
Trapping Cancers as They Adapt to Survive [In the Spotlight]
Summary: The evolution of cancer cells limits the efficacy of nearly all treatments for patients with solid tumors. Characterizing how cancers adapt to treatment could therefore lead to approaches that overcome resistance to therapy. In this issue of Cancer Discovery, Song and colleagues describe the evolution of melanomas upon exposure to BRAF inhibitors, demonstrating that adaptive changes in the tumor create a vulnerability that can be targeted with immune checkpoint inhibitors. Cancer Discov; 7(11); 1216–7. ©2017 AACR.
See related article by Song et al., p. 1248. (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Authors: Haq, R. Tags: In the Spotlight Source Type: research
Inhibition of p300/CBP Suppresses Castration-Resistant Prostate Cancer [Drug Discovery]
A virtual ligand screen led to generation of A-485, a potent selective p300/CBP catalytic inhibitor. (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Tags: Drug Discovery Source Type: research
Chromosome 1q21.3 Amplification Is Linked to Breast Cancer Recurrence [Breast Cancer]
The 1q21.3 amplification can be detected in cfDNA from most patients with recurrent breast cancer. (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Tags: Breast Cancer Source Type: research
ASF1A Facilitates DNA Double-Strand Break Repair by NHEJ [DNA Repair]
ASF1A promotes NHEJ over homologous recombination for DNA double-strand break (DSB) repair. (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Tags: DNA Repair Source Type: research
PAK Signaling Promotes Acquired Resistance to BRAF and MEK Inhibitors [Drug Resistance]
PAK signaling drives resistance to BRAF inhibition and dual BRAF/MEK inhibition via distinct mechanisms. (Source: Cancer Discovery)
Source: Cancer Discovery - November 1, 2017 Category: Cancer & Oncology Tags: Drug Resistance Source Type: research
