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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cancer Letters)
Source: Cancer Letters - November 6, 2009 Category: Cancer & Oncology Source Type: journals

Control of hepatocellular carcinoma through Hepatitis B vaccination in areas of high endemicity: Perspectives for global liver cancer preventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There are approximately 360 millions chronic carriers of Hepatitis B virus worldwide. Patterns of HB carriage are variable from one region to the other. Regions with rates of carriage over 8% are commonly considered as “high endemicity” regions. HB carriers have a very significant lifetime risk of developing chronic liver diseases such as cirrhosis and/or liver cancer (hepatocellular carcinoma, HCC). An efficient HB vaccine is available since the early eighties and has been used since for universal infant vaccination in regions of high endemicity. Observations from Taiwan, where universal infant vaccination w...
Source: Cancer Letters - October 16, 2009 Category: Cancer & Oncology Authors: Amelie Plymoth, Simonetta Viviani, Pierre Hainaut Tags: Mini-reviews Source Type: journals

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(Source: Cancer Letters)
Source: Cancer Letters - September 28, 2009 Category: Cancer & Oncology Source Type: journals

Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Hepatitis B viruses (HBV) are responsible for over 50% of the worldwide attributable risk of hepatocellular carcinoma (HCC) and this figure increases even further in regions of high endemicity. Systematic sequencing of HBV genomes has identified that this common virus existed as eight distinct genotypes (denoted A–H), each regrouping variants with less than 8% divergence in their DNA sequence. These genotypes differ by their geographic distribution in populations around the globe. There is evidence that HBV genotypes also differ by their pathogenic properties, including their risk of persistence as chronic infe...
Source: Cancer Letters - August 17, 2009 Category: Cancer & Oncology Authors: Flor Helene Pujol, Maria-Cristina Navas, Pierre Hainaut, Isabelle Chemin Tags: Mini-reviews Source Type: journals

Lanthanum citrate induces anoikis of Hela cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Some reports show that lanthanum, a rare earth element, induces apoptosis in certain cancer cells. In the present paper, we report the first observation of anoikis induced by lanthanum citrate (LaCit) in Hela cells at a concentration of 0.001–0.1mmol/L after 48h-treatment. Before cell treatment, Hela cells were subjected to anoikis-resistant selection to remove anoikis-sensitive cells and ensure specificity of LaCit-induced anoikis. Anoikis was determined by Annexin/PI, AO/EB staining, cleavage of PARP and soft-agar colony forming assay. Further, findings of decreased mitochondrial membrane potential, the cleav...
Source: Cancer Letters - August 12, 2009 Category: Cancer & Oncology Authors: Xiange Su, Xiaona Zheng, Jiazuan Ni Tags: Regular Articles Source Type: journals

Novel treatments for hepatocellular cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Hepatocellular cancer (HCC) has always been considered a therapeutic challenge, given the cytoxic drug resistant nature of the cancer and associated disorder in liver function, reducing the safety of many conventional chemotherapy agents. The Multikinase inhibitor sorafenib has been found to prolong survival in patients with advanced HCC, by around 3months compared to placebo, but novel treatments need to be explored. Current experimental therapeutic approaches encompass a broad range of science, ranging from intrahepatic irradiation to virus directed immunotherapy. This chapter presents a horizon scan of novel t...
Source: Cancer Letters - August 7, 2009 Category: Cancer & Oncology Authors: S.H. Kerr, D.J. Kerr Tags: Mini-reviews Source Type: journals

XN05, a novel synthesized microtubule inhibitor, exhibits potent activity against human carcinoma cells in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The present data showed that a novel synthesized compound, N-acetyl-N-(4-(4-methoxyphenyl-3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)acetamide (XN05), exhibited potent antitumor activity against various cancer cells in vitro. XN05-treatment in human hepatocellular carcinoma cells resulted in the accumulation of G2/M phase cells and finally induced apoptosis assessed by flow cytometry analysis. Western blot and immunofluorescence experiments indicated that XN05 depolymerized microtubules similar to the effect of combretastatin-A4. In addition, XN05-treatment influenced the expression of cell cycle and apoptosis relat...
Source: Cancer Letters - August 2, 2009 Category: Cancer & Oncology Authors: Rui Wu, Wanjing Ding, Tao Liu, Hong Zhu, Yongzhou Hu, Bo Yang, Qiaojun He Tags: Regular Articles Source Type: journals

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(Source: Cancer Letters)
Source: Cancer Letters - July 22, 2009 Category: Cancer & Oncology Source Type: journals

Anti-angiogenesis and anti-tumor effects of AdNT4-anginexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Anginex is a novel artificial peptide that can inhibit angiogenesis. AdNT4-anginex was constructed by inserting the artificial anginex gene into a recombinant adenoviral vector. We demonstrated that AdNT4-anginex inhibited migration of human endothelial cells, angiogenesis and tumor growth in in vitro and in vivo studies. Tumor growth of human H22 hepatoma in mice was inhibited after AdNT4-anginex treatment for 4 weeks, and a significant decrease in tumor size was observed as compared with the control group. Overall, these studies indicate that AdNT4-anginex is an effective anti-tumor agent, and deserves more att...
Source: Cancer Letters - June 21, 2009 Category: Cancer & Oncology Authors: Dan Feng Dong, En Xiao Li, Ju Bo Wang, Yin Ying Wu, Fan Shi, Jun Jun Guo, Yuan Wu, Jun Ping Liu, Shan Xi Liu, Guang Xiao Yang Tags: Regular Articles Source Type: journals

Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Many promoter CpG islands (CGIs) are methylated as a consequence of or in association with carcinogenesis (passenger), in addition to being a cause of carcinogenesis (driver). In gastric cancers, promoter 1A of the adenomatous polyposis coli (APC) gene is frequently methylated, and is often discussed as a driver. However, the actual role of 1A methylation is unclear because the same APC protein is coded by two transcripts from two promoters, 1A and 1B, and their relative expression levels in gastric mucosae have not been quantified. To clarify this issue, we first identified detailed transcription start sites of ...
Source: Cancer Letters - June 14, 2009 Category: Cancer & Oncology Authors: Kosuke Hosoya, Satoshi Yamashita, Takayuki Ando, Takeshi Nakajima, Fumio Itoh, Toshikazu Ushijima Tags: Regular Articles Source Type: journals

Molecular pathogenesis and early detection of hepatocellular carcinoma – Perspectives from West AfricaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews mechanisms involved in development of hepatocellular carcinoma and how host and environmental factors interact at a molecular level to cause cancer. These processes are intimately linked with strategies for early detection since molecular intermediates on the carcinogenesis pathway can now be detected with increasing levels of sensitivity. Similarly host factors influencing response to environmental agents, together with substances produced by early cancers, can be assayed in fine detail with new and emerging technologies. These advances in the field of biomarkers may lead to more rapid diagnosis and u...
Source: Cancer Letters - June 12, 2009 Category: Cancer & Oncology Authors: Maimuna Mendy, Robert Walton Tags: Mini-reviews Source Type: journals

Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Doxorubicin (Dox) is a commonly used drug to treat various types of cancers. Previously, we demonstrated that coupling Dox to cell-penetrating peptides (CPPs) represent a valuable strategy to overcome drug resistance in MDA-MB 231 breast cancer cells. In the present study, we evaluated the properties of these Dox conjugates (Dox–CPPs) in terms of apoptosis induction. Dox–CPPs were found to induce apoptotic death in MDA-MB 231 cells at a lower dose than that needed for unconjugated Dox. Cell death induction was associated with Bax oligomerisation, release of cytochrome c, caspase activation, chromatin condensa...
Source: Cancer Letters - June 11, 2009 Category: Cancer & Oncology Authors: Sonia Aroui, Souhir Brahim, Michel De Waard, Jacqueline Bréard, Abderraouf Kenani Tags: Regular Articles Source Type: journals

Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A malfunction of retinoid X receptor-α (RXRα) due to phosphorylation is associated with the development of hepatocellular carcinoma (HCC) and acyclic retinoid (ACR), which targets RXRα, can prevent the development of second primary HCC. Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, induces apoptosis and cell cycle arrest in cancer cells. VPA can also enhance the sensitivity of cancer cells to retinoids. The present study examined the possible combined effects of ACR plus VPA in HepG2 human HCC cell line. The combination of 5μM ACR and 1mM VPA, about the IC25 value for both compounds, synergisti...
Source: Cancer Letters - June 10, 2009 Category: Cancer & Oncology Authors: Hideharu Tatebe, Masahito Shimizu, Yohei Shirakami, Hiroyasu Sakai, Yoichi Yasuda, Hisashi Tsurumi, Hisataka Moriwaki Tags: Regular Articles Source Type: journals

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(Source: Cancer Letters)
Source: Cancer Letters - June 9, 2009 Category: Cancer & Oncology Source Type: journals

Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The role of AFP in the retinoic acid-RAR signaling pathway was investigated in human hepatoma Bel 7402 cells. The results showed that AFP and RAR-β were co-localized and interacted in cytoplasm. AFP may inhibit translocation of RAR-β into the nucleus via competitive binding to RAR-β with ATRA, which was reversed by AFP-siRNA transfection. Our data suggest that the ATRA resistance of Bel 7402 cells is at least in part attributable to their high level of cytoplasmic AFP. Thus, by counteracting the effect of AFP, it may be possible to increase the sensitivity of tumor cells to ATRA. (Source: Cancer Letters)
Source: Cancer Letters - June 7, 2009 Category: Cancer & Oncology Authors: Mengsen Li, Hui Li, Chaoying Li, Liyuan Guo, Han Liu, Sheng Zhou, Xinhua Liu, Zhuo Chen, Shuanglin Shi, Jiang Wei, Michael A. McNutt, Gang Li Tags: Regular Articles Source Type: journals

Lebectin increases N-cadherin-mediated adhesion through PI3K/AKT pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Cell adhesion molecules, including cadherins and integrins, play an essential role during tumor progression and represent potential targets for the development of new therapeutic agents. We previously showed that lebectin, a C-type lectin protein (CLP) issued from Macrovipera lebectina snake venom, inhibits integrin-mediated migration of IGR39 melanoma cells. Here we assessed whether lebectin modulates cell–cell adhesion. We demonstrated that lebectin promotes N-cadherin/catenin complex reorganization at cell–cell contacts, inducing a strengthening of intercellular adhesion. This reorganization is associated ...
Source: Cancer Letters - June 7, 2009 Category: Cancer & Oncology Authors: Sameh Sarray, Carole Siret, Maxime Lehmann, Naziha Marrakchi, José Luis, Mohamed El Ayeb, Frédéric André Tags: Regular Articles Source Type: journals

Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Although T Central Memory cells have been described as the most effective T-cell subtype against tumor growth, little is known about the requirements needed for their optimal ex vivo generation. Hence, our goal is to establish a protocol that will lead to consistent ex vivo generation of lymphocytes skewed toward a Central Memory phenotype. Antigen-specific T-cell lines were generated by ex vivo stimulation with Class-I and Class-II melanoma peptide pulsed Dendritic Cells in the presence of either IL-2 or IL-15 plus IL-21. Tumor specific lymphocytes of both Central Memory and effector characteristics were consist...
Source: Cancer Letters - June 7, 2009 Category: Cancer & Oncology Authors: Eduardo Huarte, Jan Fisher, Mary Jo Turk, Diane Mellinger, Cathy Foster, Benita Wolf, Kenneth R. Meehan, Camilo E. Fadul, Marc S. Ernstoff Tags: Regular Articles Source Type: journals

Cancer Letters Special Issue Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cancer Letters)
Source: Cancer Letters - June 4, 2009 Category: Cancer & Oncology Tags: Foreward Source Type: journals

Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We analysed the expression of BIRC5 and BIRC5-2B in primary neuroblastoma (NB) tumors and NB model systems. In tumors, overexpression of BIRC5 correlated closely with its isoform BIRC5-2B. Expression of both transcripts was stage-dependent, associated with poor prognosis and with the expression of the transcription factor E2F1. In cell culture, we identified BIRC5 as a direct transcriptional target of activating E2Fs, primarily when p21Cip1 and p27Kip1, two other E2F1 targets, are strongly suppressed. Deregulated MYCN indirectly induces BIRC5 through suppression of CDKN1A/p21Cip1 and induction of Skp2, which in t...
Source: Cancer Letters - June 3, 2009 Category: Cancer & Oncology Authors: Isabella Eckerle, Daniel Muth, Julia Batzler, Kai-Oliver Henrich, Werner Lutz, Matthias Fischer, Olaf Witt, Manfred Schwab, Frank Westermann Tags: Regular Articles Source Type: journals

Activin is a potent growth suppressor of epithelial ovarian cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Although activin is a major cytokine produced by the ovary, its role in epithelial ovarian cancer is poorly defined. Here, we demonstrate a novel role for activin as a growth inhibitor of some (8/16) epithelial ovarian cancer cell lines. Unresponsive cell lines displayed transcriptional downregulation of the activin receptors ACTRIIA and ACTRIB, suggesting resistance to activin signalling. In response to activin, growth inhibited cell lines demonstrated activation of the canonical SMAD2/3/4, transcriptional induction of the CDK inhibitor p15INK4B, suppression of C-MYC levels and a G1 phase cell cycle arrest. Thus...
Source: Cancer Letters - June 2, 2009 Category: Cancer & Oncology Authors: Anassuya Ramachandran, Elaine S. Marshall, Donald R. Love, Bruce C. Baguley, Andrew N. Shelling Tags: Regular Articles Source Type: journals

Piceatannol, a natural stilbene from grapes, induces G1 cell cycle arrest in androgen-insensitive DU145 human prostate cancer cells via the inhibition of CDK activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We have examined whether and by what mechanism piceatannol inhibits cell cycle progression in DU145 cells. The treatment of cells with piceatannol for 24h resulted in an increase in the percentage of cells in G1 phase and dose-dependent decreases in [3H]thymidine incorporation, as well as in protein levels of cyclin A, cyclin D1, and cyclin-dependent kinase (CDK)2 and CDK4. Piceatannol exerted no effect on the levels of p21WAF1/CIP1 or p27KIP1. Piceatannol reduced CDK4 and CDK2 activity. These results indicate that delaying G1 cell cycle progression contributes to the piceatannol-mediated inhibition of DU145 cell...
Source: Cancer Letters - May 31, 2009 Category: Cancer & Oncology Authors: Yeo Myeong Lee, Do Young Lim, Han Jin Cho, Mi Ra Seon, Jin-Kyung Kim, Boo-Yong Lee, Jung Han Yoon Park Tags: Regular Articles Source Type: journals

Interacting with HBsAg compromises resistance of jumping translocation breakpoint protein to ultraviolet radiation-induced apoptosis in 293FT cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Jumping translocation breakpoint protein (JTB) is suppressed in many cancers, implying it plays a role in the neoplastic transformation of cells. In order to explore the role of JTB in the carcinogenesis of liver, we used mammalian two-hybrid, co-immunoprecipitation, GST pull-down and laser scanning confocal to verify the interaction between HBs and JTB. According to the results, HBs interacts with JTB. In addition, we further determined that S region within HBs is sufficient for binding JTB. Overexpression of JTB conferred resistance to apoptosis induced by ultraviolet radiation, whereas this effect was compromi...
Source: Cancer Letters - May 31, 2009 Category: Cancer & Oncology Authors: Jin-Shui Pan, Jia-Yan Cai, Chen-Xi Xie, Fei Zhou, Zhi-Ping Zhang, Jing Dong, Hong-Zhi Xu, Hua-Xiu Shi, Jian-Lin Ren Tags: Regular Articles Source Type: journals

Doxycycline inhibits the adhesion and migration of melanoma cells by inhibiting the expression and phosphorylation of focal adhesion kinase (FAK)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Doxycycline has been found to induce apoptosis and to inhibit the growth of a variety of tumor cells, in addition to its use as an antibiotic. However, the mechanism of its actions, especially at the molecular level, remains unknown and needs to be resolved. A crucial step possibly lies in the early period of doxycycline administration, which leads to a series of cascading effects depicting the consequential biological action of doxycycline on tumor cells. The present study focuses on the early-stage effects of doxycycline administration, specifically at the stages of treatment (before 16h). In this paper, we rep...
Source: Cancer Letters - May 31, 2009 Category: Cancer & Oncology Authors: Tao Sun, Nan Zhao, Chun-sheng Ni, Xiu-lan Zhao, Wen-zhi Zhang, Xin Su, Dan-fang Zhang, Qiang Gu, Bao-cun Sun Tags: Regular Articles Source Type: journals

Pro-apoptotic activities of novel synthetic quinones in human cancer cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Four novel quinonoid compounds are evaluated for their apoptotic potential against three cancer cell lines, i.e. MCF-7, HeLa and MG-63. APOPercentage™ assay was used for the screening of the compounds and it was established that the apoptotic potential of these compounds is cell line specific. The compound 2-(1′,4′-benzoquinon-2′-yl)-5-hydroxy-7-methyl-1,4-naphthoquinone (S4) was found to be most active, which has a potential to kill ∼99% of HeLa cancer cells in vitro after 72h at a concentration of 10μM. The compound’s ability to induce specific markers of apoptosis in HeLa cells is further confirme...
Source: Cancer Letters - May 31, 2009 Category: Cancer & Oncology Authors: Sunil Sagar, Ivan R. Green Tags: Regular Articles Source Type: journals

Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Autotaxin, also known as NPP2 (nucleotide pyrophosphatase/phosphodiesterase 2), is a secreted lysophospholipase-D that generates lysophosphatidic acid and thereby promotes the metastatic and invasive properties of tumor cell as well as angiogenesis. We show here that, in mice, NPP2 is cleared from the circulation within minutes and is retained by the liver sinusoidal endothelial cells (LSECs). The binding of NPP2 to isolated LSECs resulted in its degradation and could be competed for with ligands of the scavenger receptor family. Our finding that circulating NPP2 has a rapid turnover has important implications fo...
Source: Cancer Letters - May 31, 2009 Category: Cancer & Oncology Authors: Silvia Jansen, Maria Andries, Katrien Vekemans, Hubert Vanbilloen, Alfons Verbruggen, Mathieu Bollen Tags: Original Articles Source Type: journals

Association between X-ray repair cross complementing group 1 codon 399 and 194 polymorphisms and lung cancer risk: A meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Genetic variations in DNA repair genes are thought to modify DNA repair capacity and suggested to be related to cancer risk. However, epidemiological results have been inconsistent. In this meta-analysis, we assessed reported studies of association between polymorphisms of X-ray repair cross complementing group 1 (XRCC1) codon 399 and 194, and lung cancer risk. We found decreased lung cancer risk among subjects carrying XRCC1 codon 194 Arg/Trp genotype [odds ratio (OR)=0.88, 95% confidence interval (95% CI): 0.79–0.97], using 4848 cases and 6592 controls from 16 studies. There was no association between lung ca...
Source: Cancer Letters - May 28, 2009 Category: Cancer & Oncology Authors: Yadong Wang, Haiyan Yang, Haishan Li, Li Li, Haiyu Wang, Cui’e Liu, Yuxin Zheng Tags: Regular Articles Source Type: journals

E1B-55kD-deleted oncolytic adenovirus armed with canstatin gene yields an enhanced anti-tumor efficacy on pancreatic cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Conditionally-replicating adenovirus (CRAd) therapy is currently being tested against pancreatic cancer and has shown some promise. To improve the efficacy, a novel virus CRAd-Cans was designed by deletion of E1B-55kDa gene for selective replication in tumor cells, as well as carrying a new angiogenesis inhibitor gene, canstatin. CRAd-Cans mediated higher expression of canstatin in BxPC-3 pancreatic cancer cell line compared to the replication-deficient adenovirus Ad5-Cans. The modified CRAd-Cans manifested the same selective replication and cytocidal effects in pancreatic cancer cells as ONYX-015 in vitro, yet s...
Source: Cancer Letters - May 28, 2009 Category: Cancer & Oncology Authors: Xiao-Ping He, Chang-Qing Su, Xing-Hua Wang, Xue Pan, Zhen-Xing Tu, Yang-Fang Gong, Jun Gao, Zhuan Liao, Jing Jin, Hong-Yu Wu, Xiao-Hua Man, Zhao-Shen Li Tags: Regular Articles Source Type: journals

Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21WAF1/CIP1 and proliferating cell nuclear antigenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The present study investigated the role of Calcineurin (CaN) in the proliferation of human colorectal cancers. CaN activity and protein expression were increased in human colorectal cancers. Nuclear transcription factor NFAT, a physiological substrate for CaN, was activated in human colon cancer specimen as well as in the human colon cancer cell lines. CaN inhibitor cyclosporine A (CsA) reduced cell growth in these cell lines. CsA decreased the expressions of c-Myc and the proliferating cell nuclear antigen (PCNA) but also increased p21WAF1/CIP1 expression. Our results suggest that CaN promotes colorectal cancer ...
Source: Cancer Letters - May 28, 2009 Category: Cancer & Oncology Authors: Takashige Masuo, Shinichi Okamura, Yajing Zhang, Masatomo Mori Tags: Regular Articles Source Type: journals

Epstein–Barr virus infection leads to partial phenotypic reversion of terminally differentiated malignant B cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The B cell lymphomas associated with Epstein–Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus–tumor interaction. Here, we investigated the interaction between EBV and terminally differentiated tumor derived B cells, namely multiple myeloma (MM). The in vitro EBV infected MM expressed restricted viral latency. Acquisition of the virus was accompanied by a partial reprogramming to a mature B cell phenotype. Thus, t...
Source: Cancer Letters - May 28, 2009 Category: Cancer & Oncology Authors: Eleni Anastasiadou, Signe Vaeth, Laura Cuomo, Francesco Boccellato, Sara Vincenti, Mara Cirone, Carlo Presutti, Steffen Junker, Gösta Winberg, Luigi Frati, Paul A. Wade, Alberto Faggioni, Pankaj Trivedi Tags: Original Articles Source Type: journals

Angiogenesis inhibitor DC101 delays growth of intracerebral glioblastoma but induces morbidity when combined with irradiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The combination of irradiation with angiogenic inhibition is increasingly being investigated for treatment of glioblastoma multiforme (GBM). We investigated whether vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor DC101 affects morbidity and tumor growth in irradiated and non-irradiated intracerebral GBM-bearing mice, controlled with sham treatments. End-points were toxicity, morbidity and histology. Irradiation either or not combined, reduced tumor size strongly, whereas DC101 mono-treatment reduced tumor size by 64%. Irradiation delayed morbidity from 5.8weeks in sham-treated mice to 10.3weeks....
Source: Cancer Letters - May 26, 2009 Category: Cancer & Oncology Authors: Joost J.C. Verhoeff, Lukas J.A. Stalpers, Cornelis J.F. Van Noorden, Dirk Troost, Marja D. Ramkema, Chris van Bree, Ji-Ying Song, Mila Donker, Martha Chekenya, W. Peter Vandertop, Dick J. Richel, Wouter R. van Furth Tags: Regular Articles Source Type: journals

Antiangiogenic liposomal gene therapy with 16K human prolactin efficiently reduces tumor growthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Human 16K PRL (16K hPRL) is a potent inhibitor of angiogenesis both in vitro and in vivo. It has been shown to prevent tumor growth in three xenograft mouse models. Here we have used a gene transfer method based on cationic liposomes to produce 16K hPRL and demonstrate that 16K hPRL inhibits tumor growth in a subcutaneous B16F10 mouse melanoma model. Computer-assisted image analysis shows that 16K hPRL treatment results in the reduction of tumor vessel length and width, leading to a 57% reduction in average vessel size. We thus show, for the first time, that administration of the 16K hPRL gene complexed to cation...
Source: Cancer Letters - May 26, 2009 Category: Cancer & Oncology Authors: Virginie Kinet, Ngoc-Quynh-Nhu Nguyen, Céline Sabatel, Silvia Blacher, Agnès Noël, Joseph A. Martial, Ingrid Struman Tags: Original Articles Source Type: journals

MAC related mitochondrial pathway in oroxylin A induces apoptosis in human hepatocellular carcinoma HepG2 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Oroxylin A is a flavonoid isolated from the root of Scutellaria baicalensis Georgi. Our previous work demonstrated that the anti-tumor activity of oroxylin A was mainly attributed to its apoptosis inducing effect in cells. The present study explores the exact molecular mechanism of oroxylin A-induced apoptosis in tumor cells. We showed that oroxylin A-induced apoptosis in HepG2 cells was achieved through mitochondrial pathway. We also investigated which mitochondrial channels, PTP or MAC or both, were involved in the permeabilization of the mitochondrial outer membrane after treatment with oroxylin A. The results...
Source: Cancer Letters - May 26, 2009 Category: Cancer & Oncology Authors: Wei Liu, Rong Mu, Fei-Fei Nie, Yong Yang, Jun Wang, Qin-Sheng Dai, Na Lu, Qi Qi, Jing-Jing Rong, Rong Hu, Xiao-Tang Wang, Qi-Dong You, Qing-Long Guo Tags: Original Articles Source Type: journals

A national collection of liver tumours: Lessons learnt from 6 years of biobanking in FranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Eight liver centres in France have joined their effort to collect, preserve and distribute tissue samples from hepatocellular carcinomas, according to the recommendations for Biological Resources Centres (BRC) released by the Organisation for Economic Cooperation and Development (OECD), which were recently implemented in France. This led to the creation of a Liver cancer biobanks network which is recognized by the Ministry of research and the Ministry of health and sponsored by the main research agencies, namely Inserm and INCa. Samples are collected and stored locally, whereas related annotations are remotely co...
Source: Cancer Letters - May 25, 2009 Category: Cancer & Oncology Authors: Bruno Clément, Geneviève Chêne, Françoise Degos Tags: Mini-reviews Source Type: journals

Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: It is well known that matrix metalloproteinases (MMPs) act an important role in the invasion, metastasis and angiogenesis of cancer cells. Agents suppressed the MMPs could inhibited the cancer cells migration and invasion. Numerous evidences had shown that curcumin (the active constituent of the dietary spice turmeric) has potential for the prevention and therapy of cancer. Curcumin can inhibit the formation of tumors in animal models of carcinogenesis and act on a variety of molecular targets involved in cancer development. There is however, no available information to address the effects of curcumin on migratio...
Source: Cancer Letters - May 24, 2009 Category: Cancer & Oncology Authors: Song-Shei Lin, Kuang-Chi Lai, Shu-Chun Hsu, Jai-Sing Yang, Chao-Lin Kuo, Jing-Pin Lin, Yi-Shih Ma, Chih-Chung Wu, Jing-Gung Chung Tags: Regular Articles Source Type: journals

MicroRNAs: Novel regulators in the hallmarks of human cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs of 18–25 nucleotides in length that function as negative regulators. miRNAs post-transcriptionally regulate gene expression by either inhibiting mRNA translation or inducing mRNA degradation, and participate in a wide variety of physiological and pathological cellular processes. Recent reports have revealed that the deregulation of miRNAs correlates with various human cancers and is involved in the initiation and progression of human cancers. miRNAs can act as oncogenes or tumor suppressors to inhibit the expression of cancer-related target genes and to promote or su...
Source: Cancer Letters - May 24, 2009 Category: Cancer & Oncology Authors: Kai Ruan, Xiaoguang Fang, Gaoliang Ouyang Tags: Mini-reviews Source Type: journals

Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpeneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In the Western world, an average of 250mg per day of triterpenes (member of phytosterol family), largely derived from vegetable oils, cereals, fruits and vegetables is consumed by humans. During the last decade, there has been an unprecedented escalation of interest in triterpenes due to their cholesterol-lowering properties and evidence of this phenomenon include at least 25 clinical studies, 20 patents and at least 10 major commercially triterpene-based products currently being sold all around the world. Lupeol a triterpene (also known as Fagarsterol) found in white cabbage, green pepper, strawberry, olive, man...
Source: Cancer Letters - May 24, 2009 Category: Cancer & Oncology Authors: Mohammad Saleem Tags: Mini-reviews Source Type: journals

Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Five lanostane (2, 3, 4, 6 and 8) and three ergostane-type (1, 5 and 7) triterpenes isolated from the fruiting bodies of Antrodia camphorata were evaluated for their in vitro cytotoxic data against various cancer cell types. The three zhankuic acids, 1, 5 and 7 displayed the most potent cytotoxic effect with an IC50 value of 22.3–75.0μM. The compound 3 was selectively cytotoxic in three colon cancer cell lines (HT-29, HCT-116 and SW-480) and a breast cancer model (MDA-MB-231), whereas 8 only showed its cytotoxicity against MDA-MB-231. None of these isolates was toxic to mammary epithelial (MCF10A) and primary ...
Source: Cancer Letters - May 24, 2009 Category: Cancer & Oncology Authors: Chi-Tai Yeh, Yerra Koteswara Rao, Chih-Jung Yao, Chuan-Feng Yeh, Chi-Han Li, Shuang-En Chuang, John H.T. Luong, Gi-Ming Lai, Yew-Min Tzeng Tags: Regular Articles Source Type: journals

Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the efficacy of combination treatments utilizing cytotoxic drugs plus inhibitors to members of the ErbB–ERK signal pathway in human prostate cancer (PCa) LNCaP C-81 cells. Under an androgen-reduced condition, 50nM gemcitabine caused about 40% growth suppression on C-81 cells. Simultaneous treatment of gemcitabine plus 10μM AG825 produced 60% suppression (p (Source: Cancer Letters)
Source: Cancer Letters - May 24, 2009 Category: Cancer & Oncology Authors: Li Zhang, Jeffrey S. Davis, Stanislav Zelivianski, Fen-Fen Lin, Rachel Schutte, Thomas L. Davis, Ralph Hauke, Surinder K. Batra, Ming-Fong Lin Tags: Regular Articles Source Type: journals

Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth and induce caspase-dependent apoptosis concentration-dependently, with dihydrotanshinone being the most potent. All four tanshinones were found to induce ROS generation, but only dihydrotanshinone can induce activation of p38 MAPK. The p38 MAPK activation by dihydrotanshinone was inhibited by N-acetyl ...
Source: Cancer Letters - May 24, 2009 Category: Cancer & Oncology Authors: Wayne Y.W. Lee, Ken W.K. Liu, John H.K. Yeung Tags: Regular Articles Source Type: journals

Hepatitis B virus X gene is implicated in liver carcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Hepatitis B virus (HBV) is a small hepatotropic and highly species-specific enveloped DNA virus. The carcinogenicity of this virus has become focused on the X gene and its coded X protein. The X protein itself is unable to bind to DNA directly, but works as a potent transcriptional activator through multiple cis-acting elements and mediates several signal transduction cascades. Two regions of the X protein, aa.61–69 and aa.105–140, are found essential for the viral replication and expression as well. These functions interacting with transcription factors and signaling cascades are acting cooperatively to caus...
Source: Cancer Letters - May 22, 2009 Category: Cancer & Oncology Authors: Katsuro Koike Tags: Mini-reviews Source Type: journals

Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via β-catenin/TCF7L2 pathway in adult T cell leukemia cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of this study is to evaluate the effect of heat shock protein 90 (Hsp90) inhibition, and to identify molecular pathways responsible for anti-proliferative effect on adult T cell leukemia/lymphoma (ATL) cells. For Hsp90 inhibition, we used geldanamycin derivates, 17-AAG (17-allylamino-17-demethoxygeldanamycin) and 17-DMAG (17-(dimethylaminoethylamino) 17-demethoxygeldanamycin) in this study. The inhibitory concentration (IC50) of 17-AAG in an ATL cell line, designated as TaY, and two HTLV-1 transformed cell lines (MT-2 and MT-4) was 300–700nM, and that of 17-DMAG was 150–200nM. Fresh ATL cells obtained...
Source: Cancer Letters - May 21, 2009 Category: Cancer & Oncology Authors: Ryosuke Kurashina, Junko H. Ohyashiki, Chiaki Kobayashi, Ryoko Hamamura, Yu Zhang, Toshihiko Hirano, Kazuma Ohyashiki Tags: Original Articles Source Type: journals

Methotrexate-induced senescence in human adenocarcinoma cells is accompanied by induction of p21waf1/cip1 expression and lack of polyploidyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Human colorectal adenocarcinoma C85 cells, treated with high dose methotrexate (1μM; IC50=51nM), undergo accelerated senescence, as the cells (i) are growth arrested at the G1 and S phases of the cell cycle, (ii) are SA-β-galactosidase-positive, (iii) show induced expression of p21waf1/cip1 and decreased expression of p16INK4a, and (iv) show DNA synthesis continued at the reduced level. The fraction of C85 cells with DNA content higher than 4N is maintained at the same level (14%) in cells untreated, as well as regrown after the treatment. Multinucleation is found as the main karyotypic abnormality. (Source: Cancer Letters)
Source: Cancer Letters - May 20, 2009 Category: Cancer & Oncology Authors: Magdalena Dabrowska, Grazyna Mosieniak, Janusz Skierski, Ewa Sikora, Wojciech Rode Tags: Original Articles Source Type: journals

Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We investigated the response of human cervix adenocarcinoma HeLa cells to Corosolic acid (CRA) treatment. Our results showed that CRA significantly inhibited cell viability in both a dose- and a time-dependent manner. CRA treatment induced S cell-cycle arrest and caused apoptotic death in HeLa cells. We found that CRA increased in Bax/Bcl-2 ratios by up-regulating Bax expression, disrupted mitochondrial membrane potential and triggered the release of cytochrome c from mitochondria into the cytoplasm. Moreover, CRA treatment triggered the activation of caspase-8, -9 and -3 in HeLa cells. All these results indicate...
Source: Cancer Letters - May 19, 2009 Category: Cancer & Oncology Authors: Yanfeng Xu, Ruiliang Ge, Juan Du, Hailiang Xin, Tingjiao Yi, Jiayu Sheng, Yongzi Wang, Changquan Ling Tags: Original Articles Source Type: journals

Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the mechanism of ATO action on APL-derived NB4 cells and gastric cancer cell lines. ATO decreased the viability of both cell lines, but gastric cancer cells were much less susceptible. ATO-induced G2/M phase arrest and p53 degradation in gastric cancer MGC803 cells. In contrast, ATO-induced apoptosis in NB4 cells without degradation of p53. Both processes were accompanied by transient activation of Akt. The PI3K/Akt inhibitor LY294002 significantly increased the amount of p53 protein and ATO-induced apoptosis in both cell lines and decreased G2/M phase arrest of MGC803 cells. In addition, ATO...
Source: Cancer Letters - May 19, 2009 Category: Cancer & Oncology Authors: Yingchun Li, Xiujuan Qu, Jinglei Qu, Ye Zhang, Jing Liu, Yuee Teng, Xuejun Hu, Kezuo Hou, Yunpeng Liu Tags: Original Articles Source Type: journals

Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, and relevant biological pathways. However, it is difficult to study the biological involvement of NPAS2 in cancer development, as little is known about its direct transcriptional targets. The aim of the current study is to create a transcriptional profile of genes regulated by NPAS2, using a human bin...
Source: Cancer Letters - May 19, 2009 Category: Cancer & Oncology Authors: Chun-Hui Yi, Tongzhang Zheng, Derek Leaderer, Aaron Hoffman, Yong Zhu Tags: Original Articles Source Type: journals

Transcriptome profiling and network pathway analysis of genes associated with invasive phenotype in oral cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of this study was to clarify relevant alterations of gene expression associated with the invasive phenotype of oral cancer. To reduce heterogeneity and to obtain data on genes specifically involved in invasive mechanism, we established a highly invasive ORC subline through in vitro Matrigel invasion method. Affymetrix microarrays were used for transcriptome profiling between parental and the highly invasive subline. Seventy-nine genes were differentially expressed at least 2-fold, including 38 up-regulated and 41 down-regulated. After analyzing the microarray data by MetaCore™ algorithm, a total of 12 r...
Source: Cancer Letters - May 19, 2009 Category: Cancer & Oncology Authors: Chung-Jan Kang, Yin-Ju Chen, Chun-Ta Liao, Hung-Ming Wang, Joseph T. Chang, Chien-Yu Lin, Li-Yu Lee, Tzu-Hao Wang, Tzu-Chen Yen, Chia-Rui Shen, I-How Chen, Ching-Chi Chiu, Ann-Joy Cheng Tags: Original Articles Source Type: journals

Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we showed that via STAT3 signaling, IFN-β suppressed the proliferation, self-renewal, and tumorigenesis of GICs, induced their terminal differentiation to mature oligodendroglia-like cells, and exhibited synergistic cytotoxicity with temozolomide. Therefore, IFN may be a potential therapeutic agent for inducing the terminal differentiation of GICs. (Source: Cancer Letters)
Source: Cancer Letters - May 19, 2009 Category: Cancer & Oncology Authors: Kanako Yuki, Atsushi Natsume, Hidenori Yokoyama, Yutaka Kondo, Masasuke Ohno, Takenori Kato, Phassarin Chansakul, Motokazu Ito, Seung-Up Kim, Toshihiko Wakabayashi Tags: Original Articles Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cancer Letters)
Source: Cancer Letters - May 19, 2009 Category: Cancer & Oncology Source Type: journals